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Aliases for PAOX Gene

Aliases for PAOX Gene

  • Polyamine Oxidase (Exo-N4-Amino) 2 3 5
  • PAO 3 4
  • Peroxisomal N1-Acetyl-Spermine/Spermidine Oxidase 3
  • Polyamine Oxidase 4
  • EC 1.5.3.13 4

External Ids for PAOX Gene

Previous GeneCards Identifiers for PAOX Gene

  • GC10P134665
  • GC10P134666
  • GC10P135081
  • GC10P135042
  • GC10P135192
  • GC10P128736

Summaries for PAOX Gene

GeneCards Summary for PAOX Gene

PAOX (Polyamine Oxidase (Exo-N4-Amino)) is a Protein Coding gene. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include receptor binding and polyamine oxidase activity. An important paralog of this gene is KDM1B.

UniProtKB/Swiss-Prot for PAOX Gene

  • Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.

Tocris Summary for PAOX Gene

Gene Wiki entry for PAOX Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAOX Gene

Genomics for PAOX Gene

Regulatory Elements for PAOX Gene

Promoters for PAOX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAOX on UCSC Golden Path with GeneCards custom track

Genomic Location for PAOX Gene

Chromosome:
10
Start:
133,379,234 bp from pter
End:
133,391,696 bp from pter
Size:
12,463 bases
Orientation:
Plus strand

Genomic View for PAOX Gene

Genes around PAOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAOX Gene

Proteins for PAOX Gene

  • Protein details for PAOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6QHF9-PAOX_HUMAN
    Recommended name:
    Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
    Protein Accession:
    Q6QHF9
    Secondary Accessions:
    • D3DXI6
    • Q5VWY0
    • Q6QHF5
    • Q6QHF6
    • Q6QHF7
    • Q6QHF8
    • Q6QHG0
    • Q6QHG1
    • Q6QHG2
    • Q6QHG3
    • Q6QHG4
    • Q6QHG5
    • Q6QHG6
    • Q86WP9
    • Q8N555
    • Q8NCX3

    Protein attributes for PAOX Gene

    Size:
    649 amino acids
    Molecular mass:
    70290 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N(4)-nitrogen (By similarity).

    Alternative splice isoforms for PAOX Gene

neXtProt entry for PAOX Gene

Proteomics data for PAOX Gene at MOPED

Post-translational modifications for PAOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PAOX Gene

Domains & Families for PAOX Gene

Protein Domains for PAOX Gene

Graphical View of Domain Structure for InterPro Entry

Q6QHF9

UniProtKB/Swiss-Prot:

PAOX_HUMAN :
  • Belongs to the flavin monoamine oxidase family.
Family:
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with PAOX: view

No data available for Gene Families for PAOX Gene

Function for PAOX Gene

Molecular function for PAOX Gene

UniProtKB/Swiss-Prot CatalyticActivity:
N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
N(1),N(12)-diacetylspermine + O(2) + H(2)O = N(1)-acetylspermidine + 3-acetamidobutanal + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
UniProtKB/Swiss-Prot Induction:
By polyamine analogs.

Enzyme Numbers (IUBMB) for PAOX Gene

Gene Ontology (GO) - Molecular Function for PAOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0052899 N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity IEA --
GO:0052903 N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity IEA --
GO:0052904 N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity TAS --
genes like me logo Genes that share ontologies with PAOX: view
genes like me logo Genes that share phenotypes with PAOX: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAOX Gene

Localization for PAOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAOX Gene

Peroxisome. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAOX Gene COMPARTMENTS Subcellular localization image for PAOX gene
Compartment Confidence
peroxisome 5
cytosol 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PAOX Gene

Pathways & Interactions for PAOX Gene

genes like me logo Genes that share pathways with PAOX: view

Pathways by source for PAOX Gene

UniProtKB/Swiss-Prot Q6QHF9-PAOX_HUMAN

  • Pathway: Amine and polyamine metabolism; spermine metabolism.

Interacting Proteins for PAOX Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278060%0d%0a9606.ENSP00000407401%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: ENSP00000278060 for PAOX Gene via STRING

Gene Ontology (GO) - Biological Process for PAOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006596 polyamine biosynthetic process TAS --
GO:0006598 polyamine catabolic process IDA 12477380
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0046203 spermidine catabolic process IDA 16354669
GO:0046208 spermine catabolic process IDA 16354669
genes like me logo Genes that share ontologies with PAOX: view

No data available for SIGNOR curated interactions for PAOX Gene

Drugs & Compounds for PAOX Gene

(7) Drugs for PAOX Gene - From: Novoseek, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
putrescine Experimental Pharma Antagonist, Pore Blocker 0
spermidine Experimental Pharma Antagonist, Pore Blocker 0
Hydrogen peroxide Pharma 46
Febuxostat Pharma Xanthine oxidase inhibitor 50

(12) Additional Compounds for PAOX Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-Acetylspermidine
  • 1-N-Acetylspermidine
  • An N-acetylspermidine
  • N(1)-Acetylspermidine
  • N-(3-((4-Aminobutyl)amino)propyl)-Acetamide
  • N-(3-((4-Aminobutyl)amino)propyl)acetamide
14278-49-0
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
3-Acetamidobutanal
Acetamidopropanal
  • 3-Acetamidopropanal
  • 3AAP
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with PAOX: view

Transcripts for PAOX Gene

Unigene Clusters for PAOX Gene

Polyamine oxidase (exo-N4-amino):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAOX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - -
SP11: -
SP12:

Relevant External Links for PAOX Gene

GeneLoc Exon Structure for
PAOX
ECgene alternative splicing isoforms for
PAOX

Expression for PAOX Gene

mRNA expression in normal human tissues for PAOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAOX Gene

This gene is overexpressed in Testis (x10.7).

Protein differential expression in normal tissues from HIPED for PAOX Gene

This gene is overexpressed in Heart (51.6) and Spleen (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAOX Gene



SOURCE GeneReport for Unigene cluster for PAOX Gene Hs.501578

mRNA Expression by UniProt/SwissProt for PAOX Gene

Q6QHF9-PAOX_HUMAN
Tissue specificity: Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.
genes like me logo Genes that share expression patterns with PAOX: view

Protein tissue co-expression partners for PAOX Gene

Primer Products

In Situ Assay Products

Orthologs for PAOX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAOX 35
  • 91.51 (n)
  • 89.42 (a)
PAOX 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAOX 36
  • 76 (a)
OneToOne
PAOX 35
  • 83.69 (n)
  • 83.76 (a)
dog
(Canis familiaris)
Mammalia PAOX 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paox 16
Paox 35
  • 80.69 (n)
  • 82.36 (a)
Paox 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAOX 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAOX 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paox 35
  • 80.03 (n)
  • 82.82 (a)
chicken
(Gallus gallus)
Aves PAOX 36
  • 58 (a)
OneToOne
PAOX 35
  • 67.09 (n)
  • 61.24 (a)
lizard
(Anolis carolinensis)
Reptilia PAOX 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12053 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6721 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-275b16.2 35
  • 57.37 (n)
  • 52.36 (a)
PAOX 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10561 36
  • 28 (a)
ManyToMany
CG5653 36
  • 29 (a)
ManyToMany
CG6034 36
  • 26 (a)
ManyToMany
CG7460 36
  • 29 (a)
ManyToMany
CG7737 36
  • 26 (a)
ManyToMany
CG8032 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea amx-3 36
  • 26 (a)
ManyToMany
hpo-15 36
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMS1 38
Species with no ortholog for PAOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAOX Gene

ENSEMBL:
Gene Tree for PAOX (if available)
TreeFam:
Gene Tree for PAOX (if available)

Paralogs for PAOX Gene

Paralogs for PAOX Gene

(4) SIMAP similar genes for PAOX Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PAOX: view

Variants for PAOX Gene

Sequence variations from dbSNP and Humsavar for PAOX Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1046175 -- 133,391,446(+) AGGCC(C/G)AGGCT nc-transcript-variant, reference, synonymous-codon, missense, utr-variant-3-prime
rs1046178 -- 133,391,505(+) GGACC(A/C/G)TCATT nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs1046182 -- 133,391,587(+) GGGCC(A/C)CCTTC nc-transcript-variant, utr-variant-3-prime
rs2185745 -- 133,382,315(-) CTGGC(A/C)ATCGC intron-variant
rs2185746 -- 133,381,828(-) AAGCA(C/T)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAOX Gene

Variant ID Type Subtype PubMed ID
nsv528260 CNV Loss 19592680
dgv328e1 CNV Complex 17122850
nsv896258 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
essv9566 CNV CNV 17122850
dgv887n71 CNV Gain 21882294
essv20368 CNV CNV 17122850
nsv428243 CNV Gain 18775914
dgv3e196 CNV Duplication 17116639
esv2750853 CNV Gain 17911159
dgv889n71 CNV Loss 21882294
nsv896314 CNV Gain 21882294
nsv832040 CNV Loss 17160897
nsv467509 CNV Loss 19166990
nsv896316 CNV Gain 21882294
nsv527785 CNV Loss 19592680
nsv470981 CNV Gain 18288195
nsv896317 CNV Loss 21882294
dgv35e55 CNV Gain 17911159
dgv329e1 CNV Complex 17122850
nsv7631 CNV Loss 18451855
dgv123n27 CNV Gain 19166990
nsv832041 CNV Gain 17160897
nsv896318 CNV Gain 21882294

Variation tolerance for PAOX Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAOX Gene

HapMap Linkage Disequilibrium report
PAOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAOX Gene

Disorders for PAOX Gene

Relevant External Links for PAOX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAOX

No disorders were found for PAOX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAOX Gene

Publications for PAOX Gene

  1. Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N(1)-acetylated polyamine oxidase. (PMID: 12660232) Wu T. … McIntire W.S. (J. Biol. Chem. 2003) 2 3 4 67
  2. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. (PMID: 12477380) Vujcic S. … Porter C.W. (Biochem. J. 2003) 3 23
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  4. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)- Pex5p affinities. (PMID: 20178365) Ghosh D. … Berg J.M. (J. Am. Chem. Soc. 2010) 3
  5. Does polyamine oxidase activity influence the oxidative metabolism of children who suffer of diabetes mellitus? (PMID: 20405312) Bjelakovic G. … Zivic S. (Mol. Cell. Biochem. 2010) 3

Products for PAOX Gene

Sources for PAOX Gene

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