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Aliases for PALM2-AKAP2 Gene

Aliases for PALM2-AKAP2 Gene

  • PALM2-AKAP2 Readthrough 2 3 5
  • PALM2-AKAP2 Readthrough Transcript 3
  • PALM2-AKAP2 Protein 3
  • AKAP2 3

External Ids for PALM2-AKAP2 Gene

Previous GeneCards Identifiers for PALM2-AKAP2 Gene

  • GC09U900652
  • GC09P111582
  • GC09P111444
  • GC09P112542
  • GC09P082144

Summaries for PALM2-AKAP2 Gene

Entrez Gene Summary for PALM2-AKAP2 Gene

  • PALM2-AKAP2 mRNAs are naturally occurring read-through products of the neighboring PALM2 and AKAP2 genes that belong to the paralemmin downstream gene (PDG) family. The significance of these read-through mRNAs and the function the resulting fusion protein products have not yet been determined. Naturally occurring mutations in this gene are associated with human height. [provided by RefSeq, May 2017]

GeneCards Summary for PALM2-AKAP2 Gene

PALM2-AKAP2 (PALM2-AKAP2 Readthrough) is a Protein Coding gene. Diseases associated with PALM2-AKAP2 include Kallmann Syndrome. An important paralog of this gene is AKAP2.

Additional gene information for PALM2-AKAP2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PALM2-AKAP2 Gene

Genomics for PALM2-AKAP2 Gene

Regulatory Elements for PALM2-AKAP2 Gene

Enhancers for PALM2-AKAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H110026 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.9 +249.5 249487 6.3 FOXA2 ATF1 ZFP64 YY1 FOS ATF7 ZNF202 REST PPARG ZNF623 PALM2-AKAP2 PALM2 RPL21P87 AKAP2
GH09H109965 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.1 +188.2 188184 5.7 HDGF TBL1XR1 BMI1 BATF RAD21 ZNF207 ATF7 ETV6 RUNX3 CREM AKAP2 PALM2-AKAP2 PALM2 GC09M110025
GH09H109971 1.4 Ensembl ENCODE dbSUPER 8.6 +193.5 193518 4.8 HDGF PKNOX1 TBL1XR1 RB1 BMI1 BATF ZBTB40 ZNF143 ZNF207 ATF7 AKAP2 PALM2-AKAP2 PALM2 GC09M110025
GH09H109922 1.2 Ensembl ENCODE dbSUPER 9.7 +143.1 143137 1.6 CTCF FOXA2 MAX REST RAD21 YY1 JUND ATF3 POLR2A HNF4A AKAP2 PALM2-AKAP2 PALM2 GC09M110025
GH09H109745 1 Ensembl ENCODE 11.3 -34.5 -34537 1.2 PKNOX1 INSM2 MAX FEZF1 ZIC2 ZNF2 YY1 POLR2A ZNF600 ZBTB20 PALM2 ENSG00000232939 PALM2-AKAP2 AKAP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PALM2-AKAP2 on UCSC Golden Path with GeneCards custom track

Promoters for PALM2-AKAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000239588 403 1801 CTCF LEF1 MXI1 TAF1 MAX ZIC2 RAD21 YY1 GLIS2 POLR2A

Genomic Locations for PALM2-AKAP2 Gene

Genomic Locations for PALM2-AKAP2 Gene
392,216 bases
Plus strand

Genomic View for PALM2-AKAP2 Gene

Genes around PALM2-AKAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PALM2-AKAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PALM2-AKAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PALM2-AKAP2 Gene

Proteins for PALM2-AKAP2 Gene

  • Protein details for PALM2-AKAP2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    PALM2-AKAP2 readthrough
    Protein Accession:

    Protein attributes for PALM2-AKAP2 Gene

    433 amino acids
    Molecular mass:
    47627 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PALM2-AKAP2 Gene

Post-translational modifications for PALM2-AKAP2 Gene

No Post-translational modifications

Other Protein References for PALM2-AKAP2 Gene

No data available for DME Specific Peptides for PALM2-AKAP2 Gene

Domains & Families for PALM2-AKAP2 Gene

Gene Families for PALM2-AKAP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PALM2-AKAP2 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PALM2-AKAP2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PALM2-AKAP2 Gene

Function for PALM2-AKAP2 Gene

Phenotypes From GWAS Catalog for PALM2-AKAP2 Gene

Phenotypes for PALM2-AKAP2 Gene

genes like me logo Genes that share phenotypes with PALM2-AKAP2: view

Animal Model Products

CRISPR Products

miRNA for PALM2-AKAP2 Gene

miRTarBase miRNAs that target PALM2-AKAP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PALM2-AKAP2 Gene

Localization for PALM2-AKAP2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PALM2-AKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PALM2-AKAP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for PALM2-AKAP2 Gene

Pathways & Interactions for PALM2-AKAP2 Gene

SuperPathways for PALM2-AKAP2 Gene

No Data Available

Interacting Proteins for PALM2-AKAP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000363654 for PALM2-AKAP2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PALM2-AKAP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for PALM2-AKAP2 Gene

Drugs & Compounds for PALM2-AKAP2 Gene

No Compound Related Data Available

Transcripts for PALM2-AKAP2 Gene

mRNA/cDNA for PALM2-AKAP2 Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for PALM2-AKAP2 Gene

No ASD Table

Relevant External Links for PALM2-AKAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PALM2-AKAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PALM2-AKAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PALM2-AKAP2 Gene

This gene is overexpressed in Heart (30.5), Fetal heart (14.0), Pancreas (9.4), and Adipocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for PALM2-AKAP2 Gene

Protein tissue co-expression partners for PALM2-AKAP2 Gene

genes like me logo Genes that share expression patterns with PALM2-AKAP2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PALM2-AKAP2 Gene

Orthologs for PALM2-AKAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PALM2-AKAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
PALM2 34
  • 38 (a)
(Bos Taurus)
Mammalia -- 34
  • 88 (a)
AKAP2 33
  • 85.7 (n)
PALM2 34
  • 37 (a)
(Canis familiaris)
Mammalia PALM2 34
  • 86 (a)
(Mus musculus)
Mammalia Gm20459 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia AKAP2 34
  • 71 (a)
(Monodelphis domestica)
Mammalia AKAP2 34
  • 60 (a)
(Gallus gallus)
Aves AKAP2 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
(Danio rerio)
Actinopterygii palm2 34
  • 39 (a)
Species where no ortholog for PALM2-AKAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PALM2-AKAP2 Gene

Gene Tree for PALM2-AKAP2 (if available)
Gene Tree for PALM2-AKAP2 (if available)

Paralogs for PALM2-AKAP2 Gene

Paralogs for PALM2-AKAP2 Gene

(2) SIMAP similar genes for PALM2-AKAP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PALM2-AKAP2: view

Variants for PALM2-AKAP2 Gene

Sequence variations from dbSNP and Humsavar for PALM2-AKAP2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs193920924 Uncertain significance 110,136,169(+) AAAGC(A/G/T)AGGGA reference, missense, stop-gained, utr-variant-5-prime
rs879255366 Benign 110,048,763(+) CGGAG(-/TCTCCTGGACCCCCGGAG)CGGGA intron-variant, cds-indel
rs1000007811 -- 110,107,670(+) CAAGC(A/G)ATTCT intron-variant
rs1000032814 -- 110,003,212(+) GTCCC(A/G)GAGAT intron-variant
rs1000042425 -- 110,022,679(+) CACAT(C/T)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PALM2-AKAP2 Gene

Variant ID Type Subtype PubMed ID
nsv972441 CNV duplication 23825009
nsv831688 CNV gain+loss 17160897
nsv831687 CNV gain 17160897
nsv7430 OTHER inversion 18451855
nsv615151 CNV gain 21841781
nsv615150 CNV loss 21841781
nsv527195 CNV loss 19592680
nsv524745 CNV gain 19592680
nsv515562 CNV gain 19592680
nsv499708 OTHER inversion 21111241
nsv478028 CNV novel sequence insertion 20440878
nsv476870 CNV novel sequence insertion 20440878
nsv471316 CNV gain 18288195
nsv471314 CNV loss 18288195
nsv466481 CNV gain 19166990
nsv466480 CNV loss 19166990
nsv428222 CNV loss 18775914
nsv416423 CNV insertion 16902084
nsv1150859 CNV deletion 26484159
nsv1148299 CNV deletion 26484159
nsv1141021 CNV deletion 24896259
nsv1137497 CNV deletion 24896259
nsv1136019 CNV deletion 24896259
nsv1132219 CNV deletion 24896259
nsv1128512 CNV deletion 24896259
nsv1125065 CNV duplication 24896259
nsv1124463 CNV deletion 24896259
nsv1117903 CNV deletion 24896259
nsv1113012 CNV deletion 24896259
nsv1076198 CNV deletion 25765185
nsv1045508 CNV loss 25217958
nsv1043494 CNV gain 25217958
nsv1040651 CNV gain 25217958
esv3621456 CNV gain 21293372
esv3621453 CNV gain 21293372
esv3621452 CNV loss 21293372
esv3621450 CNV gain 21293372
esv3621449 CNV gain 21293372
esv3621448 CNV gain 21293372
esv3573350 CNV loss 25503493
esv3440538 CNV insertion 20981092
esv3413070 CNV insertion 20981092
esv3369203 CNV duplication 20981092
esv3309092 CNV mobile element insertion 20981092
esv28884 CNV loss 19812545
esv2752274 CNV gain 17911159
esv2738920 CNV deletion 23290073
esv2738919 CNV deletion 23290073
esv2738916 CNV deletion 23290073
esv2738915 CNV deletion 23290073
esv2672512 CNV deletion 23128226
esv2658904 CNV deletion 23128226
esv2619523 CNV deletion 19546169
esv2501710 CNV deletion 19546169
esv2195369 CNV deletion 18987734
esv2096560 CNV deletion 18987734
esv2075173 CNV deletion 18987734
esv1090209 CNV deletion 17803354
dgv494n21 CNV gain 19592680
dgv2177e212 CNV loss 25503493

Variation tolerance for PALM2-AKAP2 Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PALM2-AKAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PALM2-AKAP2 Gene

Disorders for PALM2-AKAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PALM2-AKAP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
kallmann syndrome
  • familial hypogonadism with anosmia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PALM2-AKAP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PALM2-AKAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PALM2-AKAP2 Gene

Publications for PALM2-AKAP2 Gene

  1. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 45 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. (PMID: 11478809) Hu B … Kilimann MW (Biochemical and biophysical research communications 2001) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for PALM2-AKAP2 Gene

Sources for PALM2-AKAP2 Gene

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