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Aliases for PAK4 Gene

Aliases for PAK4 Gene

  • P21 Protein (Cdc42/Rac)-Activated Kinase 4 2 3 5
  • P21(CDKN1A)-Activated Kinase 4 2 3
  • P21-Activated Kinase 4 3 4
  • EC 2.7.11.1 4 63
  • PAK-4 3 4
  • Protein Kinase Related To S. Cerevisiae STE20, Effector For Cdc42Hs 3
  • EC 2.7.11 63
  • KIAA1142 4

External Ids for PAK4 Gene

Previous GeneCards Identifiers for PAK4 Gene

  • GC19P040228
  • GC19P040007
  • GC19P044292
  • GC19P044308
  • GC19P044274
  • GC19P039616
  • GC19P036064

Summaries for PAK4 Gene

Entrez Gene Summary for PAK4 Gene

  • PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAK4 Gene

PAK4 (P21 Protein (Cdc42/Rac)-Activated Kinase 4) is a Protein Coding gene. Diseases associated with PAK4 include breast adenoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and MicroRNAs in cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PAK1.

UniProtKB/Swiss-Prot for PAK4 Gene

  • Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

Gene Wiki entry for PAK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK4 Gene

Genomics for PAK4 Gene

Regulatory Elements for PAK4 Gene

Promoters for PAK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAK4 Gene

Chromosome:
19
Start:
39,125,770 bp from pter
End:
39,182,816 bp from pter
Size:
57,047 bases
Orientation:
Plus strand

Genomic View for PAK4 Gene

Genes around PAK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAK4 Gene

Proteins for PAK4 Gene

  • Protein details for PAK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96013-PAK4_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 4
    Protein Accession:
    O96013
    Secondary Accessions:
    • B4DGG6
    • Q8N4E1
    • Q8NCH5
    • Q8NDE3
    • Q9BU33
    • Q9ULS8

    Protein attributes for PAK4 Gene

    Size:
    591 amino acids
    Molecular mass:
    64072 Da
    Quaternary structure:
    • Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1.
    SequenceCaution:
    • Sequence=BAA86456.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11166.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PAK4 Gene

    Alternative splice isoforms for PAK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAK4 Gene

Proteomics data for PAK4 Gene at MOPED

Post-translational modifications for PAK4 Gene

  • Autophosphorylated on serine residues when activated by CDC42/p21.
  • Phosphorylated on tyrosine residues upon stimulation of FGFR2.
  • Ubiquitination at Lys 31
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PAK4 (PAK4)

Domains & Families for PAK4 Gene

Gene Families for PAK4 Gene

Graphical View of Domain Structure for InterPro Entry

O96013

UniProtKB/Swiss-Prot:

PAK4_HUMAN :
  • Contains 1 CRIB domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 CRIB domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with PAK4: view

Function for PAK4 Gene

Molecular function for PAK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

Enzyme Numbers (IUBMB) for PAK4 Gene

Gene Ontology (GO) - Molecular Function for PAK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity NAS 9822598
GO:0048365 Rac GTPase binding IBA --
genes like me logo Genes that share ontologies with PAK4: view
genes like me logo Genes that share phenotypes with PAK4: view

Animal Models for PAK4 Gene

MGI Knock Outs for PAK4:

Animal Model Products

  • Taconic Biosciences Mouse Models for PAK4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAK4 Gene

Localization for PAK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK4 Gene

Cytoplasm. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAK4 Gene COMPARTMENTS Subcellular localization image for PAK4 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PAK4 Gene

Pathways & Interactions for PAK4 Gene

genes like me logo Genes that share pathways with PAK4: view

SIGNOR curated interactions for PAK4 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PAK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process TAS 20070256
GO:0007010 cytoskeleton organization TAS 20070256
GO:0007266 Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with PAK4: view

Drugs & Compounds for PAK4 Gene

(19) Drugs for PAK4 Gene - From: ClinicalTrials, HMDB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist 361,361
Folic Acid Approved Nutra 2924
Adenosine triphosphate Approved Nutra 0
Nicotinamide Experimental Nutra 353,361
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for PAK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PAK4: view

Transcripts for PAK4 Gene

Unigene Clusters for PAK4 Gene

P21 protein (Cdc42/Rac)-activated kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAK4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13:
SP14:

Relevant External Links for PAK4 Gene

GeneLoc Exon Structure for
PAK4
ECgene alternative splicing isoforms for
PAK4

Expression for PAK4 Gene

mRNA expression in normal human tissues for PAK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PAK4 Gene

This gene is overexpressed in Breast (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAK4 Gene



SOURCE GeneReport for Unigene cluster for PAK4 Gene Hs.20447

mRNA Expression by UniProt/SwissProt for PAK4 Gene

O96013-PAK4_HUMAN
Tissue specificity: Highest expression in prostate, testis and colon.
genes like me logo Genes that share expression patterns with PAK4: view

Protein tissue co-expression partners for PAK4 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PAK4 Gene

Orthologs for PAK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAK4 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAK4 36
  • 94 (a)
OneToOne
PAK4 35
  • 91 (n)
  • 94.4 (a)
dog
(Canis familiaris)
Mammalia PAK4 35
  • 91.4 (n)
  • 95.59 (a)
PAK4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pak4 16
Pak4 36
  • 93 (a)
OneToOne
Pak4 35
  • 86.67 (n)
  • 93.22 (a)
oppossum
(Monodelphis domestica)
Mammalia PAK4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pak4 35
  • 86.89 (n)
  • 93.22 (a)
chicken
(Gallus gallus)
Aves PAK4 36
  • 82 (a)
OneToOne
PAK4 35
  • 76.62 (n)
  • 80.3 (a)
lizard
(Anolis carolinensis)
Reptilia PAK4 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia PAK5 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pak4 35
  • 65.98 (n)
  • 75.86 (a)
Str.17438 35
zebrafish
(Danio rerio)
Actinopterygii pak4 36
  • 64 (a)
OneToOne
pak4 35
  • 67.43 (n)
  • 72.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta mbt 36
  • 49 (a)
OneToMany
mbt 37
  • 78 (a)
Pak3 37
  • 48 (a)
mbt 35
  • 66.44 (n)
  • 68.76 (a)
worm
(Caenorhabditis elegans)
Secernentea C45B11.1a 37
  • 48 (a)
C45B11.1b 37
  • 48 (a)
pak-2 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE20 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10829 36
  • 42 (a)
OneToMany
Species with no ortholog for PAK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAK4 Gene

ENSEMBL:
Gene Tree for PAK4 (if available)
TreeFam:
Gene Tree for PAK4 (if available)

Paralogs for PAK4 Gene

Paralogs for PAK4 Gene

genes like me logo Genes that share paralogs with PAK4: view

Variants for PAK4 Gene

Sequence variations from dbSNP and Humsavar for PAK4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11122 -- 39,179,347(-) GGCTG(C/G)GGCTG utr-variant-3-prime
rs737450 -- 39,139,757(-) CAGTG(A/C)CTCCC intron-variant
rs471217 -- 39,131,545(+) CCATC(C/T)GGGGC intron-variant
rs474724 -- 39,128,280(+) GCTGC(C/T)GCTGC intron-variant
rs476713 -- 39,154,945(+) GGTGG(A/G)GATGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PAK4 Gene

Variant ID Type Subtype PubMed ID
nsv458571 CNV Gain 19166990
nsv833829 CNV Loss 17160897
esv2674613 CNV Deletion 23128226
esv26259 CNV Loss 19812545
esv2545161 CNV Deletion 19546169
esv2008944 CNV Deletion 18987734
esv2665610 CNV Deletion 23128226
esv2718547 CNV Deletion 23290073
esv2369247 CNV Deletion 18987734
esv2718548 CNV Deletion 23290073
esv2718549 CNV Deletion 23290073

Variation tolerance for PAK4 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAK4 Gene

HapMap Linkage Disequilibrium report
PAK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK4 Gene

Disorders for PAK4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PAK4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
breast adenoma
  • ademoma - breast
- elite association - COSMIC cancer census association via MalaCards
Search PAK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAK4

Genetic Association Database (GAD)
PAK4
Human Genome Epidemiology (HuGE) Navigator
PAK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAK4
genes like me logo Genes that share disorders with PAK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAK4 Gene

Publications for PAK4 Gene

  1. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. (PMID: 9822598) Abo A. … Minden A. (EMBO J. 1998) 2 3 4 23 67
  2. PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion. (PMID: 20406887) Wells C.M. … Jones G.E. (J. Cell. Sci. 2010) 3 23
  3. DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1. (PMID: 19778628) Li X. … Li F. (Int. J. Biochem. Cell Biol. 2010) 3 23
  4. [Expression of PAK4 in breast cancer and benign breast pathological changes]. (PMID: 20501374) Yang J.X. … Luo R.C. (Nan Fang Yi Ke Da Xue Xue Bao 2010) 3 23
  5. Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma. (PMID: 19594544) Begum A. … Inazawa J. (Cancer Sci. 2009) 3 23

Products for PAK4 Gene

Sources for PAK4 Gene

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