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Aliases for PANX1 Gene

Aliases for PANX1 Gene

  • Pannexin 1 2 3 5
  • Innexin 2 3
  • MRS1 3 4
  • UNQ2529 3
  • PX1 3

External Ids for PANX1 Gene

Previous GeneCards Identifiers for PANX1 Gene

  • GC11P096192
  • GC11P095369
  • GC11P094046
  • GC11P093550
  • GC11P093501
  • GC11P093862
  • GC11P089937

Summaries for PANX1 Gene

Entrez Gene Summary for PANX1 Gene

  • The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

GeneCards Summary for PANX1 Gene

PANX1 (Pannexin 1) is a Protein Coding gene. Diseases associated with PANX1 include pineal parenchymal tumor of intermediate differentiation and basilar artery occlusion. Among its related pathways are Adhesion and Apoptosis and Autophagy. GO annotations related to this gene include protein heterodimerization activity and actin binding. An important paralog of this gene is PANX3.

UniProtKB/Swiss-Prot for PANX1 Gene

  • Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

Tocris Summary for PANX1 Gene

  • Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANX1 Gene

Genomics for PANX1 Gene

Regulatory Elements for PANX1 Gene

Enhancers for PANX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PANX1 on UCSC Golden Path with GeneCards custom track

Promoters for PANX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PANX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PANX1 Gene

Chromosome:
11
Start:
94,128,928 bp from pter
End:
94,185,596 bp from pter
Size:
56,669 bases
Orientation:
Plus strand

Genomic View for PANX1 Gene

Genes around PANX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANX1 Gene

Proteins for PANX1 Gene

  • Protein details for PANX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD7-PANX1_HUMAN
    Recommended name:
    Pannexin-1
    Protein Accession:
    Q96RD7
    Secondary Accessions:
    • O75968
    • Q543A0
    • Q6UW26
    • Q96AM9
    • Q96L77
    • Q96RS5

    Protein attributes for PANX1 Gene

    Size:
    426 amino acids
    Molecular mass:
    48050 Da
    Quaternary structure:
    • Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).

    Alternative splice isoforms for PANX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PANX1 Gene

Proteomics data for PANX1 Gene at MOPED

Post-translational modifications for PANX1 Gene

Other Protein References for PANX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PANX1 (PANX1)
  • Cloud-Clone Corp. Antibodies for PANX1

No data available for DME Specific Peptides for PANX1 Gene

Domains & Families for PANX1 Gene

Gene Families for PANX1 Gene

HGNC:
IUPHAR :

Protein Domains for PANX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PANX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RD7

UniProtKB/Swiss-Prot:

PANX1_HUMAN :
  • Belongs to the pannexin family.
Family:
  • Belongs to the pannexin family.
genes like me logo Genes that share domains with PANX1: view

Function for PANX1 Gene

Molecular function for PANX1 Gene

UniProtKB/Swiss-Prot Function:
Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

Gene Ontology (GO) - Molecular Function for PANX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 17036048
GO:0005243 gap junction channel activity IEA --
GO:0005515 protein binding IEA --
GO:0051015 actin filament binding IEA --
GO:0097110 scaffold protein binding IEA --
genes like me logo Genes that share ontologies with PANX1: view
genes like me logo Genes that share phenotypes with PANX1: view

Animal Models for PANX1 Gene

MGI Knock Outs for PANX1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PANX1 Gene

Localization for PANX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANX1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PANX1 Gene COMPARTMENTS Subcellular localization image for PANX1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 2
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PANX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PANX1: view

Pathways & Interactions for PANX1 Gene

genes like me logo Genes that share pathways with PANX1: view

Pathways by source for PANX1 Gene

2 Cell Signaling Technology pathways for PANX1 Gene

Interacting Proteins for PANX1 Gene

Gene Ontology (GO) - Biological Process for PANX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport IDA 17036048
GO:0006816 calcium ion transport IMP 16908669
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS --
GO:0050717 positive regulation of interleukin-1 alpha secretion IEA --
GO:0050718 positive regulation of interleukin-1 beta secretion IDA 17036048
genes like me logo Genes that share ontologies with PANX1: view

No data available for SIGNOR curated interactions for PANX1 Gene

Drugs & Compounds for PANX1 Gene

(11) Drugs for PANX1 Gene - From: DrugBank, ClinicalTrials, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Probenecid Approved Pharma Inhibition, Inhibitor, Target, antagonist 27
Carbenoxolone Experimental Pharma Inhibitor 0
Flufenamic acid Experimental Pharma Channel blocker Activates TRPC6; NSAID 0
Liver Extracts Pharma 3644
10Panx Pharma Panx-1 mimetic inhibitor, Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions 0

(5) Tocris Compounds for PANX1 Gene

Compound Action Cas Number
10Panx Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions 955091-53-9
Carbenoxolone disodium Gap junction blocker. Also inhibitor of 11 beta-hydroxysteroid dehydrogenase 7421-40-1
Gap 26 Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release 197250-15-0
Gap 27 Selective gap junction blocker 198284-64-9
Scrambled 10Panx Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide 1315378-72-3
genes like me logo Genes that share compounds with PANX1: view

Transcripts for PANX1 Gene

mRNA/cDNA for PANX1 Gene

Unigene Clusters for PANX1 Gene

Pannexin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PANX1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: -

Relevant External Links for PANX1 Gene

GeneLoc Exon Structure for
PANX1
ECgene alternative splicing isoforms for
PANX1

Expression for PANX1 Gene

mRNA expression in normal human tissues for PANX1 Gene

Protein differential expression in normal tissues from HIPED for PANX1 Gene

This gene is overexpressed in Pancreas (18.0), Plasma (17.6), Peripheral blood mononuclear cells (10.5), Bone marrow mesenchymal stem cell (8.9), and Fetal Brain (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PANX1 Gene



SOURCE GeneReport for Unigene cluster for PANX1 Gene Hs.591976

genes like me logo Genes that share expression patterns with PANX1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PANX1 Gene

Orthologs for PANX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PANX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PANX1 35
  • 83.85 (n)
  • 82.98 (a)
PANX1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PANX1 35
  • 85.14 (n)
  • 84.91 (a)
PANX1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Panx1 35
  • 83.84 (n)
  • 86.59 (a)
Panx1 16
Panx1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PANX1 35
  • 99.37 (n)
  • 98.83 (a)
PANX1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Panx1 35
  • 82.51 (n)
  • 88.24 (a)
oppossum
(Monodelphis domestica)
Mammalia PANX1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PANX1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PANX1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PANX1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia panx1 35
  • 66.82 (n)
  • 66.12 (a)
Str.14956 35
zebrafish
(Danio rerio)
Actinopterygii panx1a 35
  • 59.47 (n)
  • 57.77 (a)
zgc55631 35
panx1a 36
  • 56 (a)
OneToMany
panx1b 36
  • 56 (a)
OneToMany
Species with no ortholog for PANX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PANX1 Gene

ENSEMBL:
Gene Tree for PANX1 (if available)
TreeFam:
Gene Tree for PANX1 (if available)

Paralogs for PANX1 Gene

Paralogs for PANX1 Gene

(1) SIMAP similar genes for PANX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PANX1: view

Variants for PANX1 Gene

Sequence variations from dbSNP and Humsavar for PANX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1138800 - 94,129,327(+) GCTCA(A/C)CTGGC reference, missense
rs12793348 - 94,179,870(+) TGGGC(A/G)TCTTC reference, missense
rs882937 -- 94,175,706(-) CAATC(A/G)GAAGG intron-variant
rs1046173 -- 94,185,184(+) GTGCT(C/T)TAGGC utr-variant-3-prime
rs1046805 -- 94,181,285(+) TCAGG(A/G)TATAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PANX1 Gene

Variant ID Type Subtype PubMed ID
nsv898183 CNV Loss 21882294
nsv898184 CNV Gain 21882294
nsv523082 CNV Gain 19592680
nsv508651 CNV Loss 20534489
nsv898185 CNV Loss 21882294
esv989619 CNV Deletion 20482838
nsv469980 CNV Loss 18288195
nsv468795 CNV Loss 19166990
nsv517664 CNV Loss 19592680
esv2744929 CNV Deletion 23290073
esv2674143 CNV Deletion 23128226
esv2656589 CNV Deletion 23128226

Variation tolerance for PANX1 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PANX1 Gene

HapMap Linkage Disequilibrium report
PANX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PANX1 Gene

Disorders for PANX1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PANX1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pineal parenchymal tumor of intermediate differentiation
  • pineal parenchymal tumour of intermediate differentiation
basilar artery occlusion
- elite association - COSMIC cancer census association via MalaCards
Search PANX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PANX1

Genetic Association Database (GAD)
PANX1
Human Genome Epidemiology (HuGE) Navigator
PANX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PANX1
genes like me logo Genes that share disorders with PANX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PANX1 Gene

Publications for PANX1 Gene

  1. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. (PMID: 15028292) Baranova A. … Panchin Y. (Genomics 2004) 3 4 23 67
  2. Pannexin 1 contributes to ATP release in airway epithelia. (PMID: 19213873) Ransford G.A. … Salathe M. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23 25
  3. Pannexins, a family of gap junction proteins expressed in brain. (PMID: 14597722) Bruzzone R. … Monyer H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 23
  4. Lack of coupling between membrane stretching and pannexin-1 hemichannels. (PMID: 19150332) Reyes J.P. … Arreola J. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. (PMID: 19023039) Ma W. … Surprenant A. (J. Pharmacol. Exp. Ther. 2009) 23 25

Products for PANX1 Gene

Sources for PANX1 Gene

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