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Aliases for PAMR1 Gene

Aliases for PAMR1 Gene

  • Peptidase Domain Containing Associated With Muscle Regeneration 1 2 3
  • Peptidase Domain-Containing Protein Associated With Muscle Regeneration 1 3 4
  • Regeneration-Associated Muscle Protease Homolog 3 4
  • RAMP 3 4
  • Regeneration-Associated Muscle Protease 2
  • Regeneration Associated Muscle Protease 3
  • DKFZP586H2123 3
  • FP938 3

External Ids for PAMR1 Gene

Previous GeneCards Identifiers for PAMR1 Gene

  • GC11M035410
  • GC11M035152

Summaries for PAMR1 Gene

GeneCards Summary for PAMR1 Gene

PAMR1 (Peptidase Domain Containing Associated With Muscle Regeneration 1) is a Protein Coding gene. Diseases associated with PAMR1 include duchenne muscular dystrophy. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PAMR1 Gene

  • May play a role in regeneration of skeletal muscle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAMR1 Gene

Genomics for PAMR1 Gene

Regulatory Elements for PAMR1 Gene

Genomic Location for PAMR1 Gene

Chromosome:
11
Start:
35,431,823 bp from pter
End:
35,530,300 bp from pter
Size:
98,478 bases
Orientation:
Minus strand

Genomic View for PAMR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAMR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAMR1 Gene

Proteins for PAMR1 Gene

  • Protein details for PAMR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXH9-PAMR1_HUMAN
    Recommended name:
    Inactive serine protease PAMR1
    Protein Accession:
    Q6UXH9
    Secondary Accessions:
    • A8MQ58
    • B7ZA73
    • Q5EBL7
    • Q5JPI4
    • Q6N062
    • Q71RE9
    • Q96JW2
    • Q9Y432

    Protein attributes for PAMR1 Gene

    Size:
    720 amino acids
    Molecular mass:
    80199 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ15224.1; Type=Frameshift; Positions=334; Evidence={ECO:0000305};

    Alternative splice isoforms for PAMR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAMR1 Gene

Proteomics data for PAMR1 Gene at MOPED

Post-translational modifications for PAMR1 Gene

  • Glycosylation at Asn 614
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PAMR1 Gene

Domains & Families for PAMR1 Gene

Gene Families for PAMR1 Gene

Suggested Antigen Peptide Sequences for PAMR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXH9

UniProtKB/Swiss-Prot:

PAMR1_HUMAN :
  • Contains 1 CUB domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 CUB domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase S1 domain.
  • Contains 2 Sushi (CCP/SCR) domains.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PAMR1: view

Function for PAMR1 Gene

Molecular function for PAMR1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regeneration of skeletal muscle.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated in muscle cell lines derived from biopsies of 5 Duchenne muscular dystrophy (DMD) patients compared to a normal muscle cell line.

Gene Ontology (GO) - Molecular Function for PAMR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity --
GO:0005509 calcium ion binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PAMR1: view
genes like me logo Genes that share phenotypes with PAMR1: view

Animal Model Products

miRNA for PAMR1 Gene

miRTarBase miRNAs that target PAMR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAMR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PAMR1 Gene

Localization for PAMR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAMR1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAMR1 Gene COMPARTMENTS Subcellular localization image for PAMR1 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for PAMR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PAMR1: view

Pathways & Interactions for PAMR1 Gene

SuperPathways for PAMR1 Gene

No Data Available

Interacting Proteins for PAMR1 Gene

Gene Ontology (GO) - Biological Process for PAMR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
genes like me logo Genes that share ontologies with PAMR1: view

No data available for Pathways by source and SIGNOR curated interactions for PAMR1 Gene

Drugs & Compounds for PAMR1 Gene

No Compound Related Data Available

Transcripts for PAMR1 Gene

Unigene Clusters for PAMR1 Gene

Peptidase domain containing associated with muscle regeneration 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAMR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAMR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for PAMR1 Gene

GeneLoc Exon Structure for
PAMR1
ECgene alternative splicing isoforms for
PAMR1

Expression for PAMR1 Gene

mRNA expression in normal human tissues for PAMR1 Gene

mRNA differential expression in normal tissues according to GTEx for PAMR1 Gene

This gene is overexpressed in Cervix - Endocervix (x4.8).

Protein differential expression in normal tissues from HIPED for PAMR1 Gene

This gene is overexpressed in Serum (52.3) and Gallbladder (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PAMR1 Gene



SOURCE GeneReport for Unigene cluster for PAMR1 Gene Hs.55044

genes like me logo Genes that share expression patterns with PAMR1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PAMR1 Gene

Orthologs for PAMR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAMR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAMR1 35
  • 87.92 (n)
  • 90.56 (a)
PAMR1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAMR1 35
  • 87.39 (n)
  • 90.65 (a)
PAMR1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pamr1 35
  • 86.11 (n)
  • 90.28 (a)
Pamr1 16
Pamr1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAMR1 35
  • 99.1 (n)
  • 98.91 (a)
PAMR1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pamr1 35
  • 86.09 (n)
  • 90.14 (a)
oppossum
(Monodelphis domestica)
Mammalia PAMR1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAMR1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAMR1 35
  • 74.99 (n)
  • 79.1 (a)
PAMR1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAMR1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pamr1 35
  • 68.47 (n)
  • 67.22 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560295 35
  • 53.58 (n)
  • 46.42 (a)
PAMR1 36
  • 30 (a)
OneToOne
Species with no ortholog for PAMR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAMR1 Gene

ENSEMBL:
Gene Tree for PAMR1 (if available)
TreeFam:
Gene Tree for PAMR1 (if available)

Paralogs for PAMR1 Gene

(5) SIMAP similar genes for PAMR1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PAMR1: view

No data available for Paralogs for PAMR1 Gene

Variants for PAMR1 Gene

Sequence variations from dbSNP and Humsavar for PAMR1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs678948 -- 35,505,715(-) GATGG(A/C)AAAAG intron-variant
rs678399 -- 35,506,871(-) agaac(A/T)aaaaa intron-variant
rs677897 -- 35,435,451(-) GTGGG(A/C/T)GGGTC intron-variant
rs677550 -- 35,506,009(-) ataca(C/G)taaaa intron-variant
rs676701 -- 35,506,155(-) gaatt(C/T)tttaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAMR1 Gene

Variant ID Type Subtype PubMed ID
nsv832120 CNV Gain 17160897
essv13578 CNV CNV 17122850
nsv508624 CNV Loss 20534489
esv23286 CNV Gain 19812545

Variation tolerance for PAMR1 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.23; 81.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAMR1 Gene

HapMap Linkage Disequilibrium report
PAMR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAMR1 Gene

Disorders for PAMR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PAMR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
duchenne muscular dystrophy
  • muscular dystrophy, duchenne
- elite association
Search PAMR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAMR1

Genetic Association Database (GAD)
PAMR1
Human Genome Epidemiology (HuGE) Navigator
PAMR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAMR1
genes like me logo Genes that share disorders with PAMR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAMR1 Gene

Publications for PAMR1 Gene

  1. Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients. (PMID: 15111323) Nakayama Y. … Hara T. (Am. J. Pathol. 2004) 2 23 67
  2. [Regenerative medicine of skeletal muscle]. (PMID: 16447752) Hara T. … Nara N. (Rinsho Shinkeigaku 2005) 23 67
  3. Adrenomedullin--what do we know 10 years since its discovery? (PMID: 15047974) BeA8towski J. … Jamroz A. (Pol J Pharmacol 2004) 23 67
  4. Specificity of porcine calcitonin receptor and calcitonin receptor-like receptor in the presence of receptor-activity-modifying proteins. (PMID: 12630807) Kikumoto K. … Minamino N. (Hypertens. Res. 2003) 23 67
  5. Adrenomedullin is an autocrine/paracrine growth factor for rat vascular smooth muscle cells. (PMID: 12667639) Shichiri M. … Hirata Y. (Regul. Pept. 2003) 23 67

Products for PAMR1 Gene

Sources for PAMR1 Gene

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