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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PAN3 Gene

protein-coding GIFtS: 52
GCID: GC13P028713

PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

Search for PAN3
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (S. Cerevisiae)¹ ²
PAB-Dependent Poly(A)-Specific Ribonuclease Subunit 3²
PABP-Dependent Poly(A) Nuclease 3²
PABP1-Dependent Poly A-Specific Ribonuclease Subunit PAN3²
HPan3¹
TS⁵

External Ids:	HGNC: 29991¹	Entrez Gene: 255967²	Ensembl: ENSG00000152520⁷	OMIM: 613134⁵	UniProtKB: Q58A45³

Export aliases for PAN3 gene to outside databases

Previous GC identifers: GC13P026652 GC13P026546 GC13P027646 GC13P009533

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45

Function: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding

protein which in turn stimulates PAN2 nuclease activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PAN3 gene promoter:
TBP Pbx1a STAT6 Nkx2-5 HNF-3beta AREB6 FOXC1 TFIID FOXO4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PAN3 promoter sequence

Search SABiosciences Chromatin IP Primers for PAN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.2 Ensembl cytogenetic band: 13q12.2 HGNC cytogenetic band: 13q12.2

PAN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAN3 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P028713: view genomic region (about GC identifiers)

Start:	28,712,643 bp from pter	End:	28,869,475 bp from pter
Size:	156,833 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45 (See protein sequence)

Recommended Name: PAB-dependent poly(A)-specific ribonuclease subunit 3

Size: 887 amino acids; 95613 Da

Subunit: Interacts with PAN2 to form the Pan nuclease complex. Mediates the interaction of the Pan nuclease complex

with polyadenylate-binding protein

Subcellular location: Cytoplasm

Sequence caution: Sequence=AAI28180.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=ABK41888.1; Type=Erroneous gene model prediction; Sequence=BAC03632.1; Type=Erroneous initiation;

Note=Translation N-terminally extended; Sequence=CAI12449.2; Type=Erroneous gene model prediction;

Sequence=CAI12450.2; Type=Erroneous gene model prediction; Sequence=CAI14848.1; Type=Erroneous gene model prediction;

Sequence=CAM20921.1; Type=Erroneous gene model prediction;

Secondary accessions: A0N0X1 A1A4Y8 A1A4Y9 B1ALF1 B7Z3W7 Q0D2P2 Q5HYG6 Q5T515 Q5T516 Q5TBA0 Q76E13

Q8NBA6

Alternative splicing: 4 isoforms: Q58A45-1 Q58A45-2 Q58A45-3 Q58A45-4

Explore the universe of human proteins at neXtProt for PAN3: NX_Q58A45

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q58A45

PAN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_787050.6

ENSEMBL proteins:

ENSP00000370345 ENSP00000382522 ENSP00000282391

Reactome Protein details: Q58A45
Human Recombinant Protein Products for PAN3:

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	GenScript Custom Purified and Recombinant Proteins Services for PAN3
	Novus Biologicals PAN3 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PAN3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000932	cytoplasmic mRNA processing body	IEA	--
GO:0005813	centrosome	IDA	--
GO:0005829	cytosol	TAS	--

PAN3 for ontologies About GeneDecksing

PAN3 Antibody Products:

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	Abcam antibodies for PAN3
	Uscn Antibodies for PAN3
	ThermoFisher Antibody for PAN3

Assay Products for PAN3:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for PAN3
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	Uscn ELISAs and CLIAs for PAN3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PAN3 for domains About GeneDecksing

3 InterPro domains/families:

IPR000571 Znf_CCCH

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q58A45

ProtoNet protein and cluster: Q58A45

UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45

Domain: The protein kinase domain is predicted to be catalytically inactive

Similarity: Belongs to the protein kinase superfamily

Similarity: Contains 1 C3H1-type zinc finger

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PAN3_HUMAN, Q58A45

Function: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding

protein which in turn stimulates PAN2 nuclease activity

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0004672	protein kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

PAN3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PAN3

miRNA Products:		OriGene 3'-UTR Clone: PAN3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PAN3
		8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate PAN3 (see all 108):
		hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-134 hsa-miR-519a hsa-miR-383 hsa-miR-3613-3p hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: PAN3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAN3 (see all 4) OriGene shRNA RFP: PAN3 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAN3
		Sirion Biotech Custom design and validation of potent shRNA sequences against PAN3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PAN3
			Sirion Biotech Customized adenovirus for overexpression of PAN3 Sirion Biotech Customized adenovirus for potent knockdown of PAN3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAN3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAN3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PAN3 (NM_005981)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAN3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PAN3
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		Sirion Biotech Customized stable knockdown cell line services for PAN3 Sirion Biotech Customized inducible knockdown cell line services for PAN3 Sirion Biotech Customized stable overexpressing cell line services for PAN3 Sirion Biotech Customized inducible overexpressing cell line services for PAN3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAN3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Deadenylation-dependent mRNA decay

	Deadenylation-dependent mRNA decay	1.00			Deadenylation of mRNA	0.47
	RNA degradation	0.50

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for PAN3

	Deadenylation of mRNA
	Deadenylation-dependent mRNA decay
	Metabolism of RNA
	Metabolism of mRNA
	Gene Expression

1 Kegg Pathway (Kegg details for PAN3):

RNA degradation

PAN3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PAN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/33 Interacting proteins for PAN3 (Q58A45^{2, 3} ENSP00000282391⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PABPC1	P11940³, ENSP00000313007⁴	I2D: score=3 STRING: ENSP00000313007
RAD1	O60671³, ENSP00000340879⁴	I2D: score=1 STRING: ENSP00000340879
ETF1	P62495³, ENSP00000353741⁴	I2D: score=1 STRING: ENSP00000353741
PFDN5	Q99471³, ENSP00000334188⁴	I2D: score=1 STRING: ENSP00000334188
NSUN2	Q08J23³, ENSP00000264670⁴	I2D: score=1 STRING: ENSP00000264670

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA	--
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	TAS	--
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	TAS	--
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	IEA	--
GO:0006605	protein targeting	IEA	--

PAN3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PAN3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PAN3
Search CenterWatch for drugs/clinical trials and news about PAN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PAN3 gene:

NM_175854.7

Unigene Cluster for PAN3:

PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

Hs.645015 [show with all ESTs]

Unigene Representative Sequence: NM_175854

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000503791(uc010tdo.1) ENST00000380958 ENST00000399613(uc001urz.3 uc001ury.3 uc001urx.3)

ENST00000483842 ENST00000282391

miRNA Products:		OriGene 3'-UTR Clone: PAN3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PAN3
		8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate PAN3 (see all 108):
		hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-134 hsa-miR-519a hsa-miR-383 hsa-miR-3613-3p hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: PAN3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAN3 (see all 4) OriGene shRNA RFP: PAN3 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAN3
		Sirion Biotech Custom design and validation of potent shRNA sequences against PAN3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAN3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAN3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PAN3 (NM_005981)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAN3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAN3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PAN3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAN3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAN3

Additional cDNA sequence:

AB107584.1 AB109552.1 AK091307.1 AK131556.1 AK296435.1 AY358261.1 BC024318.1 BC128179.1

BC128180.1 BX647740.1

11 DOTS entries:

DT.114369 DT.120773418 DT.406402 DT.120773458 DT.104465 DT.121112010 DT.95318906 DT.97801127

DT.40123653 DT.40261498 DT.40276265

3 AceView cDNA sequences:

BG548615 R10440 R11514

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PAN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCAATTTG

About this image

PAN3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PAN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PAN3

SOURCE GeneReport for Unigene cluster: Hs.645015

SABiosciences Custom PCR Arrays for PAN3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAN3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PAN3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAN3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAN3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAN3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PAN3 gene from 7/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pan3^{1 , 5}	PAN3 polyA specific ribonuclease subunit homolog (S. more^{1, 5}	91.47(n)¹ 95.52(a)¹		5 (86.93 cM)⁵ 72587¹ NM_028291.4¹ NP_082567.3¹ 147430161⁵
chicken (Gallus gallus)	Aves	PAN3¹	PAN3 poly(A) specific ribonuclease subunit homolog more	86.99(n) 93.54(a)		418926 XM_417120.3 XP_417120.3
lizard (Anolis carolinensis)	Reptilia	PAN3⁶	--	94(a)	1 ↔ 1	3(185775662-185841055)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4185²	Xenopus laevis transcribed sequence with weak similarity more	81.03(n)		CA973488.1
zebrafish (Danio rerio)	Actinopterygii	pan3¹	PAN3 poly(A) specific ribonuclease subunit homolog more	72.02(n) 80.85(a)		100126012 NM_001105692.2 NP_001099162.2
fruit fly (Drosophila melanogaster)	Insecta	CG11486¹	CG11486	51.43(n) 48.51(a)		38369 NM_167982.2 NP_728804.1
worm (Caenorhabditis elegans)	Secernentea	panl-3¹	Protein PANL-3	50.75(n) 43.44(a)		176391 NM_066776.4 NP_499177.3

ENSEMBL Gene Tree for PAN3 (if available)
TreeFam Gene Tree for PAN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34103436^1,2	C	--	9668662(+)	`AAAAA-/AGAGAA`	1	--	int¹		1		NA	2
rs17086473^1,2	C,F	--	9676527(+)	`TTTGGA/GAAAAG`	1	--	int¹ trp³		4		NA CSA	140
rs142161425^1,2		--	28710724(+)	`ACCAGA/GTTGGC`	2	--	us2k¹ int¹		0	--	--	--	--
rs147859537^1,2		--	28710842(+)	`AGTTAA/CAACCT`	2	--	us2k¹ int¹		0	--	--	--	--
rs189687591^1,2		--	28711011(+)	`TTTCAA/GTCCAG`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs61260403^1,2	F	--	28711016(+)	`ATCCAG/CATCTG`	2	--	nc-transcript-variantus2k¹		2		NA EA	240
rs181240120^1,2		--	28711161(+)	`TGTACC/TTGATG`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs78042704^1,2	F	--	28711250(+)	`AGTGTA/GCCACA`	2	--	us2k¹ nc-transcript-variant		1		WA	118
rs141417654^1,2		--	28711251(+)	`GTGTAC/TCACAG`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs185652711^1,2		--	28711465(+)	`TGACTC/TTGTTT`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PAN3 (28712643 - 28869475 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for PAN3
2 CNVs: 47983 101688
6 Indels: 61304 39963 25227 42896 45152 11661

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAN3

DNA2.0 Custom Variant and Variant Library Synthesis for PAN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PAN3 for disorders About MalaCards

PAN3 for disorders About GeneDecksing

OMIM gene information: 613134 OMIM disorders: --

Export disorders for PAN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PAN3 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with PAN3)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein. (PubMed id 14583602)^{1, 2, 3} Uchida N.... Katada T. (2004)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Novel interactors and a role for supervillin in early cytokinesis. (PubMed id 20309963)¹ Smith T.C....Luna E.J. (2010)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 255967	HGNC: 29991	AceView: PAN3.2	Ensembl:ENSG00000152520	euGenes: HUgn255967
ECgene: PAN3	Kegg: 255967	H-InvDB: PAN3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PAN3	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/pan3/

Intellectual Property for PAN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PAN3 gene:
Search GeneIP for patents involving PAN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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PAN3 Gene

PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

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PAN3 Gene

PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

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Protein Domains /Familiesfor PAN3 gene

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for PAN3 gene

Genomic Views
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for PAN3 gene

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for PAN3 gene

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for PAN3 gene

Transcripts
for PAN3 gene

Expression
for PAN3 gene

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Genomic Variants
for PAN3 gene

Disorders / Diseases
for PAN3 gene

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for PAN3 gene

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for PAN3 gene

Products
for PAN3 gene