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Aliases for PANX2 Gene

Aliases for PANX2 Gene

  • Pannexin 2 2 3 5
  • HPANX2 3
  • PX2 3

External Ids for PANX2 Gene

Previous GeneCards Identifiers for PANX2 Gene

  • GC22P047160
  • GC22P048791
  • GC22P048911
  • GC22P050609
  • GC22P033511

Summaries for PANX2 Gene

Entrez Gene Summary for PANX2 Gene

  • The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for PANX2 Gene

PANX2 (Pannexin 2) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Electric Transmission Across Gap Junctions. GO annotations related to this gene include channel activity and wide pore channel activity. An important paralog of this gene is PANX1.

UniProtKB/Swiss-Prot for PANX2 Gene

  • Structural component of the gap junctions and the hemichannels.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANX2 Gene

Genomics for PANX2 Gene

Regulatory Elements for PANX2 Gene

Enhancers for PANX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PANX2 on UCSC Golden Path with GeneCards custom track

Promoters for PANX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PANX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PANX2 Gene

Chromosome:
22
Start:
50,170,731 bp from pter
End:
50,180,295 bp from pter
Size:
9,565 bases
Orientation:
Plus strand

Genomic View for PANX2 Gene

Genes around PANX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANX2 Gene

Proteins for PANX2 Gene

  • Protein details for PANX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD6-PANX2_HUMAN
    Recommended name:
    Pannexin-2
    Protein Accession:
    Q96RD6
    Secondary Accessions:
    • B7Z684
    • Q96RD5
    • Q9UGX8

    Protein attributes for PANX2 Gene

    Size:
    677 amino acids
    Molecular mass:
    74447 Da
    Quaternary structure:
    • Forms PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes. Does not form homomeric channels (By similarity).

    Alternative splice isoforms for PANX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PANX2 Gene

Proteomics data for PANX2 Gene at MOPED

Post-translational modifications for PANX2 Gene

  • Glycosylation at Asn 86
  • Modification sites at PhosphoSitePlus

Other Protein References for PANX2 Gene

No data available for DME Specific Peptides for PANX2 Gene

Domains & Families for PANX2 Gene

Gene Families for PANX2 Gene

HGNC:
IUPHAR :

Protein Domains for PANX2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PANX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RD6

UniProtKB/Swiss-Prot:

PANX2_HUMAN :
  • Belongs to the pannexin family.
Family:
  • Belongs to the pannexin family.
genes like me logo Genes that share domains with PANX2: view

Function for PANX2 Gene

Molecular function for PANX2 Gene

UniProtKB/Swiss-Prot Function:
Structural component of the gap junctions and the hemichannels.
genes like me logo Genes that share phenotypes with PANX2: view

Animal Models for PANX2 Gene

MGI Knock Outs for PANX2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PANX2 Gene

Localization for PANX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANX2 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PANX2 Gene COMPARTMENTS Subcellular localization image for PANX2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PANX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005921 gap junction IEA --
genes like me logo Genes that share ontologies with PANX2: view

Pathways & Interactions for PANX2 Gene

genes like me logo Genes that share pathways with PANX2: view

Pathways by source for PANX2 Gene

Interacting Proteins for PANX2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379183%0d%0a9606.ENSP00000227638%0d%0a9606.ENSP00000339007%0d%0a
Selected Interacting proteins: ENSP00000379183 Q96RD6-PANX2_HUMAN for PANX2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PANX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with PANX2: view

No data available for SIGNOR curated interactions for PANX2 Gene

Drugs & Compounds for PANX2 Gene

(2) Drugs for PANX2 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbenoxolone Experimental Pharma Inhibitor 0
Flufenamic acid Experimental Pharma Channel blocker Activates TRPC6; NSAID 0
genes like me logo Genes that share compounds with PANX2: view

Transcripts for PANX2 Gene

Unigene Clusters for PANX2 Gene

Pannexin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PANX2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2: -

Relevant External Links for PANX2 Gene

GeneLoc Exon Structure for
PANX2
ECgene alternative splicing isoforms for
PANX2

Expression for PANX2 Gene

mRNA expression in normal human tissues for PANX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PANX2 Gene

This gene is overexpressed in Brain - Cortex (x5.0), Brain - Cerebellum (x4.5), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for PANX2 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PANX2 Gene



SOURCE GeneReport for Unigene cluster for PANX2 Gene Hs.440092

genes like me logo Genes that share expression patterns with PANX2: view

Protein tissue co-expression partners for PANX2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PANX2 Gene

Orthologs for PANX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PANX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PANX2 35
  • 88.37 (n)
  • 88.01 (a)
PANX2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PANX2 35
  • 90.11 (n)
  • 91.91 (a)
PANX2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Panx2 35
  • 88.21 (n)
  • 92.27 (a)
Panx2 16
Panx2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PANX2 35
  • 99.2 (n)
  • 99.25 (a)
PANX2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Panx2 35
  • 87.81 (n)
  • 92.09 (a)
oppossum
(Monodelphis domestica)
Mammalia PANX2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PANX2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PANX2 35
  • 69.55 (n)
  • 76.67 (a)
PANX2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PANX2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486454 35
  • 63.36 (n)
  • 71.62 (a)
zebrafish
(Danio rerio)
Actinopterygii panx2 35
  • 71.81 (n)
  • 77.95 (a)
panx2 36
  • 64 (a)
OneToOne
Species with no ortholog for PANX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PANX2 Gene

ENSEMBL:
Gene Tree for PANX2 (if available)
TreeFam:
Gene Tree for PANX2 (if available)

Paralogs for PANX2 Gene

Paralogs for PANX2 Gene

(2) SIMAP similar genes for PANX2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PANX2: view

Variants for PANX2 Gene

Sequence variations from dbSNP and Humsavar for PANX2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036575 A breast cancer sample
rs7288406 -- 50,179,678(+) CCAGA(G/T)CCAGG nc-transcript-variant, utr-variant-3-prime
rs2294397 -- 50,175,285(+) TTCCC(A/G)TCTCC intron-variant
rs2295225 -- 50,180,368(-) GTCCT(C/G)CAGCA downstream-variant-500B
rs2295226 -- 50,180,309(-) GTCCC(C/T)GGCGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PANX2 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
nsv915519 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
nsv915525 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
nsv829333 CNV Gain 20364138
dgv5056n71 CNV Loss 21882294
dgv5057n71 CNV Loss 21882294
nsv914511 CNV Loss 21882294
esv2724754 CNV Deletion 23290073

Variation tolerance for PANX2 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PANX2 Gene

Disorders for PANX2 Gene

Relevant External Links for PANX2

Genetic Association Database (GAD)
PANX2
Human Genome Epidemiology (HuGE) Navigator
PANX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PANX2

No disorders were found for PANX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PANX2 Gene

Publications for PANX2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Pannexin2 as a novel growth regulator in C6 glioma cells. (PMID: 19749789) Lai C.P. … Naus C.C. (Oncogene 2009) 3 23
  3. What is hidden in the pannexin treasure trove: the sneak peek and the guesswork. (PMID: 16989724) Litvin O. … Baranova A. (J. Cell. Mol. Med. 2006) 3 23
  4. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. (PMID: 15028292) Baranova A. … Panchin Y. (Genomics 2004) 3 23
  5. Pannexins, a family of gap junction proteins expressed in brain. (PMID: 14597722) Bruzzone R. … Monyer H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3

Products for PANX2 Gene

Sources for PANX2 Gene

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