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Aliases for PANK4 Gene

Aliases for PANK4 Gene

  • Pantothenate Kinase 4 2 3
  • Pantothenic Acid Kinase 4 3 4
  • EC 2.7.1.33 4 63
  • HPanK4 3 4

External Ids for PANK4 Gene

Previous GeneCards Identifiers for PANK4 Gene

  • GC01M002452
  • GC01M002100
  • GC01M002309
  • GC01M002472
  • GC01M002429
  • GC01M001719

Summaries for PANK4 Gene

Entrez Gene Summary for PANK4 Gene

  • This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for PANK4 Gene

PANK4 (Pantothenate Kinase 4) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include pantothenate kinase activity. An important paralog of this gene is PANK1.

UniProtKB/Swiss-Prot for PANK4 Gene

  • Plays a role in the physiological regulation of the intracellular CoA concentration.

Gene Wiki entry for PANK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANK4 Gene

Genomics for PANK4 Gene

Regulatory Elements for PANK4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PANK4 Gene

Chromosome:
1
Start:
2,508,531 bp from pter
End:
2,526,628 bp from pter
Size:
18,098 bases
Orientation:
Minus strand

Genomic View for PANK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PANK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANK4 Gene

Proteins for PANK4 Gene

  • Protein details for PANK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVE7-PANK4_HUMAN
    Recommended name:
    Pantothenate kinase 4
    Protein Accession:
    Q9NVE7
    Secondary Accessions:
    • B9DI84
    • Q53EU3
    • Q5TA84
    • Q7RTX3
    • Q9H3X5

    Protein attributes for PANK4 Gene

    Size:
    773 amino acids
    Molecular mass:
    85991 Da
    Quaternary structure:
    • Homodimer. Interacts with PKM (By similarity).

neXtProt entry for PANK4 Gene

Proteomics data for PANK4 Gene at MOPED

Post-translational modifications for PANK4 Gene

  • Ubiquitination at Lys 137, Lys 234, and Lys 487
  • Modification sites at PhosphoSitePlus

Other Protein References for PANK4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PANK4 (PANK4)

Domains & Families for PANK4 Gene

Suggested Antigen Peptide Sequences for PANK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVE7

UniProtKB/Swiss-Prot:

PANK4_HUMAN :
  • Belongs to the type II pantothenate kinase family.
Family:
  • Belongs to the type II pantothenate kinase family.
genes like me logo Genes that share domains with PANK4: view

No data available for Gene Families for PANK4 Gene

Function for PANK4 Gene

Molecular function for PANK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (R)-pantothenate = ADP + (R)-4-phosphopantothenate
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by feedback inhibition by CoA and its thioesters.
UniProtKB/Swiss-Prot Function:
Plays a role in the physiological regulation of the intracellular CoA concentration.

Enzyme Numbers (IUBMB) for PANK4 Gene

Gene Ontology (GO) - Molecular Function for PANK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004594 pantothenate kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PANK4: view
genes like me logo Genes that share phenotypes with PANK4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PANK4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PANK4 Gene

Localization for PANK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANK4 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for PANK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PANK4: view

No data available for Subcellular locations from COMPARTMENTS for PANK4 Gene

Pathways & Interactions for PANK4 Gene

genes like me logo Genes that share pathways with PANK4: view

UniProtKB/Swiss-Prot Q9NVE7-PANK4_HUMAN

  • Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5

Gene Ontology (GO) - Biological Process for PANK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015937 coenzyme A biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with PANK4: view

No data available for SIGNOR curated interactions for PANK4 Gene

Drugs & Compounds for PANK4 Gene

(2) Drugs for PANK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Pantothenic acid Nutra 18

(6) Additional Compounds for PANK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Phosphopantothenoylcysteine
  • (R)-4'-phospho-N-pantothenoyl-L-cysteine
  • (R)-N-[N-[2-hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-b-alanyl]-L-Cysteine
  • (R)-N-[N-[2-hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-beta-alanyl]-L-Cysteine
  • 4'-P-N-Pantothenoylcysteine
  • 4'-Phospho-N-pantothenoylcysteine
7196-09-0
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
D-4'-Phosphopantothenate
  • (R)-4'-phosphopantothenate
  • 4'-P-Pantothenate
  • 4'-Phosphopantothenate
  • D-4'-Phosphopantothenate
  • D-4'-Phosphopantothenic acid
D-Pantothenoyl-L-cysteine
  • N-((R)-Pantothenoyl)-L-cysteine
  • N-Pantothenoylcystein
pantetheine
  • (R)-Pantetheine
  • D-Pantetheine
  • Lactobacillus bulgaricus factor
  • LBF
  • Pantotheine
496-65-1
genes like me logo Genes that share compounds with PANK4: view

Transcripts for PANK4 Gene

Unigene Clusters for PANK4 Gene

Pantothenate kinase 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PANK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PANK4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6:
SP7:
SP8: - - -
SP9:
SP10: - -
SP11: -

ExUns: 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for PANK4 Gene

GeneLoc Exon Structure for
PANK4
ECgene alternative splicing isoforms for
PANK4

Expression for PANK4 Gene

mRNA expression in normal human tissues for PANK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PANK4 Gene

This gene is overexpressed in Lymph node (7.9) and Brain (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PANK4 Gene



SOURCE GeneReport for Unigene cluster for PANK4 Gene Hs.26156

mRNA Expression by UniProt/SwissProt for PANK4 Gene

Q9NVE7-PANK4_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression in the muscle.
genes like me logo Genes that share expression patterns with PANK4: view

Protein tissue co-expression partners for PANK4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PANK4 Gene

Orthologs for PANK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PANK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PANK4 35
  • 87.54 (n)
  • 94.05 (a)
PANK4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PANK4 35
  • 87.15 (n)
  • 94.05 (a)
PANK4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pank4 35
  • 85.36 (n)
  • 92.48 (a)
Pank4 16
Pank4 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PANK4 35
  • 99.35 (n)
  • 99.61 (a)
PANK4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pank4 35
  • 86.03 (n)
  • 92.5 (a)
oppossum
(Monodelphis domestica)
Mammalia PANK4 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PANK4 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PANK4 35
  • 76.37 (n)
  • 88.62 (a)
PANK4 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pank4 35
  • 72 (n)
  • 83.07 (a)
Str.20093 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2107 35
zebrafish
(Danio rerio)
Actinopterygii pank4 35
  • 74.5 (n)
  • 85.24 (a)
zgc66285 35
pank4 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010073 35
  • 49.12 (n)
  • 42.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5828 35
  • 51.95 (n)
  • 45.91 (a)
CG5828 36
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pnk-4 35
  • 46.52 (n)
  • 40.35 (a)
pnk-1 36
  • 33 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR729C 35
  • 57.51 (n)
  • 51.53 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00869g 35
  • 52.45 (n)
  • 50.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB1 35
  • 50.16 (n)
  • 46.65 (a)
CAB1 36
  • 40 (a)
OneToMany
CAB1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PANK2 35
  • 50.7 (n)
  • 46.13 (a)
rice
(Oryza sativa)
Liliopsida Os09g0533100 35
  • 50.86 (n)
  • 46.37 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03154 35
  • 58.47 (n)
  • 53.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4B4.01c 35
  • 50.15 (n)
  • 49.26 (a)
Species with no ortholog for PANK4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PANK4 Gene

ENSEMBL:
Gene Tree for PANK4 (if available)
TreeFam:
Gene Tree for PANK4 (if available)

Paralogs for PANK4 Gene

Paralogs for PANK4 Gene

(2) SIMAP similar genes for PANK4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PANK4: view

Variants for PANK4 Gene

Sequence variations from dbSNP and Humsavar for PANK4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs733307 -- 2,512,216(+) CGGGA(A/G)GGGCC intron-variant
rs744112 -- 2,512,787(-) GTCAC(A/G)TGGCG intron-variant
rs878496 -- 2,526,376(+) ccctt(C/G)gtcct intron-variant
rs1980789 -- 2,524,424(-) TTGTT(G/T)GTTAC intron-variant
rs2236394 -- 2,515,521(-) GCCGC(A/G)GCCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PANK4 Gene

Variant ID Type Subtype PubMed ID
dgv64n71 CNV Loss 21882294
dgv69n71 CNV Loss 21882294
dgv71n71 CNV Loss 21882294
dgv72n71 CNV Loss 21882294
dgv75n71 CNV Loss 21882294
nsv470684 CNV Loss 18288195
dgv1n27 CNV Loss 19166990
dgv77n71 CNV Gain 21882294
dgv78n71 CNV Gain+Loss 21882294
dgv79n71 CNV Loss 21882294
nsv470685 CNV Gain 18288195
dgv80n71 CNV Loss 21882294
dgv81n71 CNV Loss 21882294
nsv871726 CNV Loss 21882294
nsv870655 CNV Loss 21882294
nsv871912 CNV Gain 21882294
nsv871255 CNV Loss 21882294
nsv823920 CNV Gain 20364138
nsv818222 CNV Loss 17921354
nsv7171 OTHER Inversion 18451855
dgv82n71 CNV Loss 21882294
nsv824031 CNV Gain 20364138
dgv83n71 CNV Loss 21882294
esv2583485 CNV Insertion 19546169
esv1165961 CNV Insertion 17803354
dgv84n71 CNV Loss 21882294
nsv1 OTHER Inversion 15895083

Variation tolerance for PANK4 Gene

Residual Variation Intolerance Score: 4.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.77; 91.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PANK4 Gene

HapMap Linkage Disequilibrium report
PANK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PANK4 Gene

Disorders for PANK4 Gene

Relevant External Links for PANK4

Genetic Association Database (GAD)
PANK4
Human Genome Epidemiology (HuGE) Navigator
PANK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PANK4
genes like me logo Genes that share disorders with PANK4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PANK4 Gene

Publications for PANK4 Gene

  1. High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2). (PMID: 16132722) Li Y. … Fang F. (Mol. Cell. Biochem. 2005) 23 67
  2. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. (PMID: 11479594) Zhou B. … Hayflick S.J. (Nat. Genet. 2001) 2 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 67
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67

Products for PANK4 Gene

Sources for PANK4 Gene

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