PAK2 Gene
protein-coding GIFtS: 66
GCID: GC03P196466
|
|
p21 protein (Cdc42/Rac)-activated kinase 2(Previous name: p21 (CDKN1A)-activated kinase 2 )
| |
Aliases
for PAK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| P21 Protein (Cdc42/Rac)-Activated Kinase 21 2 | | S6/H4 Kinase2 3 | | PAK651 2 3 5 | | EC 2.7.11.13 8 | | PAKgamma1 2 | | Gamma-PAK3 | | P21 (CDKN1A)-Activated Kinase 21 2 | | Serine/Threonine-Protein Kinase PAK 22 | | PAK-22 3 | | Gamma-PAK3 | | P21-Activated Kinase 22 3 | | EC 2.7.118 | | P581 | | |
Export aliases for PAK2 gene to outside databasesPrevious GC identifers: GC15P018867 GC03P196858 GC03P197874 GC03P197793 GC03P197955 GC03P193763 |
Summaries
for PAK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PAK2:
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclearsignaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP bindingproteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded bythis gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulatingthe apoptotic events in the dying cell. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways includingcytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstreameffector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in aconformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-lengthPAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targetMAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role inEGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to performkinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimulisuch as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment thattranslocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activatedPAK2 phosphorylates MKNK1 and reduces cellular translation
Gene Wiki entry for PAK2
|
Genomic Views
for PAK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_029928.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PAK2 gene promoter:
GR AML1a HTF POU6F1 (c2) YY1 FAC1 HSF2 Chx10 STAT3 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for PAK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29PAK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P196466: view genomic region
(about GC identifiers)
Start:
|
196,466,728 bp from pter |
End:
|
196,559,518 bp from pter |
Size:
|
92,791 bases |
Orientation:
|
plus strand |
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Proteins
for PAK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase PAK 2 Size: 524 amino acids; 58043 Da
Subunit: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts withand activated by HIV-1 Nef. Interacts with SCRIB. Interacts with ARHGEF7 and GIT1. PAK-2p34 interacts with ARHGAP10
Subcellular location: Serine/threonine-protein kinase PAK 2: Cytoplasm. Note=MYO18A mediates the cellular distributionof the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane
Subcellular location: PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction withARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34location to the membrane
1 PDB 3D structure from  and Proteopedia  for PAK2:3PCS (3D)
Secondary accessions: Q13154 Q6ISC3Explore the universe of human proteins at neXtProt for PAK2: NX_Q13177
Post-translational modifications:
Full length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 andPAK-2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonineresidues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent onphosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate1
During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p341
Ubiquitinated, leading to its proteasomal degradation1
PAK-2p34 is myristoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13177
4/27 DME Specific Peptides for PAK2 (Q13177) (see all 27)
PAK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002568.2
ENSEMBL proteins: ENSP00000314067 ENSP00000402927 Reactome Protein details: Q13177
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
PAK2 for ontologies About GeneDecksing
PAK2 Antibody Products:
Assay Products for PAK2: |
Protein
Domains /
Families
for PAK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PAK2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13177ProtoNet protein and cluster: Q13177 1 Blocks protein family: IPB000095 PAK-box/P21-Rho-binding
UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 CRIB domainSimilarity: Contains 1 protein kinase domain |
Function
for PAK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways includingcytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstreameffector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in aconformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-lengthPAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targetMAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role inEGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to performkinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimulisuch as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment thattranslocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activatedPAK2 phosphorylates MKNK1 and reduces cellular translationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatoryregion releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domainto adopt an active structure (By similarity). Following caspase cleavage, autophosphorylated PAK-2p34 isconstitutively activeEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PAK2 (NM_002577) | |  | Sino Biological Human cDNA Clone for PAK2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAK2 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
PAK2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for PAK2:
Animal Models:
Mouse knock-out Pak2tm1Rjak for PAK2
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Pak2):
PAK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PAK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/53 super-pathways (see all 53) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling_RAC1 in cellular process | | | 2 | Integrin Pathway | | | 3 | Ubiquitinated Orc1 is degraded by the proteasome | | | 4 | Immune response Fc epsilon RI pathway | | | 5 | CD28 co-stimulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for PAK2
1  R&D Systems Pathway for PAK2
5/36 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PAK2 (see all 36)
1 
Cell Signaling Technology (CST) Pathway for PAK2
5  GeneGo (Thomson Reuters) Pathways for PAK2
5/11  BioSystems Pathways for PAK2 (see all 11)
5/26 
Reactome Pathways for PAK2 (see all 26)
5/7 
Kegg Pathways (Kegg details for PAK2) (see all 7):
PAK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PAK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/203 Interacting proteins for PAK2 (Q131771, 2, 3 ENSP000003140674) via UniProtKB, MINT, STRING, and/or I2D (see all 203)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ARHGEF7 | Q141552, 3, ENSP000003648934 | MINT-7147251 MINT-7147308 MINT-2792166 MINT-2792798 I2D:
score=3 STRING: ENSP00000364893 | | ARHGEF6 | Q150522, 3, ENSP000002506174 | MINT-2792185 MINT-2792817 I2D:
score=4 STRING: ENSP00000250617 | | SORBS3 | O605042, 3, ENSP000002401234 | MINT-2792855 MINT-2792242 I2D:
score=3 STRING: ENSP00000240123 | | HCK | P086312, 3, ENSP000003650124 | MINT-2792038 MINT-2792779 I2D:
score=2 STRING: ENSP00000365012 | | LIMK1 | P536671, 3, ENSP000003367404 | EBI-1045887,EBI-444403 I2D:
score=3 STRING: ENSP00000336740 |
About this table
Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table
PAK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PAK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PAK2 for compounds About GeneDecksing
 Browse Tocris compounds for PAK2
1 HMDB Compound for PAK2 About this table
10/21 Novoseek chemical compound relationships for PAK2 gene (see all 21) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sp 600125 |
59.1 |
1 |
17131386 (1) |
| threonine |
55.6 |
3 |
9693111 (1), 19628037 (1), 16867995 (1) |
| serine |
44.8 |
6 |
16718496 (2), 19628037 (1), 16867995 (1), 10748018 (1) |
| rose bengal |
39 |
1 |
10998365 (1) |
| curcumin |
35.5 |
4 |
14505349 (1), 16624471 (1), 15095415 (1) |
| tyrosine |
31.6 |
21 |
12215529 (5), 11121037 (2), 15292195 (1), 15908432 (1) (see all 8) |
| alpha tocopherol |
28.2 |
2 |
10998365 (1), 9989786 (1) |
| sphingosine |
23.2 |
8 |
11684097 (3), 11345898 (1) |
| phosphoinositide |
21.2 |
1 |
10531298 (1) |
| saponins |
20.7 |
2 |
10047984 (1), 10748018 (1) |
Search CenterWatch for drugs/clinical trials and news about PAK2
|
Transcripts
for PAK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PAK2 gene: NM_002577.4 Unigene Cluster for PAK2: P21 protein (Cdc42/Rac)-activated kinase 2 Hs.518530 [show with all ESTs]Unigene Representative Sequence: NM_0025774 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000327134(uc003fwy.4) ENST00000488224 ENST00000481344 ENST00000426668
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PAK2 (NM_002577) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAK2 |
Additional cDNA sequence: AK291339.1 BC031667.1 BC046197.2 BC063539.1 BC069613.1 DQ786200.1 U25975.1 21 DOTS entries: DT.95277844 DT.92450523 DT.99974345 DT.75117060 DT.91788405 DT.97792643 DT.100824650 DT.101960572 DT.86835945 DT.91785574 DT.92450517 DT.92450532 DT.95216865 DT.95277845 DT.97808984 DT.97855397 DT.100699230 DT.100723254 DT.100824652 DT.121053025 DT.95239182 24/372 AceView cDNA sequences (see all 372): BU155009 CB216717 NM_002577 AU131426 AA262968 BQ946107 AI359584 AI903926 BM829142 D79035 AA505056 CD722577 AA382549 AL710101 BE047085 BE857179 BU189597 AA992535 BX505834 CR600384 AW673916 AI536775 BM698698 CD644040
GeneLoc Exon Structure
|
Expression
for PAK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PAK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PAK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PAK2
SOURCE GeneReport for Unigene cluster: Hs.518530
UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177Tissue specificity: Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen
SABiosciences Expression via Pathway-Focused PCR Arrays including PAK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PAK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAK2 |
Orthologs
for PAK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PAK2 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PAK21 |
p21 protein (Cdc42/Rac)-activated kinase 2 |
82.82(n)
93.46(a) |
|
424860 XM_422671.2 XP_422671.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PAK26 |
-- |
85(a) |
1 ↔ 1 |
3(30846625-30863195) |
African clawed frog
(Xenopus laevis) |
Amphibia |
PAK22 |
p21 activated kinase 2 |
80.99(n) |
|
AJ242726.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
pak2a1 |
p21 (CDKN1A)-activated kinase 2a |
76.5(n)
88.87(a) |
|
266749 NM_001002717.1 NP_001002717.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pak3 |
axon guidance protein serine/threonine
kinase |
79(a)
(best of 2) |
|
3 83E4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y38F1A.103 |
Eukaryotic protein kinase domain |
57(a)
(best of 3) |
|
II(13015261-13020425) -- |
ENSEMBL Gene Tree for PAK2 (if available)
TreeFam Gene Tree for PAK2 (if available) |
Paralogs
for PAK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PAK2 gene
- PAK62 PAK32 PAK72 PAK12 PAK42
18/88 SIMAP similar genes for PAK2 using alignment to 3 protein entries: PAK2_HUMAN (see all proteins)
(see all similar genes):PAK1 PAK3 PAK4 STK25 PAK7 OXSR1
DKFZp686J1430 STK24 MAP4K5 MST4 MAP4K3 TAOK3
MST094 STK3 MINK1 MAP3K2 MAP4K1 MAPK8
PAK2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PAK2
PGOHUM00000246635
|
Genomic Variants
for PAK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PAK2 (196466728 - 196559518 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for PAK2
12 CNVs: 80110 91838 80108 80109 32555 4369 91837 31139 91839 80111 68559 68558
1 Indel: 46380
2 Inversions: 37243 0568 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAK2 |
|
Disorders
/ Diseases
for PAK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PAK2 for disorders About GeneDecksing
OMIM gene information: 605022
OMIM disorders: --
14  diseases for PAK2: About MalaCardsrenal cell carcinoma hepatitis c papilloma alzheimer's disease
pharyngitis immunodeficiency prostate cancer breast cancer
hepatitis carcinoma prostatitis schizophrenia
neuronitis hiv type 1
8 Novoseek disease relationships for PAK2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| immunodeficiency |
34.9 |
14 |
11160719 (2), 17881449 (1), 18094167 (1), 16407193 (1) (see all 7) |
| virus infection |
0 |
1 |
16501114 (1) |
| necrosis |
0 |
3 |
9624143 (1), 11278362 (1), 12853446 (1) |
| shock |
0 |
7 |
9717744 (3), 9989786 (2) |
| aids |
0 |
1 |
17881449 (1) |
| tumors |
0 |
9 |
19289088 (3), 9624143 (1), 12853446 (1), 11278362 (1) |
| carcinoma |
0 |
2 |
15095415 (1), 10797567 (1) |
| cancer |
0 |
1 |
15072767 (1) |
Human Genome Epidemiology (HuGE) Navigator: PAK2 (12 documents)
Export disorders for PAK2 gene to outside databases
|
Publications
for PAK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PAK2 gene, integrated from 9 sources (see all 216):
(articles sorted by number of sources associating them with PAK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. (PubMed id 7744004)1, 2, 3 Martin G.A.... Abo A. (1995)
- Lentivirus Nef specifically activates Pak2. (PubMed id 11070003)1, 2, 9 Arora V.K.... Garcia J.V. (2000)
- Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. (PubMed id 15234964)1, 2, 9 Orton K.C....Traugh J.A. (2004)
- Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation. (PubMed id 12853446)1, 2, 9 Jakobi R.... Stringer D.K. (2003)
- Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. (PubMed id 15471851)1, 2, 9 Koeppel M.A.... Jakobi R. (2004)
- Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. (PubMed id 9786869)1, 2, 9 Walter B.N.... Traugh J.A. (1998)
- Identification of MYO18A as a novel interacting partn er of the PAK2/betaPIX/GIT1 complex and its potential function in modulating ep ithelial cell migration. (PubMed id 19923322)1, 2, 9 Hsu R.M....Yu J.S. (2010)
- Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. (PubMed id 16617111)1, 2, 9 Vilas G.L....Berthiaume L.G. (2006)
- Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation. (PubMed id 7673144)1, 2, 9 Benner G.E.... Masaracchia R.A. (1995)
- Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PubMed id 21724829)1, 2 Kang B....Zhang Z. (2011)
|
External Searches for PAK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing PAK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing PAK2 gene
(According to HUGE)
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| -- |
Specialized Databases showing PAK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for PAK2 gene:
Search GeneIP for patents involving PAK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PAK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for PAK2 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAK2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PAK2 | | OriGene 3'-UTR Clone for PAK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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