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Aliases for PAN3 Gene

Aliases for PAN3 Gene

  • PAN3 Poly(A) Specific Ribonuclease Subunit 2 3 5
  • PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (S. Cerevisiae) 2
  • PAN Deadenylation Complex Subunit 3 4
  • PAB1P-Dependent Poly(A)-Nuclease 4
  • HPan3 4

External Ids for PAN3 Gene

Previous GeneCards Identifiers for PAN3 Gene

  • GC13P026652
  • GC13P026546
  • GC13P027646
  • GC13P028713
  • GC13P009533

Summaries for PAN3 Gene

GeneCards Summary for PAN3 Gene

PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and poly(A)-specific ribonuclease activity.

UniProtKB/Swiss-Prot for PAN3 Gene

  • Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3-5 exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5-3 exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAN3 Gene

Genomics for PAN3 Gene

Regulatory Elements for PAN3 Gene

Enhancers for PAN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F028160 1 Ensembl ENCODE 18.5 +24.9 24884 3.2 ATF1 INSM2 ZNF76 KLF17 FEZF1 ZEB1 ZNF366 SCRT2 ZNF391 ZNF362 PAN3 PAN3-AS1 EEF1A1P3
GH13F028268 0.2 ENCODE 18 +132.4 132395 1.7 PKNOX1 TBL1XR1 BMI1 RAD21 YY1 CBX5 ETV6 RCOR1 CREM CBFB PAN3 GC13M028296 GC13P028239
GH13F028251 0.5 Ensembl 16.5 +114.9 114884 0.8 POLR2A IRF1 PAN3 GC13P028239 GC13M028296
GH13F027160 0.5 Ensembl 16.1 -975.7 -975717 1.6 ZNF202 PAN3 RPL21 SNORA27 USP12 USP12-AS1
GH13F027139 0.6 ENCODE 16.1 -997.0 -996979 0.2 ZNF202 ZNF680 ZFP64 ZBTB11 ZBTB8A ZNF623 ZNF518A ZNF781 ZNF101 PRDM12 PAN3 RPL21 SNORA27 WASF3 PAN3-AS1 USP12-AS1 USP12
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PAN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAN3 Gene

Chromosome:
13
Start:
28,136,717 bp from pter
End:
28,295,338 bp from pter
Size:
158,622 bases
Orientation:
Plus strand

Genomic View for PAN3 Gene

Genes around PAN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAN3 Gene

Proteins for PAN3 Gene

  • Protein details for PAN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58A45-PAN3_HUMAN
    Recommended name:
    PAB-dependent poly(A)-specific ribonuclease subunit PAN3
    Protein Accession:
    Q58A45
    Secondary Accessions:
    • A0N0X1
    • A1A4Y8
    • A1A4Y9
    • B1ALF1
    • B7Z3W7
    • Q0D2P2
    • Q5HYG6
    • Q5T515
    • Q5T516
    • Q5TBA0
    • Q76E13
    • Q8NBA6

    Protein attributes for PAN3 Gene

    Size:
    887 amino acids
    Molecular mass:
    95613 Da
    Quaternary structure:
    • Homodimer. Interacts with the catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
    SequenceCaution:
    • Sequence=AAI28180.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABK41888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC03632.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12449.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12450.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM20921.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PAN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAN3 Gene

Post-translational modifications for PAN3 Gene

  • Ubiquitination at Lys 594
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PAN3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PAN3

No data available for DME Specific Peptides for PAN3 Gene

Domains & Families for PAN3 Gene

Protein Domains for PAN3 Gene

Suggested Antigen Peptide Sequences for PAN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q58A45

UniProtKB/Swiss-Prot:

PAN3_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive. However it still binds ATP and ATP-binding is required for mRNA degradation.
  • Belongs to the protein kinase superfamily. PAN3 family.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive. However it still binds ATP and ATP-binding is required for mRNA degradation.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. PAN3 family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with PAN3: view

No data available for Gene Families for PAN3 Gene

Function for PAN3 Gene

Molecular function for PAN3 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3-5 exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5-3 exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins.

Gene Ontology (GO) - Molecular Function for PAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004535 contributes_to poly(A)-specific ribonuclease activity IDA 14583602
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 14583602
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IEA,IBA --
genes like me logo Genes that share ontologies with PAN3: view
genes like me logo Genes that share phenotypes with PAN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PAN3

miRNA for PAN3 Gene

miRTarBase miRNAs that target PAN3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAN3 Gene

Localization for PAN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAN3 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAN3 Gene COMPARTMENTS Subcellular localization image for PAN3 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA,IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0031251 PAN complex IEA,IDA 14583602
genes like me logo Genes that share ontologies with PAN3: view

Pathways & Interactions for PAN3 Gene

genes like me logo Genes that share pathways with PAN3: view

Pathways by source for PAN3 Gene

1 KEGG pathway for PAN3 Gene

Gene Ontology (GO) - Biological Process for PAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IEA,TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA,IBA --
GO:0006397 mRNA processing IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PAN3: view

No data available for SIGNOR curated interactions for PAN3 Gene

Transcripts for PAN3 Gene

mRNA/cDNA for PAN3 Gene

(13) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAN3 Gene

PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAN3 Gene

No ASD Table

Relevant External Links for PAN3 Gene

GeneLoc Exon Structure for
PAN3
ECgene alternative splicing isoforms for
PAN3

Expression for PAN3 Gene

mRNA expression in normal human tissues for PAN3 Gene

Protein differential expression in normal tissues from HIPED for PAN3 Gene

This gene is overexpressed in Placenta (15.4), Blymphocyte (14.9), Peripheral blood mononuclear cells (12.7), CD8 Tcells (10.9), and Platelet (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAN3 Gene



Protein tissue co-expression partners for PAN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PAN3 Gene:

PAN3

SOURCE GeneReport for Unigene cluster for PAN3 Gene:

Hs.645015
genes like me logo Genes that share expression patterns with PAN3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PAN3 Gene

Orthologs for PAN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAN3 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia PAN3 34 35
  • 95.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PAN3 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAN3 34 35
  • 93.98 (n)
rat
(Rattus norvegicus)
Mammalia Pan3 34
  • 91.46 (n)
mouse
(Mus musculus)
Mammalia Pan3 34 16 35
  • 89.42 (n)
oppossum
(Monodelphis domestica)
Mammalia PAN3 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAN3 34 35
  • 86.99 (n)
lizard
(Anolis carolinensis)
Reptilia PAN3 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pan3 34
  • 79.31 (n)
Str.17142 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4185 34
zebrafish
(Danio rerio)
Actinopterygii pan3 34 35
  • 72.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11486 35
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea panl-3 35
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAN3 34 35 37
  • 45.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08097g 34
  • 45.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR172W 34
  • 43.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8760 35
  • 65 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01929 34
  • 45.51 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4729 34
Species where no ortholog for PAN3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAN3 Gene

ENSEMBL:
Gene Tree for PAN3 (if available)
TreeFam:
Gene Tree for PAN3 (if available)

Paralogs for PAN3 Gene

No data available for Paralogs for PAN3 Gene

Variants for PAN3 Gene

Sequence variations from dbSNP and Humsavar for PAN3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10161772 -- 28,170,472(+) TGGCA(A/T)GTTCA intron-variant
rs10161915 -- 28,169,483(+) acctc(A/G)gcctc intron-variant
rs10162126 -- 28,167,347(+) tagag(A/T)tgggg intron-variant
rs10507381 -- 28,294,156(+) ATTGA(A/G)TCCAC utr-variant-3-prime
rs10545190 -- 28,252,189(+) GGCCC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAN3 Gene

Variant ID Type Subtype PubMed ID
dgv935n106 CNV deletion 24896259
esv1004538 CNV deletion 20482838
esv1220684 CNV deletion 17803354
esv1931997 CNV deletion 18987734
esv2644170 CNV deletion 19546169
esv2747192 CNV deletion 23290073
esv2747193 CNV deletion 23290073
esv34052 CNV loss 18971310
esv3550236 CNV deletion 23714750
esv4105 CNV loss 18987735
esv8541 CNV loss 19470904
nsv1046460 CNV loss 25217958
nsv1070580 CNV deletion 25765185
nsv1148651 CNV deletion 26484159
nsv478014 CNV novel sequence insertion 20440878
nsv478557 CNV novel sequence insertion 20440878
nsv525459 CNV loss 19592680
nsv64676 CNV deletion 16902084
nsv958107 CNV deletion 24416366
nsv974072 CNV duplication 23825009

Variation tolerance for PAN3 Gene

Residual Variation Intolerance Score: 5.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAN3 Gene

Disorders for PAN3 Gene

Relevant External Links for PAN3

Genetic Association Database (GAD)
PAN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAN3

No disorders were found for PAN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAN3 Gene

Publications for PAN3 Gene

  1. Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein. (PMID: 14583602) Uchida N. … Katada T. (J. Biol. Chem. 2004) 2 3 4 64
  2. GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. (PMID: 21981923) Braun J.E. … Izaurralde E. (Mol. Cell 2011) 3 4 64
  3. Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein. (PMID: 17595167) Siddiqui N. … Gehring K. (J. Biol. Chem. 2007) 3 4 64
  4. Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases. (PMID: 18056425) Funakoshi Y. … Hoshino S. (Genes Dev. 2007) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for PAN3 Gene

Sources for PAN3 Gene

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