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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PALLD Gene

protein-coding GIFtS: 57
GCID: GC04P169418

palladin, cytoskeletal associated protein

Explore 25 diseases affiliated with
PALLD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Palladin, Cytoskeletal Associated Protein¹ ²		CGI-151¹
SIH002¹ ² ³		CGI151²
KIAA0992¹ ³ ⁵		MYN²
Sarcoma Antigen NY-SAR-77² ³		Myoneurin¹
PNCA1² ⁵		Palladin¹

External Ids:	HGNC: 17068¹	Entrez Gene: 23022²	Ensembl: ENSG00000129116⁷	OMIM: 608092⁵	UniProtKB: Q8WX93³

Export aliases for PALLD gene to outside databases

Previous GC identifers: GC04P169793 GC04P169654 GC04P165170

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PALLD:

This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a

component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and

contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also

with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. (provided by

RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93

Function: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell

morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May

function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of

existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous

actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles.

Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes

associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci

Gene Wiki entry for PALLD (Palladin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PALLD gene promoter:
USF1 Pax-2 Pax-2a RelA Tal-1beta NF-kappaB E47 GATA-1 USF-1 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PALLD promoter sequence

Search SABiosciences Chromatin IP Primers for PALLD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PALLD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3 Ensembl cytogenetic band: 4q32.3 HGNC cytogenetic band: 4q32.3

PALLD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PALLD gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P169418: view genomic region (about GC identifiers)

Start:	169,418,217 bp from pter	End:	169,849,608 bp from pter
Size:	431,392 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93 (See protein sequence)

Recommended Name: Palladin

Size: 1383 amino acids; 150564 Da

Subunit: Interacts with EPS8, LASP1 and VASP (By similarity). Interacts with ACTN, ARGBP2, LPP, PFN1, SPIN90, SRC and

EZR

Subcellular location: Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle. Cell projection,

lamellipodium. Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to stress fibers and Z lines

Caution: Was wrongly assigned as myoneurin (Ref.2)

Sequence caution: Sequence=AAD34146.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=AAO65174.1; Type=Frameshift; Positions=1150, 1154; Sequence=BAA76836.1; Type=Erroneous initiation;

Note=Translation N-terminally shortened; Sequence=BAC04796.1; Type=Erroneous initiation; Note=Translation N-terminally

extended;

2 PDB 3D structures from and Proteopedia for PALLD:

2DM2 (3D)

2DM3 (3D)

Secondary accessions: B3KTG2 B5MD56 B7ZMM5 Q7L3E0 Q7Z3W0 Q86WE8 Q8N1M2 Q9UGA0 Q9UQF5 Q9Y2J6 Q9Y3E9

Alternative splicing: 9 isoforms: Q8WX93-1 Q8WX93-2 Q8WX93-3 Q8WX93-4 Q8WX93-5 Q8WX93-6 Q8WX93-7 Q8WX93-8

Q8WX93-9 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PALLD: NX_Q8WX93

Post-translational modifications:

Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines (By similarity). Phosphorylation at

Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WX93

PALLD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001159580.1 NP_001159581.1 NP_001159582.1 NP_057165.3

ENSEMBL proteins:

ENSP00000261509 ENSP00000425556 ENSP00000423640 ENSP00000423063 ENSP00000424121

ENSP00000426947 ENSP00000422016 ENSP00000424288 ENSP00000422135 ENSP00000377327

ENSP00000424016 ENSP00000425729 ENSP00000328945 ENSP00000336735

Human Recombinant Protein Products for PALLD:

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	Novus Biologicals PALLD Protein
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PALLD

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IEA	--
GO:0005634	nucleus	IDA	11598191
GO:0005884	actin filament	IDA	11598191
GO:0005925	focal adhesion	IEA	--
GO:0030018	Z disc	IEA	--

PALLD for ontologies About GeneDecksing

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Assay Products for PALLD:

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	Uscn ELISAs and CLIAs for PALLD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PALLD for domains About GeneDecksing

4 InterPro domains/families:

IPR003598 Ig_sub2

IPR013098 Ig_I-set

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q8WX93

ProtoNet protein and cluster: Q8WX93

2 Blocks protein families:

IPB000634 Serine/threonine dehydratase

IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93

Similarity: Belongs to the myotilin/palladin family

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PALLD_HUMAN, Q8WX93

Function: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell

morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May

function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of

existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous

actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles.

Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes

associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci

Induction: Isoform 3 is expressed de novo. Isoform 4 is up-regulated by TGFB1 during myofibroblast differentiation

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	11598191
GO:0051371	muscle alpha-actinin binding	TAS	16125169

PALLD for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Palld):

cellular

embryogenesis

mortality/aging

nervous system

PALLD for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Palld^tm1Zgwg for PALLD

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PALLD

miRNA Products:		OriGene 3'-UTR Clone (see all 4): PALLD Browse MicroRNA Expression Plasmids
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		hsa-miR-19b-2* hsa-miR-520d-5p hsa-miR-548k hsa-miR-25 hsa-miR-340 hsa-miR-124 hsa-miR-4325 hsa-miR-2116

		SwitchGear 3'UTR luciferase reporter plasmid: PALLD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PALLD

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PALLD

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/52 Interacting proteins for PALLD (Q8WX93^{2, 3} ENSP00000261509⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCKIPSD	Q9NZQ3²^,³, ENSP00000294129⁴	MINT-8109267 I2D: score=1 STRING: ENSP00000294129
SRC	P12931²^,³, ENSP00000350941⁴	MINT-8109298 I2D: score=1 STRING: ENSP00000350941
SORBS2	O94875², ENSP00000284776⁴	MINT-7213563 MINT-7213547 STRING: ENSP00000284776
EZR	P15311³, ENSP00000338934⁴	I2D: score=3 STRING: ENSP00000338934
ACTN2	P35609³, ENSP00000355537⁴	I2D: score=1 STRING: ENSP00000355537

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007010	cytoskeleton organization	NAS	11598191
GO:0032438	melanosome organization	--	--

PALLD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PALLD
Search CenterWatch for drugs/clinical trials and news about PALLD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PALLD gene (4 alternative transcripts):

NM_001166108.1 NM_001166109.1 NM_001166110.1 NM_016081.3

Unigene Cluster for PALLD:

Palladin, cytoskeletal associated protein

Hs.151220 [show with all ESTs]

Unigene Representative Sequence: NM_001166108

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000261509(uc011cjx.2 uc003iru.3 uc003irv.3) ENST00000505667

ENST00000511948 ENST00000508898 ENST00000504519 ENST00000512127 ENST00000513245

ENST00000503457 ENST00000510998 ENST00000393726 ENST00000507735(uc003irw.3)

ENST00000511611 ENST00000507325 ENST00000513187 ENST00000507699(uc003irx.3)

ENST00000511682 ENST00000503290 ENST00000333488

miRNA Products:		OriGene 3'-UTR Clone (see all 4): PALLD Browse OriGene MicroRNA Expression Plasmids
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		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PALLD (see all 21):
		hsa-miR-19b-2* hsa-miR-520d-5p hsa-miR-548k hsa-miR-25 hsa-miR-340 hsa-miR-124 hsa-miR-4325 hsa-miR-2116

		SwitchGear 3'UTR luciferase reporter plasmid: PALLD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PALLD

Additional cDNA sequence:

AB023209.1 AF077041.1 AF151909.1 AF464873.1 AK000845.1 AK025843.1 AK057697.1 AK095512.1

AK096458.1 AL050093.1 AY211921.1 BC013867.2 BC140850.1 BC144666.1 BX537391.1

24/25 DOTS entries (see all 25):

DT.100824205 DT.453461 DT.95279621 DT.100031936 DT.99999343 DT.100662414 DT.100824207 DT.40248784

DT.100824211 DT.75178414 DT.95252571 DT.121642668 DT.99939264 DT.95204031 DT.95357104 DT.121241852

DT.121242024 DT.101961009 DT.121241806 DT.121241815 DT.121241923 DT.121241924 DT.95106857 DT.95279620

24/577 AceView cDNA sequences (see all 577):

CA406033 AK025843 CA414101 AA609693 BP353859 AI719079 BQ020184 AA905600

AA150081 AA115223 AI418424 BP379135 BM786132 AA605013 BM839730 BM771910

AA907093 AI290213 BG680017 AI559477 AA424854 BE175786 AA912741 AA886258

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PALLD (see all 10) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17a	·	17b	·	17c	^	18a	·	18b	^	19	^
SP1:																															-				-		-
SP2:
SP3:											-
SP4:																									-		-				-				-		-
SP5:

ExUns:	20a	·	20b	^	21	^	22	^	23	^	24a	·	24b
SP1:									-
SP2:									-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PALLD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PALLD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCTATCTC

About this image

PALLD expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Heart

Outflow Tract

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (Generation of mesend...)

See PALLD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PALLD

SOURCE GeneReport for Unigene cluster: Hs.151220

UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93

Tissue specificity: Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and

kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is

overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines

SABiosciences Custom PCR Arrays for PALLD

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PALLD

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PALLD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PALLD gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PALLD⁶	Uncharacterized protein	59(a)	1 ↔ 1	4(26147216-26287325)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	75(a) 68(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	GL343216.1(466445-496797) GL343216.1(337830-364241)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1924²	Xenopus laevis transcribed sequence with moderate similarity more	78.47(n)		BJ041619.1
zebrafish (Danio rerio)	Actinopterygii	si:dkey-90m5.1⁶	si:dkey-90m5.1	48(a)	1 ↔ 1	20(23489189-23636541)
worm (Caenorhabditis elegans)	Secernentea	unc-89⁶	Muscle M-line assembly protein unc-89	3(a)	possible ortholog	I(4035746-4090963)

ENSEMBL Gene Tree for PALLD (if available)
TreeFam Gene Tree for PALLD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PALLD gene

MYOT² MYPN²

10 SIMAP similar genes for PALLD using alignment to 12 protein entries: PALLD_HUMAN (see all proteins):

DKFZp586L0518 KIAA0992 MYPN MYOT TTN MYLK

DKFZp686I10125 DCC MUSK OBSCN

PALLD for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28707413^1,2	F	--	165169550(+)	`TTTTTA/TTTTTT`	2	--	us2k¹ tfbs³		2		WA NA	238
rs113417609^1,2	C	--	165169627(+)	`GCTCCA/GCCTCC`	2	--	us2k¹		0	--	--	--	--
rs77999421^1,2	C	--	165169839(+)	`CCAGCC/TGTAAG`	2	--	us2k¹		3		NA WA	240
rs75030650^1,2		--	165170428(+)	`ACTTAC/TTTAAT`	2	--	us2k¹		0	--	--	--	--
rs28573750^1,2	C,F	--	165170438(+)	`TACTAT/CTATAG`	2	--	us2k¹		5		NA WA	244
rs62333818^1,2	C	--	165171184(+)	`GTTTTT/CCTGAA`	2	--	int¹		3		NA WA	240
rs62333819^1,2	C	--	165171284(+)	`AATACG/ATAAGA`	2	--	int¹		3		NA WA	240
rs77217354^1,2	C	--	165171424(+)	`AGATCG/ATGTAT`	2	--	int¹		2		NA	122
rs62333820^1,2		--	165171640(+)	`ATTCAT/CGCATA`	2	--	int¹		3		NA WA	240
rs62333821^1,2	C,F	--	165171727(+)	`TAAACA/GTCACA`	2	--	int¹		4		NA WA	242

HapMap Linkage Disequilibrium report for PALLD (169418217 - 169668217 bp, first 250kb of PALLD)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for PALLD
5 CNVs: 6350 68838 1696 6351 47920
1 Indel: 41556
Human Gene Mutation Database (HGMD): PALLD

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PALLD

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PALLD for disorders           About GeneDecksing

OMIM gene information: 608092
OMIM disorders: 606856
UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93

Genetic variations in PALLD are associated with susceptibility to pancreatic cancer type 1 (PNCA1)

[MIM:606856]. Expression is increased early in the development of pancreatic cancer: in normal-appearing whole tissue

immediately adjacent to cancer, in the pre-cancer, and in both the familial and sporadic forms of the cancer

Note=Genetic variations in PALLD may be associated with myocardial infarction

20/25 diseases for PALLD (see all 25): About MalaCards

myocardial infarction pancreatic cancer pancreatitis tibial muscular dystrophy

pancreatic cancer susceptibility 1 temporal lobe epilepsy sarcoma beta thalassemia

muscular dystrophy fatty liver disease thalassemia familial pancreatic cancer

lipoma liver disease renal cell carcinoma kidney disease

pharyngitis cardiomyopathy melanoma breast cancer

2 diseases from the University of Copenhagen DISEASES database for PALLD:

Dysplastic nevus syndrome Pancreatic cancer

Human Genome Epidemiology (HuGE) Navigator: PALLD (16 documents)

Export disorders for PALLD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PALLD gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with PALLD)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2, 3} Nagase T.... Ohara O. (1999)
Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. (PubMed id 17194196)^{1, 2, 9} Pogue-Geile K.L.... Brentnall T.A. (2006)
Identification of four gene variants associated with myocardial infarction. (PubMed id 16175505)^{1, 2, 9} Shiffman D.... Kane J.P. (2005)
The actin-bundling protein palladin is an Akt1-specif ic substrate that regulates breast cancer cell migration. (PubMed id 20471940)^{1, 2} Chin Y.R. and Toker A. (2010)
The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer. (PubMed id 17415588)^{1, 2} Zogopoulous G.... Gallinger S. (2007)
Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling. (PubMed id 17537434)^{1, 2} Ronty M....Carpen O. (2007)
Palladin mutation causes familial pancreatic cancer: absence in European families. (PubMed id 17455999)^{1, 2} Slater E.... Greenhalf W. (2007)
Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration. (PubMed id 17322171)^{1, 2} Jin L.... Somlyo A.V. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Isoform-specific regulation of the actin-organizing protein Palladin during TGF-beta1-induced myofibroblast differentiation. (PubMed id 16794588)^{1, 2} Roenty M.J.... Carpen O.M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23022	HGNC: 17068	AceView: KIAA0992	Ensembl:ENSG00000129116	euGenes: HUgn23022
ECgene: PALLD	H-InvDB: PALLD

(According to HUGE)
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HUGE: KIAA0992

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PALLD	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PALLD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PALLD gene:
Search GeneIP for patents involving PALLD

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PALLD Gene

palladin, cytoskeletal associated protein

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PALLD Gene

palladin, cytoskeletal associated protein

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