External Ids for PANX1 Gene
Previous GeneCards Identifiers for PANX1 Gene
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
GeneCards Summary for PANX1 Gene
PANX1 (Pannexin 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include protein heterodimerization activity and actin filament binding. An important paralog of this gene is PANX2.
UniProtKB/Swiss-Prot for PANX1 Gene
Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.