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PAK4 Gene

protein-coding   GIFtS: 74
GCID: GC19P039616

P21 Protein (Cdc42/Rac)-Activated Kinase 4

(Previous name: p21(CDKN1A)-activated kinase 4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
P21 Protein (Cdc42/Rac)-Activated Kinase 41 2     Protein Kinase Related To S. Cerevisiae STE20, Effector For Cdc42Hs2
P21(CDKN1A)-Activated Kinase 41 2     Serine/Threonine-Protein Kinase PAK 42
PAK-42 3     KIAA11423
P21-Activated Kinase 42 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 160591   Entrez Gene: 102982   Ensembl: ENSG000001306697   OMIM: 6054515   UniProtKB: O960133   

Export aliases for PAK4 gene to outside databases

Previous GC identifers: GC19P040228 GC19P040007 GC19P044292 GC19P044308 GC19P044274 GC19P036064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PAK4 Gene:
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins
are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as
targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological
activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of
MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin
cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PAK4 Gene:
PAK4 (p21 protein (Cdc42/Rac)-activated kinase 4) is a protein-coding gene. Diseases associated with PAK4 include breast adenoma, and adenofibroma. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is PAK6.

UniProtKB/Swiss-Prot: PAK4_HUMAN, O96013
Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including
cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors
including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent
autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein
phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor
cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase
that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility.
Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly
of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of
cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a
kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle
regulatory protein CDKN1A and by phosphorylating RAN

Gene Wiki entry for PAK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAK4 gene promoter:
         NF-kappaB   E47   AREB6   NF-kappaB2   Hand1   NF-kappaB1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PAK4 promoter sequence
   Search Chromatin IP Primers for PAK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19p11-q11

PAK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAK4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039616:  view genomic region     (about GC identifiers)

Start:
39,616,410 bp from pter      End:
39,673,456 bp from pter
Size:
57,047 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PAK4_HUMAN, O96013 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase PAK 4  
Size: 591 amino acids; 64072 Da
Subunit: Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound
CDC42/p21 and weakly with RAC1
Sequence caution: Sequence=BAA86456.1; Type=Erroneous initiation; Sequence=BAC11166.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for PAK4 (see all 18):
2BVA (3D)        2CDZ (3D)        2J0I (3D)        2OV2 (3D)        2Q0N (3D)        2X4Z (3D)    
Secondary accessions: B4DGG6 Q8N4E1 Q8NCH5 Q8NDE3 Q9BU33 Q9ULS8
Alternative splicing: 4 isoforms:  O96013-1   O96013-2   O96013-3   O96013-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PAK4: NX_O96013

Explore proteomics data for PAK4 at MOPED

Post-translational modifications: 

  • Autophosphorylated on serine residues when activated by CDC42/p211
  • Phosphorylated on tyrosine residues upon stimulation of FGFR2 (By similarity)1
  • Ubiquitination2 at Lys31
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PAK4 (O96013) (see all 11)
     DFGFCAQ  GPEVDIWS  EVDIWSLG  KIGEGSTG 


    See PAK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001014831.1  NP_001014832.1  NP_001014834.1  NP_001014835.1  NP_005875.1  

    ENSEMBL proteins: 
     ENSP00000471318   ENSP00000470284   ENSP00000326864   ENSP00000472862   ENSP00000351049  
     ENSP00000469413   ENSP00000471157   ENSP00000473215   ENSP00000472061   ENSP00000392753  
     ENSP00000353625  
    Reactome Protein details: O96013

    PAK4 Human Recombinant Protein Products:

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    OriGene MassSpec for PAK4
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    GenScript Custom Purified and Recombinant Proteins Services for PAK4
    Novus Biologicals PAK4 Proteins
    Novus Biologicals PAK4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PAK4
    Cloud-Clone Corp. Proteins for PAK4

    PAK4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PAK4
    R&D Systems Antibodies for PAK4
    Cell Signaling Technology (CST) Antibodies for PAK4 
    OriGene Antibodies for PAK4
    OriGene Custom Antibody Services for PAK4
    Novus Biologicals PAK4 Antibodies
    Abcam antibodies for PAK4 (O96013, Q9NQU5)
    Cloud-Clone Corp. Antibodies for PAK4
    ThermoFisher Antibody for PAK4
    LSBio Antibodies in human, mouse, rat for PAK4

    PAK4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PAK4
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    Cloud-Clone Corp. ELISAs for PAK4
    Cloud-Clone Corp. CLIAs for PAK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: p21 protein (Cdc42/Rac)-activated kinase 4
    PAKB subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR000095 CRIB_dom

    Graphical View of Domain Structure for InterPro Entry O96013

    ProtoNet protein and cluster: O96013

    1 Blocks protein domain: IPB000095 PAK-box/P21-Rho-binding

    UniProtKB/Swiss-Prot: PAK4_HUMAN, O96013
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 protein kinase domain


    PAK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAK4_HUMAN, O96013
    Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including
    cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors
    including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent
    autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein
    phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor
    cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase
    that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility.
    Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly
    of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of
    cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a
    kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle
    regulatory protein CDKN1A and by phosphorylating RAN
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS9822598
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    PAK4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PAK4:
     Decreased focal adhesion (FA)   Decreased mitotic index  Decreased substrate adherent c  Increased colony dispersion (i 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Pak4):
     cardiovascular system  cellular  embryogenesis  growth/size/body  integument 
     mortality/aging  nervous system  no phenotypic analysis 

    PAK4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PAK4: Pak4tm2.2Amin Pak4tm1Amin

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAK4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAK4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAK4

    miRNA
    Products:
        
    miRTarBase miRNAs that target PAK4:
    hsa-let-7c-5p (MIRT051766), hsa-mir-324-5p (MIRT043240), hsa-mir-744-5p (MIRT037459), hsa-mir-1229-3p (MIRT036391), hsa-mir-24-3p (MIRT030445), hsa-mir-145-5p (MIRT006899), hsa-mir-18a-3p (MIRT040764)

    Block miRNA regulation of human, mouse, rat PAK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAK4 (see all 32):
    hsa-miR-199a-3p hsa-miR-9 hsa-miR-181b hsa-miR-3163 hsa-miR-433 hsa-miR-222* hsa-miR-548e hsa-miR-4255
    SwitchGear 3'UTR luciferase reporter plasmidPAK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PAK4
    Predesigned siRNA for gene silencing in human, mouse, rat PAK4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PAK4

    Clone
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    OriGene clones in human, mouse for PAK4 (see all 31)
    OriGene ORF clones in mouse, rat for PAK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): PAK4 (NM_005884)
    Sino Biological Human cDNA Clone for PAK4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAK4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PAK4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAK4_HUMAN, O96013: Cytoplasm. Note=Seems to shuttle between cytoplasmic compartments depending on the
    activating effector. For example, can be found on the cell periphery after activation of growth-factor or
    integrin-mediated signaling pathways
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    cytosol3
    cytoskeleton2
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005794Golgi apparatus TAS9822598

    PAK4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAK4 About   (see all 37)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    4Integrin Pathway
    FAK1 Signaling0.67
    GnRH Signaling0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    5GPCR Pathway
    Ras Pathway0.73
    GPCR Pathway0.62
    Paxillin Interactions0.73

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PAK4 (see all 32)
        MAPK Signaling
    Actin-Based Motility by Rho Family GTPases
    Paxillin Interactions
    Semaphorin Signaling
    Guidance Cues and Growth Cone Motility

    1 Cell Signaling Technology (CST) Pathway for PAK4
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for PAK4
        Cytoskeleton remodeling Role of PDGFs in cell migration
    Cytoskeleton remodeling CDC42 in cellular processes

    Selected BioSystems Pathways for PAK4 (see all 7)
        Focal Adhesion
    Integrin-mediated cell adhesion
    ErbB signaling pathway
    Regulation of Actin Cytoskeleton
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

    1 Sino Biological Pathway for PAK4
        TGF-beta Signaling Pathway

    1 Reactome Pathway for PAK4
        Activation of Rac


    Selected Kegg Pathways  (Kegg details for PAK4) (see all 8):
        ErbB signaling pathway
    Ras signaling pathway
    Axon guidance
    Focal adhesion
    T cell receptor signaling pathway


    PAK4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PAK4: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PAK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PAK4 (O960131, 2, 3 ENSP000003510494) via UniProtKB, MINT, STRING, and/or I2D (see all 937)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATAD2AQ86YP42, 3, ENSP000003515524MINT-7945693 MINT-65003 MINT-7947479 I2D: score=4 STRING: ENSP00000351552
    SFNP319472, 3MINT-3975099 I2D: score=2 
    CDC42P609531, 2, 3, ENSP000003144584EBI-713738,EBI-81752 MINT-8402413 I2D: score=5 STRING: ENSP00000314458
    YWHAZP631042, 3, ENSP000003095034MINT-51017 MINT-3308034 I2D: score=5 STRING: ENSP00000309503
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278NOT mitotic cell cycle IBA--
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process TAS--
    GO:0006928cellular component movement TAS9822598
    GO:0007010cytoskeleton organization TAS--

    PAK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PAK4

    3 HMDB Compounds for PAK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for PAK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 58.4 2 11413130 (2)
    serine 48.8 3 11413130 (2), 11668177 (1)



    PAK4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PAK4 gene (6 alternative transcripts): 
    NM_001014831.2  NM_001014832.1  NM_001014834.2  NM_001014835.1  NM_005884.3  NM_001014833.1  

    Unigene Cluster for PAK4:

    P21 protein (Cdc42/Rac)-activated kinase 4
    Hs.20447  [show with all ESTs]
    Unigene Representative Sequence: AB032968
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602004 ENST00000599470 ENST00000321944(uc002okm.1 uc002oko.1)
    ENST00000593480 ENST00000358301(uc002okl.1 uc002okn.1 uc002okp.1)
    ENST00000597766 ENST00000593690 ENST00000599386 ENST00000599657 ENST00000597715
    ENST00000600350 ENST00000435673 ENST00000360442(uc002okj.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PAK4 (see all 32):
    hsa-miR-199a-3p hsa-miR-9 hsa-miR-181b hsa-miR-3163 hsa-miR-433 hsa-miR-222* hsa-miR-548e hsa-miR-4255
    SwitchGear 3'UTR luciferase reporter plasmidPAK4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PAK4
    Predesigned siRNA for gene silencing in human, mouse, rat PAK4
    Clone
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    OriGene clones in human, mouse for PAK4 (see all 31)
    OriGene ORF clones in mouse, rat for PAK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): PAK4 (NM_005884)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAK4
    Primer
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    OriGene qPCR primer pairs and template standards for PAK4
    OriGene qSTAR qPCR primer pairs in human, mouse for PAK4
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      QuantiTect SYBR Green Assays in human, mouse, rat PAK4
      QuantiFast Probe-based Assays in human, mouse, rat PAK4

    Additional mRNA sequence: 

    AB032968.1 AF005046.1 AJ011855.1 AK074728.1 AK291839.1 AK293517.1 AK294586.1 AK300632.1 
    AK304651.1 AL834236.1 BC002921.2 BC011368.1 BC025282.1 BC034511.1 

    15 DOTS entries:

    DT.415172  DT.100790544  DT.97799422  DT.100698283  DT.100790551  DT.95157024  DT.100836192  DT.121439007 
    DT.100790554  DT.95306700  DT.100790545  DT.121439028  DT.121439054  DT.95157005  DT.95157026 

    Selected AceView cDNA sequences (see all 319):

    BQ962487 BU846500 BQ225576 CB852777 BU163574 AW611828 BM911358 BQ232965 
    BM912016 BM129818 AX775867 AW673492 BU178718 BE257592 CK819727 BQ689783 
    AA470415 BQ691622 CD675716 AL834236 BM664249 BQ230551 AA313096 AW673851 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PAK4 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:                                                                                                                          -                           
    SP2:                                            -                       -                                                                                 
    SP3:                                            -     -                                                                                                   
    SP4:                                            -     -           -                                                                                       
    SP5:                                            -     -                 -                                                                                 


    ECgene alternative splicing isoforms for PAK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PAK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTCCGAA
    PAK4 Expression
    About this image


    PAK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Prostate (Endocrine System)
    PAK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.20447

    UniProtKB/Swiss-Prot: PAK4_HUMAN, O96013
    Tissue specificity: Highest expression in prostate, testis and colon

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PAK4: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PAK4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pak41 , 5 p21 protein (Cdc42/Rac)-activated kinase 41, 5 86.67(n)1
    93.22(a)1
      7 (16.84 cM)5
    705841  NM_027470.31  NP_081746.11 
     285588195 
    chicken
    (Gallus gallus)
    Aves PAK41 p21 protein (Cdc42/Rac)-activated kinase 4 76.62(n)
    80.3(a)
      770462  XM_001233795.3  XP_001233796.3 
    lizard
    (Anolis carolinensis)
    Reptilia PAK46
    p21 protein (Cdc42/Rac)-activated kinase 4
    65(a)
    1 ↔ 1
    GL343755.1(48938-83986)
    African clawed frog
    (Xenopus laevis)
    Amphibia PAK52 PAK5 protein 76.73(n)    AJ277826.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pak41 p21 protein (Cdc42/Rac)-activated kinase 4 67.43(n)
    72.46(a)
      431769  NM_001002222.1  NP_001002222.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mbt1 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    mushroom bodies tiny1
    78(a)
    (best of 2)3
    66.44(n)1
    68.76(a)1
      14F23
    326311  NM_078651.31  NP_523375.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C45B11.1a3 serine/threonine kinase (PAK/STE20
    subfamily)
    48(a)
    (best of 2)
      V(11039350-11042917)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE206
    Cdc42p-activated signal transducing kinase of the ...
    21(a)
    1 → many
    VIII(95118-97937) YHL007C


    ENSEMBL Gene Tree for PAK4 (if available)
    TreeFam Gene Tree for PAK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAK4 gene
    PAK62  PAK32  PAK72  PAK12  PAK22  
    Selected SIMAP similar genes for PAK4 using alignment to 6 protein entries:     PAK4_HUMAN (see all proteins) (see all similar genes):
    PAK2    PAK7    PAK6    PAK1    PAK3    STK3
    MAP4K4    DKFZp686J1430    MAP4K3    NEK9    STK4    TNIK
    MST4    NRK    MAP4K5    MINK1    STK24    MAP4K1

    PAK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAK4 (see all 1435)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480481401,2
    C--39614497(+) AGAAA-/GAAG  
            
    GAAGG
    5 -- us2k10--------
    rs720102581,2
    C--39614513(+) GGAAG-/GAAGGAAA
    GAAAGAGAAA
    GAAAG
    5 -- us2k10--------
    rs1448269321,2
    C--39614528(+) AAGAG-/AAAGAA
    AGAAAGAA
    AAAGA
    5 -- us2k10--------
    rs1125121751,2
    C--39614541(+) AAAGAA/GAAAGA 5 -- us2k10--------
    rs6919751,2
    C,F,A,H--39614567(+) ttagcC/Tggtgt 5 -- us2k112Minor allele frequency- T:0.42NA WA CSA EA 376
    rs615874821,2
    C--39614686(+) AAAAA-/ACAAAA 5 -- us2k11Minor allele frequency- A:0.00NA 2
    rs3757407891,2
    C--39614715(+) CAAAA-/CAAAC 
            
    AAAAA
    5 -- us2k10--------
    rs1381024631,2
    C--39614719(+) AAAAA-/ACGAAT 5 -- us2k10--------
    rs113261931,2
    C--39614720(+) CAAAC-/AAAAAA 5 -- us2k1 tfbs3 trp31Minor allele frequency- A:0.00NA 2
    rs2000670011,2
    --39614722(+) ACAAA-/CAAAAA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for PAK4 (39616410 - 39673456 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PAK4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2008944CNV Deletion18987734
    esv2718548CNV Deletion23290073
    esv2674613CNV Deletion23128226
    esv2718549CNV Deletion23290073
    esv2665610CNV Deletion23128226
    esv2369247CNV Deletion18987734
    esv2545161CNV Deletion19546169
    esv2718547CNV Deletion23290073
    nsv833829CNV Loss17160897
    esv26259CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing PAK4:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing PAK4
    DNA2.0 Custom Variant and Variant Library Synthesis for PAK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605451    OMIM disorders: --

    20 diseases for PAK4:    
    About MalaCards
    breast adenoma    adenofibroma    gallbladder cancer    choriocarcinoma
    oral squamous cell carcinoma    endometriosis    pneumonia    adenoma
    parkinson's disease    renal cell carcinoma    squamous cell carcinoma    pancreatic cancer
    pancreatitis    ovarian cancer    hepatocellular carcinoma    prostate cancer
    prostatitis    endotheliitis    cerebritis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for PAK4:
    Breast adenoma

    PAK4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for PAK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 20.2 9 16227624 (2), 19050074 (1), 19793168 (1), 20439741 (1) (see all 7)
    cancer 5.49 10 20501374 (2), 16227624 (2), 11668177 (1), 19778628 (1) (see all 6)
    necrosis 0 4 16227624 (2), 11278822 (1), 14560027 (1)

    Genetic Association Database (GAD): PAK4
    Human Genome Epidemiology (HuGE) Navigator: PAK4 (2 documents)

    Export disorders for PAK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAK4 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with PAK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. (PubMed id 9822598)1, 2, 3, 9 Abo A.... Minden A. (EMBO J. 1998)
    2. P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. (PubMed id 12356872)1, 2, 9 Zhang H.... Stromblad S. (J. Cell Biol. 2002)
    3. PAK4 mediates morphological changes through the regulation of GEF- H1. (PubMed id 15827085)1, 2, 9 Callow M.G.... Smeal T. (J. Cell Sci. 2005)
    4. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)1, 2, 9 Soosairajah J.... Bernard O. (EMBO J. 2005)
    5. p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration. (PubMed id 20507994)1, 2 Li Z.... Stromblad S. (J. Biol. Chem. 2010)
    6. Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B. (PubMed id 20631255)1, 2 Wallace S.W.... Hall A. (Mol. Biol. Cell 2010)
    7. Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis. (PubMed id 20805321)1, 2 Bompard G.... Morin N. (J. Cell Biol. 2010)
    8. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (PLoS ONE 2008)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10298 HGNC: 16059 AceView: PAK4 Ensembl:ENSG00000130669 euGenes: HUgn10298
    ECgene: PAK4 Kegg: 10298 H-InvDB: PAK4

    (According to HUGE)
    About This Section

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    HUGE: KIAA1142

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PAK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PAK4 gene:
    Search GeneIP for patents involving PAK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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