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REG3A Gene

protein-coding   GIFtS: 54

GC02M079296
regenerating islet-derived 3 alpha
(Previous name: pancreatitis-associated protein )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PAP)
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Aliases &
Descriptions
for REG3A

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
HIP 1, 2, 3
INGAP 2
PAP 2, 3
PAP-H 2
PAP1 1, 2, 3
PBCGF 1, 2
REG-III 1, 2
REG3 1, 2
hepatocarcinoma-intestine-pancreas 2
Descriptions
PAP homologous protein 2
Pancreatitis-associated protein 1 3
Reg III-alpha 3
pancreatic beta cell growth factor 2
pancreatitis-associated protein 1, 2
proliferation-inducing protein 34 2
proliferation-inducing protein 42 2
regenerating islet-derived 3 alpha 2
External Ids
HGNC: 86011
Entrez Gene: 50682
UniProtKB: Q061413
Ensembl: ENSG000001720167
Search outside databases for aliases for REG3A gene

Summaries
for REG3A

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for REG3A:
This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or
differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of
this gene is observed during pancreatic inflammation and liver carcinogenesis. Multiple
alternatively spliced transcript variants encoding the same protein have been described for this
gene but the full length nature of some transcripts is not yet known. [provided by RefSeq]

UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141
Function: Might be a stress protein involved in the control of bacterial proliferation

Gene Wiki entry for REG3A

Genomic Location
for REG3A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the REG3A gene  

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p12

REG3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M079296:     (about GC identifiers)

Start:
 79,237,640 bp from pter
End:
 79,240,387 bp from pter
Size:
 2,748 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  

Proteins
for REG3A

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141 (See protein sequence)
Recommended Name: Regenerating islet-derived protein 3 alpha precursor  
Size: 175 amino acids; 19395 Da
Subcellular location: Secreted. Note=Found in the apical region of pancreatic acinar cells
PDB structure from and Proteopedia :
1UV0 (3D)    2GO0 (3D)    

REFSEQ proteins (3 alternative transcripts): 
NP_002571.1  NP_620354.1  NP_620355.1  


ENSEMBL proteins: 
ENSP00000386630 ENSP00000304311 ENSP00000377456 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Reg3a)
Human Recombinant Proteins from Abnova (REG3A)
               OriGene Purified Recombinant Human Proteins (see all 2): REG3A  

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005615 extracellular space TAS8997243
GO:0005625 soluble fraction TAS1325291
GO:0005737 cytoplasm TAS8997243
About this table

Antibodies for REG3A: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for REG3A
R&D Systems Antibodies for REG3A (Reg IIIa)
Antibodies from Abcam (Reg3a), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (REG3A)
Novus Biologicals Antibody for REG3A

Assays for REG3A: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for REG3A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro domains/families:
 IPR018378 C-type_lectin_CS
 IPR016186 C-type_lectin-like
 IPR001304 C-type_lectin
 IPR003990 Pancreatis_ac


   GeneDecks  REG3A for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q06141

ProtoNet protein and cluster: Q06141

1 Blocks protein family: IPB003990 Pancreatitis-associated protein signature

UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141
Similarity: Contains 1 C-type lectin domain

Gene Function
for REG3A

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (REG3A)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (REG3A)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_138937

              Applied Biosystems Silencer® siRNAs for REG3A

              Sigma-Aldrich siRNA for REG3A  
                     Sigma-Aldrich shRNA Panels and shRNA for REG3A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for REG3A
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002580
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002580
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002580 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_002580

UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141
Function: Might be a stress protein involved in the control of bacterial proliferation
Induction: Appears in pancreatic juice after induction of pancreatic inflammation

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005488 binding IEA--
GO:0005529 sugar binding TAS1325291
About this table

Pathways & Interactions
for REG3A

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  REG3A 


5/6 Interacting proteins for REG3A (ENSP000003043113) via UniProtKB, MINT, and/or STRING (see all 6 )
InteractantInteraction Details
GeneCardExternal ID(s)
PDX1ENSP000003704213STRING (score=.951)
NEUROG3ENSP000002424623STRING (score=.937)
ISL1ENSP000002306583STRING (score=.922)
NEUROD1ENSP000002951083STRING (score=.907)
IL6ENSP000002587433STRING (score=.861)
About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006953 acute-phase response IEA--
GO:0006954 inflammatory response IEA--
GO:0007157 heterophilic cell adhesion TAS8997243
GO:0007275 multicellular organismal development TAS8997243
GO:0008283 cell proliferation TAS8997243
About this table

Drugs & Compounds
for REG3A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for REG3A
2 Novoseek chemical compound relationships for REG3A gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
trypsinogen 69.70 3 10325788 (1), 16182665 (1), 15850341 (1)
thymidine 0.00 2 9151782 (1), 9849975 (1)
About this table


Transcripts
for REG3A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (REG3A)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (REG3A)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_138937

              Sigma-Aldrich siRNA for REG3A  
                     Sigma-Aldrich shRNA Panels and shRNA for REG3A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_002580  NM_138937  NM_138938  

REFSEQ mRNAs for REG3A gene (3 alternative transcripts): 

NM_002580.1   NM_138937.1   NM_138938.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_002580  NM_138937  NM_138938  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002580
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002580
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002580 

Additional cDNA sequence: 

AK291973.1 AK311523.1 AK311526.1 AY544128.1 AY544130.1 BC036776.1 D13510.1 M84337.1 
S51768.1 X68641.1 

7 DOTS entries:

DT.97855666  DT.95246610  DT.120944265  DT.100748110  DT.97822561  DT.97855667  DT.95164560 

24/168 AceView cDNA sequences (see all 168 ):

BM769224 BU790202 BM830701 BM830699 BM831062 BU074396 X68641 BM769945 
BM826749 BM769893 BM769304 BQ083397 BM768702 BM770023 BU951923 BM770013 
AI478673 BI324977 BM768845 BM853940 BM825547 BM825512 BM856286 BM768574 

highest scoring ESTs for REG3A:

AU076793 BM765945 BM767032 BM768460 BM768523 BM768574 BM768702 BM768792 BM768845 BM768932 

Unigene Cluster for REG3A:

Regenerating islet-derived 3 alpha
Hs.567312  [show with all ESTs]
Unigene Representative Sequence: NM_138938


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for REG3A

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1:              -           -                           
SP2:                          -                           
SP3:              -                                       

About this scheme

ECgene alternative splicing isoforms for REG3A

3 Ensembl transcripts including schematic representations:
ENST00000409839  ENST00000305165  ENST00000393878  

Expression
for REG3A

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

REG3A expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for REG3A

1 / 2 / 3

5 probe-sets matching REG3A gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
39946_at2, 3 U95-A 2 1.00 0.91 1.00 1.00 L15533 0.20 1.00 0.72 1

205815_at2, 3 U133-A 2 1.00 0.86 -- -- NM_002580 0.60 1.00 0.82 1

234280_at2 U133-B 1 0.91 1.00 -- -- -- -- -- -- --

205815_at2 U133Plus2 2 1.00 0.86 -- -- -- -- -- -- --

234280_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
GeneDecks  REG3A for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGAGAGAAAT

SOURCE GeneReport for Unigene cluster: Hs.567312

UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141
Tissue specificity: Constitutively expressed in intestine. Low expression is found in healthy
pancreas

Orthologs
for REG3A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for REG3A gene from 4 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 REG3A1   -- regenerating islet-derived 3 alpha 99.05(n)
98.29(a)		 459349  XM_001164292.1  XP_001164292.1 
cow
(Bos taurus)		 REG3A1   -- regenerating islet-derived 3 alpha 80.57(n)
70.29(a)		 404114  NM_205787.1  NP_991356.1 
rat
(Rattus norvegicus)		 Reg3g1   -- regenerating islet-derived 3 gamma 75.39(n)
69.19(a)		 24620  NM_173097.1  NP_775120.1 
mouse
(Mus musculus)		 Reg3b5
Reg3g1		 65
 regenerating islet-derived 3 beta5
regenerating islet-derived 3 gamma1		 74.42(n)1
67.44(a)1		 196951  NM_011260.11  NP_035390.11 
 AB0352125  BC0275255  (see all 8)
About this table        Species with no ortholog for REG3A

ENSEMBL Gene Tree for REG3A

Paralogs
for REG3A

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for REG3A gene
REG3G2  REG1B2  REG1A2  

SNPs/Variants
for REG3A

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for REG3A

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 167805

UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141
  • Overexpressed during the acute phase of pancreatitis and in some patients with chronic
    pancreatitis

    • 10/20 Novoseek disease relationships for REG3A gene (see all 20 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute pancreatitis 71.37 42 9026481 (9), 9382059 (5), 8119544 (3), 1469087 (3) (see all 11)
    pancreatitis 67.80 37 9026481 (3), 11396234 (3), 10325788 (2), 7890213 (2) (see all 15)
    pancreatic diseases 53.35 4 12120267 (3), 12757156 (1), 17497124 (1)
    chronic pancreatitis 51.85 5 12757156 (2), 10389686 (1), 19077460 (1), 1469087 (1)
    cystadenoma mucinous 48.72 1 12757156 (1)
    hepatocellular carcinoma 45.20 10 1325291 (2), 17192462 (1), 9520086 (1), 19051257 (1) (see all 7)
    pancreatic cancer 34.04 11 11396234 (4), 12757156 (3), 10389686 (2), 9520086 (1)
    colorectal carcinoma 32.25 19 19051257 (8)
    colorectal tumors 31.59 1 12455032 (1)
    inflammatory bowel diseases 30.58 3 15870231 (2)
    About this table

    Human Genome Epidemiology Navigator: REG3A (1 document)

    Medical News
    for REG3A

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for REG3A

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/97 PubMed articles for REG3A gene (see all 97 ):

    Search for REG3A

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing REG3A

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 5068 HGNC: 8601 AceView: PAP Ensembl:ENSG00000172016 euGenes: HUgn5068
    ECgene: REG3A H-InvDB: REG3A

    Other Databases showing REG3A

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing REG3A

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for REG3A Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_256

    Licensable Technologies
    for REG3A

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for REG3A

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for REG3A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for REG3A Antibodies for REG3A
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for REG3A Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (Reg3a)
     Antibodies (Reg3a)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for REG3A




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for REG3A

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