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Aliases for PANX1 Gene

Aliases for PANX1 Gene

  • Pannexin 1 2 3
  • Innexin 2 3
  • MRS1 3 4
  • PX1 3 6
  • Pannexin-1 3
  • UNQ2529 3

External Ids for PANX1 Gene

Previous GeneCards Identifiers for PANX1 Gene

  • GC11P096192
  • GC11P095369
  • GC11P094046
  • GC11P093550
  • GC11P093501
  • GC11P093862
  • GC11P089937

Summaries for PANX1 Gene

Entrez Gene Summary for PANX1 Gene

  • The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

GeneCards Summary for PANX1 Gene

PANX1 (Pannexin 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include protein heterodimerization activity and actin filament binding. An important paralog of this gene is PANX2.

UniProtKB/Swiss-Prot for PANX1 Gene

  • Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

Tocris Summary for PANX1 Gene

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANX1 Gene

Genomics for PANX1 Gene

Regulatory Elements for PANX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PANX1 Gene

Start:
94,128,928 bp from pter
End:
94,185,596 bp from pter
Size:
56,669 bases
Orientation:
Plus strand

Genomic View for PANX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PANX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANX1 Gene

Proteins for PANX1 Gene

  • Protein details for PANX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD7-PANX1_HUMAN
    Recommended name:
    Pannexin-1
    Protein Accession:
    Q96RD7
    Secondary Accessions:
    • O75968
    • Q543A0
    • Q6UW26
    • Q96AM9
    • Q96L77
    • Q96RS5

    Protein attributes for PANX1 Gene

    Size:
    426 amino acids
    Molecular mass:
    48050 Da
    Quaternary structure:
    • Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).

    Alternative splice isoforms for PANX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PANX1 Gene

Proteomics data for PANX1 Gene at MOPED

Post-translational modifications for PANX1 Gene

Other Protein References for PANX1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PANX1 Gene

Domains for PANX1 Gene

Gene Families for PANX1 Gene

HGNC:
  • PANX :Ion channels / Pannexins
IUPHAR :

Protein Domains for PANX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PANX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RD7

UniProtKB/Swiss-Prot:

PANX1_HUMAN :
  • Q96RD7
Family:
  • Belongs to the pannexin family.
genes like me logo Genes that share domains with PANX1: view

Function for PANX1 Gene

Molecular function for PANX1 Gene

UniProtKB/Swiss-Prot Function: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

Gene Ontology (GO) - Molecular Function for PANX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0003779 actin binding --
GO:0005102 receptor binding IPI 17036048
GO:0005243 gap junction channel activity --
GO:0005262 calcium channel activity IMP 16908669
genes like me logo Genes that share ontologies with PANX1: view
genes like me logo Genes that share phenotypes with PANX1: view

Animal Models for PANX1 Gene

MGI Knock Outs for PANX1:

Animal Model Products

miRNA for PANX1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PANX1 Gene

Localization for PANX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANX1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PANX1 Gene COMPARTMENTS Subcellular localization image for PANX1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for PANX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16908669
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005921 gap junction IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PANX1: view

Pathways for PANX1 Gene

genes like me logo Genes that share pathways with PANX1: view

PCR Array Products

Interacting Proteins for PANX1 Gene

Gene Ontology (GO) - Biological Process for PANX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0006812 cation transport IDA 17036048
GO:0006816 calcium ion transport IMP 16908669
GO:0007267 cell-cell signaling IBA --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with PANX1: view

Compounds for PANX1 Gene

(5) Tocris Compounds for PANX1 Gene

Compound Action Cas Number
10Panx Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions [955091-53-9]
Carbenoxolone disodium Gap junction blocker. Also inhibitor of 11 beta-hydroxysteroid dehydrogenase [7421-40-1]
Gap 26 Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release [197250-15-0]
Gap 27 Selective gap junction blocker [198284-64-9]
Scrambled 10Panx Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide [1315378-72-3]

(1) Drugbank Compounds for PANX1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Probenecid
57-66-9 target antagonist

(2) IUPHAR Ligand for PANX1 Gene

Ligand Type Action Affinity Pubmed IDs
flufenamic acid Channel blocker None
carbenoxolone Inhibitor None

(2) Novoseek inferred chemical compound relationships for PANX1 Gene

Compound -log(P) Hits PubMed IDs
atp 54.3 19
calcium 16.6 3
genes like me logo Genes that share compounds with PANX1: view

Transcripts for PANX1 Gene

Unigene Clusters for PANX1 Gene

Pannexin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PANX1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PANX1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: -

Relevant External Links for PANX1 Gene

GeneLoc Exon Structure for
PANX1
ECgene alternative splicing isoforms for
PANX1

Expression for PANX1 Gene

mRNA expression in normal human tissues for PANX1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PANX1 Gene

SOURCE GeneReport for Unigene cluster for PANX1 Gene Hs.591976

genes like me logo Genes that share expressions with PANX1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PANX1 Gene

Orthologs for PANX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PANX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PANX1 35
  • 99.37 (n)
  • 98.83 (a)
PANX1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PANX1 35
  • 83.85 (n)
  • 82.98 (a)
PANX1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PANX1 35
  • 85.14 (n)
  • 84.91 (a)
PANX1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Panx1 35
  • 83.84 (n)
  • 86.59 (a)
Panx1 16
Panx1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PANX1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PANX1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Panx1 35
  • 82.51 (n)
  • 88.24 (a)
chicken
(Gallus gallus)
Aves PANX1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PANX1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia panx1 35
  • 66.82 (n)
  • 66.12 (a)
Str.14956 35
zebrafish
(Danio rerio)
Actinopterygii panx1a 35
  • 59.47 (n)
  • 57.77 (a)
panx1a 36
  • 56 (a)
OneToMany
panx1b 36
  • 56 (a)
OneToMany
zgc55631 35
Species with no ortholog for PANX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PANX1 Gene

ENSEMBL:
Gene Tree for PANX1 (if available)
TreeFam:
Gene Tree for PANX1 (if available)

Paralogs for PANX1 Gene

Paralogs for PANX1 Gene

Selected SIMAP similar genes for PANX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PANX1: view

Variants for PANX1 Gene

Sequence variations from dbSNP and Humsavar for PANX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1070 -- 94,181,790(-) AAGCA(C/T)GCCAA utr-variant-3-prime
rs1071 -- 94,181,824(-) CGCTA(A/C)GTTTT utr-variant-3-prime
rs8830 -- 94,181,928(+) ACTGG(C/T)GGAGA utr-variant-3-prime
rs13655 -- 94,181,312(+) TATGT(C/G)CCCTT utr-variant-3-prime
rs882937 -- 94,175,706(-) CAATC(A/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PANX1 Gene

Variant ID Type Subtype PubMed ID
nsv898183 CNV Loss 21882294
nsv898184 CNV Gain 21882294
nsv523082 CNV Gain 19592680
nsv508651 CNV Loss 20534489
nsv898185 CNV Loss 21882294
esv989619 CNV Deletion 20482838
nsv469980 CNV Loss 18288195
nsv468795 CNV Loss 19166990
nsv517664 CNV Loss 19592680
esv2744929 CNV Deletion 23290073
esv2674143 CNV Deletion 23128226
esv2656589 CNV Deletion 23128226

Relevant External Links for PANX1 Gene

HapMap Linkage Disequilibrium report
PANX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PANX1 Gene

Disorders for PANX1 Gene

Relevant External Links for PANX1

Genetic Association Database (GAD)
PANX1
Human Genome Epidemiology (HuGE) Navigator
PANX1
genes like me logo Genes that share disorders with PANX1: view

No data available for UniProtKB/Swiss-Prot for PANX1 Gene

Publications for PANX1 Gene

  1. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. (PMID: 15028292) Baranova A. … Panchin Y. (Genomics 2004) 3 4 23
  2. Pannexins, a family of gap junction proteins expressed in brain. (PMID: 14597722) Bruzzone R. … Monyer H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 23
  3. Functional implications of calcium permeability of the channel formed by pannexin 1. (PMID: 16908669) Vanden Abeele F. … Prevarskaya N. (J. Cell Biol. 2006) 3 4 23
  4. Pannexin 1 contributes to ATP release in airway epithelia. (PMID: 19213873) Ransford G.A. … Salathe M. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23 25
  5. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. (PMID: 19056988) Thompson R.J. … MacVicar B.A. (Science 2008) 3 23

Products for PANX1 Gene

Sources for PANX1 Gene

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