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PALM Gene

protein-coding   GIFtS: 55
GCID: GC19P000708

Paralemmin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
paralemmin1 2
Paralemmin3
paralemmin-12
KIAA02703

External Ids:    HGNC: 85941   Entrez Gene: 50642   Ensembl: ENSG000000998647   OMIM: 6081345   UniProtKB: O757813   

Export aliases for PALM gene to outside databases

Previous GC identifers: GC19P000760 GC19P000648 GC19P000660 GC19P000659 GC19P000489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PALM Gene:
This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and
palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in
plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have
been identified, but the full-length nature of only two transcript variants has been determined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PALM Gene:
PALM (paralemmin) is a protein-coding gene. Diseases associated with PALM include toxocariasis, and vesicoureteral reflux. GO annotations related to this gene include D3 dopamine receptor binding. An important paralog of this gene is PALMD.

UniProtKB/Swiss-Prot: PALM_HUMAN, O75781
Function: Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary
for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a
palmitoylation-dependent manner

Gene Wiki entry for PALM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PALM gene promoter:
         HEN1   USF1   MAZR   USF-1   USF2   Lmo2   STAT3   USF-1:USF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPALM promoter sequence
   Search Chromatin IP Primers for PALM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PALM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PALM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PALM gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000708:  view genomic region     (about GC identifiers)

Start:
708,953 bp from pter      End:
748,330 bp from pter
Size:
39,378 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PALM_HUMAN, O75781 (See protein sequence)
Recommended Name: Paralemmin-1 precursor  
Size: 387 amino acids; 42076 Da
Subunit: Interacts with dopamine receptor DRD3
Secondary accessions: O43359 O95673 Q92559 Q9UPJ4 Q9UQS2 Q9UQS3
Alternative splicing: 2 isoforms:  O75781-1   O75781-2   

Explore the universe of human proteins at neXtProt for PALM: NX_O75781

Explore proteomics data for PALM at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PALM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035224.1  NP_002570.2  

    ENSEMBL proteins: 
     ENSP00000264560   ENSP00000341911  

    PALM Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for PALM

    PALM Assay Products:

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    Cloud-Clone Corp. CLIAs for PALM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004965 Paralemmin

    Graphical View of Domain Structure for InterPro Entry O75781

    ProtoNet protein and cluster: O75781

    1 Blocks protein domain: IPB004965 Paralemmin

    UniProtKB/Swiss-Prot: PALM_HUMAN, O75781
    Similarity: Belongs to the paralemmin family


    PALM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PALM_HUMAN, O75781
    Function: Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary
    for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a
    palmitoylation-dependent manner

         Genatlas biochemistry entry for PALM:
    paralemmin,constituent of brain synaptic plasma membranes,also expressed in the kidney,adrenal medulla and at low
    level in many tissues

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16386234
    GO:0031750D3 dopamine receptor binding IEA--
         
    PALM for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PALM
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PALM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PALM

    miRNA
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    miRTarBase miRNAs that target PALM:
    hsa-mir-324-5p (MIRT043056)

    Block miRNA regulation of human, mouse, rat PALM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PALM (see all 16):
    hsa-miR-194* hsa-miR-642a hsa-miR-330-5p hsa-miR-29a hsa-miR-29c hsa-miR-3155 hsa-miR-484 hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidPALM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PALM
    Predesigned siRNA for gene silencing in human, mouse, rat PALM

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PALM

    Clone
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    OriGene clones in human, mouse for PALM (see all 12)
    OriGene ORF clones in mouse, rat for PALM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PALM (NM_001040134)
    Sino Biological Human cDNA Clone for PALM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PALM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PALM

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PALM 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PALM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PALM_HUMAN, O75781: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane;
    Lipid-anchor. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell projection,
    dendritic spine (By similarity). Basolateral cell membrane; Lipid-anchor (By similarity). Apicolateral cell
    membrane; Lipid-anchor (By similarity). Note=Translocation to the plasma membrane is enhanced upon stimulation of
    neuronal activity
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IDA--
    GO:0005887integral component of plasma membrane TAS9813098

    PALM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PALM
    Interactions:

        Search GeneGlobe Interaction Network for PALM

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for PALM (O757813 ENSP000003419114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463I2D: score=1 
    POT1ENSP000003502494STRING: ENSP00000350249
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9813098
    GO:0007010cytoskeleton organization IEA--
    GO:0007194negative regulation of adenylate cyclase activity IDA16386234
    GO:0008104protein localization ----
    GO:0008360regulation of cell shape IEA--

    PALM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PALM



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PALM gene (2 alternative transcripts): 
    NM_001040134.1  NM_002579.2  

    Unigene Cluster for PALM:

    Paralemmin
    Hs.631841  [show with all ESTs]
    Unigene Representative Sequence: NM_002579
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264560(uc010xft.2 uc002lpn.1) ENST00000587219 ENST00000592870
    ENST00000338448(uc002lpm.1 uc010xfu.1) ENST00000586055 ENST00000586776
    ENST00000589012 ENST00000593172 ENST00000592155 ENST00000590161 ENST00000587513

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PALM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PALM (see all 16):
    hsa-miR-194* hsa-miR-642a hsa-miR-330-5p hsa-miR-29a hsa-miR-29c hsa-miR-3155 hsa-miR-484 hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidPALM 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PALM
    Clone
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    OriGene clones in human, mouse for PALM (see all 12)
    OriGene ORF clones in mouse, rat for PALM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PALM (NM_001040134)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PALM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PALM
    Primer
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    OriGene qPCR primer pairs and template standards for PALM
    OriGene qSTAR qPCR primer pairs in human, mouse for PALM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PALM
      QuantiTect SYBR Green Assays in human, mouse, rat PALM
      QuantiFast Probe-based Assays in human, mouse, rat PALM

    Additional mRNA sequence: 

    AK022919.1 AK299809.1 AK301181.1 AK315168.1 BC032449.1 D87460.1 Y14770.1 Y16278.1 

    11 DOTS entries:

    DT.444400  DT.91751780  DT.100686585  DT.100780233  DT.100780238  DT.121439881  DT.121439901  DT.121439894 
    DT.121439997  DT.100027760  DT.121439999 

    Selected AceView cDNA sequences (see all 180):

    CR604455 BI764723 Z40777 D87460 BQ437899 BQ888302 BG059831 BC032449 
    BI836158 AL541731 CB140900 BM549577 AW118542 BU186065 BQ420997 BQ668377 
    AI955574 BM712053 AI572417 BG222528 BX281202 AI015689 R10936 BI759138 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PALM (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:        -     -                                   -     -     -                                       
    SP2:                                                  -     -     -           -                           
    SP3:              -                                                                                       
    SP4:                                                              -                                       
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for PALM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PALM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCACCCG
    PALM Expression
    About this image


    PALM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Heart (Cardiovascular System)
             Endocardial Tube Cells Endocardium
     
     Eye (Sensory Organs)
             Retinal Pigmented Epithelium
     
     Adipose (Muscoskeletal System)
    PALM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PALM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631841

    UniProtKB/Swiss-Prot: PALM_HUMAN, O75781
    Tissue specificity: Widely expressed with highest expression in brain and testis and intermediate expression in
    heart and adrenal gland

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PALM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PALM gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Palm1 , 5 paralemmin1, 5 80.16(n)1
    81.2(a)1
      10 (39.72 cM)5
    184831  NM_023128.41  NP_075617.31 
     797935725 
    chicken
    (Gallus gallus)
    Aves PALM1 paralemmin 70.79(n)
    66.76(a)
      395709  NM_204892.1  NP_990223.1 
    lizard
    (Anolis carolinensis)
    Reptilia PALM6
    paralemmin
    64(a)
    1 ↔ 1
    AAWZ02040696(519-5142)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia palm1 paralemmin 59.63(n)
    57.79(a)
      594906  XM_002937379.2  XP_002937425.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635232 hypothetical protein MGC63523 75.34(n)   393573  BC056777.1 


    ENSEMBL Gene Tree for PALM (if available)
    TreeFam Gene Tree for PALM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PALM gene
    PALMD2  AKAP22  PALM22  PALM2-AKAP22  
    2 SIMAP similar genes for PALM using alignment to 1 protein entry:     PALM_HUMAN:
    PALM2-AKAP2    PALM2

    PALM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PALM (see all 1123)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs285101671,2
    --706997(+) CCTGGA/GCAACA 2 -- us2k10--------
    rs1144197371,2
    F--707016(+) ACTCCG/ATCCAC 2 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1431005111,2
    C--707128(+) CAGGCA/GTGAGC 2 -- us2k10--------
    rs1482192671,2
    C--707138(+) CCACCA/GCGCCC 2 -- us2k10--------
    rs1112493571,2
    C,F--707143(+) GCGCCG/CGGCCT 2 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs286417121,2
    C,F--707144(+) CGCCCG/AGCCTG 2 -- us2k15Minor allele frequency- A:0.12NA CSA WA 244
    rs1835240601,2
    --707188(+) TCAGCC/TTCCCA 2 -- us2k10--------
    rs1393632681,2
    --707221(+) AGCCAC/TGGCGC 2 -- us2k10--------
    rs1872052561,2
    C--707225(+) ACGGCA/GCCTGG 2 -- us2k10--------
    rs1433460701,2
    --707396(+) CACTAC/TGGCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PALM (708953 - 748330 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PALM (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717775CNV Deletion23290073
    esv2717780CNV Deletion23290073
    esv2717777CNV Deletion23290073
    esv2717771CNV Deletion23290073
    dgv526e201CNV Deletion23290073
    esv1010920CNV Deletion20482838
    esv2717774CNV Deletion23290073
    esv2717776CNV Deletion23290073
    esv2717778CNV Deletion23290073
    esv2717779CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PALM
    DNA2.0 Custom Variant and Variant Library Synthesis for PALM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608134    OMIM disorders: --

    4 diseases for PALM:    
    About MalaCards
    toxocariasis    vesicoureteral reflux    neuronitis    retinitis

    1 disease from the University of Copenhagen DISEASES database for PALM:
    Vesicoureteral reflux

    PALM for disorders           About GeneDecksing


    Export disorders for PALM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PALM gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with PALM)
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    1. Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation. (PubMed id 9813098)1, 2, 3, 9 Kutzleb C.... Kilimann M.W. (J. Cell Biol. 1998)
    2. Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice. (PubMed id 9615234)1, 2, 3, 9 Burwinkel B.... Kilimann M.W. (Genomics 1998)
    3. Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling. (PubMed id 16386234)1, 2, 9 Basile M....Kester M. (Arch. Biochem. Biophys. 2006)
    4. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. (PubMed id 14978216)1, 2, 9 Gauthier-Campbell C.... El-Husseini A. (Mol. Biol. Cell 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5064 HGNC: 8594 AceView: PALM Ensembl:ENSG00000099864 euGenes: HUgn5064
    ECgene: PALM H-InvDB: PALM

    (According to HUGE)
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    HUGE: KIAA0270

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PALM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PALM gene:
    Search GeneIP for patents involving PALM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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