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Aliases for PAN3 Gene

Aliases for PAN3 Gene

  • PAN3 Poly(A) Specific Ribonuclease Subunit 2 3
  • PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (S. Cerevisiae) 2
  • PAN Deadenylation Complex Subunit 3 4
  • PAB1P-Dependent Poly(A)-Nuclease 4
  • HPan3 4
  • TS 6

External Ids for PAN3 Gene

Summaries for PAN3 Gene

GeneCards Summary for PAN3 Gene

PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include protein kinase activity and poly(A)-specific ribonuclease activity.

UniProtKB/Swiss-Prot for PAN3 Gene

  • Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3-5 exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5-3 exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAN3 Gene

Genomics for PAN3 Gene

Genomic Location for PAN3 Gene

Start:
28,136,860 bp from pter
End:
28,295,338 bp from pter
Size:
158,479 bases
Orientation:
Plus strand

Genomic View for PAN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAN3 Gene

Regulatory Elements for PAN3 Gene

Proteins for PAN3 Gene

  • Protein details for PAN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58A45-PAN3_HUMAN
    Recommended name:
    PAB-dependent poly(A)-specific ribonuclease subunit PAN3
    Protein Accession:
    Q58A45
    Secondary Accessions:
    • A0N0X1
    • A1A4Y8
    • A1A4Y9
    • B1ALF1
    • B7Z3W7
    • Q0D2P2
    • Q5HYG6
    • Q5T515
    • Q5T516
    • Q5TBA0
    • Q76E13
    • Q8NBA6

    Protein attributes for PAN3 Gene

    Size:
    887 amino acids
    Molecular mass:
    95613 Da
    Quaternary structure:
    • Homodimer. Interacts with the catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate-specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
    SequenceCaution:
    • Sequence=AAI28180.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABK41888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC03632.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12449.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12450.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM20921.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PAN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAN3 Gene

Proteomics data for PAN3 Gene at MOPED

Post-translational modifications for PAN3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys594

Other Protein References for PAN3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PAN3 Gene

Domains for PAN3 Gene

Protein Domains for PAN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PAN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q58A45

UniProtKB/Swiss-Prot:

PAN3_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive. However it still binds ATP and ATP-binding is required for mRNA degradation.:
    • Q58A45
  • Contains 1 protein kinase domain.:
    • Q58A45
Family:
  • Belongs to the protein kinase superfamily. PAN3 family.:
    • Q58A45
Similarity:
  • Contains 1 C3H1-type zinc finger.:
    • Q58A45
genes like me logo Genes that share domains with PAN3: view

No data available for Gene Families for PAN3 Gene

Function for PAN3 Gene

Molecular function for PAN3 Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3-5 exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5-3 exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins.

Gene Ontology (GO) - Molecular Function for PAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004535 contributes_to poly(A)-specific ribonuclease activity IDA 14583602
GO:0004672 protein kinase activity --
GO:0005515 protein binding IPI 14583602
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
genes like me logo Genes that share ontologies with PAN3: view

miRNA for PAN3 Gene

miRTarBase miRNAs that target PAN3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PAN3 Gene

Localization for PAN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAN3 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAN3 Gene COMPARTMENTS Subcellular localization image for PAN3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005829 cytosol TAS --
GO:0031251 PAN complex IDA 14583602
genes like me logo Genes that share ontologies with PAN3: view

Pathways for PAN3 Gene

genes like me logo Genes that share pathways with PAN3: view

Pathways by source for PAN3 Gene

1 KEGG pathway for PAN3 Gene

Gene Ontology (GO) - Biological Process for PAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0006468 protein phosphorylation --
GO:0006605 protein targeting IEA --
genes like me logo Genes that share ontologies with PAN3: view

Transcripts for PAN3 Gene

mRNA/cDNA for PAN3 Gene

(9) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAN3 Gene

PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAN3 Gene

No ASD Table

Relevant External Links for PAN3 Gene

GeneLoc Exon Structure for
PAN3
ECgene alternative splicing isoforms for
PAN3

Expression for PAN3 Gene

mRNA expression in normal human tissues for PAN3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAN3 Gene

SOURCE GeneReport for Unigene cluster for PAN3 Gene Hs.645015

genes like me logo Genes that share expressions with PAN3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PAN3 Gene

Orthologs for PAN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAN3 35
  • 99.7 (n)
  • 99.89 (a)
PAN3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAN3 35
  • 93.98 (n)
  • 97.71 (a)
PAN3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAN3 35
  • 95.3 (n)
  • 98.42 (a)
PAN3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pan3 35
  • 89.42 (n)
  • 92.83 (a)
Pan3 16
Pan3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAN3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAN3 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pan3 35
  • 91.46 (n)
  • 96.05 (a)
chicken
(Gallus gallus)
Aves PAN3 35
  • 86.99 (n)
  • 93.54 (a)
PAN3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAN3 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4185 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pan3 35
  • 79.31 (n)
  • 88.67 (a)
Str.17142 35
zebrafish
(Danio rerio)
Actinopterygii pan3 35
  • 72.18 (n)
  • 81.36 (a)
pan3 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11486 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea panl-3 36
  • 36 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR172W 35
  • 43.71 (n)
  • 33.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAN3 35
  • 45.33 (n)
  • 30.82 (a)
PAN3 36
  • 25 (a)
OneToOne
PAN3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08097g 35
  • 45.27 (n)
  • 29.59 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01929 35
  • 45.51 (n)
  • 36.23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4729 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8760 36
  • 65 (a)
OneToOne
Species with no ortholog for PAN3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAN3 Gene

ENSEMBL:
Gene Tree for PAN3 (if available)
TreeFam:
Gene Tree for PAN3 (if available)

Paralogs for PAN3 Gene

No data available for Paralogs for PAN3 Gene

Variants for PAN3 Gene

Sequence variations from dbSNP and Humsavar for PAN3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs719368 -- 28,277,195(-) TTTCA(C/T)AGGTA intron-variant
rs884219 -- 28,259,144(-) tctca(A/T)aaaaa intron-variant
rs961341 -- 28,212,083(-) CTGAA(C/T)TCACA intron-variant
rs961342 -- 28,211,771(-) GCTGT(A/T)ACATA intron-variant
rs1054886 -- 28,274,159(+) GAATA(A/T)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAN3 Gene

Variant ID Type Subtype PubMed ID
esv34052 CNV Loss 18971310
nsv525459 CNV Loss 19592680
dgv1568n71 CNV Loss 21882294
esv2644170 CNV Deletion 19546169
esv1931997 CNV Deletion 18987734
esv4105 CNV Deletion 18987735
esv2747192 CNV Deletion 23290073
esv1004538 CNV Deletion 20482838
nsv64676 CNV Loss 16902084
esv8541 CNV Loss 19470904
esv1220684 CNV Deletion 17803354
esv2747193 CNV Deletion 23290073

Relevant External Links for PAN3 Gene

HapMap Linkage Disequilibrium report
PAN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAN3 Gene

Disorders for PAN3 Gene

Relevant External Links for PAN3

Genetic Association Database (GAD)
PAN3
genes like me logo Genes that share disorders with PAN3: view

No data available for UniProtKB/Swiss-Prot for PAN3 Gene

Publications for PAN3 Gene

  1. Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein. (PMID: 14583602) Uchida N. … Katada T. (J. Biol. Chem. 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases. (PMID: 18056425) Funakoshi Y. … Hoshino S. (Genes Dev. 2007) 3 4

Products for PAN3 Gene

  • Addgene plasmids for PAN3

Sources for PAN3 Gene

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