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PALLD Gene

protein-coding   GIFtS: 59
GCID: GC04P169418

Palladin, Cytoskeletal Associated Protein

  See PALLD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Palladin, Cytoskeletal Associated Protein1 2     CGI1512
Sarcoma Antigen NY-SAR-772 3     MYN2
SIH0022 3     myoneurin2
PNCA12 5     palladin2
KIAA09923 5     

External Ids:    HGNC: 170681   Entrez Gene: 230222   Ensembl: ENSG000001291167   OMIM: 6080925   UniProtKB: Q8WX933   

Export aliases for PALLD gene to outside databases

Previous GC identifers: GC04P169793 GC04P169654 GC04P165170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PALLD Gene:
This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a
component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and
contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and
also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Oct 2009)

GeneCards Summary for PALLD Gene:
PALLD (palladin, cytoskeletal associated protein) is a protein-coding gene. Diseases associated with PALLD include pancreatic cancer susceptibility 1, and pancreatic cancer 1. GO annotations related to this gene include muscle alpha-actinin binding and actin binding. An important paralog of this gene is MYOT.

UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93
Function: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell
morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May
function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of
existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous
actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles.
Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal
changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci

Gene Wiki entry for PALLD (Palladin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PALLD gene promoter:
         USF1   Pax-2   Pax-2a   RelA   Tal-1beta   NF-kappaB   E47   GATA-1   USF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PALLD promoter sequence
   Search Chromatin IP Primers for PALLD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PALLD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q32.3

PALLD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PALLD gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P169418:  view genomic region     (about GC identifiers)

Start:
169,418,217 bp from pter      End:
169,849,608 bp from pter
Size:
431,392 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93 (See protein sequence)
Recommended Name: Palladin  
Size: 1383 amino acids; 150564 Da
Subunit: Interacts with EPS8, LASP1 and VASP (By similarity). Interacts with ACTN, ARGBP2, LPP, PFN1, SPIN90, SRC
and EZR
Caution: Was wrongly assigned as myoneurin (Ref.2)
Sequence caution: Sequence=AAD34146.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAO65174.1; Type=Frameshift; Positions=1150, 1154; Sequence=BAA76836.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=BAC04796.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
2 PDB 3D structures from and Proteopedia for PALLD:
2DM2 (3D)        2DM3 (3D)    
Secondary accessions: B3KTG2 B5MD56 B7ZMM5 Q7L3E0 Q7Z3W0 Q86WE8 Q8N1M2 Q9UGA0 Q9UQF5 Q9Y2J6
Q9Y3E9
Alternative splicing: 9 isoforms:  Q8WX93-1   Q8WX93-2   Q8WX93-3   Q8WX93-4   Q8WX93-5   Q8WX93-6   Q8WX93-7   Q8WX93-8   
Q8WX93-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PALLD: NX_Q8WX93

Explore proteomics data for PALLD at MOPED

Post-translational modifications: 

  • Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines (By similarity). Phosphorylation at
    Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PALLD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001159580.1  NP_001159581.1  NP_001159582.1  NP_057165.3  

    ENSEMBL proteins: 
     ENSP00000261509   ENSP00000425556   ENSP00000423640   ENSP00000423063   ENSP00000424121  
     ENSP00000426947   ENSP00000422016   ENSP00000424288   ENSP00000422135   ENSP00000377327  
     ENSP00000424016   ENSP00000425729   ENSP00000328945   ENSP00000336735  

    PALLD Human Recombinant Protein Products:

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    Novus Biologicals PALLD Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PALLD

     
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    Cloud-Clone Corp. ELISAs for PALLD
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    Search eBioscience for ELISAs for PALLD 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8WX93

    ProtoNet protein and cluster: Q8WX93

    2 Blocks protein domains:
    IPB000634 Serine/threonine dehydratase
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93
    Similarity: Belongs to the myotilin/palladin family
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with PALLD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PALLD_HUMAN, Q8WX93
    Function: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell
    morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May
    function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of
    existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous
    actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles.
    Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal
    changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci
    Induction: Isoform 3 is expressed de novo. Isoform 4 is up-regulated by TGFB1 during myofibroblast differentiation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI11598191
    GO:0051371muscle alpha-actinin binding TAS16125169
         
    Find genes that share ontologies with PALLD           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Palld):
     cellular  embryogenesis  mortality/aging  nervous system 

    Find genes that share phenotypes with PALLD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Palldtm1Zgwg for PALLD

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PALLD
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PALLD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PALLD

    miRNA
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    miRTarBase miRNAs that target PALLD:
    hsa-mir-19b-3p (MIRT031101), hsa-mir-196a-5p (MIRT048248), hsa-mir-155-5p (MIRT020550), hsa-mir-124-3p (MIRT022312), hsa-mir-21-5p (MIRT030662)

    Block miRNA regulation of human, mouse, rat PALLD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PALLD (see all 21):
    hsa-miR-19b-2* hsa-miR-520d-5p hsa-miR-548k hsa-miR-25 hsa-miR-340 hsa-miR-124 hsa-miR-4325 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidPALLD 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PALLD

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): PALLD (NM_016081)
    Sino Biological Human cDNA Clone for PALLD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PALLD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PALLD

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PALLD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PALLD_HUMAN, Q8WX93: Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle. Cell
    projection, lamellipodium. Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to stress fibers and Z lines
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005634nucleus IDA11598191
    GO:0005884actin filament IDA11598191
    GO:0005925focal adhesion IEA--
    GO:0030018Z disc IEA--

    Find genes that share ontologies with PALLD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PALLD
    Interactions:

        Search GeneGlobe Interaction Network for PALLD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PALLD (Q8WX931, 2, 3 ENSP000002615094) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SORBS2O948751, 2, ENSP000002847764EBI-2803991,EBI-311323 MINT-7213563 MINT-7213547 STRING: ENSP00000284776
    NCKIPSDQ9NZQ32, 3, ENSP000002941294MINT-8109267 I2D: score=1 STRING: ENSP00000294129
    SRCP129312, 3, ENSP000003509414MINT-8109298 I2D: score=1 STRING: ENSP00000350941
    EZRP153113, ENSP000003389344I2D: score=3 STRING: ENSP00000338934
    ACTN2P356093, ENSP000003555374I2D: score=1 STRING: ENSP00000355537
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization NAS11598191

    Find genes that share ontologies with PALLD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PALLD



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PALLD gene (4 alternative transcripts): 
    NM_001166108.1  NM_001166109.1  NM_001166110.1  NM_016081.3  

    Unigene Cluster for PALLD:

    Palladin, cytoskeletal associated protein
    Hs.151220  [show with all ESTs]
    Unigene Representative Sequence: NM_001166108
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000261509(uc011cjx.2 uc003iru.3 uc003irv.3) ENST00000505667
    ENST00000511948 ENST00000508898 ENST00000504519 ENST00000512127 ENST00000513245
    ENST00000503457 ENST00000510998 ENST00000393726 ENST00000507735(uc003irw.3)
    ENST00000511611 ENST00000507325 ENST00000513187 ENST00000507699(uc003irx.3)
    ENST00000511682 ENST00000503290 ENST00000333488
    miRNA
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    Block miRNA regulation of human, mouse, rat PALLD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PALLD (see all 21):
    hsa-miR-19b-2* hsa-miR-520d-5p hsa-miR-548k hsa-miR-25 hsa-miR-340 hsa-miR-124 hsa-miR-4325 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidPALLD 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PALLD (NM_016081)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PALLD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PALLD
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PALLD
      QuantiFast Probe-based Assays in human, mouse, rat PALLD

    Additional mRNA sequence: 

    AB023209.1 AF077041.1 AF151909.1 AF464873.1 AK000845.1 AK025843.1 AK057697.1 AK095512.1 
    AK096458.1 AL050093.1 AY211921.1 BC013867.2 BC140850.1 BC144666.1 BX537391.1 

    24 DOTS entries:

    DT.100824205  DT.95279621  DT.453461  DT.100031936  DT.99999343  DT.100662414  DT.100824207  DT.40248784 
    DT.75178414  DT.95252571  DT.121642668  DT.100824211  DT.99939264  DT.95204031  DT.95357104  DT.121241852 
    DT.121242024  DT.101961009  DT.121241806  DT.121241815  DT.121241923  DT.121241924  DT.95106857  DT.91835033 

    Selected AceView cDNA sequences (see all 577):

    BQ020184 AA905600 AA115223 AA150081 AI418424 BP379135 AA605013 BM786132 
    BM839730 AA907093 AI290213 BM771910 BG680017 AI559477 AA424854 BE175786 
    AA708460 AA912741 AA886258 AL046932 AI284363 BQ787095 BI335744 CA406033 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PALLD (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
    SP1:                                                                                            -           -     -                                             
    SP2:                                                                                                                                                            
    SP3:                                -                                                                                                                           
    SP4:                                                                          -     -           -           -     -                                             
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b
    SP1:                          -               
    SP2:                          -               
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for PALLD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PALLD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTATCTC
    PALLD Expression
    About this image


    PALLD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Kidney (Urinary System)
             Ureteric Bud Cells Ureteric Bud
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
    PALLD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PALLD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151220

    UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93
    Tissue specificity: Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and
    kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level).
    Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines

        Custom PCR Arrays for PALLD
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PALLD gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Palld1 , 5 palladin, cytoskeletal associated protein1, 5 85.02(n)1
    88.07(a)1
      8 (31.23 cM)5
    723331  NM_001081390.11  NP_001074859.11 
     615132465 
    chicken
    (Gallus gallus)
    Aves PALLD1 palladin, cytoskeletal associated protein 73.01(n)
    70.82(a)
      422428  XM_420396.4  XP_420396.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    75(a)
    69(a)
    1 ↔ many
    1 ↔ many
    GL343216.1(466445-496797)
    GL343216.1(337830-364241)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19242 Xenopus laevis transcribed sequence with moderate similarity more 78.47(n)    BJ041619.1 
    zebrafish
    (Danio rerio)
    Actinopterygii palld1 palladin, cytoskeletal associated protein 62.35(n)
    63.41(a)
      557660  XM_003200701.2  XP_003200749.1 


    ENSEMBL Gene Tree for PALLD (if available)
    TreeFam Gene Tree for PALLD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PALLD gene
    MYOT2  MYPN2  OBSL12  
    9 SIMAP similar genes for PALLD using alignment to 12 protein entries:     PALLD_HUMAN (see all proteins):
    DKFZp586L0518    KIAA0992    MYPN    MYOT    TTN    DKFZp686I10125
    MYLK    DCC    MUSK

    Find genes that share paralogs with PALLD           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PALLD (see all 9262)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357864741,2
    C--165174303(+) GTCTC-/ACTCTTT 2 -- int11Minor allele frequency- AC:0.00NA 2
    rs2011281131,2
    --165177017(+) GTAAC-/CCAG  
            
    CCAGT
    2 -- int10--------
    rs30363211,2
    C--165177024(+) CCCAGACAG/-  
            
    TGTGC
    2 -- int11Minor allele frequency- -:0.00NA 2
    rs112994231,2
    C--165182693(+) AGTCTC/-CCCCT 2 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs590291931,2
    C--165185224(+) AAAAC-/TTATATT 2 -- int12Minor allele frequency- TT:0.25CSA 4
    rs792247221,2
    --165185224(+) AAAACA/TTATAT 2 -- int10--------
    rs2018002351,2
    C--165188027(+) AAAAGA/GAAAAA 2 -- int10--------
    rs1408821001,2
    C--165189781(+) GATTA-/AACAACAG 2 -- int10--------
    rs341966121,2
    C--165191937(+) CTAAA-/CT    
       T
    /TCT
    CTGAT
    4 -- cds11CSA 2
    rs1480367201,2
    C--165193223(+) AAAAT-/ACTG  
            
    ACTTT
    2 -- int10--------

    HapMap Linkage Disequilibrium report for PALLD (169418217 - 169668217 bp, first 250kb of PALLD)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PALLD (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658080CNV Deletion23128226
    esv2728717CNV Deletion23290073
    esv2666829CNV Deletion23128226
    esv2728715CNV Deletion23290073
    esv2673045CNV Deletion23128226
    esv2728714CNV Deletion23290073
    esv2728716CNV Deletion23290073
    esv4297CNV Deletion18987735
    esv2666909CNV Deletion23128226
    esv1342986CNV Insertion17803354

    Human Gene Mutation Database (HGMD): PALLD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PALLD
    DNA2.0 Custom Variant and Variant Library Synthesis for PALLD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608092   
    OMIM disorders: 606856  
    UniProtKB/Swiss-Prot: PALLD_HUMAN, Q8WX93
  • Pancreatic cancer 1 (PNCA1) [MIM:606856]: A malignant neoplasm of the pancreas. Tumors can arise from
    both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion,
    including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Note=Genetic variations in PALLD may be associated with myocardial infarction

  • 6 diseases for PALLD:    
    About MalaCards
    pancreatic cancer susceptibility 1    pancreatic cancer 1    dysplastic nevus syndrome    pancreatic endocrine carcinoma
    pancreatic cancer    myocardial infarction

    2 diseases from the University of Copenhagen DISEASES database for PALLD:
    Dysplastic nevus syndrome     Pancreatic cancer

    Find genes that share disorders with PALLD           About GenesLikeMe

    Genetic Association Database (GAD): PALLD
    Human Genome Epidemiology (HuGE) Navigator: PALLD (16 documents)

    Export disorders for PALLD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PALLD gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with PALLD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer. (PubMed id 17415588)1, 2, 4 Zogopoulous G.... Gallinger S. (Hum. Genet. 2007)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    3. Absence of deleterious palladin mutations in patients with familial pancreatic cancer. (PubMed id 19336541)1, 4, 9 Klein A.P....Goggins M. (amp 2009)
    4. Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. (PubMed id 17194196)1, 2, 9 Pogue-Geile K.L.... Brentnall T.A. (PLoS Med. 2006)
    5. Identification of four gene variants associated with myocardial infarction. (PubMed id 16175505)1, 2, 9 Shiffman D.... Kane J.P. (Am. J. Hum. Genet. 2005)
    6. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PubMed id 19709766)1, 4 Koch W....Kastrati A. (Int. J. Cardiol. 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. (PubMed id 20471940)1, 2 Chin Y.R. and Toker A. (Mol. Cell 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)1, 4 Yoshida T....Yamada Y. (Genomics 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23022 HGNC: 17068 AceView: KIAA0992 Ensembl:ENSG00000129116 euGenes: HUgn23022
    ECgene: PALLD H-InvDB: PALLD

    (According to HUGE)
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    HUGE: KIAA0992

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PALLD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PALLD gene:
    Search GeneIP for patents involving PALLD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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