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Aliases for PALD1 Gene

Aliases for PALD1 Gene

  • Phosphatase Domain Containing, Paladin 1 2 3 5
  • KIAA1274 2 3 4
  • PALD 3 4
  • Palladin 3
  • Paladin 2

External Ids for PALD1 Gene

Previous HGNC Symbols for PALD1 Gene

  • PALD
  • KIAA1274

Previous GeneCards Identifiers for PALD1 Gene

  • GC10P072239

Summaries for PALD1 Gene

GeneCards Summary for PALD1 Gene

PALD1 (Phosphatase Domain Containing, Paladin 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PALD1 Gene

Genomics for PALD1 Gene

Regulatory Elements for PALD1 Gene

Enhancers for PALD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PALD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PALD1 Gene

Chromosome:
10
Start:
70,458,545 bp from pter
End:
70,568,450 bp from pter
Size:
109,906 bases
Orientation:
Plus strand

Genomic View for PALD1 Gene

Genes around PALD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PALD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PALD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PALD1 Gene

Proteins for PALD1 Gene

  • Protein details for PALD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULE6-PALD_HUMAN
    Recommended name:
    Paladin
    Protein Accession:
    Q9ULE6
    Secondary Accessions:
    • B2RMS1
    • B9EGC6
    • Q5JTK7
    • Q5JTK8

    Protein attributes for PALD1 Gene

    Size:
    856 amino acids
    Molecular mass:
    96754 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86588.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI41274.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PALD1 Gene

Proteomics data for PALD1 Gene at MOPED

Post-translational modifications for PALD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PALD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PALD1 Gene

Domains & Families for PALD1 Gene

Protein Domains for PALD1 Gene

Suggested Antigen Peptide Sequences for PALD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULE6

UniProtKB/Swiss-Prot:

PALD_HUMAN :
  • Belongs to the paladin family.
Family:
  • Belongs to the paladin family.
genes like me logo Genes that share domains with PALD1: view

No data available for Gene Families for PALD1 Gene

Function for PALD1 Gene

Gene Ontology (GO) - Molecular Function for PALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IBA --
genes like me logo Genes that share ontologies with PALD1: view

Phenotypes for PALD1 Gene

MGI mutant phenotypes for PALD1:
inferred from 1 alleles
GenomeRNAi human phenotypes for PALD1:
genes like me logo Genes that share phenotypes with PALD1: view

Animal Models for PALD1 Gene

MGI Knock Outs for PALD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PALD1

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PALD1 Gene

Localization for PALD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PALD1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PALD1 Gene COMPARTMENTS Subcellular localization image for PALD1 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 22354871
genes like me logo Genes that share ontologies with PALD1: view

Pathways & Interactions for PALD1 Gene

SuperPathways for PALD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PALD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PALD1 Gene

Drugs & Compounds for PALD1 Gene

(1) Additional Compounds for PALD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PALD1: view

Transcripts for PALD1 Gene

mRNA/cDNA for PALD1 Gene

Unigene Clusters for PALD1 Gene

Phosphatase domain containing, paladin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PALD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:

Relevant External Links for PALD1 Gene

GeneLoc Exon Structure for
PALD1
ECgene alternative splicing isoforms for
PALD1

Expression for PALD1 Gene

mRNA expression in normal human tissues for PALD1 Gene

Protein differential expression in normal tissues from HIPED for PALD1 Gene

This gene is overexpressed in Heart (54.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PALD1 Gene



SOURCE GeneReport for Unigene cluster for PALD1 Gene Hs.202351

mRNA Expression by UniProt/SwissProt for PALD1 Gene

Q9ULE6-PALD_HUMAN
Tissue specificity: Expressed in endothelial cells, and in certain larger vessels, in mural cells. In the brain, possibly expressed in microglia. Expressed in peripheral blood mononuclear cells (at protein level).
genes like me logo Genes that share expression patterns with PALD1: view

Protein tissue co-expression partners for PALD1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PALD1 Gene

Orthologs for PALD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PALD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA1274 35
  • 87.17 (n)
  • 85.21 (a)
-- 36
  • 78 (a)
OneToMany
KIAA1274 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KIAA1274 35
  • 86.49 (n)
  • 86.21 (a)
PALD1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pald1 35
  • 81.81 (n)
  • 81.43 (a)
Pald1 16
Pald1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PALD1 35
  • 97.64 (n)
  • 97.35 (a)
PALD1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pald1 35
  • 81.93 (n)
  • 82.36 (a)
oppossum
(Monodelphis domestica)
Mammalia PALD1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PALD1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves PALD1 35
  • 72.22 (n)
  • 66.94 (a)
PALD1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PALD1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pald1 35
  • 63.44 (n)
  • 63.4 (a)
zebrafish
(Danio rerio)
Actinopterygii pald 35
pald1a 35
  • 62.51 (n)
  • 56.18 (a)
pald1b 36
  • 50 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62010 35
  • 41.68 (n)
  • 31.64 (a)
rice
(Oryza sativa)
Liliopsida Os03g0586700 35
  • 41.56 (n)
  • 31.6 (a)
Species with no ortholog for PALD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PALD1 Gene

ENSEMBL:
Gene Tree for PALD1 (if available)
TreeFam:
Gene Tree for PALD1 (if available)

Paralogs for PALD1 Gene

No data available for Paralogs for PALD1 Gene

Variants for PALD1 Gene

Sequence variations from dbSNP and Humsavar for PALD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2275060 - 70,530,022(+) CCTCT(C/T)AGGGT nc-transcript-variant, reference, missense
rs3740447 - 70,547,345(-) CACAC(A/G)GTGCC nc-transcript-variant, reference, missense
rs10999406 - 70,566,644(+) AGAGC(A/G)GGGAG reference, missense
rs1547717 -- 70,551,580(+) GGCTT(C/G)CTGCC intron-variant, nc-transcript-variant
rs1556612 -- 70,567,570(-) ATCCT(A/G)GGCTG utr-variant-3-prime

Variation tolerance for PALD1 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.60; 91.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PALD1 Gene

Disorders for PALD1 Gene

Relevant External Links for PALD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PALD1

No disorders were found for PALD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PALD1 Gene

Publications for PALD1 Gene

  1. Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. (PMID: 22354871) Wallgard E. … Hellstrom M. (Dev. Dyn. 2012) 3 4 67
  2. Negative regulators of insulin signaling revealed in a genome-wide functional screen. (PMID: 19727444) Huang S.M. … Gekakis N. (PLoS ONE 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PMID: 21903422) Li S. … Dorf M.E. (Immunity 2011) 3

Products for PALD1 Gene

Sources for PALD1 Gene

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