Aliases for PAM Gene
- Peptidylglycine Alpha-Amidating Monooxygenase 2 3 5
- Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase 2 3
- Peptidylglycine Alpha-Hydroxylating Monooxygenase 2 3
- Pancreatic Peptidylglycine Alpha-Amidating Monooxygenase 3
- Peptidyl-Glycine Alpha-Amidating Monooxygenase 3
- Peptidyl Alpha-Amidating Enzyme 3
External Ids for PAM Gene
Previous GeneCards Identifiers for PAM Gene
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for PAM Gene
PAM (Peptidylglycine Alpha-Amidating Monooxygenase) is a Protein Coding gene. Diseases associated with PAM include Menkes Disease and Phaeohyphomycosis. GO annotations related to this gene include copper ion binding and L-ascorbic acid binding. An important paralog of this gene is DBH.
UniProtKB/Swiss-Prot for PAM Gene
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.