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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PAM16 Gene

protein-coding   GIFtS: 50
GCID: GC16M004381

Presequence Translocase-Associated Motor 16 Homolog (S....

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Presequence Translocase-Associated Motor 16 Homolog (S. Cerevisiae)1 2     TIMM162 3
Mitochondria Associated Protein Involved In Granulocyte Macrophage Colony
Stimulating Factor Signal Transduction1 2
     Magmas-Like Protein2
Mitochondria-Associated Granulocyte Macrophage CSF-Signaling Molecule2 3     Mitochondrial Import Inner Membrane Translocase Subunit TIM162
MAGMAS2 3     Presequence Translocated-Associated Motor Subunit PAM163
TIM162 3     

External Ids:    HGNC: 296791   Entrez Gene: 510252   Ensembl: ENSG000002179307   OMIM: 6143365   UniProtKB: Q9Y3D73   

Export aliases for PAM16 gene to outside databases

Previous GC identifer: GC16M004357


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PAM16 Gene: 
PAM16 (presequence translocase-associated motor 16 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with PAM16 include acth-secreting pituitary adenoma, and pituitary adenoma, and among its related super-pathways are Post-translational protein modification.

UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7
Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19
stimulation of HSPA9/Mortalin ATPase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PAM16
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PAM16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAM16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PAM16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAM16 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004381:  view genomic region     (about GC identifiers)

Start:
4,381,550 bp from pter      End:
4,405,608 bp from pter
Size:
24,059 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit TIM16  
Size: 125 amino acids; 13825 Da
Subunit: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or
GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Associates with the
TIM23 complex
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Secondary accessions: Q6I9Z3 Q9H5X3

Explore the universe of human proteins at neXtProt for PAM16: NX_Q9Y3D7

Explore proteomics data for PAM16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3D7

  • PAM16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PAM16 Protein Expression
    REFSEQ proteins: NP_057153.8  
    ENSEMBL proteins: 
     ENSP00000459113   ENSP00000315693   ENSP00000459955   ENSP00000458412   ENSP00000460708  
     ENSP00000458914   ENSP00000459802   ENSP00000461047   ENSP00000460434  
    Reactome Protein details: Q9Y3D7
    Human Recombinant Protein Products for PAM16: 
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    Novus Biologicals PAM16 Lysate
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005744mitochondrial inner membrane presequence translocase complex IEA--

    PAM16 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005341 Tim16

    Graphical View of Domain Structure for InterPro Entry Q9Y3D7

    ProtoNet protein and cluster: Q9Y3D7

    1 Blocks protein domain: IPB005341 Protein of unknown function UPF0108

    UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7
    Domain: The J-like region, although related to the J domain does not have co-chaperone activity (By similarity)
    Similarity: Belongs to the TIM16/PAM16 family


    PAM16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM16_HUMAN, Q9Y3D7
    Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19
    stimulation of HSPA9/Mortalin ATPase activity
    Induction: By CSF2/GM-CSF

    Animal Models:

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PAM16 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for PAM16
        Mitochondrial Protein Import
    Metabolism of proteins



    PAM16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PAM16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for PAM16 (Q9Y3D72, 3 ENSP000003156934) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FEZ1Q996892, 3, ENSP000002789194MINT-65847 MINT-8259390 I2D: score=4 STRING: ENSP00000278919
    GPM6AP516742, 3, ENSP000002801874MINT-8259401 I2D: score=2 STRING: ENSP00000280187
    BLOC1S2Q6QNY12, 3MINT-8259354 I2D: score=2 
    CEP70Q8NHQ12, 3MINT-8259368 I2D: score=2 
    DNMT3BQ9UBC32, 3MINT-8259379 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0030150protein import into mitochondrial matrix IEA--
    GO:0044267cellular protein metabolic process TAS--

    PAM16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PAM16 (TIM16)

    Search CenterWatch for drugs/clinical trials and news about PAM16 / TIM16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PAM16 gene: 
    NM_016069.9  

    Unigene Cluster for PAM16:

    Presequence translocase-associated motor 16 homolog (S. cerevisiae)
    Hs.730693  [show with all ESTs]
    Unigene Representative Sequence: BQ233017
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577031 ENST00000318059(uc002cwd.3) ENST00000573236 ENST00000573450
    ENST00000573553 ENST00000575848 ENST00000571941 ENST00000575636 ENST00000573614
    ENST00000571986 ENST00000576217 ENST00000571178 ENST00000571819 ENST00000575884
    ENST00000575942
    miRNA
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    Additional mRNA sequence: 

    AF151894.1 AF349455.1 AK026514.1 BC005024.1 CR457362.1 

    15 DOTS entries:

    DT.449076  DT.100035684  DT.95162083  DT.97843012  DT.100035681  DT.100035683  DT.120686847  DT.40192918 
    DT.120686778  DT.40191766  DT.120686850  DT.95162076  DT.95162084  DT.99986281  DT.91786594 

    24/277 AceView cDNA sequences (see all 277):

    AK126176 BM469939 CA419484 AI865884 AI268592 AW071929 AI800826 AI922770 
    AI057511 AY313265 BM702213 AW249037 CA314889 BM710070 AK026514 AI424481 
    BQ011933 BU931694 AI672921 AW205935 AA338859 NM_016069 CB152664 AI288705 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PAM16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGTACC
    PAM16 Expression
    About this image


    See PAM16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PAM16

    SOURCE GeneReport for Unigene cluster: Hs.730693

    UniProtKB/Swiss-Prot: TIM16_HUMAN, Q9Y3D7
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PAM16 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pam161 , 5 presequence translocase-asssociated motor 16 homolog more1, 5 88.8(n)1
    96(a)1
      16 (2.45 cM)5
    664491  NM_025571.11  NP_079847.11 
     46164645 
    chicken
    (Gallus gallus)
    Aves PAM161 presequence translocase-associated motor 16 homolog more 76.53(n)
    79.2(a)
      416669  NM_001004377.2  NP_001004377.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAM166
    Uncharacterized protein
    75(a)
    1 ↔ 1
    GL343856.1(39309-43432)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136022 Xenopus laevis transcribed sequence with moderate similarity more 76.73(n)    BJ096700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733562 hypothetical protein MGC73356 74.36(n)   393777  BC059670.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta blp1 black pearl 60.23(n)
    58.77(a)
      41937  NM_079646.2  NP_524370.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F45G2.81 Protein F45G2.8 53.27(n)
    50.89(a)
      176769  NM_067374.4  NP_499775.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PAM16(YJL104W)4 Constituent of the import motor (PAM complex) component more   --   10(227327-227776) 853340  NP_012431.1 


    ENSEMBL Gene Tree for PAM16 (if available)
    TreeFam Gene Tree for PAM16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PAM16 gene
    9 SIMAP similar genes for PAM16 using alignment to 6 protein entries:     TIM16_HUMAN (see all proteins):
    ADCY7    L3MBTL2    RHBDD3    NAA15    DDX19A    TTC7A
    ETFA    ABCG5    KIAA0586

    PAM16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in PAM16 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0137644
    ----see VAR_0137642 Q K mis40--------

    HapMap Linkage Disequilibrium report for PAM16 (4381550 - 4405608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for PAM16 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667108CNV Deletion23128226
    esv1548790CNV Insertion17803354
    esv1211300CNV Insertion17803354
    nsv471075CNV Loss18288195
    nsv905222CNV Loss21882294
    nsv527866CNV Loss19592680
    nsv905224CNV Loss21882294
    nsv905223CNV Loss21882294
    nsv103783CNV Loss16902084
    dgv2586n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614336    OMIM disorders: --

    4 diseases for PAM16:    About MalaCards
    acth-secreting pituitary adenoma    pituitary adenoma    adenoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for PAM16:
    ACTH-secreting pituitary adenoma

    PAM16 for disorders           About GeneDecksing


    Export disorders for PAM16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PAM16 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with PAM16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of Magmas, a novel mitochondria- associated protein involved in granulocyte-macrophage colony- stimulating factor signal transduction. (PubMed id 11750097)1, 2, 3, 9 Jubinsky P.T.... Short M.K. (2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Role of Magmas in protein transport and human mitocho ndria biogenesis. (PubMed id 20053669)1, 2, 9 Sinha D....D'Silva P. (2010)
    4. Magmas expression in neoplastic human prostate. (PubMed id 15704001)1, 2 Jubinsky P.T....Li M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Magmas, a gene newly identified as overexpressed in h uman and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli. (PubMed id 20719856)1 Tagliati F....Zatelli M.C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51025 HGNC: 29679 AceView: MagmasandCRN7 Ensembl:ENSG00000217930 euGenes: HUgn51025
    ECgene: PAM16 H-InvDB: PAM16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PAM16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PAM16 gene:
    Search GeneIP for patents involving PAM16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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