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Aliases for PANK3 Gene

Aliases for PANK3 Gene

  • Pantothenate Kinase 3 2 3 5
  • Pantothenic Acid Kinase 3 3 4
  • EC 2.7.1.33 4 61
  • HPanK3 3 4

External Ids for PANK3 Gene

Previous GeneCards Identifiers for PANK3 Gene

  • GC05M168623
  • GC05M167918
  • GC05M167963
  • GC05M167915
  • GC05M163081
  • GC05M167975

Summaries for PANK3 Gene

Entrez Gene Summary for PANK3 Gene

  • This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]

GeneCards Summary for PANK3 Gene

PANK3 (Pantothenate Kinase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include pantothenate kinase activity. An important paralog of this gene is PANK2.

UniProtKB/Swiss-Prot for PANK3 Gene

  • Plays a role in the physiological regulation of the intracellular CoA concentration.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANK3 Gene

Genomics for PANK3 Gene

Regulatory Elements for PANK3 Gene

Enhancers for PANK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F168551 0.2 ENCODE 12.2 +27.4 27356 1.2 POLR2A ZNF366 FBLL1 PANK3 RARS ENSG00000254192 GC05M168548 SLC2A3P1
GH05F168600 0.2 ENCODE 11.9 -21.1 -21066 0.9 MLX FEZF1 ZNF48 YY1 NFYC KAT8 MIER3 GLIS1 KLF1 ZNF792 PANK3 ENSG00000254192 LOC101927969 SLIT3 FBLL1 RPL10P9
GH05F168624 1.1 FANTOM5 ENCODE 10.8 -45.4 -45439 1.5 ELF3 ATF1 MLX ARID4B ZNF48 ZSCAN9 RAD21 RARA KAT2B YY1 ENSG00000254192 PANK3 LOC101927969 SLIT3 FBLL1 RPL10P9
GH05F168485 0.2 ENCODE 10.6 +92.7 92676 2.2 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RARS ENSG00000254192 FBLL1 PANK3
GH05F168653 0.9 Ensembl ENCODE 10.3 -74.7 -74692 1.4 SMARCA4 SIN3A REST RAD21 LOC101927969 PANK3 SLIT3 FBLL1 ENSG00000254192 RPL10P9
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PANK3 on UCSC Golden Path with GeneCards custom track

Promoters for PANK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001296141 609 2801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143

Genomic Location for PANK3 Gene

Chromosome:
5
Start:
168,548,495 bp from pter
End:
168,579,609 bp from pter
Size:
31,115 bases
Orientation:
Minus strand

Genomic View for PANK3 Gene

Genes around PANK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANK3 Gene

Proteins for PANK3 Gene

  • Protein details for PANK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H999-PANK3_HUMAN
    Recommended name:
    Pantothenate kinase 3
    Protein Accession:
    Q9H999
    Secondary Accessions:
    • D3DQL1
    • Q53FJ9
    • Q7RTX4

    Protein attributes for PANK3 Gene

    Size:
    370 amino acids
    Molecular mass:
    41094 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PANK3 Gene

neXtProt entry for PANK3 Gene

Post-translational modifications for PANK3 Gene

  • Ubiquitination at Lys 71
  • Modification sites at PhosphoSitePlus

Other Protein References for PANK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PANK3 Gene

Protein Domains for PANK3 Gene

Suggested Antigen Peptide Sequences for PANK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H999

UniProtKB/Swiss-Prot:

PANK3_HUMAN :
  • Belongs to the type II pantothenate kinase family.
Family:
  • Belongs to the type II pantothenate kinase family.
genes like me logo Genes that share domains with PANK3: view

No data available for Gene Families for PANK3 Gene

Function for PANK3 Gene

Molecular function for PANK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (R)-pantothenate = ADP + (R)-4-phosphopantothenate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by feedback inhibition by CoA and its thioesters.
UniProtKB/Swiss-Prot Function:
Plays a role in the physiological regulation of the intracellular CoA concentration.

Enzyme Numbers (IUBMB) for PANK3 Gene

Gene Ontology (GO) - Molecular Function for PANK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004594 pantothenate kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PANK3: view
genes like me logo Genes that share phenotypes with PANK3: view

Animal Models for PANK3 Gene

MGI Knock Outs for PANK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PANK3

miRNA for PANK3 Gene

miRTarBase miRNAs that target PANK3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PANK3

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PANK3 Gene

Localization for PANK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANK3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PANK3 Gene COMPARTMENTS Subcellular localization image for PANK3 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PANK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PANK3: view

Pathways & Interactions for PANK3 Gene

genes like me logo Genes that share pathways with PANK3: view

UniProtKB/Swiss-Prot Q9H999-PANK3_HUMAN

  • Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.

Interacting Proteins for PANK3 Gene

Gene Ontology (GO) - Biological Process for PANK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015937 coenzyme A biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with PANK3: view

No data available for SIGNOR curated interactions for PANK3 Gene

Drugs & Compounds for PANK3 Gene

(2) Drugs for PANK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Pantothenic acid Vet_approved Nutra 25

(6) Additional Compounds for PANK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Phosphopantothenoylcysteine
  • (R)-4'-phospho-N-pantothenoyl-L-cysteine
  • (R)-N-[N-[2-hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-b-alanyl]-L-Cysteine
  • (R)-N-[N-[2-hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-beta-alanyl]-L-Cysteine
  • 4'-P-N-Pantothenoylcysteine
  • 4'-Phospho-N-pantothenoylcysteine
7196-09-0
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
D-4'-Phosphopantothenate
  • (R)-4'-phosphopantothenate
  • 4'-P-Pantothenate
  • 4'-Phosphopantothenate
  • D-4'-Phosphopantothenate
  • D-4'-Phosphopantothenic acid
D-Pantothenoyl-L-cysteine
  • N-((R)-Pantothenoyl)-L-cysteine
  • N-Pantothenoylcystein
pantetheine
  • (R)-Pantetheine
  • D-Pantetheine
  • Lactobacillus bulgaricus factor
  • LBF
  • Pantotheine
496-65-1
genes like me logo Genes that share compounds with PANK3: view

Transcripts for PANK3 Gene

mRNA/cDNA for PANK3 Gene

Unigene Clusters for PANK3 Gene

Pantothenate kinase 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PANK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PANK3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for PANK3 Gene

GeneLoc Exon Structure for
PANK3
ECgene alternative splicing isoforms for
PANK3

Expression for PANK3 Gene

mRNA expression in normal human tissues for PANK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PANK3 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PANK3 Gene



Protein tissue co-expression partners for PANK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PANK3 Gene:

PANK3

SOURCE GeneReport for Unigene cluster for PANK3 Gene:

Hs.388400

mRNA Expression by UniProt/SwissProt for PANK3 Gene:

Q9H999-PANK3_HUMAN
Tissue specificity: Highly expressed in the liver.
genes like me logo Genes that share expression patterns with PANK3: view

Primer Products

No data available for mRNA differential expression in normal tissues for PANK3 Gene

Orthologs for PANK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PANK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PANK3 34 35
  • 99.91 (n)
oppossum
(Monodelphis domestica)
Mammalia PANK3 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PANK3 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PANK3 34 35
  • 95.68 (n)
cow
(Bos Taurus)
Mammalia PANK3 34 35
  • 94.23 (n)
mouse
(Mus musculus)
Mammalia Pank3 34 16 35
  • 93.33 (n)
rat
(Rattus norvegicus)
Mammalia Pank3 34
  • 93.06 (n)
chicken
(Gallus gallus)
Aves PANK3 34 35
  • 85.59 (n)
lizard
(Anolis carolinensis)
Reptilia PANK3 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pank3 34
  • 79.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6777 34
zebrafish
(Danio rerio)
Actinopterygii pank2 35
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fbl 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pnk-4 35
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB1 35
  • 31 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.8793 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
Species where no ortholog for PANK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PANK3 Gene

ENSEMBL:
Gene Tree for PANK3 (if available)
TreeFam:
Gene Tree for PANK3 (if available)

Paralogs for PANK3 Gene

Paralogs for PANK3 Gene

(3) SIMAP similar genes for PANK3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PANK3 Gene

genes like me logo Genes that share paralogs with PANK3: view

Variants for PANK3 Gene

Sequence variations from dbSNP and Humsavar for PANK3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10056428 -- 168,581,422(+) tgcct(A/G)tggag upstream-variant-2KB
rs10061365 -- 168,557,215(+) ACAAA(A/C/T)ATTCA utr-variant-3-prime
rs10064717 -- 168,577,637(+) cctag(C/T)cCTAT intron-variant
rs10070122 -- 168,568,216(+) TACTA(A/G)CCAAA intron-variant
rs10640361 -- 168,563,574(+) TAGAG(-/TA)TATAT intron-variant

Variation tolerance for PANK3 Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.30; 76.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PANK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PANK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PANK3 Gene

Disorders for PANK3 Gene

Relevant External Links for PANK3

Genetic Association Database (GAD)
PANK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PANK3

No disorders were found for PANK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PANK3 Gene

Publications for PANK3 Gene

  1. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. (PMID: 11479594) Zhou B. … Hayflick S.J. (Nat. Genet. 2001) 2 3 4 64
  2. Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. (PMID: 17631502) Hong B.S. … Park H.W. (J. Biol. Chem. 2007) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain. (PMID: 20797618) Leonardi R. … Jackowski S. (Chem. Biol. 2010) 3 64

Products for PANK3 Gene

Sources for PANK3 Gene

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