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Aliases for PALM Gene

Aliases for PALM Gene

  • Paralemmin 2 3 4 5
  • KIAA0270 4

External Ids for PALM Gene

Previous GeneCards Identifiers for PALM Gene

  • GC19P000760
  • GC19P000648
  • GC19P000660
  • GC19P000659
  • GC19P000489

Summaries for PALM Gene

Entrez Gene Summary for PALM Gene

  • This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PALM Gene

PALM (Paralemmin) is a Protein Coding gene. GO annotations related to this gene include D3 dopamine receptor binding. An important paralog of this gene is PALMD.

UniProtKB/Swiss-Prot for PALM Gene

  • Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.

Gene Wiki entry for PALM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PALM Gene

Genomics for PALM Gene

Regulatory Elements for PALM Gene

Enhancers for PALM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PALM on UCSC Golden Path with GeneCards custom track

Promoters for PALM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PALM on UCSC Golden Path with GeneCards custom track

Genomic Location for PALM Gene

708,939 bp from pter
748,330 bp from pter
39,392 bases
Plus strand

Genomic View for PALM Gene

Genes around PALM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PALM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PALM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PALM Gene

Proteins for PALM Gene

  • Protein details for PALM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O43359
    • O95673
    • Q92559
    • Q9UPJ4
    • Q9UQS2
    • Q9UQS3

    Protein attributes for PALM Gene

    387 amino acids
    Molecular mass:
    42076 Da
    Quaternary structure:
    • Interacts with dopamine receptor DRD3.

    Alternative splice isoforms for PALM Gene


neXtProt entry for PALM Gene

Proteomics data for PALM Gene at MOPED

Post-translational modifications for PALM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PALM Gene

Antibody Products

No data available for DME Specific Peptides for PALM Gene

Domains & Families for PALM Gene

Protein Domains for PALM Gene


Suggested Antigen Peptide Sequences for PALM Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the paralemmin family.
  • Belongs to the paralemmin family.
genes like me logo Genes that share domains with PALM: view

No data available for Gene Families for PALM Gene

Function for PALM Gene

Molecular function for PALM Gene

GENATLAS Biochemistry:
paralemmin,constituent of brain synaptic plasma membranes,also expressed in the kidney,adrenal medulla and at low level in many tissues
UniProtKB/Swiss-Prot Function:
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.
genes like me logo Genes that share phenotypes with PALM: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PALM Gene

Localization for PALM Gene

Subcellular locations from UniProtKB/Swiss-Prot for PALM Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine. Basolateral cell membrane; Lipid-anchor. Apicolateral cell membrane; Lipid-anchor. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.

Subcellular locations from

Jensen Localization Image for PALM Gene COMPARTMENTS Subcellular localization image for PALM gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PALM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA,IDA 16386234
GO:0005887 integral component of plasma membrane TAS 9813098
GO:0016020 membrane IEA --
GO:0016327 apicolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with PALM: view

Pathways & Interactions for PALM Gene

SuperPathways for PALM Gene

No Data Available

Interacting Proteins for PALM Gene

Gene Ontology (GO) - Biological Process for PALM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007194 negative regulation of adenylate cyclase activity IEA,IDA 16386234
GO:0051491 positive regulation of filopodium assembly IEA,IDA 14978216
GO:0060074 synapse maturation IEA --
GO:0060160 negative regulation of dopamine receptor signaling pathway IDA 16386234
genes like me logo Genes that share ontologies with PALM: view

No data available for Pathways by source and SIGNOR curated interactions for PALM Gene

Drugs & Compounds for PALM Gene

No Compound Related Data Available

Transcripts for PALM Gene

Unigene Clusters for PALM Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PALM Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: -
SP7: - -

Relevant External Links for PALM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PALM Gene

mRNA expression in normal human tissues for PALM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PALM Gene

This gene is overexpressed in Brain (32.9) and Frontal cortex (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PALM Gene

SOURCE GeneReport for Unigene cluster for PALM Gene Hs.631841

mRNA Expression by UniProt/SwissProt for PALM Gene

Tissue specificity: Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland.
genes like me logo Genes that share expression patterns with PALM: view

Protein tissue co-expression partners for PALM Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for PALM Gene

Orthologs for PALM Gene

This gene was present in the common ancestor of chordates.

Orthologs for PALM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PALM 35
  • 83.9 (n)
  • 84.16 (a)
  • 82 (a)
(Canis familiaris)
Mammalia PALM 35
  • 85.15 (n)
  • 84.35 (a)
  • 84 (a)
(Mus musculus)
Mammalia Palm 35
  • 80.16 (n)
  • 81.2 (a)
Palm 16
Palm 36
  • 81 (a)
(Pan troglodytes)
Mammalia PALM 35
  • 97.14 (n)
  • 97.14 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Palm 35
  • 79.37 (n)
  • 80.42 (a)
(Monodelphis domestica)
Mammalia PALM 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia PALM 36
  • 65 (a)
(Gallus gallus)
Aves PALM 35
  • 70.79 (n)
  • 66.76 (a)
-- 36
  • 61 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia PALM 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia palm 35
  • 59.63 (n)
  • 57.79 (a)
(Danio rerio)
Actinopterygii palm1a 35
  • 66.67 (n)
  • 68.27 (a)
zgc63523 35
palm1a 36
  • 53 (a)
palm1b 36
  • 51 (a)
Species with no ortholog for PALM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PALM Gene

Gene Tree for PALM (if available)
Gene Tree for PALM (if available)

Paralogs for PALM Gene

Paralogs for PALM Gene

(2) SIMAP similar genes for PALM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PALM: view

Variants for PALM Gene

Sequence variations from dbSNP and Humsavar for PALM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1050457 - 731,144(+) CAGCC(A/G)CTGCC reference, missense
rs7257535 -- 733,674(+) GCGGG(A/G)GTATG intron-variant
rs7258499 -- 728,476(+) TGGGG(G/T)TGTTC intron-variant
rs7259530 -- 722,169(+) cgcct(C/T)ggcct intron-variant
rs12975809 -- 735,665(+) GGATC(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PALM Gene

Variant ID Type Subtype PubMed ID
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3528n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
dgv3537n71 CNV Loss 21882294
dgv3541n71 CNV Loss 21882294
nsv910260 CNV Loss 21882294
dgv3542n71 CNV Loss 21882294
dgv3543n71 CNV Loss 21882294
dgv3544n71 CNV Gain 21882294
nsv910269 CNV Gain+Loss 21882294
esv1111384 CNV Insertion 17803354
dgv3545n71 CNV Loss 21882294
nsv910272 CNV Gain+Loss 21882294
dgv3546n71 CNV Loss 21882294
esv2717771 CNV Deletion 23290073
esv2717772 CNV Deletion 23290073
esv2717774 CNV Deletion 23290073
esv2717775 CNV Deletion 23290073
esv2717776 CNV Deletion 23290073
nsv458320 CNV Loss 19166990
nsv910276 CNV Gain 21882294
esv2717777 CNV Deletion 23290073
dgv526e201 CNV Deletion 23290073
esv2717778 CNV Deletion 23290073
esv2717779 CNV Deletion 23290073
nsv910279 CNV Loss 21882294
esv1010920 CNV Deletion 20482838
esv2717780 CNV Deletion 23290073
nsv910280 CNV Gain 21882294

Variation tolerance for PALM Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PALM Gene

Disorders for PALM Gene

Relevant External Links for PALM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PALM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PALM Gene

Publications for PALM Gene

  1. Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation. (PMID: 9813098) Kutzleb C. … Kilimann M.W. (J. Cell Biol. 1998) 2 3 4 23 67
  2. Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice. (PMID: 9615234) Burwinkel B. … Kilimann M.W. (Genomics 1998) 2 3 23
  3. Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling. (PMID: 16386234) Basile M. … Kester M. (Arch. Biochem. Biophys. 2006) 3 23
  4. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. (PMID: 14978216) Gauthier-Campbell C. … El-Husseini A. (Mol. Biol. Cell 2004) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PALM Gene

Sources for PALM Gene