PAK4 Gene
protein-coding GIFtS: 69
GCID: GC19P039616
|
|
p21 protein (Cdc42/Rac)-activated kinase 4(Previous name: p21(CDKN1A)-activated kinase 4 )
| |
Aliases
for PAK4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| P21 Protein (Cdc42/Rac)-Activated Kinase 41 2 | | Protein Kinase Related To S. Cerevisiae STE20, Effector For Cdc42Hs2 | | P21(CDKN1A)-Activated Kinase 41 2 | | Serine/Threonine-Protein Kinase PAK 42 | | PAK-42 3 | | KIAA11423 | | P21-Activated Kinase 42 3 | | EC 2.7.118 | | EC 2.7.11.13 8 | | |
Export aliases for PAK4 gene to outside databasesPrevious GC identifers: GC19P040228 GC19P040007 GC19P044292 GC19P044308 GC19P044274 GC19P036064 |
Summaries
for PAK4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PAK4:
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins arecritical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targetsfor the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities.PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases.PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton.Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (providedby RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PAK4_HUMAN, O96013Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways includingcytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectorsincluding growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequentautophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the proteinphosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin.Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that alsoinhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. PhosphorylatesARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesionsand actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD.Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independentmanner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A andby phosphorylating RAN
Gene Wiki entry for PAK4
|
Genomic Views
for PAK4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PAK4 gene promoter:
NF-kappaB E47 AREB6 NF-kappaB2 Hand1 NF-kappaB1 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for PAK4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAK4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19p11-q11PAK4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P039616: view genomic region
(about GC identifiers)
Start:
|
39,616,420 bp from pter |
End:
|
39,670,046 bp from pter |
Size:
|
53,627 bases |
Orientation:
|
plus strand |
|
Proteins
for PAK4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PAK4_HUMAN, O96013 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase PAK 4 Size: 591 amino acids; 64072 Da
Subunit: Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21and weakly with RAC1
Subcellular location: Cytoplasm. Note=Seems to shuttle between cytoplasmic compartments depending on the activatingeffector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediatedsignaling pathways
Sequence caution: Sequence=BAA86456.1; Type=Erroneous initiation; Sequence=BAC11166.1; Type=Erroneous initiation;
6/13 PDB 3D structures from  and Proteopedia  for PAK4 (see all 13):2BVA (3D)
2CDZ (3D)
2J0I (3D)
2OV2 (3D)
2Q0N (3D)
2X4Z (3D)
Secondary accessions: B4DGG6 Q8N4E1 Q8NCH5 Q8NDE3 Q9BU33 Q9ULS8Alternative splicing: 4 isoforms: O96013-1 O96013-2 O96013-3 O96013-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PAK4: NX_O96013
Post-translational modifications:
Autophosphorylated on serine residues when activated by CDC42/p211
Phosphorylated on tyrosine residues upon stimulation of FGFR2 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O96013
4/11 DME Specific Peptides for PAK4 (O96013) (see all 11)
PAK4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001014831.1 NP_001014832.1 NP_001014834.1 NP_001014835.1 NP_005875.1
ENSEMBL proteins: ENSP00000351049 ENSP00000326864 ENSP00000392753 ENSP00000353625 Reactome Protein details: O96013
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
PAK4 for ontologies About GeneDecksing
PAK4 Antibody Products:
Assay Products for PAK4: |
Protein
Domains /
Families
for PAK4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PAK4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O96013ProtoNet protein and cluster: O96013 1 Blocks protein family: IPB000095 PAK-box/P21-Rho-binding
UniProtKB/Swiss-Prot: PAK4_HUMAN, O96013Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 CRIB domainSimilarity: Contains 1 protein kinase domain |
Function
for PAK4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PAK4_HUMAN, O96013Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways includingcytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectorsincluding growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequentautophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the proteinphosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin.Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that alsoinhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. PhosphorylatesARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesionsand actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD.Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independentmanner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A andby phosphorylating RANCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAK4 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAK4 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): PAK4 (NM_005884) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAK4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAK4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAK4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
PAK4 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for PAK4:
Animal Models:
Mouse knock-outs for PAK4: Pak4tm2.2Amin Pak4tm1Amin
8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Pak4):
PAK4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PAK4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Integrin Pathway | | | 2 | Rho Family GTPases | | | 3 | GPCR Pathway | | | 4 | CCR3 Pathway in Eosinophils | | | 5 | Focal Adhesion | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for PAK4
5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PAK4 (see all 32)
1 
Cell Signaling Technology (CST) Pathway for PAK4
2  GeneGo (Thomson Reuters) Pathways for PAK4
5/7  BioSystems Pathways for PAK4 (see all 7)
4 
Reactome Pathways for PAK4
5/6 
Kegg Pathways (Kegg details for PAK4) (see all 6):
PAK4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PAK4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/783 Interacting proteins for PAK4 (O960132, 3 ENSP000003510494) via UniProtKB, MINT, STRING, and/or I2D (see all 783)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
PAK4 for ontologies About GeneDecksing
|
Drugs & Compounds
for PAK4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PAK4 for compounds About GeneDecksing
 Browse Tocris compounds for PAK4
3 HMDB Compounds for PAK4 About this table
2 Novoseek chemical compound relationships for PAK4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
58.4 |
2 |
11413130 (2) |
| serine |
48.8 |
3 |
11413130 (2), 11668177 (1) |
Search CenterWatch for drugs/clinical trials and news about PAK4
|
Transcripts
for PAK4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PAK4 gene (6 alternative transcripts): NM_001014831.2 NM_001014832.1 NM_001014834.2 NM_001014835.1 NM_005884.3 NM_001014833.1 Unigene Cluster for PAK4: P21 protein (Cdc42/Rac)-activated kinase 4 Hs.20447 [show with all ESTs]Unigene Representative Sequence: AB0329684 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358301(uc002okl.1 uc002okn.1 uc002okp.1) ENST00000321944(uc002okm.1 uc002oko.1)
ENST00000435673 ENST00000360442(uc002okj.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAK4 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAK4 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): PAK4 (NM_005884) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAK4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAK4 |
Additional cDNA sequence: AB032968.1 AF005046.1 AJ011855.1 AK074728.1 AK291839.1 AK293517.1 AK294586.1 AK300632.1 AK304651.1 AL834236.1 BC002921.2 BC011368.1 BC025282.1 BC034511.1 15 DOTS entries: DT.415172 DT.100790544 DT.97799422 DT.100698283 DT.100790551 DT.95157024 DT.100836192 DT.121439007 DT.100790554 DT.95306700 DT.100790545 DT.121439028 DT.121439054 DT.95157005 DT.95157026 24/319 AceView cDNA sequences (see all 319): BU145359 BU174406 BU163574 AL044908 CD675716 BQ229553 AI566295 BU846500 AW015017 AX775865 AW673851 BM826969 BU185233 AW611828 BE378630 BU178718 AI268292 BM911358 AW673492 AX775867 BQ230551 AA313096 BQ962487 AL834236
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PAK4 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PAK4
|
Expression
for PAK4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PAK4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGTCCGAA
About this image
See PAK4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PAK4
SOURCE GeneReport for Unigene cluster: Hs.20447
UniProtKB/Swiss-Prot: PAK4_HUMAN, O96013Tissue specificity: Highest expression in prostate, testis and colon
SABiosciences Expression via Pathway-Focused PCR Arrays including PAK4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAK4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PAK4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAK4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAK4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAK4 |
Orthologs
for PAK4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PAK4 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PAK41 |
p21 protein (Cdc42/Rac)-activated kinase 4 |
77.17(n)
80.18(a) |
|
770462 XM_001233795.2 XP_001233796.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PAK46 |
-- |
64(a) |
1 ↔ 1 |
GL343755.1(60259-83986) |
African clawed frog
(Xenopus laevis) |
Amphibia |
PAK52 |
PAK5 protein |
76.73(n) |
|
AJ277826.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
pak41 |
p21 protein (Cdc42/Rac)-activated kinase 4 |
67.12(n)
72.73(a) |
|
431769 NM_001002222.1 NP_001002222.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mbt3 |
protein amino acid phosphorylation protein
serine/threonine more |
78(a)
(best of 2) |
|
14F2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C45B11.1a3 |
serine/threonine kinase (PAK/STE20
subfamily) |
48(a)
(best of 2) |
|
V(11039350-11042917) -- |
ENSEMBL Gene Tree for PAK4 (if available)
TreeFam Gene Tree for PAK4 (if available) |
Paralogs
for PAK4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PAK4 gene
- PAK62 PAK32 PAK12 PAK72 PAK22
18/118 SIMAP similar genes for PAK4 using alignment to 6 protein entries: PAK4_HUMAN (see all proteins)
(see all similar genes):PAK2 PAK7 PAK1 PAK3 STK3 TNIK
PAK6 MAP4K3 MINK1 MAP4K4 STK25 DKFZp686J1430
MAP4K1 MST4 NRK MAP4K5 STK24 TAOK3
PAK4 for paralogs About GeneDecksing
|
Genomic Variants
for PAK4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PAK4 (39616420 - 39670046 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PAK4
1 CNV: 102839
2 Indels: 67542 45770 | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing PAK4: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAK4 |
|
Disorders
/ Diseases
for PAK4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PAK4 for disorders About GeneDecksing
OMIM gene information: 605451
OMIM disorders: --
20  diseases for PAK4: About MalaCardsoral squamous cell carcinoma adenofibroma squamous cell carcinoma renal cell carcinoma
gallbladder cancer breast adenoma parkinson's disease choriocarcinoma
hepatocellular carcinoma ovarian cancer gastric cancer pharyngitis
carcinoma pancreatic cancer prostate cancer breast cancer
pancreatitis adenoma pneumonia prostatitis
1 disease from the University of Copenhagen DISEASES database for PAK4:Breast adenoma 3 Novoseek disease relationships for PAK4 gene About this table
Human Genome Epidemiology (HuGE) Navigator: PAK4 (2 documents)
Export disorders for PAK4 gene to outside databases
|
Publications
for PAK4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PAK4 gene, integrated from 9 sources (see all 90):
(articles sorted by number of sources associating them with PAK4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. (PubMed id 9822598)1, 2, 3, 9 Abo A.... Minden A. (1998)
- P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. (PubMed id 12356872)1, 2, 9 Zhang H....Stromblad S. (2002)
- PAK4 mediates morphological changes through the regulation of GEF-H1. (PubMed id 15827085)1, 2, 9 Callow M.G....Smeal T. (2005)
- Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)1, 2, 9 Soosairajah J.... Bernard O. (2005)
- p21-activated kinase 4 phosphorylation of integrin be ta5 Ser-759 and Ser-762 regulates cell migration. (PubMed id 20507994)1, 2 Li Z....StrAPmblad S. (2010)
- Cdc42 regulates apical junction formation in human br onchial epithelial cells through PAK4 and Par6B. (PubMed id 20631255)1, 2 Wallace S.W....Hall A. (2010)
- Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis. (PubMed id 20805321)1, 2 Bompard G.... Morin N. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
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External Searches for PAK4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PAK4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PAK4 gene
(According to HUGE)
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Specialized Databases showing PAK4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for PAK4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PAK4 gene:
Search GeneIP for patents involving PAK4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PAK4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for PAK4 | | OriGene shRNA RFP for PAK4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAK4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAK4 | | | OriGene Protein Over-expression Lysate for PAK4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PAK4 | | OriGene 3'-UTR Clone for PAK4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAK4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAK4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PAK4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PAK4 | | OriGene Custom Protein Services for PAK4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PAK4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAK4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAK4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAK4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAK4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAK4 |
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| | Antibodies & Assays for PAK4 |
| | | | Search Tocris compounds for PAK4 |
| |  |  |  |  | | | | | | Recombinant Protein for PAK4 |
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 | | | PAK4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAK4 |
|  |  |  | | | | ThermoFisher Antibody for PAK4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAK4 |
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