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Aliases for PAM16 Gene

Aliases for PAM16 Gene

  • Presequence Translocase-Associated Motor 16 Homolog (S. Cerevisiae) 2 3 5
  • Mitochondria Associated Protein Involved In Granulocyte Macrophage Colony Stimulating Factor Signal Transduction 2 3
  • Mitochondria-Associated Granulocyte Macrophage CSF-Signaling Molecule 3 4
  • MAGMAS 3 4
  • TIMM16 3 4
  • TIM16 3 4
  • Presequence Translocated-Associated Motor Subunit PAM16 4
  • Magmas-Like Protein 3
  • CGI-136 3
  • SMDMDM 3

External Ids for PAM16 Gene

Previous GeneCards Identifiers for PAM16 Gene

  • GC16M004357
  • GC16M004381

Summaries for PAM16 Gene

GeneCards Summary for PAM16 Gene

PAM16 (Presequence Translocase-Associated Motor 16 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with PAM16 include Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melike Type and Autosomal Recessive Spondylometaphyseal Dysplasia, Mégarbané Type. Among its related pathways are Mitochondrial protein import and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for PAM16 Gene

  • Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAM16 Gene

Genomics for PAM16 Gene

Regulatory Elements for PAM16 Gene

Enhancers for PAM16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PAM16 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAM16 Gene

4,331,549 bp from pter
4,355,607 bp from pter
24,059 bases
Minus strand

Genomic View for PAM16 Gene

Genes around PAM16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAM16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAM16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAM16 Gene

Proteins for PAM16 Gene

  • Protein details for PAM16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial import inner membrane translocase subunit TIM16
    Protein Accession:
    Secondary Accessions:
    • Q6I9Z3
    • Q9H5X3

    Protein attributes for PAM16 Gene

    125 amino acids
    Molecular mass:
    13825 Da
    Quaternary structure:
    • Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Directly interacts with DNAJC15; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with the TIM23 complex.

neXtProt entry for PAM16 Gene

Proteomics data for PAM16 Gene at MOPED

Post-translational modifications for PAM16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PAM16 Gene

Domains & Families for PAM16 Gene

Protein Domains for PAM16 Gene


Suggested Antigen Peptide Sequences for PAM16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The J-like region, although related to the J domain does not have co-chaperone activity.
  • Belongs to the TIM16/PAM16 family.
  • The J-like region, although related to the J domain does not have co-chaperone activity.
  • Belongs to the TIM16/PAM16 family.
genes like me logo Genes that share domains with PAM16: view

No data available for Gene Families for PAM16 Gene

Function for PAM16 Gene

Molecular function for PAM16 Gene

UniProtKB/Swiss-Prot Function:
Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.
UniProtKB/Swiss-Prot Induction:

Phenotypes for PAM16 Gene

MGI mutant phenotypes for PAM16:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PAM16: view

Human Phenotype Ontology for PAM16 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PAM16 Gene

MGI Knock Outs for PAM16:

Animal Model Products

CRISPR Products

miRNA for PAM16 Gene

miRTarBase miRNAs that target PAM16

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for PAM16 Gene

Localization for PAM16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAM16 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

Jensen Localization Image for PAM16 Gene COMPARTMENTS Subcellular localization image for PAM16 gene
Compartment Confidence
mitochondrion 5
extracellular 2

Gene Ontology (GO) - Cellular Components for PAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031314 extrinsic component of mitochondrial inner membrane IDA 20053669
genes like me logo Genes that share ontologies with PAM16: view

Pathways & Interactions for PAM16 Gene

genes like me logo Genes that share pathways with PAM16: view

Pathways by source for PAM16 Gene

2 Reactome pathways for PAM16 Gene

Gene Ontology (GO) - Biological Process for PAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032780 negative regulation of ATPase activity IDA 19564938
genes like me logo Genes that share ontologies with PAM16: view

No data available for SIGNOR curated interactions for PAM16 Gene

Drugs & Compounds for PAM16 Gene

No Compound Related Data Available

Transcripts for PAM16 Gene

Unigene Clusters for PAM16 Gene

Presequence translocase-associated motor 16 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAM16 Gene

No ASD Table

Relevant External Links for PAM16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PAM16 Gene

mRNA expression in normal human tissues for PAM16 Gene

Protein differential expression in normal tissues from HIPED for PAM16 Gene

This gene is overexpressed in Bone (8.8) and Breast (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAM16 Gene

SOURCE GeneReport for Unigene cluster for PAM16 Gene Hs.730693

mRNA Expression by UniProt/SwissProt for PAM16 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with PAM16: view

Protein tissue co-expression partners for PAM16 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PAM16 Gene

Orthologs for PAM16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAM16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PAM16 35
  • 89.6 (n)
  • 92 (a)
PAM16 36
  • 92 (a)
(Canis familiaris)
Mammalia PAM16 35
  • 89.33 (n)
  • 94.4 (a)
PAM16 36
  • 94 (a)
(Mus musculus)
Mammalia Pam16 35
  • 88.8 (n)
  • 96 (a)
Pam16 16
Gm9803 36
  • 96 (a)
Pam16 36
  • 96 (a)
(Pan troglodytes)
Mammalia PAM16 35
  • 99.47 (n)
  • 99.2 (a)
PAM16 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pam16 35
  • 88.53 (n)
  • 95.2 (a)
(Monodelphis domestica)
Mammalia PAM16 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia PAM16 36
  • 91 (a)
(Gallus gallus)
Aves PAM16 35
  • 76.53 (n)
  • 79.2 (a)
PAM16 36
  • 79 (a)
(Anolis carolinensis)
Reptilia PAM16 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pam16 35
  • 73.87 (n)
  • 79.2 (a)
Str.19906 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13602 35
(Danio rerio)
Actinopterygii pam16 35
  • 71.88 (n)
  • 81.74 (a)
zgc73356 35
pam16 36
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1411 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013212 35
  • 65.45 (n)
  • 69.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta blp 35
  • 61.31 (n)
  • 61.61 (a)
blp 36
  • 49 (a)
CG1409 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea F45G2.8 35
  • 52.38 (n)
  • 47.06 (a)
F45G2.8 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAM16 36
  • 32 (a)
PAM16 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4672 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.831 36
  • 55 (a)
Species with no ortholog for PAM16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAM16 Gene

Gene Tree for PAM16 (if available)
Gene Tree for PAM16 (if available)

Paralogs for PAM16 Gene

(9) SIMAP similar genes for PAM16 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PAM16: view

No data available for Paralogs for PAM16 Gene

Variants for PAM16 Gene

Sequence variations from dbSNP and Humsavar for PAM16 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_013764 -
VAR_073419 Spondylometaphyseal dysplasia, Megarbane-Dagher-Melike type (SMDMDM)

Structural Variations from Database of Genomic Variants (DGV) for PAM16 Gene

Variant ID Type Subtype PubMed ID
nsv527866 CNV Loss 19592680
nsv905222 CNV Loss 21882294
nsv905223 CNV Loss 21882294
nsv905224 CNV Loss 21882294
dgv2585n71 CNV Loss 21882294
dgv2586n71 CNV Loss 21882294
nsv471075 CNV Loss 18288195
esv23732 CNV Gain 19812545
esv1211300 CNV Insertion 17803354
nsv103783 CNV Loss 16902084
esv1548790 CNV Insertion 17803354
esv2667108 CNV Deletion 23128226
nsv905232 CNV Loss 21882294

Variation tolerance for PAM16 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.77; 78.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAM16 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAM16 Gene

Disorders for PAM16 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PAM16 Gene - From: OMIM, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spondylometaphyseal dysplasia, megarbane-dagher-melike type
  • chondrodysplasia, megarbane-dagher-melike type
autosomal recessive spondylometaphyseal dysplasia, mégarbané type
pituitary adenoma, acth-secreting
  • pituitary-dependent cushing's disease
functioning pituitary adenoma
  • secretory adenoma of the pituitary gland
- elite association - COSMIC cancer census association via MalaCards
Search PAM16 in MalaCards View complete list of genes associated with diseases


  • Spondylometaphyseal dysplasia, Megarbane-Dagher-Melike type (SMDMDM) [MIM:613320]: An autosomal recessive disease characterized by pre- and postnatal short stature, developmental delay, dysmorphic facial appearance, narrow chest, prominent abdomen, platyspondyly, and short limbs. {ECO:0000269 PubMed:24786642}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PAM16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PAM16: view

No data available for Genatlas for PAM16 Gene

Publications for PAM16 Gene

  1. Identification and characterization of Magmas, a novel mitochondria- associated protein involved in granulocyte-macrophage colony- stimulating factor signal transduction. (PMID: 11750097) Jubinsky P.T. … Short M.K. (Exp. Hematol. 2001) 2 3 4 23 67
  2. Role of Magmas in protein transport and human mitochondria biogenesis. (PMID: 20053669) Sinha D. … D'Silva P. (Hum. Mol. Genet. 2010) 3 23
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PAM16 Gene

Sources for PAM16 Gene