PAM16 Gene
protein-coding GIFtS: 47
GCID: GC16M004381
|
|
presequence translocase-associated motor 16 homolog (S....
| |
Aliases
for PAM16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Presequence Translocase-Associated Motor 16 Homolog (S. Cerevisiae)1 2 | | Tim161 | | TIMM161 2 3 | | Magmas-Like Protein2 | | Mitochondria-Associated Granulocyte Macrophage CSF-Signaling Molecule2 3 | | Mitochondria Associated Protein Involved In Granulocyte Macrophage ColonyStimulating Factor Signal Transduction2 | | MAGMAS2 3 | | Mitochondrial Import Inner Membrane Translocase Subunit TIM162 | | TIM162 3 | | Presequence Translocated-Associated Motor Subunit PAM163 | | Magmas1 | | |
Export aliases for PAM16 gene to outside databasesPrevious GC identifer: GC16M004357 |
Summaries
for PAM16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation ofHSPA9/Mortalin ATPase activity
|
Genomic Views
for PAM16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PAM16
Other transcription factors
Search SABiosciences Chromatin IP Primers for PAM16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAM16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3PAM16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M004381: view genomic region
(about GC identifiers)
Start:
|
4,381,550 bp from pter |
End:
|
4,405,608 bp from pter |
Size:
|
24,059 bases |
Orientation:
|
minus strand |
|
Proteins
for PAM16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7 (See
protein sequence)Recommended Name: Mitochondrial import inner membrane translocase subunit TIM16 Size: 125 amino acids; 13825 Da
Subunit: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2,TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Associates with the TIM23 complex
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Secondary accessions: Q6I9Z3 Q9H5X3Explore the universe of human proteins at neXtProt for PAM16: NX_Q9Y3D7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3D7
PAM16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057153.8
ENSEMBL proteins: ENSP00000459113 ENSP00000315693 ENSP00000459955 ENSP00000458412 ENSP00000460708 ENSP00000458914 ENSP00000459802 ENSP00000461047 ENSP00000460434 Reactome Protein details: Q9Y3D7
Human Recombinant Protein Products for PAM16:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005743 | mitochondrial inner membrane |
IEA | -- |
PAM16 for ontologies About GeneDecksing
PAM16 Antibody Products:
Assay Products for PAM16: |
Protein
Domains /
Families
for PAM16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PAM16 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3D7ProtoNet protein and cluster: Q9Y3D7 1 Blocks protein family: IPB005341 Protein of unknown function UPF0108
UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7Domain: The J-like region, although related to the J domain does not have co-chaperone activity (By similarity)Similarity: Belongs to the TIM16/PAM16 family |
Function
for PAM16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TIM16_HUMAN, Q9Y3D7Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation ofHSPA9/Mortalin ATPase activityInduction: By CSF2/GM-CSFAnimal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAM16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for PAM16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAM16 |
|
Pathways & Interactions
for PAM16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for PAM16
PAM16 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PAM16
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for PAM16 (Q9Y3D72, 3 ENSP000003156934) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006626 | protein targeting to mitochondrion |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
PAM16 for ontologies About GeneDecksing
|
Drugs & Compounds
for PAM16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PAM16
Search CenterWatch for drugs/clinical trials and news about PAM16 / TIM16
|
Transcripts
for PAM16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PAM16 gene: NM_016069.9 Unigene Cluster for PAM16: Presequence translocase-associated motor 16 homolog (S. cerevisiae) Hs.730693 [show with all ESTs]Unigene Representative Sequence: BQ23301715 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000577031 ENST00000318059(uc002cwd.3) ENST00000573236 ENST00000573450
ENST00000573553 ENST00000575848 ENST00000571941 ENST00000575636 ENST00000573614
ENST00000571986 ENST00000576217 ENST00000571178 ENST00000571819 ENST00000575884
ENST00000575942
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAM16 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAM16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PAM16 (NM_016069) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAM16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAM16 |
Additional cDNA sequence: AF151894.1 AF349455.1 AK026514.1 BC005024.1 CR457362.1 15 DOTS entries: DT.449076 DT.100035684 DT.95162083 DT.97843012 DT.100035681 DT.100035683 DT.120686847 DT.40192918 DT.120686778 DT.40191766 DT.120686850 DT.95162076 DT.95162084 DT.99986281 DT.91786594 24/277 AceView cDNA sequences (see all 277): AW249037 AK025674 CA419484 AK126176 BM853406 BM469939 AI268592 BQ882990 NM_016069 BM450422 AI807763 CB152664 AI800826 AA338859 BC005024 BQ711832 CA314889 BM710221 BU931694 AI672921 AI420340 BM702213 AI922770 AW205935
GeneLoc Exon Structure
|
Expression
for PAM16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PAM16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAAGTACC
About this image
See PAM16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PAM16
SOURCE GeneReport for Unigene cluster: Hs.730693
UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for PAM16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAM16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PAM16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAM16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAM16 |
Orthologs
for PAM16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PAM16 gene from 9/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Pam161 , 5 |
presequence translocase-asssociated motor 16 homolog (S. cerevisiae) less1, 5 |
88.8(n)1
96(a)1 |
|
16 (2.45 cM)5
664491 NM_025571.11 NP_079847.11
46164645 |
chicken
(Gallus gallus) |
Aves |
PAM161 |
presequence translocase-associated motor 16 homolog (S. cerevisiae) less |
76.53(n)
79.2(a) |
|
416669 NM_001004377.2 NP_001004377.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PAM166 |
-- |
76(a) |
1 ↔ 1 |
GL343856.1(39309-43432) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.136022 |
Xenopus laevis transcribed sequence with moderate similarity to protein spQ9Y3D7 (H.sapiens) YCD6_HUMAN Hypothetical protein CGI-136 less |
76.73(n) |
|
BJ096700.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc733562 |
hypothetical protein MGC73356 |
74.36(n) |
|
393777 BC059670.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
blp1 |
black pearl |
60.23(n)
58.77(a) |
|
41937 NM_079646.2 NP_524370.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
F45G2.81 |
Protein F45G2.8 |
53.27(n)
50.89(a) |
|
176769 NM_067374.4 NP_499775.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TXR16AT5G618806 |
Protein Transporter, Pam16 |
38(a)36(a) |
many → 1many → 1 |
3(21908913-21910722) 5(24850257-24851776) |
rice
(Oryza sativa) |
Liliopsida |
---- |
mitochondrial import inner membrane translocase su...mitochondrial import inner membrane translocase su... |
37(a)35(a) |
many → 1many → 1 |
10(17935715-17938518) 1(42360282-42362621) |
ENSEMBL Gene Tree for PAM16 (if available)
TreeFam Gene Tree for PAM16 (if available) |
Paralogs
for PAM16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PAM16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PAM16 (4381550 - 4405608 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PAM16: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAM16 |
|
Disorders
/ Diseases
for PAM16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PAM16 for disorders About GeneDecksing
OMIM gene information: 614336
OMIM disorders: --
4  diseases for PAM16: About MalaCardsacth-secreting pituitary adenoma pituitary adenoma adenoma prostatitis
1 disease from the University of Copenhagen DISEASES database for PAM16:ACTH-secreting pituitary adenoma Export disorders for PAM16 gene to outside databases
|
Publications
for PAM16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PAM16 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with PAM16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of Magmas, a novel mitochondria- associated protein involved in granulocyte-macrophage colony- stimulating factor signal transduction. (PubMed id 11750097)1, 2, 3, 9 Jubinsky P.T.... Short M.K. (2001)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- Role of Magmas in protein transport and human mitocho ndria biogenesis. (PubMed id 20053669)1, 2, 9 Sinha D....D'Silva P. (2010)
- Magmas expression in neoplastic human prostate. (PubMed id 15704001)1, 2 Jubinsky P.T....Li M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Magmas, a gene newly identified as overexpressed in h uman and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli. (PubMed id 20719856)1 Tagliati F....Zatelli M.C. (2010)
|
External Searches for PAM16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PAM16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PAM16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PAM16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PAM16 gene:
Search GeneIP for patents involving PAM16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PAM16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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