PALB2 Gene
protein-coding GIFtS: 57
GCID: GC16M023614
|
|
partner and localizer of BRCA2
| |
Aliases
for PALB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Partner And Localizer Of BRCA21 2 | | FANCN1 2 3 5 | | PNCA32 5 | | FLJ218161 |
Export aliases for PALB2 gene to outside databasesPrevious GC identifers: GC16M023522 GC16M021704 |
Summaries
for PALB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PALB2:
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with thebreast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localizationand accumulation of BRCA2. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PALB2_HUMAN, Q86YC2Function: Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51to DNA breaks. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essentialfor homologous recombination. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes thenucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effectof replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51.Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinationalrepair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures,allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop,which comprises single-stranded, double-stranded and branched DNA structures
Gene Wiki entry for PALB2
|
Genomic Views
for PALB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PALB2 gene promoter:
AhR AML1a ATF-2 FOXD1 CUTL1 NF-kappaB Arnt NF-kappaB2 c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PALB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PALB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.2 Ensembl cytogenetic band: 16p12.2 HGNC cytogenetic band: 16p12.1PALB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M023614: view genomic region
(about GC identifiers)
Start:
|
23,614,483 bp from pter |
End:
|
23,652,678 bp from pter |
Size:
|
38,196 bases |
Orientation:
|
minus strand |
|
Proteins
for PALB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PALB2_HUMAN, Q86YC2 (See
protein sequence)Recommended Name: Partner and localizer of BRCA2 Size: 1186 amino acids; 131295 Da
Subunit: Homooligomer. Oligomerization is essential for its focal accumulation at DNA breaks. Part of a trimericcomplex containing BRCA1, BRCA2 and PALB2. Interacts with BRCA1 and this interaction is essential for its function inHRR. Interacts with RAD51, BRCA2, RAD51AP1 and MORF4L1/MRG15
Subcellular location: Nucleus. Note=Colocalizes with BRCA2 in nuclear foci
Sequence caution: Sequence=BAB15140.1; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for PALB2:2W18 (3D)
3EU7 (3D)
Secondary accessions: A6NIE1 Q8N7Y6 Q8ND31 Q9H6W1Explore the universe of human proteins at neXtProt for PALB2: NX_Q86YC2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86YC2
PALB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078951.2
ENSEMBL proteins: ENSP00000459237 ENSP00000454703 ENSP00000261584 ENSP00000459882 ENSP00000455524 ENSP00000460666 Reactome Protein details: Q86YC2
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- |
PALB2 for ontologies About GeneDecksing
PALB2 Antibody Products:
Assay Products for PALB2: |
Protein
Domains /
Families
for PALB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PALB2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86YC2ProtoNet protein and cluster: Q86YC2 UniProtKB/Swiss-Prot: PALB2_HUMAN, Q86YC2Domain: Interaction with BRCA2 occurs through a hydrophobic pocket at the crossover between WD repeats 4 and 5Similarity: Contains 7 WD repeats |
Function
for PALB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PALB2_HUMAN, Q86YC2Function: Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51to DNA breaks. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essentialfor homologous recombination. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes thenucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effectof replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51.Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinationalrepair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures,allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop,which comprises single-stranded, double-stranded and branched DNA structures
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PALB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PALB2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PALB2 (NM_024675) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PALB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PALB2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PALB2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
PALB2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for PALB2:
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Palb2):
PALB2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PALB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Fanconi Anemia pathway | | | 2 | Nucleotide Excision Repair | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for PALB2
PALB2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PALB2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/19 Interacting proteins for PALB2 (Q86YC22, 3 ENSP000002615844) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
PALB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PALB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PALB2
Search CenterWatch for drugs/clinical trials and news about PALB2
|
Transcripts
for PALB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PALB2 gene: NM_024675.3 Unigene Cluster for PALB2: Partner and localizer of BRCA2 Hs.444664 [show with all ESTs]Unigene Representative Sequence: BX6471256 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000566069 ENST00000568219 ENST00000261584(uc002dlx.1) ENST00000565038
ENST00000567003 ENST00000561514
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PALB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PALB2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PALB2 (NM_024675) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PALB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PALB2 |
Additional cDNA sequence: AK025469.1 AK097533.1 AK299152.1 AL834425.1 BC044254.2 BX647125.1 BX647130.1 CR749637.1 6 DOTS entries: DT.100740431 DT.311816 DT.92419621 DT.100737924 DT.427922 DT.75190630 24/66 AceView cDNA sequences (see all 66): BX647125 BQ009434 AA428136 BX647130 BC044254 AA219568 AW129312 NM_024675 BX117589 BE670820 CR749637 BQ217294 AA251848 CD632201 AA384612 AK097533 CD632199 BF110755 CA446257 BU620325 AL834425 AA579758 CA424379 AK025469
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PALB2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for PALB2
|
Expression
for PALB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PALB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTTTTAAA
About this image
See PALB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PALB2
SOURCE GeneReport for Unigene cluster: Hs.444664
SABiosciences Custom PCR Arrays for PALB2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PALB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PALB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PALB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PALB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PALB2 |
Orthologs
for PALB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PALB2 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for PALB2 (if available)
TreeFam Gene Tree for PALB2 (if available) |
Paralogs
for PALB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PALB2 gene
PALB2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PALB2
PGOHUM00000248764
|
Genomic Variants
for PALB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PALB2 (23614483 - 23652678 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PALB2
1 CNV: 58756
Human Gene Mutation Database (HGMD): PALB2
Locus Specific Mutation Databases (LSDB): PALB2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PALB2 |
|
Disorders
/ Diseases
for PALB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PALB2 for disorders About GeneDecksing
OMIM gene information: 610355
OMIM disorders: 610832 114480 613348
UniProtKB/Swiss-Prot: PALB2_HUMAN, Q86YC2
Defects in PALB2 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancyoriginating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasiveductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous.Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more thanone locus can be involved in different families or even in the same case. Note=Breast cancer susceptibility isstrongly associated with PALB2 truncating mutations. Conversely, rare missense mutations do not strongly influencebreast cancer risk (PubMed:22241545) Defects in PALB2 are the cause of Fanconi anemia complementation group N (FANCN) [MIM:610832]. It is adisorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associatedwith cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development ofmalignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomalinstability (increased chromosome breakage) and defective DNA repair Defects in PALB2 are the cause of pancreatic cancer type 3 (PNCA3) [MIM:613348]. It is a malignant neoplasm ofthe pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them developfrom the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue
20/21  diseases for PALB2 (see all 21): About MalaCardsfanconi anemia, complementation group n breast cancer pancreatic cancer susceptibility 3 fanconi's anemia
breast cancer susceptibility breast-ovarian cancer male breast cancer pancreatic cancer
anemia familial breast cancer wilms tumor bipolar disorder
leukopenia hereditary pancreatitis familial melanoma pancreatitis
ovarian cancer melanoma prostate cancer prostatitis
3 diseases from the University of Copenhagen DISEASES database for PALB2:Fanconi's anemia Breast cancer Ovarian cancer GeneTests: PALB2
Fanconi Anemia
Human Genome Epidemiology (HuGE) Navigator: PALB2 (39 documents)
Export disorders for PALB2 gene to outside databases
|
Publications
for PALB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PALB2 gene, integrated from 9 sources (see all 92):
(articles sorted by number of sources associating them with PALB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. (PubMed id 17200672)1, 2, 3 Xia B.... de Winter J.P. (2007)
- Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. (PubMed id 16793542)1, 2, 3 Xia B.... Livingston D.M. (2006)
- Rare germline mutations in PALB2 and breast cancer risk: a population-based study. (PubMed id 22241545)1, 2 Tischkowitz M.... Begg C.B. (2012)
- Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer. (PubMed id 21618343)1, 2 Hellebrand H.... Meindl A. (2011)
- Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. (PubMed id 20871616)1, 2 Dray E.... Sung P. (2010)
- MRG15 binds directly to PALB2 and stimulates homology -directed repair of chromosomal breaks. (PubMed id 20332121)1, 2 Hayakawa T....Andreassen P.R. (2010)
- Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. (PubMed id 20871615)1, 2 Buisson R.... Masson J.Y. (2010)
- Structural basis for recruitment of BRCA2 by PALB2. (PubMed id 19609323)1, 2 Oliver A.W.... Pearl L.H. (2009)
- Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. (PubMed id 19264984)1, 2 Jones S....Klein A.P. (2009)
- PALB2 is an integral component of the BRCA complex re quired for homologous recombination repair. (PubMed id 19369211)1, 2 Sy S.M....Chen J. (2009)
|
External Searches for PALB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PALB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PALB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PALB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PALB2 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PALB2 |
|
| | |
About This Section
| Patent Information for PALB2 gene:
Search GeneIP for patents involving PALB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PALB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for PALB2 | | OriGene shRNA RFP for PALB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PALB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PALB2 | | | OriGene Protein Over-expression Lysate for PALB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PALB2 | | OriGene 3'-UTR Clone for PALB2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PALB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PALB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PALB2 | | OriGene Custom Protein Services for PALB2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PALB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PALB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PALB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PALB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PALB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PALB2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for PALB2 |
| |  |  |  |  | | | | |
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 | | | PALB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PALB2 |
|  |  |  | | | | ThermoFisher Antibodies for PALB2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PALB2 |
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