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Aliases for PALM Gene

Aliases for PALM Gene

  • Paralemmin 2 3 4
  • Paralemmin-1 3
  • KIAA0270 4

External Ids for PALM Gene

Previous GeneCards Identifiers for PALM Gene

  • GC19P000760
  • GC19P000648
  • GC19P000660
  • GC19P000659
  • GC19P000489

Summaries for PALM Gene

Entrez Gene Summary for PALM Gene

  • This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PALM Gene

PALM (Paralemmin) is a Protein Coding gene. GO annotations related to this gene include D3 dopamine receptor binding. An important paralog of this gene is PALMD.

UniProtKB/Swiss-Prot for PALM Gene

  • Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.

Gene Wiki entry for PALM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PALM Gene

Genomics for PALM Gene

Regulatory Elements for PALM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PALM Gene

Start:
708,953 bp from pter
End:
748,330 bp from pter
Size:
39,378 bases
Orientation:
Plus strand

Genomic View for PALM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PALM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PALM Gene

Proteins for PALM Gene

  • Protein details for PALM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75781-PALM_HUMAN
    Recommended name:
    Paralemmin-1
    Protein Accession:
    O75781
    Secondary Accessions:
    • O43359
    • O95673
    • Q92559
    • Q9UPJ4
    • Q9UQS2
    • Q9UQS3

    Protein attributes for PALM Gene

    Size:
    387 amino acids
    Molecular mass:
    42076 Da
    Quaternary structure:
    • Interacts with dopamine receptor DRD3.

    Alternative splice isoforms for PALM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PALM Gene

Proteomics data for PALM Gene at MOPED

Post-translational modifications for PALM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PALM Gene

Antibody Products

No data available for DME Specific Peptides for PALM Gene

Domains for PALM Gene

Protein Domains for PALM Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PALM Gene

Graphical View of Domain Structure for InterPro Entry

O75781

UniProtKB/Swiss-Prot:

PALM_HUMAN :
  • O75781
Family:
  • Belongs to the paralemmin family.
genes like me logo Genes that share domains with PALM: view

No data available for Gene Families for PALM Gene

Function for PALM Gene

Molecular function for PALM Gene

GENATLAS Biochemistry:
paralemmin,constituent of brain synaptic plasma membranes,also expressed in the kidney,adrenal medulla and at low level in many tissues
UniProtKB/Swiss-Prot Function:
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.

Gene Ontology (GO) - Molecular Function for PALM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16386234
GO:0031750 D3 dopamine receptor binding IEA --
genes like me logo Genes that share ontologies with PALM: view

miRNA for PALM Gene

miRTarBase miRNAs that target PALM

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PALM Gene

Localization for PALM Gene

Subcellular locations from UniProtKB/Swiss-Prot for PALM Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine. Basolateral cell membrane; Lipid-anchor. Apicolateral cell membrane; Lipid-anchor. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PALM Gene COMPARTMENTS Subcellular localization image for PALM gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PALM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0005886 plasma membrane IDA --
GO:0005887 integral component of plasma membrane TAS 9813098
genes like me logo Genes that share ontologies with PALM: view

Pathways for PALM Gene

SuperPathways for PALM Gene

No Data Available

Interacting Proteins for PALM Gene

Gene Ontology (GO) - Biological Process for PALM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9813098
GO:0007010 cytoskeleton organization IEA --
GO:0007194 negative regulation of adenylate cyclase activity IDA 16386234
GO:0008104 protein localization --
GO:0008360 regulation of cell shape IEA --
genes like me logo Genes that share ontologies with PALM: view

No data available for Pathways by source for PALM Gene

Transcripts for PALM Gene

Unigene Clusters for PALM Gene

Paralemmin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PALM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PALM Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7: - -

Relevant External Links for PALM Gene

GeneLoc Exon Structure for
PALM
ECgene alternative splicing isoforms for
PALM

Expression for PALM Gene

mRNA expression in normal human tissues for PALM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PALM Gene

This gene is overexpressed in Brain (32.9) and Frontal cortex (11.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PALM Gene

SOURCE GeneReport for Unigene cluster for PALM Gene Hs.631841

mRNA Expression by UniProt/SwissProt for PALM Gene

O75781-PALM_HUMAN
Tissue specificity: Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland
genes like me logo Genes that share expressions with PALM: view

Expression partners for PALM Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PALM Gene

Orthologs for PALM Gene

This gene was present in the common ancestor of chordates.

Orthologs for PALM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PALM 35
  • 83.9 (n)
  • 84.16 (a)
PALM 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PALM 35
  • 85.15 (n)
  • 84.35 (a)
PALM 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Palm 35
  • 80.16 (n)
  • 81.2 (a)
Palm 16
Palm 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PALM 35
  • 97.14 (n)
  • 97.14 (a)
PALM 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Palm 35
  • 79.37 (n)
  • 80.42 (a)
oppossum
(Monodelphis domestica)
Mammalia PALM 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PALM 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves PALM 35
  • 70.79 (n)
  • 66.76 (a)
-- 36
  • 61 (a)
OneToMany
PALM 36
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PALM 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia palm 35
  • 59.63 (n)
  • 57.79 (a)
zebrafish
(Danio rerio)
Actinopterygii palm1a 35
  • 66.67 (n)
  • 68.27 (a)
zgc63523 35
palm1a 36
  • 53 (a)
OneToMany
palm1b 36
  • 51 (a)
OneToMany
Species with no ortholog for PALM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PALM Gene

ENSEMBL:
Gene Tree for PALM (if available)
TreeFam:
Gene Tree for PALM (if available)

Paralogs for PALM Gene

Paralogs for PALM Gene

Selected SIMAP similar genes for PALM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PALM: view

Variants for PALM Gene

Sequence variations from dbSNP and Humsavar for PALM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7927 -- 748,083(+) CACCT(C/T)GGATG utr-variant-3-prime
rs757162 -- 734,851(+) CGGAA(C/T)GTGTC intron-variant
rs1009690 -- 730,297(-) GAGTG(C/T)GTAAG intron-variant
rs1009691 -- 730,235(-) TCCCC(C/T)CCAAC intron-variant
rs1050457 - 731,144(+) CAGCC(A/G)CTGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PALM Gene

Variant ID Type Subtype PubMed ID
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3528n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
dgv3537n71 CNV Loss 21882294
dgv3541n71 CNV Loss 21882294
nsv910260 CNV Loss 21882294
dgv3542n71 CNV Loss 21882294
dgv3543n71 CNV Loss 21882294
dgv3544n71 CNV Gain 21882294
nsv910269 CNV Gain+Loss 21882294
esv1111384 CNV Insertion 17803354
dgv3545n71 CNV Loss 21882294
nsv910272 CNV Gain+Loss 21882294
dgv3546n71 CNV Loss 21882294
esv2717771 CNV Deletion 23290073
esv2717772 CNV Deletion 23290073
esv2717774 CNV Deletion 23290073
esv2717775 CNV Deletion 23290073
esv2717776 CNV Deletion 23290073
nsv458320 CNV Loss 19166990
nsv910276 CNV Gain 21882294
esv2717777 CNV Deletion 23290073
dgv526e201 CNV Deletion 23290073
esv2717778 CNV Deletion 23290073
esv2717779 CNV Deletion 23290073
nsv910279 CNV Loss 21882294
esv1010920 CNV Deletion 20482838
esv2717780 CNV Deletion 23290073
nsv910280 CNV Gain 21882294

Relevant External Links for PALM Gene

HapMap Linkage Disequilibrium report
PALM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PALM Gene

Disorders for PALM Gene

(1) University of Copenhagen DISEASES for PALM Gene

genes like me logo Genes that share disorders with PALM: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for PALM Gene

Publications for PALM Gene

  1. Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice. (PMID: 9615234) Burwinkel B. … Kilimann M.W. (Genomics 1998) 2 3 4 23
  2. Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation. (PMID: 9813098) Kutzleb C. … Kilimann M.W. (J. Cell Biol. 1998) 2 3 4 23
  3. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. (PMID: 14978216) Gauthier-Campbell C. … El-Husseini A. (Mol. Biol. Cell 2004) 3 4 23
  4. Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling. (PMID: 16386234) Basile M. … Kester M. (Arch. Biochem. Biophys. 2006) 3 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PALM Gene

Sources for PALM Gene

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