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PAM16 Gene

protein-coding   GIFtS: 48
GCID: GC16M004381

Presequence Translocase-Associated Motor 16 Homolog (S....

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Presequence Translocase-Associated Motor 16 Homolog (S. Cerevisiae)1 2     TIMM162 3
MAGMAS2 3 5     Magmas-Like Protein2
Mitochondria Associated Protein Involved In Granulocyte Macrophage Colony
Stimulating Factor Signal Transduction1 2
     Mitochondrial Import Inner Membrane Translocase Subunit TIM162
Mitochondria-Associated Granulocyte Macrophage CSF-Signaling Molecule2 3     Presequence Translocated-Associated Motor Subunit PAM163
TIM162 3     

External Ids:    HGNC: 296791   Entrez Gene: 510252   Ensembl: ENSG000002179307   OMIM: 6143365   UniProtKB: Q9Y3D73   

Export aliases for PAM16 gene to outside databases

Previous GC identifer: GC16M004357


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PAM16 Gene:
PAM16 (presequence translocase-associated motor 16 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with PAM16 include acth-secreting pituitary adenoma, and pituitary adenoma.

UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7
Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19
stimulation of HSPA9/Mortalin ATPase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for PAM16
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PAM16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAM16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PAM16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAM16 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004381:  view genomic region     (about GC identifiers)

Start:
4,381,550 bp from pter      End:
4,405,608 bp from pter
Size:
24,059 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit TIM16  
Size: 125 amino acids; 13825 Da
Subunit: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or
GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Directly interacts with
DNAJC15; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with the
TIM23 complex
Secondary accessions: Q6I9Z3 Q9H5X3

Explore the universe of human proteins at neXtProt for PAM16: NX_Q9Y3D7

Explore proteomics data for PAM16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PAM16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057153.8  
    ENSEMBL proteins: 
     ENSP00000459113   ENSP00000315693   ENSP00000459955   ENSP00000458412   ENSP00000460708  
     ENSP00000458914   ENSP00000459802   ENSP00000461047   ENSP00000460434  
    Reactome Protein details: Q9Y3D7

    PAM16 Human Recombinant Protein Products:

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    Novus Biologicals PAM16 Lysate
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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

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    PAM16 Assay Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005341 Tim16

    Graphical View of Domain Structure for InterPro Entry Q9Y3D7

    ProtoNet protein and cluster: Q9Y3D7

    1 Blocks protein domain: IPB005341 Protein of unknown function UPF0108

    UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7
    Domain: The J-like region, although related to the J domain does not have co-chaperone activity (By similarity)
    Similarity: Belongs to the TIM16/PAM16 family


    PAM16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM16_HUMAN, Q9Y3D7
    Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19
    stimulation of HSPA9/Mortalin ATPase activity
    Induction: By CSF2/GM-CSF

    Animal Models:

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    miRNA
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    miRTarBase miRNAs that target PAM16:
    hsa-mir-155-5p (MIRT020614)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAM16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIM16_HUMAN, Q9Y3D7: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005744mitochondrial inner membrane presequence translocase complex IEA--

    PAM16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAM16 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for PAM16
        Mitochondrial protein import



    PAM16 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PAM16
    Interactions:

        Search GeneGlobe Interaction Network for PAM16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PAM16 (Q9Y3D72, 3 ENSP000003156934) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FEZ1Q996892, 3, ENSP000002789194MINT-65847 MINT-8259390 I2D: score=4 STRING: ENSP00000278919
    GPM6AP516742, 3, ENSP000002801874MINT-8259401 I2D: score=2 STRING: ENSP00000280187
    BLOC1S2Q6QNY12, 3MINT-8259354 I2D: score=2 
    CEP70Q8NHQ12, 3MINT-8259368 I2D: score=2 
    DNMT3BQ9UBC32, 3MINT-8259379 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0030150protein import into mitochondrial matrix IEA--
    GO:0044267cellular protein metabolic process TAS--

    PAM16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PAM16 (TIM16)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PAM16 gene: 
    NM_016069.9  

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577031 ENST00000318059(uc002cwd.3) ENST00000573236 ENST00000573450
    ENST00000573553 ENST00000575848 ENST00000571941 ENST00000575636 ENST00000573614
    ENST00000571986 ENST00000576217 ENST00000571178 ENST00000571819 ENST00000575884
    ENST00000575942
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PAM16
      QuantiFast Probe-based Assays in human, mouse, rat PAM16

    Selected AceView cDNA sequences (see all 277):

    NM_016069 AK094596 BM853406 BU931694 AI268592 AI498278 AI672921 BM450422 
    NM_024535 BM710221 AI801913 AI800826 AI922770 BQ882990 BM710070 AK026514 
    BM841885 BQ060714 BM702213 BC005024 AW205935 CB152664 BM469939 AI807763 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PAM16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGTACC
    PAM16 Expression
    About this image

    PAM16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAM16 Protein Expression

    UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for PAM16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAM16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PAM16 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pam161 , 5 presequence translocase-asssociated motor 16 homolog more1, 5 88.8(n)1
    96(a)1
      16 (2.45 cM)5
    664491  NM_025571.11  NP_079847.11 
     46164645 
    chicken
    (Gallus gallus)
    Aves PAM161 presequence translocase-associated motor 16 homolog more 76.53(n)
    79.2(a)
      416669  NM_001004377.2  NP_001004377.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAM166
    presequence translocase-associated motor 16 homolo...
    76(a)
    1 ↔ 1
    GL343856.1(39309-43432)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136022 Xenopus laevis transcribed sequence with moderate similarity more 76.73(n)    BJ096700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733562 hypothetical protein MGC73356 74.36(n)   393777  BC059670.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta blp1 black pearl 61.31(n)
    61.61(a)
      41937  NM_079646.3  NP_524370.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F45G2.81 F45G2.8 52.38(n)
    47.06(a)
      176769  NM_067374.5  NP_499775.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PAM16(YJL104W)4 Constituent of the import motor (PAM complex) component more   --   10(227327-227776) 853340  NP_012431.1 


    ENSEMBL Gene Tree for PAM16 (if available)
    TreeFam Gene Tree for PAM16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAM16 gene
    9 SIMAP similar genes for PAM16 using alignment to 6 protein entries:     TIM16_HUMAN (see all proteins):
    ADCY7    L3MBTL2    RHBDD3    NAA15    DDX19A    TTC7A
    ETFA    ABCG5    KIAA0586

    PAM16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for PAM16    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119891,2,4
    ----see VAR_0137642 mis40--------

    HapMap Linkage Disequilibrium report for PAM16 (4381550 - 4405608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PAM16 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667108CNV Deletion23128226
    esv1548790CNV Insertion17803354
    esv1211300CNV Insertion17803354
    nsv471075CNV Loss18288195
    nsv905222CNV Loss21882294
    nsv527866CNV Loss19592680
    nsv905224CNV Loss21882294
    nsv905223CNV Loss21882294
    nsv103783CNV Loss16902084
    dgv2586n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614336    OMIM disorders: --

    4 diseases for PAM16:    About MalaCards
    acth-secreting pituitary adenoma    pituitary adenoma    adenoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for PAM16:
    ACTH-secreting pituitary adenoma

    PAM16 for disorders           About GeneDecksing


    Export disorders for PAM16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAM16 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with PAM16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of Magmas, a novel mitochondria- associated protein involved in granulocyte-macrophage colony- stimulating factor signal transduction. (PubMed id 11750097)1, 2, 3, 9 Jubinsky P.T.... Short M.K. (Exp. Hematol. 2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. Role of Magmas in protein transport and human mitochondria biogenesis. (PubMed id 20053669)1, 2, 9 Sinha D.... D'Silva P. (Hum. Mol. Genet. 2010)
    4. Magmas expression in neoplastic human prostate. (PubMed id 15704001)1, 2 Jubinsky P.T....Li M. (J. Mol. Histol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. (PubMed id 23263864)2 Schusdziarra C....Hell K. (Hum. Mol. Genet. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51025 HGNC: 29679 AceView: MagmasandCRN7 Ensembl:ENSG00000217930 euGenes: HUgn51025
    ECgene: PAM16 H-InvDB: PAM16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PAM16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PAM16 gene:
    Search GeneIP for patents involving PAM16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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