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Aliases for PAK7 Gene

Aliases for PAK7 Gene

  • P21 Protein (Cdc42/Rac)-Activated Kinase 7 2 3
  • P21(CDKN1A)-Activated Kinase 7 2 3
  • P21-Activated Kinase 5 3 4
  • P21-Activated Kinase 7 3 4
  • EC 2.7.11.1 4 63
  • PAK-5 3 4
  • PAK-7 3 4
  • PAK5 3 4
  • Serine/Threonine-Protein Kinase PAK7 3
  • P21CDKN1A-Activated Kinase 7 3
  • Protein Kinase PAK5 3
  • EC 2.7.11 63
  • KIAA1264 4

External Ids for PAK7 Gene

Previous GeneCards Identifiers for PAK7 Gene

  • GC20M009506
  • GC20M009513
  • GC20M009466
  • GC20M009518
  • GC20M009470

Summaries for PAK7 Gene

Entrez Gene Summary for PAK7 Gene

  • The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAK7 Gene

PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PAK1.

UniProtKB/Swiss-Prot for PAK7 Gene

  • Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

Gene Wiki entry for PAK7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK7 Gene

Genomics for PAK7 Gene

Regulatory Elements for PAK7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PAK7 Gene

Chromosome:
20
Start:
9,537,389 bp from pter
End:
9,839,041 bp from pter
Size:
301,653 bases
Orientation:
Minus strand

Genomic View for PAK7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAK7 Gene

Proteins for PAK7 Gene

  • Protein details for PAK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P286-PAK7_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 7
    Protein Accession:
    Q9P286
    Secondary Accessions:
    • A8K5T6
    • D3DW14
    • Q5W115
    • Q9BX09
    • Q9ULF6

    Protein attributes for PAK7 Gene

    Size:
    719 amino acids
    Molecular mass:
    80745 Da
    Quaternary structure:
    • Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with MARK2, leading to inhibit MARK2 independently of kinase activity. Interacts with RHOD and RHOH.
    SequenceCaution:
    • Sequence=BAA86578.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PAK7 Gene

neXtProt entry for PAK7 Gene

Proteomics data for PAK7 Gene at MOPED

Post-translational modifications for PAK7 Gene

Other Protein References for PAK7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PAK7 (PAK5)

Domains & Families for PAK7 Gene

Gene Families for PAK7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P286

UniProtKB/Swiss-Prot:

PAK7_HUMAN :
  • An autoinhibitory domain is present in the N-terminal region of the protein.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • An autoinhibitory domain is present in the N-terminal region of the protein.
  • Contains 1 CRIB domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with PAK7: view

Function for PAK7 Gene

Molecular function for PAK7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

Enzyme Numbers (IUBMB) for PAK7 Gene

Gene Ontology (GO) - Molecular Function for PAK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0048365 Rac GTPase binding IBA --
genes like me logo Genes that share ontologies with PAK7: view
genes like me logo Genes that share phenotypes with PAK7: view

Animal Models for PAK7 Gene

MGI Knock Outs for PAK7:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAK7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PAK7 Gene

Localization for PAK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK7 Gene

Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAK7 Gene COMPARTMENTS Subcellular localization image for PAK7 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PAK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with PAK7: view

Pathways & Interactions for PAK7 Gene

genes like me logo Genes that share pathways with PAK7: view

Pathways by source for PAK7 Gene

1 Sino Biological pathway for PAK7 Gene
1 Cell Signaling Technology pathway for PAK7 Gene
2 BioSystems pathways for PAK7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PAK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006915 apoptotic process TAS 20070256
GO:0007010 cytoskeleton organization TAS 20070256
GO:0007165 signal transduction TAS 20070256
GO:0007266 Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with PAK7: view

No data available for SIGNOR curated interactions for PAK7 Gene

Drugs & Compounds for PAK7 Gene

(1) Drugs for PAK7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PAK7: view

Transcripts for PAK7 Gene

mRNA/cDNA for PAK7 Gene

(5) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAK7 Gene

P21 protein (Cdc42/Rac)-activated kinase 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAK7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAK7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: - -
SP4: - - - -

Relevant External Links for PAK7 Gene

GeneLoc Exon Structure for
PAK7
ECgene alternative splicing isoforms for
PAK7

Expression for PAK7 Gene

mRNA expression in normal human tissues for PAK7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAK7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.6), Brain - Cerebellum (x7.2), Brain - Frontal Cortex (BA9) (x5.4), Brain - Cortex (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for PAK7 Gene

This gene is overexpressed in Fetal Brain (50.9) and Frontal cortex (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PAK7 Gene



SOURCE GeneReport for Unigene cluster for PAK7 Gene Hs.32539

mRNA Expression by UniProt/SwissProt for PAK7 Gene

Q9P286-PAK7_HUMAN
Tissue specificity: Predominantly expressed in brain
genes like me logo Genes that share expression patterns with PAK7: view

Protein tissue co-expression partners for PAK7 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PAK7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAK7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAK7 35
  • 89.62 (n)
  • 94.02 (a)
PAK7 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAK7 35
  • 91.75 (n)
  • 96.94 (a)
PAK7 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pak7 35
  • 89.57 (n)
  • 93.88 (a)
Pak7 16
Pak7 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAK7 35
  • 99.68 (n)
  • 99.72 (a)
PAK7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pak7 35
  • 89.37 (n)
  • 94.57 (a)
oppossum
(Monodelphis domestica)
Mammalia PAK7 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAK7 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAK7 35
  • 76.93 (n)
  • 83.01 (a)
PAK7 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAK7 36
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pak7 35
  • 65.4 (n)
  • 68.22 (a)
pak7 36
  • 42 (a)
OneToMany
PAK7 (1 of 2) 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mbt 37
  • 79 (a)
Pak3 37
  • 49 (a)
mbt 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C45B11.1a 37
  • 46 (a)
C45B11.1b 37
  • 46 (a)
pak-2 35
  • 54.54 (n)
  • 55.66 (a)
pak-2 36
  • 45 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE20 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10829 36
  • 45 (a)
OneToMany
Species with no ortholog for PAK7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PAK7 Gene

ENSEMBL:
Gene Tree for PAK7 (if available)
TreeFam:
Gene Tree for PAK7 (if available)

Paralogs for PAK7 Gene

Paralogs for PAK7 Gene

(13) SIMAP similar genes for PAK7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PAK7: view

Variants for PAK7 Gene

Sequence variations from dbSNP and Humsavar for PAK7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs219861 -- 9,616,908(+) GGAAA(A/G)TCTTT intron-variant
rs219862 -- 9,617,497(+) AAACT(G/T)AGGCT intron-variant
rs221011 -- 9,836,384(-) CGGAC(A/G)TCATT intron-variant
rs221012 -- 9,834,927(-) GTCAA(C/T)AAATA intron-variant
rs221013 -- 9,834,880(+) AAGGG(C/T)GTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAK7 Gene

Variant ID Type Subtype PubMed ID
esv2664724 CNV Deletion 23128226
esv273065 CNV Insertion 20981092
esv268995 CNV Insertion 20981092
nsv521694 CNV Loss 19592680
nsv524114 CNV Gain 19592680
esv271424 CNV Insertion 20981092
nsv522383 CNV Loss 19592680
esv1680592 CNV Insertion 17803354
esv269557 CNV Insertion 20981092
esv272769 CNV Insertion 20981092
esv1922572 CNV Deletion 18987734
esv2658643 CNV Deletion 23128226
esv2722168 CNV Deletion 23290073
esv2722169 CNV Deletion 23290073
esv2722170 CNV Deletion 23290073
dgv85n6 CNV Loss 16902084
esv2676789 CNV Deletion 23128226
nsv458867 CNV Loss 19166990
nsv517670 CNV Loss 19592680
esv1107872 CNV Insertion 17803354
esv2722171 CNV Deletion 23290073
esv273784 CNV Insertion 20981092

Variation tolerance for PAK7 Gene

Residual Variation Intolerance Score: 28.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAK7 Gene

HapMap Linkage Disequilibrium report
PAK7
Human Gene Mutation Database (HGMD)
PAK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK7 Gene

Disorders for PAK7 Gene

Relevant External Links for PAK7

Genetic Association Database (GAD)
PAK7
Human Genome Epidemiology (HuGE) Navigator
PAK7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAK7
genes like me logo Genes that share disorders with PAK7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAK7 Gene

Publications for PAK7 Gene

  1. P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. (PMID: 19415746) Gong W. … Zhang H. (Int. J. Cancer 2009) 23 67
  2. Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma. (PMID: 16845324) Pavey S. … Hayward N. (Melanoma Res. 2006) 23 67
  3. Signaling from MARK to tau: regulation, cytoskeletal crosstalk, and pathological phosphorylation. (PMID: 17047359) Timm T. … Mandelkow E.M. (Neurodegener Dis 2006) 23 67
  4. Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. (PMID: 16581795) Cotteret S. … Chernoff J. (Mol. Cell. Biol. 2006) 23 67
  5. PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. (PMID: 11756552) Dan C. … Minden A. (Mol. Cell. Biol. 2002) 2 67

Products for PAK7 Gene

Sources for PAK7 Gene

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