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PAK2 Gene

protein-coding GIFtS: 63

GC03P197955

p21 protein (Cdc42/Rac)-activated kinase 2
(Previous name: p21 (CDKN1A)-activated kinase 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.1 ^³
Gamma-PAK ^³
PAK-2 ^³
PAK65 ^¹, ², ³, ⁵
PAKgamma ^¹, ²
p58 ^³

Descriptions
S6/H4 kinase ^², ³
p21 (CDKN1A)-activated kinase 2 ^¹, ²
p21 protein (Cdc42/Rac)-activated kinase 2 ^²
p21-activated kinase 2 ^², ³

External Ids
HGNC: 8591¹
Entrez Gene: 5062²
UniProtKB: Q13177³
Ensembl: ENSG00000180370⁷

Search outside databases for aliases for PAK2 gene

Previous GC identifers: GC15P018867 GC03P196858 GC03P197874 GC03P197793

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAK2:

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton

reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases

that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated

in a wide range of biological activities. The protein encoded by this gene is activated by

proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the

apoptotic events in the dying cell. [provided by RefSeq]

UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177

Function: The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6,

histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth.

The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD.

Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK

signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form

Gene Wiki entry for PAK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PAK2 gene

Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29

PAK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P197955: (about GC identifiers)

Start:	197,951,312 bp from pter
End:	198,043,756 bp from pter
Size:	92,445 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_029928.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase PAK 2

Size: 524 amino acids; 58043 Da

Subunit: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with

SH3MD4. Interacts with and activated by HIV-1 Nef. PAK-2p34 interacts with ARHGAP10

Subcellular location: Serine/threonine-protein kinase PAK 2: Cytoplasm

Subcellular location: PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor.

Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear

region. Myristoylation changes PAK-2p34 location to the membrane

Secondary accessions: Q13154 Q6ISC3

Post-translational modifications:

Full length PAK 2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both

peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated, with PAK-2p27 being

phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of

PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402,

because PAK-2p27 is acting as an exogenous substrate¹

During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active

PAK-2p34¹

Ubiquitinated, leading to its proteosomal degradation¹

PAK-2p34 is myristoylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002568.2

ENSEMBL proteins:

ENSP00000314067

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PAK2
	Millipore Purified and/or Recombinant PAK2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PAK2
	Recombinant Proteins from Abcam (PAK1 + PAK2 + PAK3, PAK1 + PAK2, PAK2)
	Human Recombinant Proteins from Abnova (PAK2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	15234964
GO:0016020	membrane	IEA	--

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Antibodies for PAK2:

	Invitrogen Antibodies for PAK2
	Millipore Mono- and Polyclonal Antibodies for the study of PAK2
	Sigma-Aldrich Antibodies for PAK2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PAK2
	Antibodies from Abcam (PAK1 + PAK2 + PAK3, PAK1 + PAK2, PAK2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for PAK2

Assays for PAK2:

	Invitrogen Assays for PAK2
	Millipore Kits and Assays for the Analysis of PAK2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13177

ProtoNet protein and cluster: Q13177

1 Blocks protein family: IPB000095 PAK-box/P21-Rho-binding

UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20

subfamily

Similarity: Contains 1 CRIB domain

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAK2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAK2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002577

Applied Biosystems Silencer® siRNAs for PAK2

Sigma-Aldrich siRNA and siRNA Panels for PAK2

Sigma-Aldrich shRNA Panels and shRNA for PAK2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PAK2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002577
untagged cDNA clone in CMV expression vector: XM_039354

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002577

UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177

Function: The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6,

histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth.

The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD.

Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK

signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the

autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of

Thr-402 and allows the kinase domain to adopt an active structure (By similarity). Following

caspase cleavage, autophosphorylted PAK-2p34 is constitutively active

Enzyme Number (IUBMB): EC 2.7.11.1

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IDA	11805089
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--
GO:0042802	identical protein binding	IPI	16837009

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/20 Sigma-Aldrich "Your Favorite Gene" Pathways for PAK2 (Your Favorite Gene powered by Ingenuity) (see all 20 )

Nicotinate and Nicotinamide Metabolism
Inositol Phosphate Metabolism
Agrin Interactions at Neuromuscular Junction
Molecular Mechanisms of Cancer
GNRH Signaling

GeneDecks PAK2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PAK2

5/118 Interacting proteins for PAK2 (ENSP00000314067³ Q13177^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 118 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LIMK1	P53667¹	STRING (score=.925) EBI-1045887, EBI-444403
RAF1	P04049¹	STRING (score=.926) EBI-1045887, EBI-365996
GIT1	Q9Y2X7¹	EBI-1045887, EBI-466061
GIT2	Q14161¹	EBI-1045887, EBI-1046878
MCM3	P25205¹	EBI-1045887, EBI-355153

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006469	negative regulation of protein kinase activity	TAS	10748018
GO:0006915	apoptosis	IEA	--
GO:0007165	signal transduction	TAS	7744004
GO:0040008	regulation of growth	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAK2
10/14 Novoseek chemical compound relationships for PAK2 gene (see all 14 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	55.61	2	9693111 (1), 16867995 (1)
sp 600125	49.38	1	17131386 (1)
rose bengal	39.90	1	10998365 (1)
tyrosine	33.70	21	12215529 (5), 11121037 (2), 15292195 (1), 15908432 (1) (see all 8)
sphingosine	25.50	8	11684097 (3), 11345898 (1)
phosphoinositide	23.51	1	10531298 (1)
saponins	23.22	2	10047984 (1), 10748018 (1)
wortmannin	16.96	2	10531298 (1), 16188976 (1)
gtp	16.19	1	9535855 (1)
atp	10.05	7	18984590 (2), 12549935 (1), 10047984 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAK2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAK2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002577

Sigma-Aldrich siRNA and siRNA Panels for PAK2

Sigma-Aldrich shRNA Panels and shRNA for PAK2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002577

REFSEQ mRNAs for PAK2 gene:

NM_002577.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002577

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002577
untagged cDNA clone in CMV expression vector: XM_039354

Additional cDNA sequence:

AK291339.1 BC031667.1 BC046197.2 BC063539.1 BC069613.1 CR600384.1 CR620221.1 CR624656.1

DQ786200.1 U25975.1

21 DOTS entries:

DT.95277844 DT.92450523 DT.75117060 DT.99974345 DT.91788405 DT.92450517 DT.97792643 DT.100723254

DT.100824650 DT.101960572 DT.86835945 DT.91785574 DT.92450532 DT.95216865 DT.95277845 DT.97808984

DT.97855397 DT.100699230 DT.100824652 DT.121053025 DT.95239182

24/372 AceView cDNA sequences (see all 372 ):

BQ424929 AW575807 AI140979 BE047085 AA262968 BM698698 CD644040 AA999820

AI918910 BM670792 AW673916 AW337613 BM541651 AU131426 AI190809 BX505834

BE466478 BM829142 AA992535 AA552526 BU685000 AI080323 CD722577 BE503920

highest scoring ESTs for PAK2:

N25547 U25975 W74494 AA004735 AA127227 AA127228 AA195194 AA195310 AA236312 AA262968

Unigene Cluster for PAK2:

P21 protein (Cdc42/Rac)-activated kinase 2

Hs.518530 [show with all ESTs]

Unigene Representative Sequence: NM_002577

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000327134

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAK2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAK2

¹ / ² / ³

19 probe-sets matching PAK2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1559_at²^{, 3}	U95-A	1	1.00	1.00	0.31	0.35	U24153	0.80	1.00	0.91	1
55663_at²^{, 3}	U95-B	1	1.00	1.00	0.75	1.57	W74494	1.00	1.00	1.00	1
1245_i_at²^{, 3}	U95-A	2	1.00	0.67	0.38	0.74	U25975	1.00	1.00	1.00	1
34329_at²^{, 3}	U95-A	3	1.00	0.65	0.66	1.18	N25547	1.00	1.00	1.00	1
1560_g_at²^{, 3}	U95-A	3	1.00	0.52	0.87	0.54	U24153	0.80	1.00	0.91	1
82375_at²^{, 3}	U95-D	1	0.81	1.00	0.83	1.72	AA287921	0.20	0.50	0.38	1
208877_at²^{, 3}	U133-A	1	1.00	1.00	--	--	W74494	1.00	1.00	1.00	1
205962_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002577	0.60	1.00	0.82	1
208878_s_at²^{, 3}	U133-A	2	1.00	0.82	--	--	AF092132	0.80	1.00	0.91	1
208875_s_at²^{, 3}	U133-A	2	1.00	0.68	--	--	BF796470	0.80	1.00	0.91	1
208876_s_at²^{, 3}	U133-A	3	1.00	0.67	--	--	AI076186	0.60	1.00	0.82	1
236283_x_at²^{, 3}	U133-B	1	0.55	1.00	--	--	AA287921	0.20	0.50	0.38	1
208877_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205962_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208878_s_at²	U133Plus2	2	1.00	0.82	--	--	--	--	--	--	--
208875_s_at²	U133Plus2	2	1.00	0.68	--	--	--	--	--	--	--
208876_s_at²	U133Plus2	3	1.00	0.67	--	--	--	--	--	--	--
1559052_s_at²	U133Plus2	2	1.00	0.55	--	--	--	--	--	--	--
236283_x_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.518530
Expression variation in blood from EXPOLDB for PAK2
UniProtKB/Swiss-Prot: PAK2_HUMAN, Q13177
Tissue specificity: Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus
and spleen

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAK2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PAK2¹	--	p21 protein (Cdc42/Rac)-activated kinase 2	91.03(n) 94.08(a)	612814 XM_853851.1 XP_858944.1
chimpanzee (Pan troglodytes)	PAK2¹	--	p21 protein (Cdc42/Rac)-activated kinase 2	98.15(n) 98.28(a)	460965 XM_001165217.1 XP_001165217.1
rat (Rattus norvegicus)	Pak2¹	--	p21 (CDKN1A)-activated kinase 2	89.25(n) 96.56(a)	29432 NM_053306.2 NP_445758.2
mouse (Mus musculus)	Pak2^{1, 5}	16 (21.20 cM)⁵	p21 protein (Cdc42/Rac)-activated kinase 2⁵ p21 (CDKN1A)-activated kinase 2¹	89.69(n)¹ 97.14(a)¹	224105¹ NM_177326.2¹ NP_796300.1¹ AI646056⁵ AI836325⁵ (see all 22)
chicken (Gallus gallus)	PAK2¹	--	p21 (CDKN1A)-activated kinase 2	81.67(n) 91.73(a)	424860 XM_001232773.1 XP_001232774.1

About this table Species with no ortholog for PAK2

ENSEMBL Gene Tree for PAK2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PAK2 gene

PAK3² PAK1²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/710 NCBI SNPs in PAK2 are shown (see all 710 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 133)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs9109^1,2	A,C,F,H	198041240(+)	`GGAGTA/GGGTGT`	1	--	ut3¹		6		MN EU EA WA	784
--	rs15614^1,2	C,F,H,O	198043346(+)	`GAAGAA/GGCAAG`	1	--	ut3¹ trp³		10		MN EU EA WA	1210
--	rs1619646^1,2	C,F,H	197949667(+)	`tgaaaC/Ggatgt`	1	--	ng5¹		4		EU EA WA	418
	rs9222^1,2	A,F,H	198040880(+)	`AAATCG/AACTGT`	1	--	ut3¹		4		MN EU WA	612
--	rs1129168^1,2	C,F	198041206(+)	`CCTCTT/CCTTCT`	1	--	ut3¹ trp³		1		MN	184
--	rs3662^1,2	A,C	198039840(+)	`AAAGAA/CAAGTA`	1	--	ut3¹ ese³		0	--	--	--	--
	rs1046714^1,2	C,H	198031725(+)	`CAGAGG/TTGGTT`	1	V/L	mis¹ ese³		9		MN EU EA WA	996
	rs1052100^1,2	A,C	198042725(+)	`GAAGCA/GTAAGA`	1	--	ut3¹ ese³		1		MN	184
	rs1046745^1,2	F,H	198040538(+)	`GCTTTA/GTGACT`	1	--	ut3¹		5		MN EU EA WA	600
	rs1718408^1,2	C,F	197950901(-)	`CAGGTT/CTCTGC`	1	--	ng5¹		1		MN	184

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HapMap Linkage Disequilibrium images for PAK2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605022

8 Novoseek disease relationships for PAK2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	29.54	14	11160719 (2), 17881449 (1), 18094167 (1), 16407193 (1) (see all 7)
necrosis	0.00	3	9624143 (1), 11278362 (1), 12853446 (1)
shock	0.00	7	9717744 (3), 9989786 (2)
cancer	0.00	1	15072767 (1)
carcinoma	0.00	2	15095415 (1), 10797567 (1)
aids	0.00	1	17881449 (1)
tumors	0.00	9	19289088 (3), 9624143 (1), 12853446 (1), 11278362 (1)
virus infection	0.00	1	16501114 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/154 PubMed articles for PAK2 gene (see all 154 ):

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. (PubMed id 7744004)^{2, 3, 4} Martin G.A.... Abo A. (1995)
Lentivirus Nef specifically activates Pak2. (PubMed id 11070003)^{1, 3, 4} Arora V.K.... Garcia J.V. (2000)
Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation. (PubMed id 12853446)^{1, 3, 4} Jakobi R.... Stringer D.K. (2003)
Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. (PubMed id 15471851)^{1, 3, 4} Koeppel M.A.... Jakobi R. (2004)
Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. (PubMed id 9786869)^{1, 3, 4} Walter B.N.... Traugh J.A. (1998)
Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. (PubMed id 16617111)^{1, 3, 4} Vilas G.L....Berthiaume L.G. (2006)
Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation. (PubMed id 7673144)^{1, 3, 4} Benner G.E.... Masaracchia R.A. (1995)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5062	HGNC: 8591	AceView: PAK2	Ensembl:ENSG00000180370	euGenes: HUgn5062
ECgene: PAK2	H-InvDB: PAK2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PAK2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PAK2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PAK2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAK2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAK2		Antibodies for PAK2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PAK2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PAK2)
	Search for Antibodies
	Chimera RNAi (PAK2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for PAK2

	Recombinant Proteins (PAK1 + PAK2 + PAK3, PAK1 + PAK2, PAK2)
	Antibodies (PAK1 + PAK2 + PAK3, PAK1 + PAK2, PAK2)

Search OriGene for PAK2

Search Tocris compounds for PAK2

	Proteins for PAK2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PAK2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PAK2 Gene at Home site.
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PAK2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for PAK2

Summaries
for PAK2

Genomic Location
for PAK2

Proteins
for PAK2

Protein Domains/
Families
for PAK2

Gene Function
for PAK2

Pathways & Interactions
for PAK2

Drugs & Compounds
for PAK2

Transcripts
for PAK2

Expression
for PAK2

Orthologs
for PAK2

Paralogs
for PAK2

SNPs/Variants
for PAK2

Disorders & Mutations
for PAK2

Medical News
for PAK2

Publications
for PAK2

Search for PAK2

Genome Databases showing PAK2

Other Databases showing PAK2

Specialized Databases showing PAK2

Licensable Technologies
for PAK2

Services
for PAK2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAK2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor PAK2

Summariesfor PAK2

Genomic Locationfor PAK2

Proteinsfor PAK2

Protein Domains/Familiesfor PAK2

Gene Functionfor PAK2

Pathways & Interactionsfor PAK2

Drugs & Compoundsfor PAK2

Transcriptsfor PAK2

Expression for PAK2

Orthologsfor PAK2

Paralogsfor PAK2

SNPs/Variantsfor PAK2

Disorders & Mutationsfor PAK2

Medical Newsfor PAK2

Publicationsfor PAK2

Search for PAK2

Genome Databases showing PAK2

Other Databases showing PAK2

Specialized Databases showing PAK2

Licensable Technologiesfor PAK2

Servicesfor PAK2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAK2

Summaries
for PAK2

Genomic Location
for PAK2

Proteins
for PAK2

Protein Domains/
Families
for PAK2

Gene Function
for PAK2

Pathways & Interactions
for PAK2

Drugs & Compounds
for PAK2

Transcripts
for PAK2

Expression
for PAK2

Orthologs
for PAK2

Paralogs
for PAK2

SNPs/Variants
for PAK2

Disorders & Mutations
for PAK2

Medical News
for PAK2

Publications
for PAK2

Licensable Technologies
for PAK2

Services
for PAK2