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PAK2 Gene

protein-coding   GIFtS: 69
GCID: GC03P196466

P21 Protein (Cdc42/Rac)-Activated Kinase 2

(Previous name: p21 (CDKN1A)-activated kinase 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
P21 Protein (Cdc42/Rac)-Activated Kinase 21 2     EC 2.7.11.13 8
S6/H4 Kinase1 2 3     PAKgamma2
PAK652 3 5     gamma-PAK2
P21 (CDKN1A)-Activated Kinase 21 2     Serine/Threonine-Protein Kinase PAK 22
PAK-22 3     Gamma-PAK3
P21-Activated Kinase 22 3     EC 2.7.118
p582 3     

External Ids:    HGNC: 85911   Entrez Gene: 50622   Ensembl: ENSG000001803707   OMIM: 6050225   UniProtKB: Q131773   

Export aliases for PAK2 gene to outside databases

Previous GC identifers: GC15P018867 GC03P196858 GC03P197874 GC03P197793 GC03P197955 GC03P193763


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PAK2 Gene:
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and
nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small
GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The
protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play
a role in regulating the apoptotic events in the dying cell. (provided by RefSeq, Jul 2008)

GeneCards Summary for PAK2 Gene:
PAK2 (p21 protein (Cdc42/Rac)-activated kinase 2) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and identical protein binding. An important paralog of this gene is PAK6.

UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177
Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including
cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream
effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a
conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.
Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the
downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and
plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone
H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally,
associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control
during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of
PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular
apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular
translation

Gene Wiki entry for PAK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAK2 gene promoter:
         GR   AML1a   HTF   POU6F1 (c2)   YY1   FAC1   HSF2   Chx10   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAK2 promoter sequence
   Search Chromatin IP Primers for PAK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

PAK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAK2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P196466:  view genomic region     (about GC identifiers)

Start:
196,466,728 bp from pter      End:
196,559,518 bp from pter
Size:
92,791 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase PAK 2  
Size: 524 amino acids; 58043 Da
Subunit: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts
with and activated by HIV-1 Nef. Interacts with SCRIB. Interacts with ARHGEF7 and GIT1. PAK-2p34 interacts with
ARHGAP10
1 PDB 3D structure from and Proteopedia for PAK2:
3PCS (3D)    
Secondary accessions: Q13154 Q6ISC3

Explore the universe of human proteins at neXtProt for PAK2: NX_Q13177

Explore proteomics data for PAK2 at MOPED

Post-translational modifications: 

  • Full length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27
    and PAK-2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on
    threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and
    is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate1
  • During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p341
  • Ubiquitinated, leading to its proteasomal degradation1
  • PAK-2p34 is myristoylated1
  • Ubiquitination2 at Lys113, Lys136, Lys278, Lys399, Lys468
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PAK2 (Q13177) (see all 27)
     DFGFCAQ  NEILVMK  EGEPPYL  QPKKELI 


    See PAK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002568.2  
    ENSEMBL proteins: 
     ENSP00000314067   ENSP00000402927  
    Reactome Protein details: Q13177

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    Novus Biologicals PAK2 Proteins
    Novus Biologicals PAK2 Lysates
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    Cloud-Clone Corp. Proteins for PAK2

     
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    Abcam antibodies for PAK2 (Q13153, Q13177, O75914)
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    LSBio Antibodies in human, mouse, rat for PAK2

    PAK2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: p21 protein (Cdc42/Rac)-activated kinase 2
    PAKA subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q13177

    ProtoNet protein and cluster: Q13177

    1 Blocks protein domain: IPB000095 PAK-box/P21-Rho-binding

    UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PAK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAK2_HUMAN, Q13177
    Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including
    cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream
    effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a
    conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.
    Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the
    downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and
    plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone
    H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally,
    associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control
    during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of
    PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular
    apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular
    translation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory
    region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase
    domain to adopt an active structure (By similarity). Following caspase cleavage, autophosphorylated PAK-2p34 is
    constitutively active

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10748018
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10607567
         
    Find genes that share ontologies with PAK2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PAK2:
     Decreased 12E8 tau but not tot  Decreased substrate adherent c  Increased cell death HMECs cel  Increased cell number in G1, s 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Pak2):
     cellular  embryogenesis  growth/size/body  hematopoietic system  mortality/aging 
     nervous system 

    Find genes that share phenotypes with PAK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pak2tm1Rjak for PAK2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAK2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAK2

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    Block miRNA regulation of human, mouse, rat PAK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAK2 (see all 79):
    hsa-miR-411* hsa-miR-3194-5p hsa-miR-520e hsa-miR-15a hsa-miR-218-1* hsa-miR-519a hsa-miR-642b hsa-miR-3148
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAK2_HUMAN, Q13177: Serine/threonine-protein kinase PAK 2: Cytoplasm. Note=MYO18A mediates the cellular
    distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane
    PAK2_HUMAN, Q13177: PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction
    with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes
    PAK-2p34 location to the membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with PAK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAK2 About   (see all 53)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Stimulation of the cell death response by PAK-2p340.00
    FAS pathway and Stress induction of HSP regulation0.44
    2Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    VEGF - VEGF R2 Signaling Pathways0.35
    3Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    4Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50


    Find genes that share SuperPaths with PAK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for PAK2
        VEGF - VEGF R2 Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PAK2 (see all 36)
        Paxillin Interactions
    JNK Pathway
    PDGF Pathway
    Tec Kinases Signaling
    TNFR1 Pathway

    1 Cell Signaling Technology (CST) Pathway for PAK2
        Cytoskeletal Signaling

    5 GeneGo (Thomson Reuters) Pathways for PAK2
        Development VEGF signaling via VEGFR2 - generic cascades
    Apoptosis and survival FAS signaling cascades
    Immune response Fc epsilon RI pathway
    G-protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes

    Selected BioSystems Pathways for PAK2 (see all 11)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    FAS pathway and Stress induction of HSP regulation
    Regulation of Actin Cytoskeleton

    1 Sino Biological Pathway for PAK2
        TGF-beta Signaling Pathway

    Selected Reactome Pathways for PAK2 (see all 9)
        FCERI mediated MAPK activation
    CD28 dependent Vav1 pathway
    Activation of Rac
    Nef and signal transduction
    Regulation of PAK-2p34 activity by PS-GAP/RHG10


    Selected Kegg Pathways  (Kegg details for PAK2) (see all 8):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Axon guidance
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PAK2: 
              TNF Ligands & Receptors in human mouse rat
              Focal Adhesions in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PAK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PAK2 (Q131771, 2, 3 ENSP000003140674) via UniProtKB, MINT, STRING, and/or I2D (see all 347)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF7Q141551, 2, 3, ENSP000003648934EBI-1045887,EBI-717515 MINT-7147251 MINT-7147308 MINT-2792166 MINT-2792798 I2D: score=3 STRING: ENSP00000364893
    SORBS3O605041, 2, 3, ENSP000002401234EBI-1045887,EBI-741237 MINT-2792855 MINT-2792242 I2D: score=3 STRING: ENSP00000240123
    GRB2P629931, 2, 3, ENSP000003390074EBI-1045887,EBI-401755 MINT-2792147 MINT-2792931 I2D: score=2 STRING: ENSP00000339007
    HCKP086311, 2, 3, ENSP000003650124EBI-1045887,EBI-346340 MINT-2792038 MINT-2792779 I2D: score=2 STRING: ENSP00000365012
    SORBS1Q9BX661, 2, 3, ENSP000003551364EBI-1045887,EBI-433642 MINT-2792264 MINT-2792874 I2D: score=2 STRING: ENSP00000355136
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278NOT mitotic cell cycle IBA--
    GO:0006468protein phosphorylation IDA11805089
    GO:0006469negative regulation of protein kinase activity TAS10748018
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--

    Find genes that share ontologies with PAK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for PAK2

    1 HMDB Compound for PAK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for PAK2 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp 600125 59.1 1 17131386 (1)
    threonine 55.6 3 9693111 (1), 19628037 (1), 16867995 (1)
    serine 44.8 6 16718496 (2), 19628037 (1), 16867995 (1), 10748018 (1)
    rose bengal 39 1 10998365 (1)
    curcumin 35.5 4 14505349 (1), 16624471 (1), 15095415 (1)
    tyrosine 31.6 21 12215529 (5), 11121037 (2), 15292195 (1), 15908432 (1) (see all 8)
    alpha tocopherol 28.2 2 10998365 (1), 9989786 (1)
    sphingosine 23.2 8 11684097 (3), 11345898 (1)
    phosphoinositide 21.2 1 10531298 (1)
    saponins 20.7 2 10047984 (1), 10748018 (1)



    Find genes that share compounds with PAK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PAK2 gene: 
    NM_002577.4  

    Unigene Cluster for PAK2:

    P21 protein (Cdc42/Rac)-activated kinase 2
    Hs.518530  [show with all ESTs]
    Unigene Representative Sequence: NM_002577
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327134(uc003fwy.4) ENST00000481344 ENST00000426668
    miRNA
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    hsa-miR-411* hsa-miR-3194-5p hsa-miR-520e hsa-miR-15a hsa-miR-218-1* hsa-miR-519a hsa-miR-642b hsa-miR-3148
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    eBioscience FlowRNA Probe Sets ( VA1-12254) for PAK2 

    Additional mRNA sequence: 

    AK291339.1 BC031667.1 BC046197.2 BC063539.1 BC069613.1 DQ786200.1 U25975.1 

    21 DOTS entries:

    DT.95277844  DT.92450523  DT.99974345  DT.75117060  DT.91788405  DT.97792643  DT.100824650  DT.101960572 
    DT.86835945  DT.91785574  DT.92450517  DT.92450532  DT.95216865  DT.95277845  DT.97808984  DT.100699230 
    DT.100723254  DT.100824652  DT.121053025  DT.95239182  DT.97855397 

    Selected AceView cDNA sequences (see all 372):

    BQ100927 AA367467 CD722577 AW008765 H99770 BE503920 BM841591 AI088894 
    AA552526 AW841831 AW129776 AA999820 AI684598 BE466366 AW337613 CD644040 
    BC046197 BM670792 BM698698 AI094113 BU685000 CB112829 BX505703 BX426469 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PAK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PAK2 Expression
    About this image


    PAK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    PAK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518530

    UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177
    Tissue specificity: Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PAK2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PAK2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pak21 , 5 p21 protein (Cdc42/Rac)-activated kinase 21, 5 89.69(n)1
    97.14(a)1
      16 (22.40 cM)5
    2241051  NM_177326.31  NP_796300.11 
     320162905 
    chicken
    (Gallus gallus)
    Aves PAK21 p21 protein (Cdc42/Rac)-activated kinase 2 82.82(n)
    93.46(a)
      424860  XM_004936995.1  XP_004937052.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAK26
    p21 protein (Cdc42/Rac)-activated kinase 2
    86(a)
    1 ↔ 1
    3(30846625-30863195)
    African clawed frog
    (Xenopus laevis)
    Amphibia PAK22 p21 activated kinase 2 80.99(n)    AJ242726.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pak2a1 p21 (CDKN1A)-activated kinase 2a 75.89(n)
    87.91(a)
      266749  NM_001002717.1  NP_001002717.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pak3 axon guidance protein serine/threonine
    kinase
    79(a)
    (best of 2)
      3 83E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y38F1A.103 Eukaryotic protein kinase domain 57(a)
    (best of 3)
      II(13015261-13020425)   --


    ENSEMBL Gene Tree for PAK2 (if available)
    TreeFam Gene Tree for PAK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAK2 gene
    PAK62  PAK32  PAK72  PAK12  PAK42  
    Selected SIMAP similar genes for PAK2 using alignment to 3 protein entries:     PAK2_HUMAN (see all proteins) (see all similar genes):
    PAK1    PAK3    PAK4    STK25    PAK7    OXSR1
    DKFZp686J1430    STK24    MAP4K5    MST4    MAP4K3    TAOK3
    MST094    STK3    MINK1    MAP3K2    MAP4K1    MAPK8

    Find genes that share paralogs with PAK2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PAK2
    PGOHUM00000246635


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAK2 (see all 2507)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs76270901,2
    C,F,A,H--196320390(+) agaccG/Caggtt 1 -- us2k111Minor allele frequency- C:0.21EA NS WA NA CSA 668
    rs1815852421,2
    --196320461(+) GCCTGA/GGACCA 1 -- us2k10--------
    rs1133171921,2
    C--196320617(+) TAGGGT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1400075231,2
    --196320809(+) GCTTAC/GCACTC 1 -- us2k10--------
    rs781844621,2
    C--196320838(+) TCAGGG/TTGAGT 1 -- us2k10--------
    rs777196171,2
    C--196320842(+) GTTGAG/TTGTGA 1 -- us2k10--------
    rs16196461,2
    C,F,H--196320906(+) tgaaaC/Ggatgt 1 -- us2k121Minor allele frequency- G:0.17EA NS NA WA CSA 1729
    rs1498120421,2
    C--196321018(+) ACTGCA/CTCAAT 1 -- us2k10--------
    rs1866804641,2
    --196321041(+) TCTACA/GTTGAT 1 -- us2k10--------
    rs786083791,2
    F--196321272(+) GTAGTG/CTTTTC 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for PAK2 (196466728 - 196559518 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PAK2 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2102177CNV Deletion18987734
    esv2678966CNV Deletion23128226
    esv2726593CNV Deletion23290073
    esv2726592CNV Deletion23290073
    esv2670483CNV Deletion23128226
    esv1008888CNV Insertion20482838
    nsv4184CNV Insertion18451855
    nsv508979CNV Insertion20534489
    nsv878190CNV Loss21882294
    esv999373CNV Loss20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605022    OMIM disorders: --


    Find genes that share disorders with PAK2           About GenesLikeMe

    8 Novoseek inferred disease relationships for PAK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 34.9 14 11160719 (2), 17881449 (1), 18094167 (1), 16407193 (1) (see all 7)
    virus infection 0 1 16501114 (1)
    necrosis 0 3 9624143 (1), 11278362 (1), 12853446 (1)
    shock 0 7 9717744 (3), 9989786 (2)
    aids 0 1 17881449 (1)
    tumors 0 9 19289088 (3), 9624143 (1), 12853446 (1), 11278362 (1)
    carcinoma 0 2 15095415 (1), 10797567 (1)
    cancer 0 1 15072767 (1)

    Genetic Association Database (GAD): PAK2
    Human Genome Epidemiology (HuGE) Navigator: PAK2 (12 documents)

    Export disorders for PAK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAK2 gene, integrated from 10 sources (see all 227):
    (articles sorted by number of sources associating them with PAK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. (PubMed id 7744004)1, 2, 3 Martin G.A.... Abo A. (EMBO J. 1995)
    2. Lentivirus Nef specifically activates Pak2. (PubMed id 11070003)1, 2, 9 Arora V.K.... Garcia J.V. (J. Virol. 2000)
    3. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. (PubMed id 15234964)1, 2, 9 Orton K.C.... Traugh J.A. (J. Biol. Chem. 2004)
    4. Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation. (PubMed id 12853446)1, 2, 9 Jakobi R.... Stringer D.K. (J. Biol. Chem. 2003)
    5. Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. (PubMed id 15471851)1, 2, 9 Koeppel M.A.... Jakobi R. (J. Biol. Chem. 2004)
    6. Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. (PubMed id 9786869)1, 2, 9 Walter B.N.... Traugh J.A. (J. Biol. Chem. 1998)
    7. Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration. (PubMed id 19923322)1, 2, 9 Hsu R.M.... Yu J.S. (Mol. Biol. Cell 2010)
    8. Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. (PubMed id 16617111)1, 2, 9 Vilas G.L....Berthiaume L.G. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    9. Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation. (PubMed id 7673144)1, 2, 9 Benner G.E.... Masaracchia R.A. (J. Biol. Chem. 1995)
    10. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PubMed id 21724829)1, 2 Kang B....Zhang Z. (Genes Dev. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5062 HGNC: 8591 AceView: PAK2 Ensembl:ENSG00000180370 euGenes: HUgn5062
    ECgene: PAK2 Kegg: 5062 H-InvDB: PAK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PAK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PAK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PAK2 gene:
    Search GeneIP for patents involving PAK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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