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PAOX Gene

protein-coding   GIFtS: 54
GCID: GC10P135192

Polyamine Oxidase (Exo-N4-Amino)

  Search for PAOX
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polyamine Oxidase (Exo-N4-Amino)1 2
PAO2 3
Peroxisomal N(1)-Acetyl-Spermine/Spermidine Oxidase2
Peroxisomal N1-Acetyl-Spermine/Spermidine Oxidase2
EC 1.5.3.133
Polyamine Oxidase3

External Ids:    HGNC: 208371   Entrez Gene: 1967432   Ensembl: ENSG000001488327   UniProtKB: Q6QHF93   

Export aliases for PAOX gene to outside databases

Previous GC identifers: GC10P134665 GC10P134666 GC10P135081 GC10P135042 GC10P128736


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PAOX Gene:
PAOX (polyamine oxidase (exo-N4-amino)) is a protein-coding gene. GO annotations related to this gene include spermine:oxygen oxidoreductase (spermidine-forming) activity and receptor binding. An important paralog of this gene is KDM1B.

UniProtKB/Swiss-Prot: PAOX_HUMAN, Q6QHF9
Function: Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in
the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity:
N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine.
Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act
as a determinant of cellular sensitivity to the antitumor polyamine analogs

Gene Wiki entry for PAOX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAOX gene promoter:
         Max1   Max   AP-1   SREBP-1c   ATF-2   c-Jun   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PAOX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

PAOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAOX gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P135192:  view genomic region     (about GC identifiers)

Start:
135,192,695 bp from pter      End:
135,205,198 bp from pter
Size:
12,504 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAOX_HUMAN, Q6QHF9 (See protein sequence)
Recommended Name: Peroxisomal N(1)-acetyl-spermine/spermidine oxidase  
Size: 649 amino acids; 70290 Da
Cofactor: Binds 1 FAD per subunit (By similarity)
Subunit: Monomer (By similarity)
Miscellaneous: Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes
spermine on the endo-side of the N(4)-nitrogen (By similarity)
Secondary accessions: D3DXI6 Q5VWY0 Q6QHF5 Q6QHF6 Q6QHF7 Q6QHF8 Q6QHG0 Q6QHG1 Q6QHG2 Q6QHG3
Q6QHG4 Q6QHG5 Q6QHG6 Q86WP9 Q8N555 Q8NCX3
Alternative splicing: 11 isoforms:  Q6QHF9-1   Q6QHF9-2   Q6QHF9-6   Q6QHF9-5   Q6QHF9-4   Q6QHF9-8   Q6QHF9-3   Q6QHF9-7   
Q6QHF9-9   Q6QHF9-10   Q6QHF9-11   (Ref.2 (AAS64377) sequence differs from that shown due to a frameshift in position 26)

Explore the universe of human proteins at neXtProt for PAOX: NX_Q6QHF9

Explore proteomics data for PAOX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PAOX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_690875.1  NP_997010.1  NP_997011.1  

    ENSEMBL proteins: 
     ENSP00000278060   ENSP00000349847   ENSP00000348654   ENSP00000434550   ENSP00000432737  
     ENSP00000432517   ENSP00000435514   ENSP00000357527  
    Reactome Protein details: Q6QHF9

    PAOX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Cloud-Clone Corp. Proteins for PAOX

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry Q6QHF9

    ProtoNet protein and cluster: Q6QHF9

    UniProtKB/Swiss-Prot: PAOX_HUMAN, Q6QHF9
    Similarity: Belongs to the flavin monoamine oxidase family


    Find genes that share domains with PAOX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAOX_HUMAN, Q6QHF9
    Function: Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in
    the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity:
    N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine.
    Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act
    as a determinant of cellular sensitivity to the antitumor polyamine analogs
    Catalytic activity: N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2)
    Catalytic activity: N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2)
    Catalytic activity: N(1),N(12)-diacetylspermine + O(2) + H(2)O = N(1)-acetylspermidine + 3-acetamidobutanal +
    H(2)O(2)
    Induction: By polyamine analogs

         Enzyme Number (IUBMB): EC 1.5.3.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0016491oxidoreductase activity ----
    GO:0046592polyamine oxidase activity IDA12477380
    GO:0052899N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity IEA--
    GO:0052901spermine:oxygen oxidoreductase (spermidine-forming) activity IEA--
         
    Find genes that share ontologies with PAOX           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PAOX:
     Decreased influenza A/WSN/33 r  Increased cell number in S and 

         1 MGI phenotypic allele for Paox (no phenotypes)

    Find genes that share phenotypes with PAOX           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAOX
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAOX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAOX

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAOX_HUMAN, Q6QHF9: Peroxisome (By similarity). Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome4
    extracellular2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005782peroxisomal matrix TAS--

    Find genes that share ontologies with PAOX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAOX About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Interconversion of polyamines0.00
    Metabolism of polyamines0.00
    Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs0.00
    2Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Amine Oxidase reactions0.00
    3Biological oxidations
    Biological oxidations0.56
    4Metabolism
    Metabolism0.38
    5spermine and spermidine degradation I
    spermine and spermidine degradation I


    Find genes that share SuperPaths with PAOX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PAOX
        spermine and spermidine degradation I

    2 Reactome Pathways for PAOX
        Interconversion of polyamines
    Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs


    1 Kegg Pathway  (Kegg details for PAOX):
        Peroxisome

    UniProtKB/Swiss-Prot: PAOX_HUMAN, Q6QHF9
    Pathway: Amine and polyamine metabolism; spermine metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PAOX
    Interactions:

        Search GeneGlobe Interaction Network for PAOX

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PAOX (ENSP000002780604) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    METTL11BENSP000004080584STRING: ENSP00000408058
    NTMT1ENSP000003615584STRING: ENSP00000361558
    SRMENSP000003661564STRING: ENSP00000366156
    UMPSENSP000002326074STRING: ENSP00000232607
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006595polyamine metabolic process TAS--
    GO:0006596polyamine biosynthetic process TAS--
    GO:0006598polyamine catabolic process IDA12477380
    GO:0006805xenobiotic metabolic process TAS--
    GO:0009446putrescine biosynthetic process IDA16354669

    Find genes that share ontologies with PAOX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PAOX available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FebuxostatXanthine oxidase inhibitor[144060-53-7]
    680C91 Potent and selective inhibitor of tryptophan 2,3-dioxygenase [163239-22-3]
    MDL 72527Polyamine oxidase (PAO) inhibitor[93565-01-6]

    8 HMDB Compounds for PAOX    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetamidopropanal3-acetamidopropanal;3AAP ----
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    IronArmco iron (see all 19)7439-89-6--
    N1-Acetylspermidine1-N-Acetylspermidine (see all 7)14278-49-0--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    6 Novoseek inferred chemical compound relationships for PAOX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n1-acetylspermine 95 4 12477380 (2), 1510731 (1), 16820885 (1)
    n1-acetylspermidine 89.8 4 1747102 (2), 16820885 (1)
    putrescine 80.8 13 1747102 (2), 12022477 (1), 12141946 (1), 9879934 (1) (see all 6)
    spermidine 79.6 12 12141946 (2), 12477380 (2), 12022477 (1), 1747102 (1) (see all 5)
    spermine 78.5 12 12141946 (5), 12477380 (2), 12022477 (1), 1747102 (1)
    amine 49.4 2 12477380 (1), 12006544 (1)



    Find genes that share compounds with PAOX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PAOX gene (6 alternative transcripts): 
    NM_207125.1  NM_207126.1  NM_207129.1  NM_152911.3  NM_207127.2  NM_207128.2  

    Unigene Cluster for PAOX:

    Polyamine oxidase (exo-N4-amino)
    Hs.501578  [show with all ESTs]
    Unigene Representative Sequence: AK095872
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278060(uc001lmv.3 uc001lmx.3 uc001lmy.3 uc001lmz.3 uc001lna.3 uc001lnb.3 uc001lnc.3 uc001lmw.3)
    ENST00000357296 ENST00000356306 ENST00000483211 ENST00000476834 ENST00000529585
    ENST00000480071 ENST00000368535 ENST00000528127 ENST00000530555 ENST00000368539

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    GenScript: all cDNA clones in your preferred vector (see all 3): PAOX (NM_152911)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAOX
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      QuantiTect SYBR Green Assays in human, mouse, rat PAOX
      QuantiFast Probe-based Assays in human, mouse, rat PAOX

    Additional mRNA sequence: 

    AF226657.1 AF312698.1 AK095872.1 AK125012.1 AK128001.1 AK292515.1 AK293988.1 AK308997.1 
    AL834535.1 AY358418.1 AY541515.1 AY541516.1 AY541519.1 AY541521.1 AY541522.1 AY541523.1 
    BC000920.2 BC004409.1 BC026039.1 BC026725.1 BC032778.1 BC035721.1 

    Selected DOTS entries (see all 37):

    DT.446844  DT.214143  DT.417386  DT.100811551  DT.102833677  DT.87016111  DT.100811548  DT.100811544 
    DT.102833675  DT.100720809  DT.109218  DT.101984656  DT.100811543  DT.101982018  DT.100811549  DT.102833679 
    DT.91967323  DT.95225971  DT.121234209  DT.100037112  DT.100777453  DT.102833674  DT.121234202  DT.91707724 

    Selected AceView cDNA sequences (see all 327):

    AA749407 BU849806 CR616123 BU737672 NM_152911 AK095872 CR606966 NM_207127 
    BQ919866 NM_207128 BQ709341 AA351036 AA404221 BC035721 AI682389 BM714035 
    CR594830 AI973043 NM_207125 BF057699 AA393552 CR592090 CF272242 BQ708770 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PAOX (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f
    SP1:                    -                       -                                         -     -     -                                       
    SP2:                    -                       -                                         -     -     -                                       
    SP3:                    -     -     -                                                     -     -     -                                       
    SP4:                    -                       -     -                                   -     -     -                                       
    SP5:                                            -                                         -     -     -                                       


    ECgene alternative splicing isoforms for PAOX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PAOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACTCTGT
    PAOX Expression
    About this image


    PAOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Testis (Reproductive System)
    PAOX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAOX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501578

    UniProtKB/Swiss-Prot: PAOX_HUMAN, Q6QHF9
    Tissue specificity: Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PAOX gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Paox1 , 5 polyamine oxidase (exo-N4-amino)1, 5 80.69(n)1
    82.36(a)1
      7 (85.14 cM)5
    2125031  NM_153783.41  NP_722478.21 
     1401256575 
    chicken
    (Gallus gallus)
    Aves PAOX1 peroxisomal N(1)-acetyl-spermine/spermidine oxidase-like 67.09(n)
    61.24(a)
      100857693  XM_003641468.2  XP_003641516.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAOX6
    polyamine oxidase (exo-N4-amino)
    61(a)
    1 ↔ 1
    GL343297.1(1178558-1189047)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.120532 Transcribed sequence with weak similarity to protein more 74.37(n)    142020835 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-275b16.21 si:dkey-275b16.2 57.37(n)
    52.36(a)
      562105  XM_685501.4  XP_690593.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80326
    CG74606
    (see all 6)
    --
    30(a)
    29(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    3R(4490085-4493076)
    3L(17733640-17735640)
    worm
    (Caenorhabditis elegans)
    Secernentea amx-36
    hpo-156
    Protein HPO-15 (hpo-15) mRNA, complete cds
    26(a)
    23(a)
    many ↔ many
    many ↔ many
    V(20898937-20903441) WBGene00000139
    V(5509933-5513830) WBGene00016061


    ENSEMBL Gene Tree for PAOX (if available)
    TreeFam Gene Tree for PAOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAOX gene
    KDM1B2  SMOX2  KDM1A2  
    4 SIMAP similar genes for PAOX using alignment to 3 protein entries:     PAOX_HUMAN (see all proteins):
    KDM1A    AOF1    KDM1B    SMOX

    Find genes that share paralogs with PAOX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAOX (see all 411)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1870019331,2
    C--135190769(+) CCCAAC/TGCGAG 3 -- us2k10--------
    rs1918237411,2
    --135191000(+) AGAGTC/GGCGAG 3 -- us2k10--------
    rs1829204671,2
    --135191008(+) GAGGCC/TCACGC 3 -- us2k10--------
    rs728683111,2
    C--135191178(+) TTCCCC/TTGGCC 3 -- us2k10--------
    rs1931839021,2
    --135191206(+) AGTTCA/CTCTGT 3 -- us2k10--------
    rs118121721,2
    C,A,H--135191283(+) GGGTGG/TGTGGT 3 -- us2k14Minor allele frequency- T:0.10NA WA 242
    rs43458851,2
    C,F,A--135191311(+) GTGCAT/CGCCAG 3 -- us2k12Minor allele frequency- C:0.08WA NA 238
    rs43902711,2
    C,F--135191352(+) AGCGGC/TTCTGC 3 -- us2k12Minor allele frequency- T:0.06WA 120
    rs21857471,2
    C,A,H--135191460(+) AAGGGG/TGTGGG 3 -- us2k110Minor allele frequency- T:0.11NA WA CSA EA 371
    rs1854977731,2
    --135191499(+) GTCGGC/GTGGGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PAOX (135192695 - 135205198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PAOX (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2e196CNV Duplication17116639
    dgv3e196CNV Duplication17116639
    nsv467509CNV Loss19166990
    nsv527785CNV Loss19592680
    nsv896258CNV Loss21882294
    dgv882n71CNV Loss21882294
    dgv880n71CNV Loss21882294
    nsv832040CNV Loss17160897
    nsv528260CNV Loss19592680
    nsv7631CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PAOX
    DNA2.0 Custom Variant and Variant Library Synthesis for PAOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with PAOX           About GenesLikeMe

    2 Novoseek inferred disease relationships for PAOX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 8 9427775 (1), 12006544 (1)
    cancer 0 2 12006544 (1)


    Export disorders for PAOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAOX gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with PAOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N(1)-acetylated polyamine oxidase. (PubMed id 12660232)1, 2, 3 Wu T.... McIntire W.S. (J. Biol. Chem. 2003)
    2. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. (PubMed id 12477380)1, 2, 9 Vujcic S.... Porter C.W. (Biochem. J. 2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)- Pex5p affinities. (PubMed id 20178365)1 Ghosh D. and Berg J.M. (J. Am. Chem. Soc. 2010)
    7. Does polyamine oxidase activity influence the oxidative metabolism of children who suffer of diabetes mellitus? (PubMed id 20405312)1 Bjelakovic G....Zivic S. (Mol. Cell. Biochem. 2010)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase. (PubMed id 16354669)1 JAorvinen A....JAonne J. (J. Biol. Chem. 2006)
    10. Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines. (PubMed id 16207710)1 Pledgie A....Casero R.A. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 196743 HGNC: 20837 AceView: SprnandPAOX Ensembl:ENSG00000148832 euGenes: HUgn196743
    ECgene: PAOX Kegg: 196743 H-InvDB: PAOX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PAOX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PAOX gene:
    Search GeneIP for patents involving PAOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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