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Aliases for PAMR1 Gene

Aliases for PAMR1 Gene

  • Peptidase Domain Containing Associated With Muscle Regeneration 1 2 3
  • Peptidase Domain-Containing Protein Associated With Muscle Regeneration 1 3 4
  • Regeneration-Associated Muscle Protease Homolog 3 4
  • RAMP 3 4
  • Regeneration-Associated Muscle Protease 2
  • Regeneration Associated Muscle Protease 3
  • Inactive Serine Protease PAMR1 3
  • DKFZP586H2123 3
  • FP938 3

External Ids for PAMR1 Gene

Previous GeneCards Identifiers for PAMR1 Gene

  • GC11M035410
  • GC11M035152

Summaries for PAMR1 Gene

GeneCards Summary for PAMR1 Gene

PAMR1 (Peptidase Domain Containing Associated With Muscle Regeneration 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PAMR1 Gene

  • May play a role in regeneration of skeletal muscle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAMR1 Gene

Genomics for PAMR1 Gene

Regulatory Elements for PAMR1 Gene

Genomic Location for PAMR1 Gene

Start:
35,431,823 bp from pter
End:
35,530,300 bp from pter
Size:
98,478 bases
Orientation:
Minus strand

Genomic View for PAMR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAMR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAMR1 Gene

Proteins for PAMR1 Gene

  • Protein details for PAMR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXH9-PAMR1_HUMAN
    Recommended name:
    Inactive serine protease PAMR1
    Protein Accession:
    Q6UXH9
    Secondary Accessions:
    • A8MQ58
    • B7ZA73
    • Q5EBL7
    • Q5JPI4
    • Q6N062
    • Q71RE9
    • Q96JW2
    • Q9Y432

    Protein attributes for PAMR1 Gene

    Size:
    720 amino acids
    Molecular mass:
    80199 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ15224.1; Type=Frameshift; Positions=334; Evidence={ECO:0000305};

    Alternative splice isoforms for PAMR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAMR1 Gene

Proteomics data for PAMR1 Gene at MOPED

Post-translational modifications for PAMR1 Gene

  • Glycosylation at Asn614
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PAMR1 Gene

Domains for PAMR1 Gene

Suggested Antigen Peptide Sequences for PAMR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXH9

UniProtKB/Swiss-Prot:

PAMR1_HUMAN :
  • Q6UXH9
Domain:
  • Contains 1 CUB domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase S1 domain.
  • Contains 2 Sushi (CCP/SCR) domains.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PAMR1: view

No data available for Gene Families for PAMR1 Gene

Function for PAMR1 Gene

Molecular function for PAMR1 Gene

UniProtKB/Swiss-Prot Function: May play a role in regeneration of skeletal muscle.
UniProtKB/Swiss-Prot Induction: Strongly down-regulated in muscle cell lines derived from biopsies of 5 Duchenne muscular dystrophy (DMD) patients compared to a normal muscle cell line.

Gene Ontology (GO) - Molecular Function for PAMR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004252 serine-type endopeptidase activity --
GO:0005509 calcium ion binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PAMR1: view

Phenotypes for PAMR1 Gene

genes like me logo Genes that share phenotypes with PAMR1: view

Animal Model Products

CRISPR Products

miRNA for PAMR1 Gene

miRTarBase miRNAs that target PAMR1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PAMR1 Gene

Localization for PAMR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAMR1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAMR1 Gene COMPARTMENTS Subcellular localization image for PAMR1 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PAMR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PAMR1: view

Pathways for PAMR1 Gene

SuperPathways for PAMR1 Gene

No Data Available

Interacting Proteins for PAMR1 Gene

Gene Ontology (GO) - Biological Process for PAMR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PAMR1: view

No data available for Pathways by source for PAMR1 Gene

Transcripts for PAMR1 Gene

Unigene Clusters for PAMR1 Gene

Peptidase domain containing associated with muscle regeneration 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAMR1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PAMR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAMR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for PAMR1 Gene

GeneLoc Exon Structure for
PAMR1
ECgene alternative splicing isoforms for
PAMR1

Expression for PAMR1 Gene

mRNA expression in normal human tissues for PAMR1 Gene

mRNA differential expression in normal tissues according to GTEx for PAMR1 Gene

This gene is overexpressed in Cervix - Endocervix (4.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PAMR1 Gene

SOURCE GeneReport for Unigene cluster for PAMR1 Gene Hs.55044

genes like me logo Genes that share expressions with PAMR1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PAMR1 Gene

Orthologs for PAMR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAMR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAMR1 35
  • 99.1 (n)
  • 98.91 (a)
PAMR1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAMR1 35
  • 87.92 (n)
  • 90.56 (a)
PAMR1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAMR1 35
  • 87.39 (n)
  • 90.65 (a)
PAMR1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pamr1 35
  • 86.11 (n)
  • 90.28 (a)
Pamr1 16
Pamr1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAMR1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAMR1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pamr1 35
  • 86.09 (n)
  • 90.14 (a)
chicken
(Gallus gallus)
Aves PAMR1 35
  • 74.99 (n)
  • 79.1 (a)
PAMR1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAMR1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pamr1 35
  • 68.47 (n)
  • 67.22 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560295 35
  • 53.58 (n)
  • 46.42 (a)
PAMR1 36
  • 30 (a)
OneToOne
Species with no ortholog for PAMR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAMR1 Gene

ENSEMBL:
Gene Tree for PAMR1 (if available)
TreeFam:
Gene Tree for PAMR1 (if available)

Paralogs for PAMR1 Gene

Selected SIMAP similar genes for PAMR1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PAMR1: view

No data available for Paralogs for PAMR1 Gene

Variants for PAMR1 Gene

Sequence variations from dbSNP and Humsavar for PAMR1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7767 -- 35,432,172(+) GGACG(C/T)GGCAT utr-variant-3-prime
rs17482 -- 35,515,585(+) GCAAC(A/G)TCTCA intron-variant
rs479011 -- 35,525,870(-) TCCCT(C/G)CCCCG utr-variant-5-prime, intron-variant
rs506859 -- 35,530,318(-) ATTGT(A/G)TAGGT upstream-variant-2KB
rs526545 -- 35,531,892(-) agtgt(C/G)tggtg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PAMR1 Gene

Variant ID Type Subtype PubMed ID
nsv832120 CNV Gain 17160897
essv13578 CNV CNV 17122850
nsv508624 CNV Loss 20534489
esv23286 CNV Gain 19812545

Relevant External Links for PAMR1 Gene

HapMap Linkage Disequilibrium report
PAMR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAMR1 Gene

Disorders for PAMR1 Gene

Relevant External Links for PAMR1

Genetic Association Database (GAD)
PAMR1
Human Genome Epidemiology (HuGE) Navigator
PAMR1
genes like me logo Genes that share disorders with PAMR1: view

No data available for UniProtKB/Swiss-Prot for PAMR1 Gene

Publications for PAMR1 Gene

  1. Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients. (PMID: 15111323) Nakayama Y. … Hara T. (Am. J. Pathol. 2004) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H. … O'Brodovich H.M. (Pediatrics 2013) 3

Products for PAMR1 Gene

Sources for PAMR1 Gene

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