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Aliases for PANX3 Gene

Aliases for PANX3 Gene

  • Pannexin 3 2 3 5
  • Gap Junction Protein Pannexin 3 3
  • Pannexin-3 3
  • PX3 3

External Ids for PANX3 Gene

Previous GeneCards Identifiers for PANX3 Gene

  • GC11P126482
  • GC11P125994
  • GC11P124515
  • GC11P124019
  • GC11P123986
  • GC11P124481
  • GC11P120423

Summaries for PANX3 Gene

Entrez Gene Summary for PANX3 Gene

  • The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PANX3 Gene

PANX3 (Pannexin 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include gap junction hemi-channel activity and wide pore channel activity. An important paralog of this gene is PANX1.

UniProtKB/Swiss-Prot for PANX3 Gene

  • Structural component of the gap junctions and the hemichannels.

Additional gene information for PANX3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANX3 Gene

Genomics for PANX3 Gene

GeneHancer (GH) Regulatory Elements for PANX3 Gene

Promoters and enhancers for PANX3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I124611 Promoter 0.5 EPDnew 550.8 -0.1 -103 0.1 PANX3 OR8Q1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PANX3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PANX3 gene promoter:

Genomic Locations for PANX3 Gene

Genomic Locations for PANX3 Gene
8,867 bases
Plus strand

Genomic View for PANX3 Gene

Genes around PANX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANX3 Gene

Proteins for PANX3 Gene

  • Protein details for PANX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for PANX3 Gene

    392 amino acids
    Molecular mass:
    44683 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PANX3 Gene

Post-translational modifications for PANX3 Gene

Other Protein References for PANX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PANX3 Gene

Domains & Families for PANX3 Gene

Gene Families for PANX3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for PANX3 Gene


Suggested Antigen Peptide Sequences for PANX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pannexin family.
  • Belongs to the pannexin family.
genes like me logo Genes that share domains with PANX3: view

Function for PANX3 Gene

Molecular function for PANX3 Gene

UniProtKB/Swiss-Prot Function:
Structural component of the gap junctions and the hemichannels.

Gene Ontology (GO) - Molecular Function for PANX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022829 wide pore channel activity IBA --
GO:0055077 gap junction hemi-channel activity ISS --
genes like me logo Genes that share ontologies with PANX3: view
genes like me logo Genes that share phenotypes with PANX3: view

Animal Models for PANX3 Gene

MGI Knock Outs for PANX3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PANX3 Gene

Localization for PANX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANX3 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PANX3 gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PANX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0005921 gap junction IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PANX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PANX3 Gene

Pathways & Interactions for PANX3 Gene

SuperPathways for PANX3 Gene

No Data Available

Interacting Proteins for PANX3 Gene

Selected Interacting proteins: Q96QZ0-PANX3_HUMAN for PANX3 Gene via IID

Gene Ontology (GO) - Biological Process for PANX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IBA --
GO:0007267 cell-cell signaling IBA,IEA --
GO:0034214 protein hexamerization ISS --
genes like me logo Genes that share ontologies with PANX3: view

No data available for Pathways by source and SIGNOR curated interactions for PANX3 Gene

Drugs & Compounds for PANX3 Gene

(2) Drugs for PANX3 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbenoxolone Experimental Pharma Inhibitor 0
Flufenamic Acid Experimental Pharma Channel blocker 1
genes like me logo Genes that share compounds with PANX3: view

Transcripts for PANX3 Gene

mRNA/cDNA for PANX3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PANX3 Gene

Pannexin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PANX3 Gene

No ASD Table

Relevant External Links for PANX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PANX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PANX3 Gene

mRNA differential expression in normal tissues according to GTEx for PANX3 Gene

This gene is overexpressed in Testis (x7.0), Minor Salivary Gland (x6.8), Brain - Putamen (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x4.3), and Brain - Hypothalamus (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of PANX3 Gene:


SOURCE GeneReport for Unigene cluster for PANX3 Gene:

genes like me logo Genes that share expression patterns with PANX3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PANX3 Gene

Orthologs for PANX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PANX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PANX3 33 34
  • 99.4 (n)
(Canis familiaris)
Mammalia PANX3 33 34
  • 88.69 (n)
(Rattus norvegicus)
Mammalia Panx3 33
  • 87.67 (n)
(Mus musculus)
Mammalia Panx3 33 16 34
  • 87.3 (n)
(Bos Taurus)
Mammalia PANX3 33 34
  • 87.07 (n)
(Monodelphis domestica)
Mammalia PANX3 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia PANX3 34
  • 77 (a)
(Gallus gallus)
Aves PANX3 33 34
  • 68.85 (n)
(Anolis carolinensis)
Reptilia PANX3 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734171 33
  • 62.84 (n)
(Danio rerio)
Actinopterygii panx3 33 34
  • 58.81 (n)
Species where no ortholog for PANX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PANX3 Gene

Gene Tree for PANX3 (if available)
Gene Tree for PANX3 (if available)

Paralogs for PANX3 Gene

Paralogs for PANX3 Gene

(2) SIMAP similar genes for PANX3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PANX3: view

Variants for PANX3 Gene

Sequence variations from dbSNP and Humsavar for PANX3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000456121 -- 124,611,733(+) C/T coding_sequence_variant, synonymous_variant
rs1001038679 -- 124,618,224(+) G/A intron_variant
rs1001098424 -- 124,619,182(+) T/C intron_variant
rs1001425122 -- 124,609,703(+) A/G upstream_transcript_variant
rs1001462648 -- 124,617,632(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PANX3 Gene

Variant ID Type Subtype PubMed ID
esv3627983 CNV loss 21293372
nsv1045156 CNV loss 25217958

Variation tolerance for PANX3 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PANX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PANX3 Gene

Disorders for PANX3 Gene

Additional Disease Information for PANX3

No disorders were found for PANX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PANX3 Gene

Publications for PANX3 Gene

  1. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. (PMID: 15028292) Baranova A … Panchin Y (Genomics 2004) 3 4 22 58
  2. Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation. (PMID: 20404334) Iwamoto T … Yamada Y (The Journal of biological chemistry 2010) 3 22 58
  3. Pannexin3 inhibits TNF-α-induced inflammatory response by suppressing NF-κB signalling pathway in human dental pulp cells. (PMID: 27679980) Song F … Huang C (Journal of cellular and molecular medicine 2017) 3 58
  4. Regulation of Skeletal Muscle Myoblast Differentiation and Proliferation by Pannexins. (PMID: 27518505) Langlois S … Cowan KN (Advances in experimental medicine and biology 2017) 3 58
  5. High Relative Expression of Pannexin 3 (PANX3) in an Axillary Sweat Gland Carcinoma With Osteosarcomatous Transformation. (PMID: 27391460) Romano RC … Nicholas RW (The American Journal of dermatopathology 2016) 3 58

Products for PANX3 Gene

Sources for PANX3 Gene

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