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PAN3 Gene

protein-coding   GIFtS: 53
GCID: GC13P028713

PAN3 Poly(A) Specific Ribonuclease Subunit

(Previous name: PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PAN3 Poly(A) Specific Ribonuclease Subunit1 2     PABP1-Dependent Poly A-Specific Ribonuclease Subunit PAN32
PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (S. Cerevisiae)1     PAN3 Poly(A) Specific Ribonuclease Subunit Homolog2
PAB-Dependent Poly(A)-Specific Ribonuclease Subunit 32     hPan33
PABP-Dependent Poly(A) Nuclease 32     TS5

External Ids:    HGNC: 299911   Entrez Gene: 2559672   Ensembl: ENSG000001525207   OMIM: 6131345   UniProtKB: Q58A453   

Export aliases for PAN3 gene to outside databases

Previous GC identifers: GC13P026652 GC13P026546 GC13P027646 GC13P009533


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PAN3 Gene:
PAN3 (PAN3 poly(A) specific ribonuclease subunit) is a protein-coding gene. Diseases associated with PAN3 include malaria. GO annotations related to this gene include poly(A)-specific ribonuclease activity and protein kinase activity.

UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45
Function: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding
protein which in turn stimulates PAN2 nuclease activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAN3 gene promoter:
         TBP   Pbx1a   STAT6   Nkx2-5   HNF-3beta   AREB6   FOXC1   TFIID   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAN3 promoter sequence
   Search Chromatin IP Primers for PAN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.2   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12.2

PAN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAN3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P028713:  view genomic region     (about GC identifiers)

Start:
28,712,643 bp from pter      End:
28,869,475 bp from pter
Size:
156,833 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45 (See protein sequence)
Recommended Name: PAB-dependent poly(A)-specific ribonuclease subunit 3  
Size: 887 amino acids; 95613 Da
Subunit: Interacts with PAN2 to form the Pan nuclease complex. Mediates the interaction of the Pan nuclease
complex with polyadenylate-binding protein
Sequence caution: Sequence=AAI28180.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=ABK41888.1; Type=Erroneous gene model prediction; Sequence=BAC03632.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAI12449.2; Type=Erroneous gene model prediction;
Sequence=CAI12450.2; Type=Erroneous gene model prediction; Sequence=CAI14848.1; Type=Erroneous gene model
prediction; Sequence=CAM20921.1; Type=Erroneous gene model prediction;
Secondary accessions: A0N0X1 A1A4Y8 A1A4Y9 B1ALF1 B7Z3W7 Q0D2P2 Q5HYG6 Q5T515 Q5T516 Q5TBA0
Q76E13 Q8NBA6
Alternative splicing: 4 isoforms:  Q58A45-1   Q58A45-2   Q58A45-3   Q58A45-4   

Explore the universe of human proteins at neXtProt for PAN3: NX_Q58A45

Explore proteomics data for PAN3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys594
  • Modification sites at PhosphoSitePlus

  • See PAN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_787050.6  
    ENSEMBL proteins: 
     ENSP00000370345   ENSP00000382522   ENSP00000282391  
    Reactome Protein details: Q58A45

    PAN3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals PAN3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PAN3

    PAN3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals PAN3 Antibody
    Search for Antibodies for PAN3 at Abcam
    Cloud-Clone Corp. Antibodies for PAN3
    ThermoFisher Antibody for PAN3
    LSBio Antibodies in human, mouse, rat for PAN3

    PAN3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PAN3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PAN3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PAN3
    Cloud-Clone Corp. CLIAs for PAN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q58A45

    ProtoNet protein and cluster: Q58A45

    UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 protein kinase domain


    PAN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAN3_HUMAN, Q58A45
    Function: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding
    protein which in turn stimulates PAN2 nuclease activity

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004535contributes to poly(A)-specific ribonuclease activity IDA14583602
    GO:0004672protein kinase activity IEA--
    GO:0005515protein binding IPI14583602
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    PAN3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAN3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PAN3:
    hsa-mir-21-5p (MIRT030761), hsa-mir-148a-3p (MIRT025981)

    Block miRNA regulation of human, mouse, rat PAN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAN3 (see all 108):
    hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-134 hsa-miR-519a hsa-miR-383 hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidPAN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PAN3
    Predesigned siRNA for gene silencing in human, mouse, rat PAN3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PAN3

    Clone
    Products:
         
    OriGene clones in human, mouse for PAN3 (see all 8)
    OriGene ORF clones in mouse, rat for PAN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PAN3 (NM_005981)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAN3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PAN3
    Browse ESI BIO Cell Lines and PureStem Progenitors for PAN3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAN3_HUMAN, Q58A45: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus2
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005813centrosome ----
    GO:0005829cytosol TAS--
    GO:0031251PAN complex IDA14583602

    PAN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAN3 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PAN3
        Deadenylation of mRNA


    1 Kegg Pathway  (Kegg details for PAN3):
        RNA degradation


    PAN3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PAN3
    Interactions:

        GeneGlobe Interaction Network for PAN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PAN3 (Q58A451, 2, 3 ENSP000002823914) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119401, 3, ENSP000003130074EBI-2513054,EBI-81531 I2D: score=3 STRING: ENSP00000313007
    PAN2Q504Q31, 3EBI-2513054,EBI-1058976 I2D: score=8 
    MAPRE1Q156913, ENSP000003647214I2D: score=1 STRING: ENSP00000364721
    MTIF2P461993, ENSP000002636294I2D: score=1 STRING: ENSP00000263629
    RAD1O606713, ENSP000003408794I2D: score=1 STRING: ENSP00000340879
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    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IEA--
    GO:0006468protein phosphorylation ----

    PAN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PAN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PAN3 gene: 
    NM_175854.7  

    Unigene Cluster for PAN3:

    PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
    Hs.645015  [show with all ESTs]
    Unigene Representative Sequence: NM_175854
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503791(uc010tdo.1) ENST00000380958 ENST00000399613(uc001urz.3 uc001ury.3 uc001urx.3)
    ENST00000483842 ENST00000282391
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PAN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAN3 (see all 108):
    hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-134 hsa-miR-519a hsa-miR-383 hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidPAN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PAN3
    Predesigned siRNA for gene silencing in human, mouse, rat PAN3
    Clone
    Products:
         
    OriGene clones in human, mouse for PAN3 (see all 8)
    OriGene ORF clones in mouse, rat for PAN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PAN3 (NM_005981)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAN3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PAN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAN3
      QuantiTect SYBR Green Assays in human, mouse, rat PAN3
      QuantiFast Probe-based Assays in human, mouse, rat PAN3

    Additional mRNA sequence: 

    AB107584.1 AB109552.1 AK091307.1 AK131556.1 AK296435.1 AY358261.1 BC024318.1 BC128179.1 
    BC128180.1 BX647740.1 

    11 DOTS entries:

    DT.114369  DT.120773418  DT.406402  DT.120773458  DT.104465  DT.121112010  DT.95318906  DT.97801127 
    DT.40123653  DT.40261498  DT.40276265 

    3 AceView cDNA sequences:

    BG548615 R10440 R11514 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PAN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCAATTTG
    PAN3 Expression
    About this image

    PAN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645015
        Custom PCR Arrays for PAN3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PAN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAN3
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    QuantiFast Probe-based Assays in human, mouse, rat PAN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PAN3 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pan31 , 5 PAN3 polyA specific ribonuclease subunit homolog (S. more1, 5 89.42(n)1
    92.83(a)1
      5 (86.93 cM)5
    725871  NM_028291.41  NP_082567.31 
     1474301615 
    chicken
    (Gallus gallus)
    Aves PAN31 PAN3 poly(A) specific ribonuclease subunit homolog more 86.99(n)
    93.54(a)
      418926  XM_004938769.1  XP_004938826.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAN36
    PAN3 poly(A) specific ribonuclease subunit homolog...
    91(a)
    1 ↔ 1
    3(185774620-185852770)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41852 Xenopus laevis transcribed sequence with weak similarity more 81.03(n)    CA973488.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pan31 PAN3 poly(A) specific ribonuclease subunit homolog more 72.18(n)
    81.36(a)
      100126012  NM_001105692.2  NP_001099162.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG114866
    --
    38(a)
    1 ↔ 1
    3L(3071133-3090406)
    worm
    (Caenorhabditis elegans)
    Secernentea panl-36
    Protein PANL-3 (panl-3) mRNA, complete cds
    36(a)
    1 ↔ 1
    III(9819294-9823123) WBGene00014015
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PAN3(YKL025C)4
    PAN31
    Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease more4
    PAN31
    45.33(n)1
    30.82(a)1
      11(392279-390240)4
    8538431, 4  NP_012900.11, 4 


    ENSEMBL Gene Tree for PAN3 (if available)
    TreeFam Gene Tree for PAN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAN3 (see all 2957)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354866801,2
    C,F--28715516(+) AAAAAC/TTTTTA 1 -- int16Minor allele frequency- T:0.14NA CSA WA EA 364
    rs361138951,2
    C--28715600(+) TTTTCC/TTTTTT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs2009551231,2
    --28715604(+) TTTTT-/CTTTTT 1 -- int10--------
    rs284104841,2
    --28715605(+) TTTTTC/TTTTTT 1 -- int1 trp30--------
    rs1122384391,2
    C,F--28715679(+) GGCTCG/ACCGCA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1821234671,2
    --28715771(+) AGCTAA/GTATTG 1 -- int10--------
    rs1119312381,2
    C,F--28715839(+) TCTCAG/CGTGAT 1 -- int11Minor allele frequency- C:0.50NA 2
    rs95791641,2
    C,F,A,H--28715928(+) GGTAGA/TAGGGC 1 -- int110Minor allele frequency- T:0.17NS EA WA CSA NA 547
    rs743316561,2
    F--28715930(+) TAGAAG/CGGCTG 1 -- int12Minor allele frequency- C:0.15CSA WA 120
    rs794465311,2
    F--28715943(+) ACTTGA/CAAGAG 1 -- int11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for PAN3 (28712643 - 28869475 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PAN3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4105CNV Deletion18987735
    esv1004538CNV Deletion20482838
    esv1220684CNV Deletion17803354
    esv1931997CNV Deletion18987734
    esv2747193CNV Deletion23290073
    esv2644170CNV Deletion19546169
    esv2747192CNV Deletion23290073
    esv8541CNV Loss19470904
    dgv1568n71CNV Loss21882294
    nsv525459CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PAN3
    DNA2.0 Custom Variant and Variant Library Synthesis for PAN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613134    OMIM disorders: --

    1 disease for PAN3:    
    About MalaCards
    malaria


    PAN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PAN3

    Export disorders for PAN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAN3 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with PAN3)
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    1. Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein. (PubMed id 14583602)1, 2, 3 Uchida N.... Katada T. (J. Biol. Chem. 2004)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Novel interactors and a role for supervillin in early cytokinesis. (PubMed id 20309963)1 Smith T.C....Luna E.J. (Cytoskeleton (Hoboken) 2010)
    10. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 255967 HGNC: 29991 AceView: PAN3.2 Ensembl:ENSG00000152520 euGenes: HUgn255967
    ECgene: PAN3 Kegg: 255967 H-InvDB: PAN3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PAN3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/pan3/

    (Patent information from GeneIP,
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    Patent Information for PAN3 gene:
    Search GeneIP for patents involving PAN3

    GeneCards and IP:
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