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Aliases for PALD1 Gene

Aliases for PALD1 Gene

  • Phosphatase Domain Containing, Paladin 1 2 3 5
  • KIAA1274 2 3 4
  • Paladin 2 3
  • PALD 3 4
  • Palladin 3

External Ids for PALD1 Gene

Previous HGNC Symbols for PALD1 Gene

  • PALD
  • KIAA1274

Previous GeneCards Identifiers for PALD1 Gene

  • GC10P072239

Summaries for PALD1 Gene

GeneCards Summary for PALD1 Gene

PALD1 (Phosphatase Domain Containing, Paladin 1) is a Protein Coding gene. Diseases associated with PALD1 include Otomycosis.

Additional gene information for PALD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PALD1 Gene

Genomics for PALD1 Gene

Regulatory Elements for PALD1 Gene

Enhancers for PALD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H070492 1.6 FANTOM5 Ensembl ENCODE dbSUPER 27.1 +35.7 35663 2.8 ETV1 MAX EBF1 ZFHX2 POLR2A EED ETV6 RUNX3 IKZF2 CHD2 PALD1 YY1P1 PRF1
GH10H070499 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +41.8 41758 2.6 BCOR JUN ZMYM3 ZIC2 THRB NR2F2 EED KDM1A RUNX3 PALD1 YY1P1 PRF1
GH10H070481 1.1 Ensembl ENCODE dbSUPER 14.7 +24.2 24198 2.2 MAX EBF1 ZIC2 RAD21 NR2F2 ZNF121 ZFP3 GLIS1 PRDM10 ZNF600 PALD1 NODAL PCBD1 YY1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PALD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PALD1 Gene

Genomic Locations for PALD1 Gene
109,906 bases
Plus strand

Genomic View for PALD1 Gene

Genes around PALD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PALD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PALD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PALD1 Gene

Proteins for PALD1 Gene

  • Protein details for PALD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RMS1
    • B9EGC6
    • Q5JTK7
    • Q5JTK8

    Protein attributes for PALD1 Gene

    856 amino acids
    Molecular mass:
    96754 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA86588.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI41274.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PALD1 Gene

Post-translational modifications for PALD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PALD1 Gene

No data available for DME Specific Peptides for PALD1 Gene

Domains & Families for PALD1 Gene

Gene Families for PALD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PALD1 Gene

Suggested Antigen Peptide Sequences for PALD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the paladin family.
  • Belongs to the paladin family.
genes like me logo Genes that share domains with PALD1: view

Function for PALD1 Gene

Phenotypes From GWAS Catalog for PALD1 Gene

Gene Ontology (GO) - Molecular Function for PALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity IBA --
GO:0004725 protein tyrosine phosphatase activity IBA --
GO:0005515 protein binding IPI 21903422
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
genes like me logo Genes that share ontologies with PALD1: view

Phenotypes for PALD1 Gene

MGI mutant phenotypes for PALD1:
inferred from 1 alleles
GenomeRNAi human phenotypes for PALD1:
genes like me logo Genes that share phenotypes with PALD1: view

Animal Models for PALD1 Gene

MGI Knock Outs for PALD1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PALD1 Gene

Localization for PALD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PALD1 Gene

Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PALD1 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 22354871
genes like me logo Genes that share ontologies with PALD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PALD1 Gene

Pathways & Interactions for PALD1 Gene

SuperPathways for PALD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PALD1: view

No data available for Pathways by source and SIGNOR curated interactions for PALD1 Gene

Drugs & Compounds for PALD1 Gene

(1) Additional Compounds for PALD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PALD1: view

Transcripts for PALD1 Gene

mRNA/cDNA for PALD1 Gene

Unigene Clusters for PALD1 Gene

Phosphatase domain containing, paladin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PALD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20

Relevant External Links for PALD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PALD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PALD1 Gene

Protein differential expression in normal tissues from HIPED for PALD1 Gene

This gene is overexpressed in Heart (54.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PALD1 Gene

Protein tissue co-expression partners for PALD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PALD1 Gene:


SOURCE GeneReport for Unigene cluster for PALD1 Gene:


mRNA Expression by UniProt/SwissProt for PALD1 Gene:

Tissue specificity: Expressed in endothelial cells, and in certain larger vessels, in mural cells. In the brain, possibly expressed in microglia. Expressed in peripheral blood mononuclear cells (at protein level).

Evidence on tissue expression from TISSUES for PALD1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PALD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PALD1 Gene

Orthologs for PALD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PALD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PALD1 33 34
  • 97.64 (n)
(Bos Taurus)
Mammalia KIAA1274 34 33
  • 87.17 (n)
-- 34
  • 78 (a)
(Canis familiaris)
Mammalia KIAA1274 33
  • 86.49 (n)
PALD1 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Pald1 33
  • 81.93 (n)
(Mus musculus)
Mammalia Pald1 33 16 34
  • 81.81 (n)
(Ornithorhynchus anatinus)
Mammalia PALD1 34
  • 71 (a)
(Monodelphis domestica)
Mammalia PALD1 34
  • 67 (a)
(Gallus gallus)
Aves PALD1 33 34
  • 72.22 (n)
(Anolis carolinensis)
Reptilia PALD1 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pald1 33
  • 63.44 (n)
(Danio rerio)
Actinopterygii pald1a 33
  • 62.51 (n)
pald1b 34
  • 50 (a)
pald 33
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62010 33
  • 41.68 (n)
(Oryza sativa)
Liliopsida Os03g0586700 33
  • 41.56 (n)
Species where no ortholog for PALD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PALD1 Gene

Gene Tree for PALD1 (if available)
Gene Tree for PALD1 (if available)

Paralogs for PALD1 Gene

No data available for Paralogs for PALD1 Gene

Variants for PALD1 Gene

Sequence variations from dbSNP and Humsavar for PALD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000046601 -- 70,500,802(+) TGGCT(A/G)GAGCC intron-variant
rs1000047686 -- 70,538,672(+) GCCTC(C/T)AGCTT intron-variant
rs1000064922 -- 70,478,406(+) TGTCG(C/T)GGGTA intron-variant, upstream-variant-2KB
rs1000134036 -- 70,549,605(+) GATGC(A/G)TGGCA intron-variant
rs1000144507 -- 70,463,060(+) CAGAT(G/T)GCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PALD1 Gene

Variant ID Type Subtype PubMed ID
nsv950976 CNV deletion 24416366
nsv7065 CNV insertion 18451855
nsv551480 CNV loss 21841781
nsv517624 CNV loss 19592680
nsv467367 CNV loss 19166990
nsv24389 CNV deletion 16902084
nsv1150136 CNV insertion 26484159
nsv1043245 CNV loss 25217958
esv3386498 CNV duplication 20981092
esv32737 CNV gain+loss 17666407

Variation tolerance for PALD1 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.60; 91.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PALD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PALD1 Gene

Disorders for PALD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PALD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • singapore ear
- elite association - COSMIC cancer census association via MalaCards
Search PALD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PALD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PALD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PALD1 Gene

Publications for PALD1 Gene

  1. Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. (PMID: 22354871) Wallgard E … Hellström M (Developmental dynamics : an official publication of the American Association of Anatomists 2012) 3 4 60
  2. Negative regulators of insulin signaling revealed in a genome-wide functional screen. (PMID: 19727444) Huang SM … Gekakis N (PloS one 2009) 3 22 60
  3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for PALD1 Gene

Sources for PALD1 Gene

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