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Aliases for PANX2 Gene

Aliases for PANX2 Gene

  • Pannexin 2 2 3 5
  • Pannexin-2 3
  • HPANX2 3
  • PX2 3

External Ids for PANX2 Gene

Previous GeneCards Identifiers for PANX2 Gene

  • GC22P047160
  • GC22P048791
  • GC22P048911
  • GC22P050609
  • GC22P033511

Summaries for PANX2 Gene

Entrez Gene Summary for PANX2 Gene

  • The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for PANX2 Gene

PANX2 (Pannexin 2) is a Protein Coding gene. Among its related pathways are Transmission across Electrical Synapses and Transmission across Chemical Synapses. GO annotations related to this gene include channel activity and wide pore channel activity. An important paralog of this gene is PANX3.

UniProtKB/Swiss-Prot for PANX2 Gene

  • Structural component of the gap junctions and the hemichannels.

Additional gene information for PANX2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANX2 Gene

Genomics for PANX2 Gene

Regulatory Elements for PANX2 Gene

Enhancers for PANX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H049942 2 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -221.5 -221490 13 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ALG12 ENSG00000272836 RABL2B PLXNB2 TUBGCP6 ZBED4 LMF2 NCAPH2 CHKB BRD1
GH22H050117 1.5 Ensembl ENCODE dbSUPER 11.9 -52.0 -52002 3 FOXA2 PKNOX1 ATF1 ARNT BRCA1 YY1 TCF12 ZNF766 GATA2 ELK1 MLC1 MOV10L1 ENSG00000273253 PANX2 SELENOO LMF2 ENSG00000280395
GH22H050183 1.6 FANTOM5 ENCODE dbSUPER 9.3 +15.1 15093 3 ARID4B DMAP1 ZNF2 ZNF121 GTF3C2 GLIS2 ZNF143 KLF7 RUNX3 SP3 TRABD BRD1 LOC105373095 SELENOO ZBED4 ALG12 ENSG00000273253 CHKB PLXNB2 LMF2
GH22H050148 1.1 Ensembl ENCODE 12.9 -21.5 -21508 0 HDAC1 RB1 ARID4B SIN3A RAD21 ZNF366 SCRT2 ZNF143 THAP11 SMARCA5 MLC1 MOV10L1 PANX2 TUBGCP6 HDAC10 SELENOO MAPK12 MAPK11 PLXNB2 TRABD
GH22H050145 1.1 Ensembl ENCODE 12.9 -24.1 -24098 2 ELF3 ARID4B THRB RAD21 RARA YY1 GLIS2 ZNF143 CREM MIXL1 MLC1 MOV10L1 MAPK12 PANX2 TUBGCP6 HDAC10 SELENOO MAPK11 PLXNB2 ENSG00000280395
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PANX2 on UCSC Golden Path with GeneCards custom track

Promoters for PANX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147686 -531 1201 TBP CTCF MXI1 RB1 BACH1 BATF ZIC2 CCNT2 FOXM1 ZNF316

Genomic Location for PANX2 Gene

Chromosome:
22
Start:
50,170,731 bp from pter
End:
50,180,295 bp from pter
Size:
9,565 bases
Orientation:
Plus strand

Genomic View for PANX2 Gene

Genes around PANX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANX2 Gene

Proteins for PANX2 Gene

  • Protein details for PANX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD6-PANX2_HUMAN
    Recommended name:
    Pannexin-2
    Protein Accession:
    Q96RD6
    Secondary Accessions:
    • B7Z684
    • Q96RD5
    • Q9UGX8

    Protein attributes for PANX2 Gene

    Size:
    677 amino acids
    Molecular mass:
    74447 Da
    Quaternary structure:
    • Forms PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes. Does not form homomeric channels (By similarity).

    Alternative splice isoforms for PANX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PANX2 Gene

Post-translational modifications for PANX2 Gene

  • Glycosylation at Asn86
  • Modification sites at PhosphoSitePlus

Other Protein References for PANX2 Gene

No data available for DME Specific Peptides for PANX2 Gene

Domains & Families for PANX2 Gene

Gene Families for PANX2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for PANX2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PANX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RD6

UniProtKB/Swiss-Prot:

PANX2_HUMAN :
  • Belongs to the pannexin family.
Family:
  • Belongs to the pannexin family.
genes like me logo Genes that share domains with PANX2: view

Function for PANX2 Gene

Molecular function for PANX2 Gene

UniProtKB/Swiss-Prot Function:
Structural component of the gap junctions and the hemichannels.

Phenotypes From GWAS Catalog for PANX2 Gene

Gene Ontology (GO) - Molecular Function for PANX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015267 channel activity IEA --
GO:0022829 wide pore channel activity IBA --
GO:0055077 gap junction hemi-channel activity ISS --
genes like me logo Genes that share ontologies with PANX2: view
genes like me logo Genes that share phenotypes with PANX2: view

Animal Models for PANX2 Gene

MGI Knock Outs for PANX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PANX2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PANX2 Gene

Localization for PANX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANX2 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PANX2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PANX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IBA,TAS --
GO:0005921 gap junction IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PANX2: view

Pathways & Interactions for PANX2 Gene

genes like me logo Genes that share pathways with PANX2: view

Pathways by source for PANX2 Gene

Interacting Proteins for PANX2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379183%0d%0a9606.ENSP00000227638%0d%0a
Selected Interacting proteins: Q96RD6-PANX2_HUMAN ENSP00000379183 for PANX2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PANX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IBA --
GO:0007267 cell-cell signaling IBA --
genes like me logo Genes that share ontologies with PANX2: view

No data available for SIGNOR curated interactions for PANX2 Gene

Drugs & Compounds for PANX2 Gene

(2) Drugs for PANX2 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbenoxolone Experimental Pharma Inhibitor 0
Flufenamic Acid Experimental Pharma Channel blocker 1
genes like me logo Genes that share compounds with PANX2: view

Transcripts for PANX2 Gene

Unigene Clusters for PANX2 Gene

Pannexin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PANX2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PANX2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2: -

Relevant External Links for PANX2 Gene

GeneLoc Exon Structure for
PANX2
ECgene alternative splicing isoforms for
PANX2

Expression for PANX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PANX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PANX2 Gene

This gene is overexpressed in Brain - Cortex (x5.0), Brain - Cerebellum (x4.5), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for PANX2 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PANX2 Gene



Protein tissue co-expression partners for PANX2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PANX2 Gene:

PANX2

SOURCE GeneReport for Unigene cluster for PANX2 Gene:

Hs.440092

Evidence on tissue expression from TISSUES for PANX2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with PANX2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PANX2 Gene

Orthologs for PANX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PANX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PANX2 33 34
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia PANX2 33 34
  • 90.11 (n)
cow
(Bos Taurus)
Mammalia PANX2 33 34
  • 88.37 (n)
mouse
(Mus musculus)
Mammalia Panx2 33 16 34
  • 88.21 (n)
rat
(Rattus norvegicus)
Mammalia Panx2 33
  • 87.81 (n)
oppossum
(Monodelphis domestica)
Mammalia PANX2 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PANX2 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PANX2 33 34
  • 69.55 (n)
lizard
(Anolis carolinensis)
Reptilia PANX2 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486454 33
  • 63.36 (n)
zebrafish
(Danio rerio)
Actinopterygii panx2 33 34
  • 71.81 (n)
Species where no ortholog for PANX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PANX2 Gene

ENSEMBL:
Gene Tree for PANX2 (if available)
TreeFam:
Gene Tree for PANX2 (if available)

Paralogs for PANX2 Gene

Paralogs for PANX2 Gene

(2) SIMAP similar genes for PANX2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PANX2: view

Variants for PANX2 Gene

Sequence variations from dbSNP and Humsavar for PANX2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036575 A breast cancer sample
rs1000053836 -- 50,179,725(+) GCCAC(A/C/G)CCCAT nc-transcript-variant, utr-variant-3-prime
rs1000217676 -- 50,169,406(+) CGTTC(A/G)TCCTG upstream-variant-2KB
rs1000244948 -- 50,178,688(+) TAGAG(C/T)TCCGC intron-variant
rs1000310777 -- 50,169,656(+) GGTGC(A/G)GGCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PANX2 Gene

Variant ID Type Subtype PubMed ID
dgv781n67 CNV gain 20364138
esv2724754 CNV deletion 23290073
nsv829333 CNV gain 20364138
nsv955199 CNV deletion 24416366

Variation tolerance for PANX2 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PANX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PANX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PANX2 Gene

Disorders for PANX2 Gene

Relevant External Links for PANX2

Genetic Association Database (GAD)
PANX2
Human Genome Epidemiology (HuGE) Navigator
PANX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PANX2

No disorders were found for PANX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PANX2 Gene

Publications for PANX2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 60
  2. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. (PMID: 15028292) Baranova A … Panchin Y (Genomics 2004) 3 4 22 60
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 60
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 60
  5. Pannexin2 as a novel growth regulator in C6 glioma cells. (PMID: 19749789) Lai CP … Naus CC (Oncogene 2009) 3 22 60

Products for PANX2 Gene

Sources for PANX2 Gene

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