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Aliases for PAN2 Gene

Aliases for PAN2 Gene

  • PAN2 Poly(A) Specific Ribonuclease Subunit 2 3 5
  • Inactive Ubiquitin Carboxyl-Terminal Hydrolase 52 3 4
  • PAN Deadenylation Complex Catalytic Subunit 2 3 4
  • PAB1P-Dependent Poly(A)-Nuclease 3 4
  • Ubiquitin Specific Peptidase 52 2 3
  • Ubiquitin Specific Protease 52 2 3
  • EC 3.1.13.4 4 63
  • USP52 3 4
  • PABP1 Dependent Poly A Specific Ribonuclease Subunit (S. Cerevisiae) 2
  • PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (S. Cerevisiae) 2
  • PAB-Dependent Poly(A)-Specific Ribonuclease Subunit 2 3
  • PAN2 Poly(A) Specific Ribonuclease Subunit Homolog 3
  • PAN2 PolyA Specific Ribonuclease Subunit 3
  • PABP-Dependent Poly(A) Nuclease 2 3
  • PAN2 Homolog 2
  • KIAA0710 4
  • HPan2 4

External Ids for PAN2 Gene

Previous HGNC Symbols for PAN2 Gene

  • USP52

Previous GeneCards Identifiers for PAN2 Gene

  • GC02M018621
  • GC12M054997
  • GC12M056710
  • GC12M053748

Summaries for PAN2 Gene

Entrez Gene Summary for PAN2 Gene

  • This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for PAN2 Gene

PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and exonuclease activity.

UniProtKB/Swiss-Prot for PAN2 Gene

  • Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3-5 exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5-3 exonucleolytic degradation by XRN1.

Gene Wiki entry for PAN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAN2 Gene

Genomics for PAN2 Gene

Regulatory Elements for PAN2 Gene

Promoters for PAN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAN2 Gene

Chromosome:
12
Start:
56,316,223 bp from pter
End:
56,334,053 bp from pter
Size:
17,831 bases
Orientation:
Minus strand

Genomic View for PAN2 Gene

Genes around PAN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAN2 Gene

Proteins for PAN2 Gene

  • Protein details for PAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q504Q3-PAN2_HUMAN
    Recommended name:
    PAB-dependent poly(A)-specific ribonuclease subunit PAN2
    Protein Accession:
    Q504Q3
    Secondary Accessions:
    • O75189
    • Q76E12
    • Q8IVE1

    Protein attributes for PAN2 Gene

    Size:
    1202 amino acids
    Molecular mass:
    135368 Da
    Quaternary structure:
    • Interacts with the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.
    SequenceCaution:
    • Sequence=BAA31685.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PAN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAN2 Gene

Proteomics data for PAN2 Gene at MOPED

Post-translational modifications for PAN2 Gene

  • Ubiquitination at Lys 706
  • Modification sites at PhosphoSitePlus

Domains & Families for PAN2 Gene

Gene Families for PAN2 Gene

Suggested Antigen Peptide Sequences for PAN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q504Q3

UniProtKB/Swiss-Prot:

PAN2_HUMAN :
  • Contains 1 exonuclease domain.
  • Belongs to the peptidase C19 family. PAN2 subfamily.
  • Contains 6 WD repeats.
Domain:
  • Contains 1 exonuclease domain.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. PAN2 subfamily.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with PAN2: view

Function for PAN2 Gene

Molecular function for PAN2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot EnzymeRegulation:
Positively regulated by the regulatory subunit PAN3.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3-5 exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5-3 exonucleolytic degradation by XRN1.

Enzyme Numbers (IUBMB) for PAN2 Gene

genes like me logo Genes that share phenotypes with PAN2: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAN2 Gene

Localization for PAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAN2 Gene

Cytoplasm. Cytoplasm, P-body. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000255 HAMAP-Rule:MF_03182, ECO:0000269 PubMed:16284618}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAN2 Gene COMPARTMENTS Subcellular localization image for PAN2 gene
Compartment Confidence
cytosol 5
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for PAN2 Gene

Pathways & Interactions for PAN2 Gene

genes like me logo Genes that share pathways with PAN2: view

Pathways by source for PAN2 Gene

1 KEGG pathway for PAN2 Gene
1 Qiagen pathway for PAN2 Gene

Gene Ontology (GO) - Biological Process for PAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic TAS --
genes like me logo Genes that share ontologies with PAN2: view

No data available for SIGNOR curated interactions for PAN2 Gene

Drugs & Compounds for PAN2 Gene

No Compound Related Data Available

Transcripts for PAN2 Gene

Unigene Clusters for PAN2 Gene

PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAN2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30a · 30b · 30c · 30d
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15: -

Relevant External Links for PAN2 Gene

GeneLoc Exon Structure for
PAN2
ECgene alternative splicing isoforms for
PAN2

Expression for PAN2 Gene

mRNA expression in normal human tissues for PAN2 Gene

Protein differential expression in normal tissues from HIPED for PAN2 Gene

This gene is overexpressed in Serum (13.3), Plasma (13.1), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAN2 Gene



SOURCE GeneReport for Unigene cluster for PAN2 Gene Hs.273397

genes like me logo Genes that share expression patterns with PAN2: view

Protein tissue co-expression partners for PAN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PAN2 Gene

Orthologs for PAN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAN2 35
  • 92.84 (n)
  • 98.08 (a)
PAN2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAN2 35
  • 93.01 (n)
  • 97.59 (a)
PAN2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pan2 35
  • 89.86 (n)
  • 96.9 (a)
Pan2 16
Pan2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC451995 35
  • 99.56 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Pan2 35
  • 89.55 (n)
  • 96.12 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PAN2 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAN2 35
  • 77.94 (n)
  • 86.03 (a)
PAN2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAN2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pan2 35
  • 72.76 (n)
  • 80.13 (a)
Str.4361 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6934 35
zebrafish
(Danio rerio)
Actinopterygii LOC792831 35
  • 70.98 (n)
  • 75.71 (a)
pan2 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2883 35
fruit fly
(Drosophila melanogaster)
Insecta CG11200 37
  • 38 (a)
CG2064 37
  • 45 (a)
CG2065 37
  • 47 (a)
CG2070 37
  • 48 (a)
CG30491 37
  • 43 (a)
CG30495 37
  • 43 (a)
CG3842 37
  • 47 (a)
CG7675 37
  • 44 (a)
CG8232 35
  • 52.78 (n)
  • 46.34 (a)
CG8232 36
  • 40 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010626 35
  • 52.24 (n)
  • 45.96 (a)
worm
(Caenorhabditis elegans)
Secernentea panl-2 36
  • 27 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL055W 35
  • 44.99 (n)
  • 31.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18877g 35
  • 43.82 (n)
  • 33.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAN2 35
  • 42.77 (n)
  • 30.91 (a)
PAN2 36
  • 27 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.865 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10733 35
  • 46.51 (n)
  • 33.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp13 35
  • 45.77 (n)
  • 37.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.723 36
  • 45 (a)
OneToOne
Species with no ortholog for PAN2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAN2 Gene

ENSEMBL:
Gene Tree for PAN2 (if available)
TreeFam:
Gene Tree for PAN2 (if available)

Paralogs for PAN2 Gene

No data available for Paralogs for PAN2 Gene

Variants for PAN2 Gene

Sequence variations from dbSNP and Humsavar for PAN2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_031162 -
rs1918496 - 56,328,276(-) ACATA(A/C)TAGAG reference, missense
VAR_036359 A colorectal cancer sample
rs773665 -- 56,323,682(+) TCAAA(C/T)TGGGA intron-variant
rs1872438 -- 56,324,324(+) GTGGT(A/T)TTTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PAN2 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Variation tolerance for PAN2 Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAN2 Gene

HapMap Linkage Disequilibrium report
PAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAN2 Gene

Disorders for PAN2 Gene

Relevant External Links for PAN2

Genetic Association Database (GAD)
PAN2
Human Genome Epidemiology (HuGE) Navigator
PAN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAN2

No disorders were found for PAN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAN2 Gene

Publications for PAN2 Gene

  1. Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein. (PMID: 14583602) Uchida N. … Katada T. (J. Biol. Chem. 2004) 2 3 4 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  4. An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay. (PMID: 24880343) Jonas S. … Izaurralde E. (Nat. Struct. Mol. Biol. 2014) 3
  5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PMID: 23398456) Bett J.S. … Hay R.T. (Biochem. J. 2013) 3

Products for PAN2 Gene

Sources for PAN2 Gene

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