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Aliases for PAM16 Gene

Aliases for PAM16 Gene

  • Presequence Translocase-Associated Motor 16 Homolog (S. Cerevisiae) 2 3
  • MAGMAS 3 4 6
  • Mitochondria Associated Protein Involved In Granulocyte Macrophage Colony Stimulating Factor Signal Transduction 2 3
  • Mitochondria-Associated Granulocyte Macrophage CSF-Signaling Molecule 3 4
  • TIMM16 3 4
  • TIM16 3 4
  • Mitochondrial Import Inner Membrane Translocase Subunit TIM16 3
  • Presequence Translocated-Associated Motor Subunit PAM16 4
  • Magmas-Like Protein 3
  • CGI-136 3
  • SMDMDM 3

External Ids for PAM16 Gene

Previous GeneCards Identifiers for PAM16 Gene

  • GC16M004357
  • GC16M004381

Summaries for PAM16 Gene

GeneCards Summary for PAM16 Gene

PAM16 (Presequence Translocase-Associated Motor 16 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with PAM16 include autosomal recessive spondylometaphyseal dysplasia, m�garban� type. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import.

UniProtKB/Swiss-Prot for PAM16 Gene

  • Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAM16 Gene

Genomics for PAM16 Gene

Genomic Location for PAM16 Gene

Start:
4,331,549 bp from pter
End:
4,355,607 bp from pter
Size:
24,059 bases
Orientation:
Minus strand

Genomic View for PAM16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAM16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAM16 Gene

No data available for Regulatory Elements for PAM16 Gene

Proteins for PAM16 Gene

  • Protein details for PAM16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D7-TIM16_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit TIM16
    Protein Accession:
    Q9Y3D7
    Secondary Accessions:
    • Q6I9Z3
    • Q9H5X3

    Protein attributes for PAM16 Gene

    Size:
    125 amino acids
    Molecular mass:
    13825 Da
    Quaternary structure:
    • Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Directly interacts with DNAJC15; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with the TIM23 complex.

neXtProt entry for PAM16 Gene

Proteomics data for PAM16 Gene at MOPED

Post-translational modifications for PAM16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAM16 Gene

No data available for DME Specific Peptides for PAM16 Gene

Domains for PAM16 Gene

Protein Domains for PAM16 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PAM16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D7

UniProtKB/Swiss-Prot:

TIM16_HUMAN :
  • Q9Y3D7
Domain:
  • The J-like region, although related to the J domain does not have co-chaperone activity.
Family:
  • Belongs to the TIM16/PAM16 family.
genes like me logo Genes that share domains with PAM16: view

No data available for Gene Families for PAM16 Gene

Function for PAM16 Gene

Molecular function for PAM16 Gene

UniProtKB/Swiss-Prot Function: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.
UniProtKB/Swiss-Prot Induction: By CSF2/GM-CSF

Gene Ontology (GO) - Molecular Function for PAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19564938
genes like me logo Genes that share ontologies with PAM16: view

miRNA for PAM16 Gene

miRTarBase miRNAs that target PAM16

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PAM16 Gene

Localization for PAM16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAM16 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAM16 Gene COMPARTMENTS Subcellular localization image for PAM16 gene
Compartment Confidence
mitochondrion 5
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001405 presequence translocase-associated import motor IGI 20053669
GO:0005744 mitochondrial inner membrane presequence translocase complex IBA --
GO:0005759 mitochondrial matrix IDA 20053669
GO:0031314 extrinsic component of mitochondrial inner membrane IDA 20053669
GO:0043234 protein complex IDA 19564938
genes like me logo Genes that share ontologies with PAM16: view

Pathways for PAM16 Gene

genes like me logo Genes that share pathways with PAM16: view

Pathways by source for PAM16 Gene

2 Reactome pathways for PAM16 Gene

Gene Ontology (GO) - Biological Process for PAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0030150 protein import into mitochondrial matrix IGI 20053669
GO:0032780 negative regulation of ATPase activity IDA 19564938
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PAM16: view

Transcripts for PAM16 Gene

Unigene Clusters for PAM16 Gene

Presequence translocase-associated motor 16 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAM16 Gene

No ASD Table

Relevant External Links for PAM16 Gene

GeneLoc Exon Structure for
PAM16
ECgene alternative splicing isoforms for
PAM16

Expression for PAM16 Gene

mRNA expression in normal human tissues for PAM16 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAM16 Gene

SOURCE GeneReport for Unigene cluster for PAM16 Gene Hs.730693

mRNA Expression by UniProt/SwissProt for PAM16 Gene

Q9Y3D7-TIM16_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with PAM16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PAM16 Gene

Orthologs for PAM16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAM16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAM16 35
  • 99.47 (n)
  • 99.2 (a)
PAM16 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAM16 35
  • 89.6 (n)
  • 92 (a)
PAM16 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAM16 35
  • 89.33 (n)
  • 94.4 (a)
PAM16 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9803 36
  • 96 (a)
OneToMany
Pam16 35
  • 88.8 (n)
  • 96 (a)
Pam16 16
Pam16 36
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PAM16 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAM16 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pam16 35
  • 88.53 (n)
  • 95.2 (a)
chicken
(Gallus gallus)
Aves PAM16 35
  • 76.53 (n)
  • 79.2 (a)
PAM16 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAM16 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13602 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pam16 35
  • 73.87 (n)
  • 79.2 (a)
Str.19906 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1411 35
zebrafish
(Danio rerio)
Actinopterygii pam16 35
  • 71.88 (n)
  • 81.74 (a)
pam16 36
  • 75 (a)
OneToOne
zgc73356 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013212 35
  • 65.45 (n)
  • 69.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta blp 35
  • 61.31 (n)
  • 61.61 (a)
blp 36
  • 49 (a)
OneToMany
CG1409 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F45G2.8 35
  • 52.38 (n)
  • 47.06 (a)
F45G2.8 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAM16 36
  • 32 (a)
OneToOne
PAM16 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4672 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.831 36
  • 55 (a)
OneToOne
Species with no ortholog for PAM16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAM16 Gene

ENSEMBL:
Gene Tree for PAM16 (if available)
TreeFam:
Gene Tree for PAM16 (if available)

Paralogs for PAM16 Gene

Selected SIMAP similar genes for PAM16 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PAM16: view

No data available for Paralogs for PAM16 Gene

Variants for PAM16 Gene

Sequence variations from dbSNP and Humsavar for PAM16 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_013764 -

Structural Variations from Database of Genomic Variants (DGV) for PAM16 Gene

Variant ID Type Subtype PubMed ID
nsv527866 CNV Loss 19592680
nsv905222 CNV Loss 21882294
nsv905223 CNV Loss 21882294
nsv905224 CNV Loss 21882294
dgv2585n71 CNV Loss 21882294
dgv2586n71 CNV Loss 21882294
nsv471075 CNV Loss 18288195
esv23732 CNV Gain 19812545
esv1211300 CNV Insertion 17803354
nsv103783 CNV Loss 16902084
esv1548790 CNV Insertion 17803354
esv2667108 CNV Deletion 23128226
nsv905232 CNV Loss 21882294

Relevant External Links for PAM16 Gene

HapMap Linkage Disequilibrium report
PAM16
Human Gene Mutation Database (HGMD)
PAM16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAM16 Gene

Disorders for PAM16 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PAM16 Gene including...

Search for PAM16 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PAM16 Gene

genes like me logo Genes that share disorders with PAM16: view

No data available for UniProtKB/Swiss-Prot for PAM16 Gene

Publications for PAM16 Gene

  1. Identification and characterization of Magmas, a novel mitochondria- associated protein involved in granulocyte-macrophage colony- stimulating factor signal transduction. (PMID: 11750097) Jubinsky P.T. … Short M.K. (Exp. Hematol. 2001) 2 3 4 23
  2. Role of Magmas in protein transport and human mitochondria biogenesis. (PMID: 20053669) Sinha D. … D'Silva P. (Hum. Mol. Genet. 2010) 3 4 23
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PAM16 Gene

Sources for PAM16 Gene

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