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Aliases for PAK6 Gene

Aliases for PAK6 Gene

  • P21 (RAC1) Activated Kinase 6 2 3 5
  • P21 Protein (Cdc42/Rac)-Activated Kinase 6 2 3
  • P21(CDKN1A)-Activated Kinase 6 2 3
  • EC 2.7.11.1 4 61
  • PAK5 3 4
  • Serine/Threonine-Protein Kinase PAK 6 3
  • P21-Activated Kinase 6 4
  • EC 2.7.11 61
  • PAK-5 4
  • PAK-6 4

External Ids for PAK6 Gene

Previous GeneCards Identifiers for PAK6 Gene

  • GC15P035899
  • GC15P033427
  • GC15P038111
  • GC15P038248
  • GC15P038319
  • GC15P040509
  • GC15P017352

Summaries for PAK6 Gene

Entrez Gene Summary for PAK6 Gene

  • This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for PAK6 Gene

PAK6 (P21 (RAC1) Activated Kinase 6) is a Protein Coding gene. Diseases associated with PAK6 include La Crosse Encephalitis and Prostate Cancer. Among its related pathways are EPHA forward signaling and Transcription Androgen Receptor nuclear signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is BUB1B-PAK6.

UniProtKB/Swiss-Prot for PAK6 Gene

  • Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.

Gene Wiki entry for PAK6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK6 Gene

Genomics for PAK6 Gene

Regulatory Elements for PAK6 Gene

Enhancers for PAK6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F040256 1.1 Ensembl ENCODE 25.8 +40.3 40252 3.0 HDAC1 PKNOX1 BMI1 ZNF664 EED ETV6 CREM MTA2 NR2F1 ZBED1 PAK6 PLCB2 CHST14 C15orf56 ENSG00000279409
GH15F040090 2.2 VISTA FANTOM5 ENCODE 10.1 -117.1 -117070 18.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ENSG00000259211 DNAJC17 BMF CHST14 RPLP0P10 BAHD1 SRP14 EIF2AK4 SRP14-AS1 ENSG00000259432
GH15F040044 1.7 FANTOM5 Ensembl ENCODE 11 -166.9 -166940 12.2 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 BMF PLCB2 EIF2AK4 RAD51-AS1 SRP14 PAK6 ANKRD63 C15orf56 RPLP0P10 SRP14-AS1
GH15F040080 1.7 FANTOM5 Ensembl ENCODE 10.2 -135.2 -135157 3.9 PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 GATA2 SP5 NFYC MXD4 SRP14 SRP14-AS1 BMF EIF2AK4 ANKRD63 BUB1B PAK6 C15orf56 PLCB2 RPLP0P10
GH15F040074 1.3 Ensembl ENCODE 10.6 -142.0 -142029 1.2 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 KLF13 ZNF263 NFYC SRP14 SRP14-AS1 ENSG00000259211 BAHD1 BUB1B BMF DNAJC17 RAD51-AS1 PAK6 C15orf56
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PAK6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAK6 Gene

Chromosome:
15
Start:
40,217,428 bp from pter
End:
40,277,487 bp from pter
Size:
60,060 bases
Orientation:
Plus strand

Genomic View for PAK6 Gene

Genes around PAK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAK6 Gene

Proteins for PAK6 Gene

  • Protein details for PAK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQU5-PAK6_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 6
    Protein Accession:
    Q9NQU5
    Secondary Accessions:
    • A8K2G2
    • B3KYB0
    • G5E9R2

    Protein attributes for PAK6 Gene

    Size:
    681 amino acids
    Molecular mass:
    74869 Da
    Quaternary structure:
    • Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.

    Three dimensional structures from OCA and Proteopedia for PAK6 Gene

    Alternative splice isoforms for PAK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAK6 Gene

Selected DME Specific Peptides for PAK6 Gene

Q9NQU5:
  • EVDIWSLG
  • DFGFCAQ
  • MDLRKQQRRELLFNEVVIMRDY
  • KIGEGSTG
  • AQELLDHP
  • AQSLGPA
  • WMAPEVI
  • VPKRKSLVGTPYWMAPEVISR
  • GTPYWMAPE
  • QGVIHRDIKSDSILL
  • EEQIATVC

Post-translational modifications for PAK6 Gene

  • Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PAK6 (PAK6)

Domains & Families for PAK6 Gene

Gene Families for PAK6 Gene

Suggested Antigen Peptide Sequences for PAK6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQU5

UniProtKB/Swiss-Prot:

PAK6_HUMAN :
  • Contains 1 CRIB domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 CRIB domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with PAK6: view

Function for PAK6 Gene

Molecular function for PAK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.

Enzyme Numbers (IUBMB) for PAK6 Gene

Gene Ontology (GO) - Molecular Function for PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 24510904
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PAK6: view
genes like me logo Genes that share phenotypes with PAK6: view

Animal Models for PAK6 Gene

MGI Knock Outs for PAK6:

Animal Model Products

  • Taconic Biosciences Mouse Models for PAK6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAK6 Gene

Localization for PAK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK6 Gene

Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAK6 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with PAK6: view

Pathways & Interactions for PAK6 Gene

genes like me logo Genes that share pathways with PAK6: view

SIGNOR curated interactions for PAK6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 NOT mitotic cell cycle IBA --
GO:0006355 regulation of transcription, DNA-templated TAS 20070256
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process TAS 20070256
GO:0007010 cytoskeleton organization TAS 20070256
genes like me logo Genes that share ontologies with PAK6: view

Drugs & Compounds for PAK6 Gene

(4) Drugs for PAK6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for PAK6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAK6: view

Transcripts for PAK6 Gene

Unigene Clusters for PAK6 Gene

P21 protein (Cdc42/Rac)-activated kinase 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAK6 Gene

No ASD Table

Relevant External Links for PAK6 Gene

GeneLoc Exon Structure for
PAK6
ECgene alternative splicing isoforms for
PAK6

Expression for PAK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAK6 Gene

mRNA differential expression in normal tissues according to GTEx for PAK6 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Cortex (x5.1), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for PAK6 Gene

This gene is overexpressed in Lung (61.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAK6 Gene



Protein tissue co-expression partners for PAK6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAK6 Gene:

PAK6

SOURCE GeneReport for Unigene cluster for PAK6 Gene:

Hs.732375

mRNA Expression by UniProt/SwissProt for PAK6 Gene:

Q9NQU5-PAK6_HUMAN
Tissue specificity: Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
genes like me logo Genes that share expression patterns with PAK6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PAK6 Gene

Orthologs for PAK6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAK6 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia PAK6 34 35
  • 92.02 (n)
cow
(Bos Taurus)
Mammalia PAK6 34 35
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Pak6 34 16 35
  • 88.79 (n)
rat
(Rattus norvegicus)
Mammalia Pak6 34
  • 87.86 (n)
oppossum
(Monodelphis domestica)
Mammalia PAK6 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves PAK6 34 35
  • 75.09 (n)
lizard
(Anolis carolinensis)
Reptilia PAK6 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pak6 34
  • 63.55 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536197 34
  • 68.83 (n)
pak6b 35
  • 57 (a)
OneToMany
PAK6 (1 of 2) 35
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mbt 36 35
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea C45B11.1a 36
  • 45 (a)
C45B11.1b 36
  • 45 (a)
pak-2 35
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE20 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10829 35
  • 40 (a)
OneToMany
Species where no ortholog for PAK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAK6 Gene

ENSEMBL:
Gene Tree for PAK6 (if available)
TreeFam:
Gene Tree for PAK6 (if available)

Paralogs for PAK6 Gene

Variants for PAK6 Gene

Sequence variations from dbSNP and Humsavar for PAK6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs201346085 A colorectal cancer sample 40,264,793(+) GTTCC(A/G)CAAGA reference, missense
VAR_040977 A lung small cell carcinoma sample
rs1006606 -- 40,272,718(+) TTCAA(C/T)GAGGT reference, synonymous-codon
rs1048163 -- 40,251,022(-) GGCCT(C/T)GGATG intron-variant, utr-variant-3-prime
rs1048164 -- 40,250,903(-) TGCTG(C/T)GTGGA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PAK6 Gene

Variant ID Type Subtype PubMed ID
nsv952611 CNV deletion 24416366
nsv569227 CNV loss 21841781
nsv517541 CNV loss 19592680
nsv510660 CNV deletion 20534489
nsv471240 CNV loss 18288195
nsv457118 CNV loss 19166990
esv3581650 CNV loss 25503493
esv3581647 CNV loss 25503493
esv3581642 CNV loss 25503493
esv34145 CNV loss 18971310
dgv731e212 CNV loss 25503493

Variation tolerance for PAK6 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.30; 76.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAK6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK6 Gene

Disorders for PAK6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PAK6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
la crosse encephalitis
  • california encephalitis
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search PAK6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAK6

Genetic Association Database (GAD)
PAK6
Human Genome Epidemiology (HuGE) Navigator
PAK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAK6
genes like me logo Genes that share disorders with PAK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAK6 Gene

Publications for PAK6 Gene

  1. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. (PMID: 11278661) Yang F. … Sun Z. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. (PMID: 20054820) Zhang M. … Chakravarti A. (Prostate 2010) 3 4 22 64
  3. Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase. (PMID: 15550393) Kaur R. … Lu M.L. (J. Biol. Chem. 2005) 3 4 22 64
  4. Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling. (PMID: 14573606) Schrantz N. … Bokoch G.M. (J. Biol. Chem. 2004) 3 4 22 64
  5. AR and ER interaction with a p21-activated kinase (PAK6). (PMID: 11773441) Lee S.R. … Balk S.P. (Mol. Endocrinol. 2002) 3 4 22 64

Products for PAK6 Gene

Sources for PAK6 Gene

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