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PANX1 Gene

protein-coding   GIFtS: 62
GCID: GC11P093862

Pannexin 1

  Search for PANX1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pannexin 11 2
innexin1 2
MRS12 3
PX12 5
UNQ25292
pannexin-12

External Ids:    HGNC: 85991   Entrez Gene: 241452   Ensembl: ENSG000001102187   OMIM: 6084205   UniProtKB: Q96RD73   

Export aliases for PANX1 gene to outside databases

Previous GC identifers: GC11P096192 GC11P095369 GC11P094046 GC11P093550 GC11P093501 GC11P089937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PANX1 Gene:
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural
components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS)
and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone
and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. (provided
by RefSeq, Jul 2008)

GeneCards Summary for PANX1 Gene:
PANX1 (pannexin 1) is a protein-coding gene. GO annotations related to this gene include actin filament binding and protein heterodimerization activity. An important paralog of this gene is PANX3.

UniProtKB/Swiss-Prot: PANX1_HUMAN, Q96RD7
Function: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel
to regulate ER Ca(2+) homeostasis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PANX1 gene promoter:
         RP58   AML1a   Tal-1   POU6F1 (c2)   STAT5A   IRF-1   HNF-3beta   Tal-1beta   E47   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPANX1 promoter sequence
   Search Chromatin IP Primers for PANX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PANX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q14-q21

PANX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PANX1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P093862:  view genomic region     (about GC identifiers)

Start:
93,862,094 bp from pter      End:
93,915,138 bp from pter
Size:
53,045 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PANX1_HUMAN, Q96RD7 (See protein sequence)
Recommended Name: Pannexin-1  
Size: 426 amino acids; 48050 Da
Subunit: Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired
Xenopus oocytes (By similarity)
Secondary accessions: O75968 Q543A0 Q6UW26 Q96AM9 Q96L77 Q96RS5
Alternative splicing: 2 isoforms:  Q96RD7-1   Q96RD7-2   

Explore the universe of human proteins at neXtProt for PANX1: NX_Q96RD7

Explore proteomics data for PANX1 at MOPED

Post-translational modifications: 

  • S-nitrosylation inhibits channel currents and ATP release (By similarity)1
  • Glycosylation2 at Asn255
  • Modification sites at PhosphoSitePlus

  • See PANX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056183.2  
    ENSEMBL proteins: 
     ENSP00000227638   ENSP00000411461  
    Reactome Protein details: Q96RD7

    PANX1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PANX1
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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for PANX1

     
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    PANX1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PANX1
    R&D Systems Antibodies for PANX1 (Pannexin-1)
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    Cloud-Clone Corp. ELISAs for PANX1
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    Search eBioscience for ELISAs for PANX1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PANX: Ion channels / Pannexins

    IUPHAR Guide to PHARMACOLOGY protein family classification: Px1
    Connexins and Pannexins

    1 InterPro protein domain:
     IPR000990 Innexin

    Graphical View of Domain Structure for InterPro Entry Q96RD7

    ProtoNet protein and cluster: Q96RD7

    UniProtKB/Swiss-Prot: PANX1_HUMAN, Q96RD7
    Similarity: Belongs to the pannexin family


    Find genes that share domains with PANX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PANX1_HUMAN, Q96RD7
    Function: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel
    to regulate ER Ca(2+) homeostasis

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0003779actin binding ----
    GO:0005102receptor binding IPI17036048
    GO:0005243gap junction channel activity ----
    GO:0005262calcium channel activity IMP16908669
         
    Find genes that share ontologies with PANX1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Panx1):
     behavior/neurological  cellular  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  nervous system  no phenotypic analysis  respiratory system  vision/eye 

    Find genes that share phenotypes with PANX1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PANX1: Panx1tm1.1Vshe Panx1tm1.2Vmd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PANX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PANX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PANX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PANX1

    miRNA
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    miRTarBase miRNAs that target PANX1:
    hsa-mir-192-5p (MIRT004125), hsa-mir-16-5p (MIRT001433), hsa-mir-10a-5p (MIRT025607), hsa-mir-125a-5p (MIRT021301)

    Block miRNA regulation of human, mouse, rat PANX1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate PANX1:
    hsa-miR-501-5p hsa-miR-330-5p hsa-miR-641 hsa-miR-326 hsa-miR-3617 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidPANX1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PANX1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PANX1 (NM_015368)
    Sino Biological Human cDNA Clone for PANX1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PANX1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PANX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PANX1_HUMAN, Q96RD7: Cell membrane; Multi-pass membrane protein (Potential). Cell junction, gap junction.
    Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA16908669
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0005921gap junction IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PANX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PANX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    Inflammasomes0.00
    2NOD-like Receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.58
    Inflammasome Activation Pathways0.51
    3Electric Transmission Across Gap Junctions
    Electric Transmission Across Gap Junctions
    Transmission across Electrical Synapses0.00
    4Transmission across Chemical Synapses
    Neuronal System0.68


    Find genes that share SuperPaths with PANX1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for PANX1
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways



    2 Reactome Pathways for PANX1
        The NLRP3 inflammasome
    Electric Transmission Across Gap Junctions


        Pathway & Disease-focused RT2 Profiler PCR Arrays including PANX1: 
              Inflammasomes in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PANX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for PANX1 (Q96RD72 ENSP000002276384) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPENSP000002849814STRING: ENSP00000284981
    NLRP3ENSP000003373834STRING: ENSP00000337383
    PANX2ENSP000003791834STRING: ENSP00000379183
    CASP3ENSP000003110324STRING: ENSP00000311032
    P2RX7ENSP000002618264STRING: ENSP00000261826
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002931response to ischemia IEA--
    GO:0006812cation transport IDA17036048
    GO:0006816calcium ion transport IMP16908669
    GO:0007267cell-cell signaling ----
    GO:0007268synaptic transmission TAS--

    Find genes that share ontologies with PANX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PANX1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Gap 27Selective gap junction blocker[198284-64-9]
    Scrambled 10Panx Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide [1315378-72-3]
    Carbenoxolone disodiumGap junction blocker. Also inhibitor of 11 beta-hydroxysteroid dehydrogenase[7421-40-1]
    10PanxPanx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions[955091-53-9]

    1 DrugBank Compound for PANX1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Probenecid-- 57-66-9targetantagonist18596212 19213873 19023039 19416975 19780818

    2 IUPHAR Ligands for PANX1 (Px1)    About this table
    LigandTypeActionAffinityPubmed IDs
    flufenamic acid
    InhibitorNone--
    carbenoxolone
    InhibitorNone--

    2 Novoseek inferred chemical compound relationships for PANX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 54.3 23 18945939 (4), 19884319 (3), 19213873 (2), 18827222 (2) (see all 12)
    calcium 16.6 3 19212823 (1), 16364313 (1), 16908669 (1)



    Find genes that share compounds with PANX1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PANX1 gene: 
    NM_015368.3  

    Unigene Cluster for PANX1:

    Pannexin 1
    Hs.591976  [show with all ESTs]
    Unigene Representative Sequence: NM_015368
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227638(uc001peq.3 uc001per.3) ENST00000436171
    miRNA
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    hsa-miR-501-5p hsa-miR-330-5p hsa-miR-641 hsa-miR-326 hsa-miR-3617 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidPANX1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PANX1
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    Primer
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    OriGene qPCR primer pairs and template standards for PANX1
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      QuantiTect SYBR Green Assays in human, mouse, rat PANX1
      QuantiFast Probe-based Assays in human, mouse, rat PANX1

    Additional mRNA sequence: 

    AF398509.1 AK074897.1 AK313074.1 AY359023.1 BC016931.1 FM201789.1 

    3 DOTS entries:

    DT.452412  DT.100760144  DT.100760146 

    Selected AceView cDNA sequences (see all 185):

    D29224 BM129194 AI696772 AW009861 AI253101 AI621252 AI632153 NM_015368 
    AI097044 AA318484 AA426036 AA461458 AW003049 AA255468 AI538029 BM717999 
    AW089077 AA252867 BQ102517 CA418094 AI679640 BQ014155 AY359023 BM800096 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PANX1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                          
    SP2:                          -               


    ECgene alternative splicing isoforms for PANX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PANX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCATATGG
    PANX1 Expression
    About this image

    PANX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PANX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591976
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PANX1: 
              Inflammasomes in human mouse rat
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PANX1
    OriGene qSTAR qPCR primer pairs in human, mouse for PANX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PANX1
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    QuantiFast Probe-based Assays in human, mouse, rat PANX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PANX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PANX1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Panx11 , 5 pannexin 11, 5 83.84(n)1
    86.59(a)1
      9 (4.52 cM)5
    559911  NM_019482.21  NP_062355.21 
     150051615 
    chicken
    (Gallus gallus)
    Aves PANX16
    pannexin 1
    67(a)
    1 ↔ 1
    1(184921760-184940455) ENSGALG00000017213
    lizard
    (Anolis carolinensis)
    Reptilia PANX16
    pannexin 1
    66(a)
    1 ↔ 1
    3(195938005-195960999)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ384474.12   -- 74.25(n)    BQ384474.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556312 similar to pannexin 1 77.7(n)   393890  BC048058.1 


    ENSEMBL Gene Tree for PANX1 (if available)
    TreeFam Gene Tree for PANX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PANX1 gene
    PANX32  PANX22  
    1 SIMAP similar gene for PANX1 using alignment to 2 protein entries:     PANX1_HUMAN (see all proteins):
    PANX3

    Find genes that share paralogs with PANX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PANX1 (see all 1221)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs781514121,2
    F--93730838(+) GGGAAG/AGCTTT 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1474986821,2
    --93730915(+) TGTGGA/GGAGTG 1 -- us2k10--------
    rs797529771,2
    F--93731221(+) CAGATT/GTGCTA 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1399965301,2
    --93731314(+) ATTCCA/GACTTG 1 -- us2k10--------
    rs1454204951,2
    --93731426(+) GCCCTA/GTGAGC 1 -- us2k10--------
    rs1143379641,2
    F--93731435(+) GCCATC/GTACGC 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1821559871,2
    --93731483(+) GGCCAA/GGCTGG 1 -- us2k10--------
    rs122896091,2
    C,F,H--93731498(+) GAGAGG/TTACAT 1 -- us2k19Minor allele frequency- T:0.01NS EA NA CSA 806
    rs1487257231,2
    --93731595(+) TGCTTC/GAAATG 1 -- us2k10--------
    rs1862621941,2
    --93731609(+) CTGGTA/GATAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PANX1 (93862094 - 93915138 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PANX1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv989619CNV Deletion20482838
    esv2656589CNV Deletion23128226
    esv2744929CNV Deletion23290073
    esv2674143CNV Deletion23128226
    nsv468795CNV Loss19166990
    nsv898185CNV Loss21882294
    nsv898183CNV Loss21882294
    nsv469980CNV Loss18288195
    nsv517664CNV Loss19592680
    nsv508651CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608420    OMIM disorders: --


    Find genes that share disorders with PANX1           About GenesLikeMe

    Genetic Association Database (GAD): PANX1
    Human Genome Epidemiology (HuGE) Navigator: PANX1 (1 document)

    Export disorders for PANX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PANX1 gene, integrated from 10 sources (see all 108):
    (articles sorted by number of sources associating them with PANX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. (PubMed id 15028292)1, 2, 9 Baranova A....Panchin Y. (Genomics 2004)
    2. Pannexin 1 contributes to ATP release in airway epithelia. (PubMed id 19213873)1, 7, 9 Ransford G.A....Salathe M. (Am. J. Respir. Cell Mol. Biol. 2009)
    3. Functional implications of calcium permeability of the channel formed by pannexin 1. (PubMed id 16908669)1, 2, 9 Vanden Abeele F.... Prevarskaya N. (J. Cell Biol. 2006)
    4. Pannexins, a family of gap junction proteins expressed in brain. (PubMed id 14597722)1, 3, 9 Bruzzone R....Monyer H. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    6. Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. (PubMed id 17715132)1, 2 Boassa D.... Sosinsky G. (J. Biol. Chem. 2007)
    7. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. P2X7 receptor-Pannexin1 complex: pharmacology and signaling. (PubMed id 18596211)1, 9 Iglesias R....Scemes E. (Am. J. Physiol., Cell Physiol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 24145 HGNC: 8599 AceView: PANX1 Ensembl:ENSG00000110218 euGenes: HUgn24145
    ECgene: PANX1 H-InvDB: PANX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PANX1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Pannexin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PANX1 gene:
    Search GeneIP for patents involving PANX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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