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Aliases for PANX3 Gene

Aliases for PANX3 Gene

  • Pannexin 3 2 3 5
  • Gap Junction Protein Pannexin 3 3
  • PX3 3

External Ids for PANX3 Gene

Previous GeneCards Identifiers for PANX3 Gene

  • GC11P126482
  • GC11P125994
  • GC11P124515
  • GC11P124019
  • GC11P123986
  • GC11P124481
  • GC11P120423

Summaries for PANX3 Gene

Entrez Gene Summary for PANX3 Gene

  • The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PANX3 Gene

PANX3 (Pannexin 3) is a Protein Coding gene. GO annotations related to this gene include gap junction hemi-channel activity and wide pore channel activity. An important paralog of this gene is PANX1.

UniProtKB/Swiss-Prot for PANX3 Gene

  • Structural component of the gap junctions and the hemichannels.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANX3 Gene

Genomics for PANX3 Gene

Genomic Location for PANX3 Gene

Chromosome:
11
Start:
124,611,490 bp from pter
End:
124,620,356 bp from pter
Size:
8,867 bases
Orientation:
Plus strand

Genomic View for PANX3 Gene

Genes around PANX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANX3 Gene

Proteins for PANX3 Gene

  • Protein details for PANX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QZ0-PANX3_HUMAN
    Recommended name:
    Pannexin-3
    Protein Accession:
    Q96QZ0

    Protein attributes for PANX3 Gene

    Size:
    392 amino acids
    Molecular mass:
    44683 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PANX3 Gene

Proteomics data for PANX3 Gene at MOPED

Post-translational modifications for PANX3 Gene

  • Glycosylation at Asn 71
  • Modification sites at PhosphoSitePlus

Other Protein References for PANX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PANX3 Gene

Domains & Families for PANX3 Gene

Gene Families for PANX3 Gene

HGNC:
IUPHAR :

Protein Domains for PANX3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PANX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QZ0

UniProtKB/Swiss-Prot:

PANX3_HUMAN :
  • Belongs to the pannexin family.
Family:
  • Belongs to the pannexin family.
genes like me logo Genes that share domains with PANX3: view

Function for PANX3 Gene

Molecular function for PANX3 Gene

UniProtKB/Swiss-Prot Function:
Structural component of the gap junctions and the hemichannels.

Phenotypes for PANX3 Gene

genes like me logo Genes that share phenotypes with PANX3: view

Animal Models for PANX3 Gene

MGI Knock Outs for PANX3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PANX3 Gene

Localization for PANX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANX3 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PANX3 Gene COMPARTMENTS Subcellular localization image for PANX3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PANX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005921 gap junction IEA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with PANX3: view

Pathways & Interactions for PANX3 Gene

SuperPathways for PANX3 Gene

No Data Available

Interacting Proteins for PANX3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284288%0d%0a9606.ENSP00000232014%0d%0a
Selected Interacting proteins: ENSP00000284288 Q96QZ0-PANX3_HUMAN for PANX3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PANX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling IEA,IBA --
genes like me logo Genes that share ontologies with PANX3: view

No data available for Pathways by source and SIGNOR curated interactions for PANX3 Gene

Drugs & Compounds for PANX3 Gene

(2) Drugs for PANX3 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbenoxolone Experimental Pharma Inhibitor 0
Flufenamic acid Experimental Pharma Channel blocker Activates TRPC6; NSAID 0
genes like me logo Genes that share compounds with PANX3: view

Transcripts for PANX3 Gene

mRNA/cDNA for PANX3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PANX3 Gene

Pannexin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PANX3 Gene

No ASD Table

Relevant External Links for PANX3 Gene

GeneLoc Exon Structure for
PANX3
ECgene alternative splicing isoforms for
PANX3

Expression for PANX3 Gene

mRNA expression in normal human tissues for PANX3 Gene

mRNA differential expression in normal tissues according to GTEx for PANX3 Gene

This gene is overexpressed in Testis (x7.0), Minor Salivary Gland (x6.8), Brain - Putamen (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x4.3), and Brain - Hypothalamus (x4.2).

SOURCE GeneReport for Unigene cluster for PANX3 Gene Hs.99235

genes like me logo Genes that share expression patterns with PANX3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PANX3 Gene

Orthologs for PANX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PANX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PANX3 35
  • 99.4 (n)
  • 98.98 (a)
PANX3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PANX3 36
  • 91 (a)
OneToOne
PANX3 35
  • 87.07 (n)
  • 91.07 (a)
dog
(Canis familiaris)
Mammalia PANX3 35
  • 88.69 (n)
  • 90.05 (a)
PANX3 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Panx3 16
Panx3 36
  • 89 (a)
OneToOne
Panx3 35
  • 87.3 (n)
  • 89 (a)
oppossum
(Monodelphis domestica)
Mammalia PANX3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PANX3 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Panx3 35
  • 87.67 (n)
  • 91.58 (a)
chicken
(Gallus gallus)
Aves PANX3 35
  • 68.85 (n)
  • 70.16 (a)
PANX3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PANX3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734171 35
  • 62.84 (n)
  • 65.55 (a)
zebrafish
(Danio rerio)
Actinopterygii panx3 36
  • 44 (a)
OneToOne
panx3 35
  • 58.81 (n)
  • 54.55 (a)
Species with no ortholog for PANX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PANX3 Gene

ENSEMBL:
Gene Tree for PANX3 (if available)
TreeFam:
Gene Tree for PANX3 (if available)

Paralogs for PANX3 Gene

Paralogs for PANX3 Gene

(2) SIMAP similar genes for PANX3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PANX3: view

Variants for PANX3 Gene

Sequence variations from dbSNP and Humsavar for PANX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs34498516 - 124,613,081(+) AGGAC(A/C/G)GGCCT reference, missense
rs35569094 - 124,619,378(+) TGGCT(A/G)CCTAC reference, missense
rs7926158 -- 124,618,658(+) GGGGG(G/T)GGGGg intron-variant
rs10893277 -- 124,610,153(+) AGACA(A/C)ACACA upstream-variant-2KB
rs56035943 -- 124,615,170(+) CTCCG(C/G)CTTCT intron-variant

Variation tolerance for PANX3 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PANX3 Gene

HapMap Linkage Disequilibrium report
PANX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PANX3 Gene

Disorders for PANX3 Gene

Relevant External Links for PANX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PANX3

No disorders were found for PANX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PANX3 Gene

Publications for PANX3 Gene

  1. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. (PMID: 15028292) Baranova A. … Panchin Y. (Genomics 2004) 3 4 23 67
  2. Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation. (PMID: 20404334) Iwamoto T. … Yamada Y. (J. Biol. Chem. 2010) 3 23
  3. Pannexin 1 and pannexin 3 channels regulate skeletal muscle myoblast proliferation and differentiation. (PMID: 25239622) Langlois S. … Cowan K.N. (J. Biol. Chem. 2014) 3
  4. Pannexin channels and their links to human disease. (PMID: 25008946) Penuela S. … Laird D.W. (Biochem. J. 2014) 3
  5. Pannexin1 and Pannexin3 exhibit distinct localization patterns in human skin appendages and are regulated during keratinocyte differentiation and carcinogenesis. (PMID: 22947051) Cowan K.N. … Laird D.W. (Cell Commun. Adhes. 2012) 3

Products for PANX3 Gene

Sources for PANX3 Gene

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