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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PAN3 Gene

protein-coding   GIFtS: 52
GCID: GC13P028713

PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
  Search for PAN3
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PAN3    

Aliases
for PAN3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (S. Cerevisiae)1 2
PAB-Dependent Poly(A)-Specific Ribonuclease Subunit 32
PABP-Dependent Poly(A) Nuclease 32
PABP1-Dependent Poly A-Specific Ribonuclease Subunit PAN32
HPan31
TS5

External Ids:    HGNC: 299911   Entrez Gene: 2559672   Ensembl: ENSG000001525207   OMIM: 6131345   UniProtKB: Q58A453   

Export aliases for PAN3 gene to outside databases

Previous GC identifers: GC13P026652 GC13P026546 GC13P027646 GC13P009533


Summaries
for PAN3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45
Function: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding
protein which in turn stimulates PAN2 nuclease activity




Genomic Views
for PAN3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PAN3 gene promoter:
         TBP   Pbx1a   STAT6   Nkx2-5   HNF-3beta   AREB6   FOXC1   TFIID   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PAN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PAN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.2   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12.2

PAN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAN3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P028713:  view genomic region     (about GC identifiers)

Start:
 28,712,643 bp from pter      End:
 28,869,475 bp from pter
Size:
 156,833 bases      Orientation:
 plus strand

Proteins
for PAN3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45 (See protein sequence)
Recommended Name: PAB-dependent poly(A)-specific ribonuclease subunit 3  
Size: 887 amino acids; 95613 Da
Subunit: Interacts with PAN2 to form the Pan nuclease complex. Mediates the interaction of the Pan nuclease complex
with polyadenylate-binding protein
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAI28180.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=ABK41888.1; Type=Erroneous gene model prediction; Sequence=BAC03632.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAI12449.2; Type=Erroneous gene model prediction;
Sequence=CAI12450.2; Type=Erroneous gene model prediction; Sequence=CAI14848.1; Type=Erroneous gene model prediction;
Sequence=CAM20921.1; Type=Erroneous gene model prediction;
Secondary accessions: A0N0X1 A1A4Y8 A1A4Y9 B1ALF1 B7Z3W7 Q0D2P2 Q5HYG6 Q5T515 Q5T516 Q5TBA0 Q76E13
Q8NBA6
Alternative splicing: 4 isoforms:  Q58A45-1   Q58A45-2   Q58A45-3   Q58A45-4   

Explore the universe of human proteins at neXtProt for PAN3: NX_Q58A45

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q58A45

    • PAN3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_787050.6  
    ENSEMBL proteins: 
     ENSP00000370345   ENSP00000382522   ENSP00000282391  
    Reactome Protein details: Q58A45
    Human Recombinant Protein Products: 
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    Novus Biologicals PAN3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PAN3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--


    PAN3 for ontologies           About GeneDecksing



    PAN3 Antibody Products: 
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    Uscn ELISAs and CLIAs for PAN3

    Protein Domains /
    Families
    for PAN3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PAN3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000571 Znf_CCCH
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q58A45

    ProtoNet protein and cluster: Q58A45

    UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 protein kinase domain


    Function
    for PAN3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PAN3_HUMAN, Q58A45
    Function: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding
    protein which in turn stimulates PAN2 nuclease activity

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PAN3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PAN3
    8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate PAN3 (see all 108):
    hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-134 hsa-miR-519a hsa-miR-383 hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: PAN3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAN3 (see all 4)
    OriGene shRNA RFP: PAN3
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAN3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PAN3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAN3 (see all 3)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAN3 

    Cell Line
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    Search LifeMap BioReagents cell lines for PAN3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAN3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004672protein kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding IEA--


    PAN3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for PAN3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deadenylation-dependent mRNA decay
    		Deadenylation-dependent mRNA decay1.00
    		Deadenylation of mRNA0.47
    		RNA degradation0.50
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for PAN3
        Deadenylation of mRNA
    Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for PAN3):
        RNA degradation


    PAN3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PAN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/33 Interacting proteins for PAN3 (Q58A452, 3 ENSP000002823914) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119403, ENSP000003130074I2D: score=3 STRING: ENSP00000313007
    RAD1O606713, ENSP000003408794I2D: score=1 STRING: ENSP00000340879
    ETF1P624953, ENSP000003537414I2D: score=1 STRING: ENSP00000353741
    PFDN5Q994713, ENSP000003341884I2D: score=1 STRING: ENSP00000334188
    NSUN2Q08J233, ENSP000002646704I2D: score=1 STRING: ENSP00000264670
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IEA--
    GO:0006605protein targeting IEA--


    PAN3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PAN3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PAN3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PAN3
    Search CenterWatch for drugs/clinical trials and news about PAN3 

    Transcripts
    for PAN3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PAN3 gene: 
    NM_175854.7  

    Unigene Cluster for PAN3:

    PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
    Hs.645015  [show with all ESTs]
    Unigene Representative Sequence: NM_175854
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503791(uc010tdo.1) ENST00000380958 ENST00000399613(uc001urz.3 uc001ury.3 uc001urx.3)
    ENST00000483842 ENST00000282391

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PAN3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PAN3
    8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate PAN3 (see all 108):
    hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-134 hsa-miR-519a hsa-miR-383 hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: PAN3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAN3 (see all 4)
    OriGene shRNA RFP: PAN3
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAN3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAN3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PAN3 (NM_005981)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAN3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAN3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PAN3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAN3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAN3

    Additional cDNA sequence: 

    AB107584.1 AB109552.1 AK091307.1 AK131556.1 AK296435.1 AY358261.1 BC024318.1 BC128179.1 
    BC128180.1 BX647740.1 

    11 DOTS entries:

    DT.114369  DT.120773418  DT.406402  DT.120773458  DT.104465  DT.121112010  DT.95318906  DT.97801127 
    DT.40123653  DT.40261498  DT.40276265 

    3 AceView cDNA sequences:

    BG548615 R10440 R11514 

    GeneLoc Exon Structure


    Expression
    for PAN3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PAN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCAATTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PAN3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartLeft VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PAN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PAN3

    SOURCE GeneReport for Unigene cluster: Hs.645015
        SABiosciences Custom PCR Arrays for PAN3
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAN3

    Orthologs
    for PAN3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PAN3 gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pan31 , 5 PAN3 polyA specific ribonuclease subunit homolog (S. more1, 5 91.47(n)1
    95.52(a)1    		   5 (86.93 cM)5
    725871  NM_028291.41  NP_082567.31 
     1474301615 
    chicken
    (Gallus gallus)    		 Aves PAN31 PAN3 poly(A) specific ribonuclease subunit homolog more 86.99(n)
    93.54(a)    		   418926  XM_417120.3  XP_417120.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PAN36
    		 --
    		 94(a)
    		 1 ↔ 1
    		 3(185775662-185841055)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.41852 Xenopus laevis transcribed sequence with weak similarity more 81.03(n)    CA973488.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii pan31 PAN3 poly(A) specific ribonuclease subunit homolog more 72.02(n)
    80.85(a)    		   100126012  NM_001105692.2  NP_001099162.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG114861 CG11486 51.43(n)
    48.51(a)    		   38369  NM_167982.2  NP_728804.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea panl-31 Protein PANL-3 50.75(n)
    43.44(a)    		   176391  NM_066776.4  NP_499177.3 


    ENSEMBL Gene Tree for PAN3 (if available)
    TreeFam Gene Tree for PAN3 (if available) 

    Paralogs
    for PAN3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PAN3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2559 NCBI SNPs in PAN3 are shown (see all 2559)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs341034361,2
    		C--9668662(+) AAAAA-/AGAGAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs170864731,2
    		C,F,--9676527(+) TTTGGA/GAAAAG 1 -- int1 trp34Minor allele frequency- G:0.02NA CSA 140
    rs1421614251,2
    		--28710724(+) ACCAGA/GTTGGC 2 -- us2k1 int10--------
    rs1478595371,2
    		--28710842(+) AGTTAA/CAACCT 2 -- us2k1 int10--------
    rs1896875911,2
    		--28711011(+) TTTCAA/GTCCAG 2 -- nc-transcript-variantus2k10--------
    rs612604031,2
    		F,--28711016(+) ATCCAG/CATCTG 2 -- nc-transcript-variantus2k12Minor allele frequency- C:0.05NA EA 240
    rs1812401201,2
    		--28711161(+) TGTACC/TTGATG 2 -- nc-transcript-variantus2k10--------
    rs780427041,2
    		F,--28711250(+) AGTGTA/GCCACA 2 -- us2k1 nc-transcript-variant1Minor allele frequency- G:0.11WA 118
    rs1414176541,2
    		--28711251(+) GTGTAC/TCACAG 2 -- nc-transcript-variantus2k10--------
    rs1856527111,2
    		--28711465(+) TGACTC/TTGTTT 2 -- nc-transcript-variantus2k10--------

    HapMap Linkage Disequilibrium report for PAN3 (28712643 - 28869475 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for PAN3
         2 CNVs: 47983 101688
         6 Indels: 61304 39963 25227 42896 45152 11661

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAN3
    DNA2.0 Custom Variant and Variant Library Synthesis for PAN3

    Disorders / Diseases
    for PAN3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PAN3 for disorders           About MalaCards

    PAN3 for disorders           About GeneDecksing

    OMIM gene information: 613134    OMIM disorders: --


    Export disorders for PAN3 gene to outside databases

    Publications
    for PAN3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PAN3 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with PAN3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein. (PubMed id 14583602)1, 2, 3 Uchida N.... Katada T. (2004)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Novel interactors and a role for supervillin in early cytokinesis. (PubMed id 20309963)1 Smith T.C....Luna E.J. (2010)
    9. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    External Searches for PAN3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PAN3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 255967 HGNC: 29991 AceView: PAN3.2 Ensembl:ENSG00000152520 euGenes: HUgn255967
    ECgene: PAN3 Kegg: 255967 H-InvDB: PAN3

    Other Databases showing PAN3 gene

    (According to HUGE)
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    Specialized Databases showing PAN3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PAN3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/pan3/

    Intellectual Property
    for PAN3 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for PAN3 gene:
    Search GeneIP for patents involving PAN3

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