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PAK6 Gene

protein-coding   GIFtS: 66
GCID: GC15P040509

P21 Protein (Cdc42/Rac)-Activated Kinase 6

(Previous name: p21(CDKN1A)-activated kinase 6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
P21 Protein (Cdc42/Rac)-Activated Kinase 61 2     PAK-53
P21(CDKN1A)-Activated Kinase 61 2     PAK-63
PAK52 3     P21-Activated Kinase 63
EC 2.7.11.13 8     EC 2.7.118
Serine/Threonine-Protein Kinase PAK 62     

External Ids:    HGNC: 160611   Entrez Gene: 569242   Ensembl: ENSG000001378437   OMIM: 6081105   UniProtKB: Q9NQU53   

Export aliases for PAK6 gene to outside databases

Previous GC identifers: GC15P035899 GC15P033427 GC15P038111 GC15P038248 GC15P038319 GC15P017352


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PAK6 Gene:
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an
amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases
function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the
mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with
androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation.
Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Mar 2013)

GeneCards Summary for PAK6 Gene:
PAK6 (p21 protein (Cdc42/Rac)-activated kinase 6) is a protein-coding gene. Diseases associated with PAK6 include la crosse encephalitis, and prostate cancer. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is PAK3.

UniProtKB/Swiss-Prot: PAK6_HUMAN, Q9NQU5
Function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase
activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of
androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription.
May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through
phosphorylation of BAD

Gene Wiki entry for PAK6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PAK6 gene promoter:
         E2F-3a   E2F-4   NF-1   E2F-5   E2F-2   AREB6   E2F-1   E2F   STAT3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAK6 promoter sequence
   Search Chromatin IP Primers for PAK6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

PAK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAK6 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P040509:  view genomic region     (about GC identifiers)

Start:
40,509,629 bp from pter      End:
40,569,688 bp from pter
Size:
60,060 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PAK6_HUMAN, Q9NQU5 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase PAK 6  
Size: 681 amino acids; 74869 Da
Subunit: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the
androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B
4 PDB 3D structures from and Proteopedia for PAK6:
2C30 (3D)        2ODB (3D)        4KS7 (3D)        4KS8 (3D)    
Secondary accessions: A8K2G2

Explore the universe of human proteins at neXtProt for PAK6: NX_Q9NQU5

Explore proteomics data for PAK6 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PAK6 (Q9NQU5) (see all 11)
     DFGFCAQ  WMAPEVI  AQSLGPA  EVDIWSLG 


    See PAK6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001122100.1  NP_001122101.1  NP_001263646.1  NP_001263647.1  NP_064553.1  

    ENSEMBL proteins: 
     ENSP00000453520   ENSP00000453407   ENSP00000409465   ENSP00000453858   ENSP00000260404  
     ENSP00000452737   ENSP00000452647   ENSP00000453005   ENSP00000453721   ENSP00000452708  
     ENSP00000453057   ENSP00000452686   ENSP00000453021   ENSP00000439597   ENSP00000406873  
     ENSP00000401153  
    Reactome Protein details: Q9NQU5

    PAK6 Human Recombinant Protein Products:

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    Novus Biologicals PAK6 Lysates
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    Cloud-Clone Corp. Proteins for PAK6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: p21 protein (Cdc42/Rac)-activated kinase 6
    PAKB subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR000095 CRIB_dom

    Graphical View of Domain Structure for InterPro Entry Q9NQU5

    ProtoNet protein and cluster: Q9NQU5

    1 Blocks protein domain: IPB000095 PAK-box/P21-Rho-binding

    UniProtKB/Swiss-Prot: PAK6_HUMAN, Q9NQU5
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 protein kinase domain


    PAK6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAK6_HUMAN, Q9NQU5
    Function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase
    activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of
    androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription.
    May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through
    phosphorylation of BAD
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    PAK6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PAK6:
     Decreased nuclei size in G2M  Decreased substrate adherent c 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pak6):
     behavior/neurological  nervous system  normal  reproductive system 

    PAK6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pak6tm1Amin for PAK6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAK6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAK6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAK6

    miRNA
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    miRTarBase miRNAs that target PAK6:
    hsa-mir-215-5p (MIRT024945), hsa-mir-26b-5p (MIRT029237), hsa-mir-192-5p (MIRT026453)

    Block miRNA regulation of human, mouse, rat PAK6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAK6 (see all 42):
    hsa-miR-328 hsa-miR-631 hsa-miR-429 hsa-miR-301a hsa-miR-486-3p hsa-miR-519a hsa-miR-9 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidPAK6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PAK6
    Predesigned siRNA for gene silencing in human, mouse, rat PAK6

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    GenScript: all cDNA clones in your preferred vector (see all 3): PAK6 (NM_001128628)
    Sino Biological Human cDNA Clone for PAK6
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAK6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAK6_HUMAN, Q9NQU5: Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen
    induction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--

    PAK6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAK6 About   (see all 33)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Integrin Pathway
    FAK1 Signaling0.67
    GnRH Signaling0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    4GPCR Pathway
    Ras Pathway0.73
    GPCR Pathway0.62
    Paxillin Interactions0.73
    5ERK Signaling
    Rho Family GTPases0.61
    MAPK Signaling0.58
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PAK6 (see all 31)
        MAPK Signaling
    Actin-Based Motility by Rho Family GTPases
    Paxillin Interactions
    Guidance Cues and Growth Cone Motility
    Semaphorin Signaling

    1 Cell Signaling Technology (CST) Pathway for PAK6
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for PAK6
        Transcription Androgen Receptor nuclear signaling

    4 BioSystems Pathways for PAK6
        Focal Adhesion
    Integrin-mediated cell adhesion
    Androgen receptor signaling pathway
    Regulation of Actin Cytoskeleton

    1 Sino Biological Pathway for PAK6
        TGF-beta Signaling Pathway

    1 Reactome Pathway for PAK6
        Activation of Rac


    Selected Kegg Pathways  (Kegg details for PAK6) (see all 7):
        ErbB signaling pathway
    Ras signaling pathway
    Axon guidance
    Focal adhesion
    T cell receptor signaling pathway


    PAK6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PAK6
    Interactions:

        GeneGlobe Interaction Network for PAK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PAK6 (Q9NQU52, 3 ENSP000002604044) via UniProtKB, MINT, STRING, and/or I2D (see all 147)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK14Q165392, 3, ENSP000002297944MINT-8265373 I2D: score=2 STRING: ENSP00000229794
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    CDC42P609533, ENSP000003144584I2D: score=4 STRING: ENSP00000314458
    AKT1P317493, ENSP000002702024I2D: score=1 STRING: ENSP00000270202
    ESR1P033723, ENSP000002062494I2D: score=2 STRING: ENSP00000206249
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278NOT mitotic cell cycle IBA--
    GO:0006355regulation of transcription, DNA-templated TAS--
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process TAS--
    GO:0007010cytoskeleton organization TAS--

    PAK6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PAK6

    3 HMDB Compounds for PAK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    4 Novoseek inferred chemical compound relationships for PAK6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 61.4 3 20054820 (1), 11773441 (1), 14573606 (1)
    serine 54.4 3 20054820 (1), 11773441 (1), 14573606 (1)
    testosterone 24.5 3 11278661 (2), 14573606 (1)
    steroid 21.5 1 11773441 (1)



    PAK6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PAK6 gene (5 alternative transcripts): 
    NM_001128628.2  NM_001128629.2  NM_001276717.1  NM_001276718.1  NM_020168.5  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000561230 ENST00000558055 ENST00000455577(uc001zky.4) ENST00000560346
    ENST00000260404(uc010bbn.3 uc001zlb.3) ENST00000558878 ENST00000558183
    ENST00000560806 ENST00000558106 ENST00000559617 ENST00000560684 ENST00000559139
    ENST00000560669 ENST00000542403 ENST00000559901 ENST00000557926 ENST00000557808
    ENST00000441369(uc010bbl.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PAK6 (see all 42):
    hsa-miR-328 hsa-miR-631 hsa-miR-429 hsa-miR-301a hsa-miR-486-3p hsa-miR-519a hsa-miR-9 hsa-miR-23a
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    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat PAK6

    Selected AceView cDNA sequences (see all 72):

    AK131522 AA350075 AI670066 AI458859 AI215775 BI089939 AA338445 CB306227 
    BQ026714 AK026592 BC035596 NM_020168 BM980032 BX280209 BM975763 AI741977 
    CA942783 CD629877 CB851051 BI828530 BI461601 BI560071 AA832523 AI769117 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PAK6 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                          -                 -     -                                         -     -     -                                   -               
    SP2:                                            -     -                                         -     -     -                                   -               
    SP3:                    -     -                 -     -                                         -     -     -                                   -     -         
    SP4:              -     -     -                 -     -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 16b · 16c ^ 17
    SP1:                  
    SP2:  -     -         
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for PAK6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PAK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTGTAA
    PAK6 Expression
    About this image

    PAK6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAK6 Protein Expression

    UniProtKB/Swiss-Prot: PAK6_HUMAN, Q9NQU5
    Tissue specificity: Selectively expressed in brain and testis, with lower levels in multiple tissues including
    prostate and breast

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PAK6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pak61 , 5 p21 protein (Cdc42/Rac)-activated kinase 61, 5 88.79(n)1
    92.66(a)1
      2 (59.41 cM)5
    2142301  NM_001033254.31  NP_001028426.21 
     1186633035 
    chicken
    (Gallus gallus)
    Aves PAK61 p21 protein (Cdc42/Rac)-activated kinase 6 75.09(n)
    78.21(a)
      428837  XM_426393.4  XP_426393.3 
    lizard
    (Anolis carolinensis)
    Reptilia PAK66
    p21 protein (Cdc42/Rac)-activated kinase 6
    74(a)
    1 ↔ 1
    GL343264.1(1373294-1435423)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pak61 p21 protein (Cdc42/Rac)-activated kinase 6 63.55(n)
    66.38(a)
      100495355  XM_002932826.2  XP_002932872.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005361971 serine/threonine-protein kinase PAK 6-like 68.83(n)
    69.46(a)
      100536197  XM_003200290.2  XP_003200338.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mbt3 protein amino acid phosphorylation
    protein serine/threonine more
    73(a)   14F2   --
    worm
    (Caenorhabditis elegans)
    Secernentea C45B11.1a3 serine/threonine kinase (PAK/STE20
    subfamily)
    45(a)
    (best of 2)
      V(11039350-11042917)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE206
    Cdc42p-activated signal transducing kinase of the ...
    21(a)
    1 → many
    VIII(95118-97937) YHL007C


    ENSEMBL Gene Tree for PAK6 (if available)
    TreeFam Gene Tree for PAK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAK6 gene
    PAK32  PAK72  PAK12  PAK42  PAK22  
    13 SIMAP similar genes for PAK6 using alignment to 12 protein entries:     PAK6_HUMAN (see all proteins):
    PAK4    PAK1    MYO3A    DKFZp564L2416    PAK2    STK11
    CDK4    PAK3    PAK7    STK17A    CCRK    KIN27
    PRKAA1

    PAK6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAK6 (see all 1296)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356314
    A colorectal cancer sample4--see VAR_0356312 R H mis40--------
    VAR_0409774
    A lung small cell carcinoma sample4--see VAR_0409772 L R mis40--------
    rs616214631,2
    C--17376647(+) GAGCT-/CAT   
      CTAGCT
    GGGGT
    4 -- int11Minor allele frequency- CATCTAGCT:0.00NA 2
    rs346248491,2
    C--17396103(+) TTTCA-/TTTTTT 5 -- int10--------
    rs1818297401,2
    --20582983(+) CAGGAC/GTTTTA 2 -- int10--------
    rs1154367381,2
    F--20583027(+) CATCTC/TACCAT 2 -- int11Minor allele frequency- T:0.01WA 118
    rs287502941,2
    C,F--20583057(+) CCGATA/GCTACT 2 -- int12Minor allele frequency- G:0.35WA 120
    rs1399172151,2
    --20583068(+) CCACTA/GTTAGA 2 -- int10--------
    rs733894871,2
    C,F--20583080(+) CCTTCG/ATCCTC 2 -- int12Minor allele frequency- A:0.35WA 120
    rs1453502391,2
    --20583084(+) CGTCCG/TCCTAT 2 -- int10--------

    HapMap Linkage Disequilibrium report for PAK6 (40509629 - 40569688 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PAK6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904098CNV Loss21882294
    nsv510660CNV Loss20534489
    nsv904095CNV Loss21882294
    nsv457118CNV Loss19166990
    nsv517541CNV Loss19592680
    dgv2359n71CNV Loss21882294
    esv34145CNV Loss18971310
    nsv471240CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PAK6
    DNA2.0 Custom Variant and Variant Library Synthesis for PAK6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608110    OMIM disorders: --

    15 diseases for PAK6:    About MalaCards
    la crosse encephalitis    prostate cancer    prostatitis    encephalitis
    thyroid cancer    lung cancer susceptibility    breast and colorectal cancer    renal cell carcinoma
    thyroiditis    esophagitis    adenocarcinoma    squamous cell carcinoma
    lung cancer    obesity    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for PAK6:
    La Crosse encephalitis

    PAK6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PAK6
    Human Genome Epidemiology (HuGE) Navigator: PAK6 (6 documents)

    Export disorders for PAK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAK6 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with PAK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. (PubMed id 11278661)1, 2, 3, 9 Yang F.... Sun Z. (J. Biol. Chem. 2001)
    2. Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. (PubMed id 20054820)1, 2, 9 Zhang M.... Chakravarti A. (Prostate 2010)
    3. AR and ER interaction with a p21-activated kinase (PAK6). (PubMed id 11773441)1, 2, 9 Lee S.R....Balk S.P. (Mol. Endocrinol. 2002)
    4. Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling. (PubMed id 14573606)1, 2, 9 Schrantz N....Bokoch G.M. (J. Biol. Chem. 2004)
    5. Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase. (PubMed id 15550393)1, 2, 9 Kaur R.... Lu M.L. (J. Biol. Chem. 2005)
    6. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    7. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    8. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    9. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    10. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56924 HGNC: 16061 AceView: PAK6 Ensembl:ENSG00000137843 euGenes: HUgn56924
    ECgene: PAK6 Kegg: 56924 H-InvDB: PAK6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PAK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PAK6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PAK6 gene:
    Search GeneIP for patents involving PAK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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