Aliases for PAOX Gene
External Ids for PAOX Gene
Previous GeneCards Identifiers for PAOX Gene
GeneCards Summary for PAOX Gene
PAOX (Polyamine Oxidase (Exo-N4-Amino)) is a Protein Coding gene. Among its related pathways are Phase II conjugation and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include receptor binding and polyamine oxidase activity. An important paralog of this gene is KDM1B.
UniProtKB/Swiss-Prot for PAOX Gene
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.