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Aliases for PAK4 Gene

Aliases for PAK4 Gene

  • P21 Protein (Cdc42/Rac)-Activated Kinase 4 2 3
  • P21(CDKN1A)-Activated Kinase 4 2 3
  • P21-Activated Kinase 4 3 4
  • EC 2.7.11.1 4 63
  • PAK-4 3 4
  • Protein Kinase Related To S. Cerevisiae STE20, Effector For Cdc42Hs 3
  • Serine/Threonine-Protein Kinase PAK 4 3
  • EC 2.7.11 63
  • KIAA1142 4

External Ids for PAK4 Gene

Previous GeneCards Identifiers for PAK4 Gene

  • GC19P040228
  • GC19P040007
  • GC19P044292
  • GC19P044308
  • GC19P044274
  • GC19P039616
  • GC19P036064

Summaries for PAK4 Gene

Entrez Gene Summary for PAK4 Gene

  • PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAK4 Gene

PAK4 (P21 Protein (Cdc42/Rac)-Activated Kinase 4) is a Protein Coding gene. Diseases associated with PAK4 include breast adenoma. Among its related pathways are RhoGDI Pathway and Ras signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is PAK1.

UniProtKB/Swiss-Prot for PAK4 Gene

  • Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

Gene Wiki entry for PAK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK4 Gene

Genomics for PAK4 Gene

Regulatory Elements for PAK4 Gene

Genomic Location for PAK4 Gene

Start:
39,125,770 bp from pter
End:
39,182,816 bp from pter
Size:
57,047 bases
Orientation:
Plus strand

Genomic View for PAK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAK4 Gene

Proteins for PAK4 Gene

  • Protein details for PAK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96013-PAK4_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 4
    Protein Accession:
    O96013
    Secondary Accessions:
    • B4DGG6
    • Q8N4E1
    • Q8NCH5
    • Q8NDE3
    • Q9BU33
    • Q9ULS8

    Protein attributes for PAK4 Gene

    Size:
    591 amino acids
    Molecular mass:
    64072 Da
    Quaternary structure:
    • Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1.
    SequenceCaution:
    • Sequence=BAA86456.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11166.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PAK4 Gene

    Alternative splice isoforms for PAK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAK4 Gene

Proteomics data for PAK4 Gene at MOPED

Post-translational modifications for PAK4 Gene

  • Autophosphorylated on serine residues when activated by CDC42/p21.
  • Phosphorylated on tyrosine residues upon stimulation of FGFR2.
  • Ubiquitination at Lys31
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PAK4 (PAK4)

Protein Products

Domains for PAK4 Gene

Gene Families for PAK4 Gene

Graphical View of Domain Structure for InterPro Entry

O96013

UniProtKB/Swiss-Prot:

PAK4_HUMAN :
  • O96013
Domain:
  • Contains 1 CRIB domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with PAK4: view

Function for PAK4 Gene

Molecular function for PAK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

Enzyme Numbers (IUBMB) for PAK4 Gene

Gene Ontology (GO) - Molecular Function for PAK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity NAS 9822598
GO:0004674 protein serine/threonine kinase activity --
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 20936779
genes like me logo Genes that share ontologies with PAK4: view
genes like me logo Genes that share phenotypes with PAK4: view

Animal Models for PAK4 Gene

MGI Knock Outs for PAK4:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAK4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PAK4 Gene

Localization for PAK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK4 Gene

Cytoplasm. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAK4 Gene COMPARTMENTS Subcellular localization image for PAK4 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PAK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 9822598
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PAK4: view

Pathways for PAK4 Gene

genes like me logo Genes that share pathways with PAK4: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PAK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 NOT mitotic cell cycle IBA --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process TAS 20070256
GO:0006928 movement of cell or subcellular component TAS 9822598
GO:0007010 cytoskeleton organization TAS 20070256
genes like me logo Genes that share ontologies with PAK4: view

Compounds for PAK4 Gene

Compound Products

(1) ApexBio Compounds for PAK4 Gene

Compound Action Cas Number
PF-3758309 PAK4 inhibitor [898044-15-0]

(3) HMDB Compounds for PAK4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for PAK4 Gene

Compound -log(P) Hits PubMed IDs
threonine 58.4 2
serine 48.8 3
genes like me logo Genes that share compounds with PAK4: view

Transcripts for PAK4 Gene

Unigene Clusters for PAK4 Gene

P21 protein (Cdc42/Rac)-activated kinase 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAK4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAK4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13:
SP14:

Relevant External Links for PAK4 Gene

GeneLoc Exon Structure for
PAK4
ECgene alternative splicing isoforms for
PAK4

Expression for PAK4 Gene

mRNA expression in normal human tissues for PAK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PAK4 Gene

This gene is overexpressed in Breast (52.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAK4 Gene

SOURCE GeneReport for Unigene cluster for PAK4 Gene Hs.20447

mRNA Expression by UniProt/SwissProt for PAK4 Gene

O96013-PAK4_HUMAN
Tissue specificity: Highest expression in prostate, testis and colon
genes like me logo Genes that share expressions with PAK4: view

Expression partners for PAK4 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PAK4 Gene

Orthologs for PAK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAK4 35
  • 91 (n)
  • 94.4 (a)
PAK4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAK4 35
  • 91.4 (n)
  • 95.59 (a)
PAK4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pak4 35
  • 86.67 (n)
  • 93.22 (a)
Pak4 16
Pak4 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pak4 35
  • 86.89 (n)
  • 93.22 (a)
oppossum
(Monodelphis domestica)
Mammalia PAK4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia PAK4 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAK4 35
  • 76.62 (n)
  • 80.3 (a)
PAK4 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAK4 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pak4 35
  • 65.98 (n)
  • 75.86 (a)
Str.17438 35
African clawed frog
(Xenopus laevis)
Amphibia PAK5 35
zebrafish
(Danio rerio)
Actinopterygii pak4 35
  • 67.43 (n)
  • 72.46 (a)
pak4 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mbt 37
  • 78 (a)
Pak3 37
  • 48 (a)
mbt 35
  • 66.44 (n)
  • 68.76 (a)
mbt 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C45B11.1a 37
  • 48 (a)
C45B11.1b 37
  • 48 (a)
pak-2 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE20 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10829 36
  • 42 (a)
OneToMany
Species with no ortholog for PAK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAK4 Gene

ENSEMBL:
Gene Tree for PAK4 (if available)
TreeFam:
Gene Tree for PAK4 (if available)

Paralogs for PAK4 Gene

Paralogs for PAK4 Gene

genes like me logo Genes that share paralogs with PAK4: view

Variants for PAK4 Gene

Sequence variations from dbSNP and Humsavar for PAK4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11122 -- 39,179,347(-) GGCTG(C/G)GGCTG utr-variant-3-prime
rs13228 -- 39,179,002(+) CAGCC(C/T)GCAAG utr-variant-3-prime
rs471217 -- 39,131,545(+) CCATC(C/T)GGGGC intron-variant
rs474724 -- 39,128,280(+) GCTGC(C/T)GCTGC intron-variant
rs476713 -- 39,154,945(+) GGTGG(A/G)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAK4 Gene

Variant ID Type Subtype PubMed ID
nsv458571 CNV Gain 19166990
nsv833829 CNV Loss 17160897
esv2674613 CNV Deletion 23128226
esv26259 CNV Loss 19812545
esv2545161 CNV Deletion 19546169
esv2008944 CNV Deletion 18987734
esv2665610 CNV Deletion 23128226
esv2718547 CNV Deletion 23290073
esv2369247 CNV Deletion 18987734
esv2718548 CNV Deletion 23290073
esv2718549 CNV Deletion 23290073

Relevant External Links for PAK4 Gene

HapMap Linkage Disequilibrium report
PAK4

PCR Panel Products

  • Copy Number PCR Panels: for PAK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK4 Gene

Disorders for PAK4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PAK4 Gene in MalaCards »

(1) Diseases for PAK4 Gene including...

(1) University of Copenhagen DISEASES for PAK4 Gene

(3) Novoseek inferred disease relationships for PAK4 Gene

Disease -log(P) Hits PubMed IDs
tumors 20.2 8
cancer 5.49 8
necrosis 0 4

Relevant External Links for PAK4

Genetic Association Database (GAD)
PAK4
Human Genome Epidemiology (HuGE) Navigator
PAK4
genes like me logo Genes that share disorders with PAK4: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PAK4 Gene

Publications for PAK4 Gene

  1. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. (PMID: 9822598) Abo A. … Minden A. (EMBO J. 1998) 2 3 4 23
  2. P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. (PMID: 12356872) Zhang H. … Stromblad S. (J. Cell Biol. 2002) 3 4 23
  3. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PMID: 15660133) Soosairajah J. … Bernard O. (EMBO J. 2005) 3 4 23
  4. PAK4 mediates morphological changes through the regulation of GEF- H1. (PMID: 15827085) Callow M.G. … Smeal T. (J. Cell Sci. 2005) 3 4 23
  5. PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor. (PMID: 16227624) Li X. … Minden A. (J. Biol. Chem. 2005) 3 23

Products for PAK4 Gene

  • Addgene plasmids for PAK4

Sources for PAK4 Gene

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