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Aliases for PAK2 Gene

Aliases for PAK2 Gene

  • P21 (RAC1) Activated Kinase 2 2 3 5
  • S6/H4 Kinase 2 3 4
  • P21 Protein (Cdc42/Rac)-Activated Kinase 2 2 3
  • P21 (CDKN1A)-Activated Kinase 2 2 3
  • P21-Activated Kinase 2 3 4
  • EC 2.7.11.1 4 61
  • Gamma-PAK 3 4
  • PAK-2 3 4
  • PAK65 3 4
  • P58 3 4
  • Serine/Threonine-Protein Kinase PAK 2 3
  • EC 2.7.11 61
  • PAKgamma 3

External Ids for PAK2 Gene

Previous GeneCards Identifiers for PAK2 Gene

  • GC15P018867
  • GC03P196858
  • GC03P197874
  • GC03P197793
  • GC03P197955
  • GC03P196466
  • GC03P193763

Summaries for PAK2 Gene

Entrez Gene Summary for PAK2 Gene

  • The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAK2 Gene

PAK2 (P21 (RAC1) Activated Kinase 2) is a Protein Coding gene. Diseases associated with PAK2 include Hiv-1. Among its related pathways are RET signaling and CD28 co-stimulation. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is PAK3.

UniProtKB/Swiss-Prot for PAK2 Gene

  • Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.

Gene Wiki entry for PAK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK2 Gene

Genomics for PAK2 Gene

Regulatory Elements for PAK2 Gene

Enhancers for PAK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F196908 0.4 FANTOM5 8.2 +169.1 169115 0.2 PAK2 CEP19 PIGX UBXN7 SENP5 RNF168 ENSG00000230732 GC03M196873
GH03F196813 0.2 ENCODE 6.8 +74.3 74321 1.1 BCOR ATF1 TAL1 JUN NCOR1 FOS NR2F6 SMARCA5 SMARCE1 NR2F1 PAK2 PIR61186 RNU6-42P GC03M196785
GH03F196739 0.5 ENCODE 6.2 +1.0 1024 3.5 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 RPL36P7 PAK2 PIGX GC03M196744
GH03F196753 0.8 Ensembl ENCODE 6.1 +14.7 14651 2.1 ELF3 ZFP64 ARID4B SIN3A DMAP1 THRB ZNF48 GATA4 GATA2 THAP11 ENSG00000260261 ENSG00000231443 LOC220729 UBXN7 RNU6-42P UBXN7-AS1 CEP19 ENSG00000230732 ENSG00000249626 PAK2
GH03F196787 0.8 ENCODE 5.9 +48.4 48380 1.4 TBL1XR1 ARNT SIN3A RAD21 NCOA1 ZEB2 MEF2D ZFP69B SMARCA4 ZNF341 PIGX PAK2 GC03M196785 RNU6-42P PIR61186
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PAK2 on UCSC Golden Path with GeneCards custom track

Promoters for PAK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001383917 943 2801 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5

Genomic Location for PAK2 Gene

Chromosome:
3
Start:
196,739,857 bp from pter
End:
196,832,647 bp from pter
Size:
92,791 bases
Orientation:
Plus strand

Genomic View for PAK2 Gene

Genes around PAK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAK2 Gene

Proteins for PAK2 Gene

  • Protein details for PAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13177-PAK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 2
    Protein Accession:
    Q13177
    Secondary Accessions:
    • Q13154
    • Q6ISC3

    Protein attributes for PAK2 Gene

    Size:
    524 amino acids
    Molecular mass:
    58043 Da
    Quaternary structure:
    • Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts with and activated by HIV-1 Nef. Interacts with SCRIB. Interacts with ARHGEF7 and GIT1. PAK-2p34 interacts with ARHGAP10.

    Three dimensional structures from OCA and Proteopedia for PAK2 Gene

neXtProt entry for PAK2 Gene

Selected DME Specific Peptides for PAK2 Gene

Q13177:
  • NEILVMK
  • QIAAVCRECLQAL
  • TGEFTGMP
  • PEQWARLLQTSNITK
  • FRDFLNRCLEMDV
  • GPKVDIW
  • NPQAVLD
  • DFGFCAQ
  • GTPYWMAPEVV
  • LQALEFLH
  • WSLGIMAIEM
  • APPVIAPRPDHTKSIYTRSVIDP
  • KLRTIVSIG
  • IHRDIKSDN
  • EGEPPYL
  • KLTDFGFCA
  • MAPEVVTR
  • KIGQGASG
  • GQEVAIK
  • NIVNFLDSYL
  • QPKKELI
  • FEHTIHVG
  • AKPLSSLTPL
  • GTPYWMAPE
  • GGSLTDV
  • KVDIWSLGIMA
  • ALYLIATNGTP

Post-translational modifications for PAK2 Gene

  • During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34.
  • Full length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate.
  • PAK-2p34 is myristoylated.
  • Ubiquitinated, leading to its proteasomal degradation.
  • Ubiquitination at Lys 136, Lys 278, and Lys 468
  • Modification sites at PhosphoSitePlus

Other Protein References for PAK2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PAK2 (PAK2)

Domains & Families for PAK2 Gene

Gene Families for PAK2 Gene

Suggested Antigen Peptide Sequences for PAK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13177

UniProtKB/Swiss-Prot:

PAK2_HUMAN :
  • Contains 1 CRIB domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 CRIB domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with PAK2: view

Function for PAK2 Gene

Molecular function for PAK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure (By similarity). Following caspase cleavage, autophosphorylated PAK-2p34 is constitutively active.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.

Enzyme Numbers (IUBMB) for PAK2 Gene

Gene Ontology (GO) - Molecular Function for PAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004672 protein kinase activity IEA,TAS 10748018
GO:0004674 protein serine/threonine kinase activity IDA,TAS --
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 10607567
genes like me logo Genes that share ontologies with PAK2: view
genes like me logo Genes that share phenotypes with PAK2: view

Animal Models for PAK2 Gene

MGI Knock Outs for PAK2:

Animal Model Products

miRNA for PAK2 Gene

miRTarBase miRNAs that target PAK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PAK2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAK2 Gene

Localization for PAK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK2 Gene

Serine/threonine-protein kinase PAK 2: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAK2 Gene COMPARTMENTS Subcellular localization image for PAK2 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 25468996
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PAK2: view

Pathways & Interactions for PAK2 Gene

genes like me logo Genes that share pathways with PAK2: view

SIGNOR curated interactions for PAK2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IBA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA,IDA 11805089
GO:0006469 negative regulation of protein kinase activity TAS 10748018
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with PAK2: view

Drugs & Compounds for PAK2 Gene

(18) Drugs for PAK2 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
FRAX597 Pharma PAK inhibitor,potent and ATP-competitive 0

(5) Additional Compounds for PAK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PAK2 Gene

Compound Action Cas Number
FRAX597 PAK inhibitor,potent and ATP-competitive 1286739-19-2
genes like me logo Genes that share compounds with PAK2: view

Transcripts for PAK2 Gene

Unigene Clusters for PAK2 Gene

P21 protein (Cdc42/Rac)-activated kinase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PAK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAK2 Gene

No ASD Table

Relevant External Links for PAK2 Gene

GeneLoc Exon Structure for
PAK2
ECgene alternative splicing isoforms for
PAK2

Expression for PAK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PAK2 Gene

This gene is overexpressed in Lymph node (7.4) and Lavage (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAK2 Gene



Protein tissue co-expression partners for PAK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PAK2 Gene:

PAK2

SOURCE GeneReport for Unigene cluster for PAK2 Gene:

Hs.518530

mRNA Expression by UniProt/SwissProt for PAK2 Gene:

Q13177-PAK2_HUMAN
Tissue specificity: Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
genes like me logo Genes that share expression patterns with PAK2: view

Primer Products

No data available for mRNA differential expression in normal tissues for PAK2 Gene

Orthologs for PAK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAK2 34 35
  • 99.24 (n)
oppossum
(Monodelphis domestica)
Mammalia PAK2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAK2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAK2 34 35
  • 93.51 (n)
cow
(Bos Taurus)
Mammalia PAK2 34 35
  • 92.43 (n)
mouse
(Mus musculus)
Mammalia Pak2 34 16 35
  • 89.69 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910732 34
  • 89.38 (n)
chicken
(Gallus gallus)
Aves PAK2 34 35
  • 82.82 (n)
lizard
(Anolis carolinensis)
Reptilia PAK2 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pak2 34
  • 78.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia PAK2 34
zebrafish
(Danio rerio)
Actinopterygii pak2b 35
  • 82 (a)
OneToMany
pak2a 34 35
  • 75.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pak 36 35
  • 79 (a)
Pak3 36
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea Y38F1A.10 36
  • 57 (a)
pak-1 35
  • 52 (a)
OneToMany
C45B11.1a 36
  • 37 (a)
C45B11.1b 36
  • 37 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03894 34
  • 59.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3720 35
  • 59 (a)
OneToMany
Species where no ortholog for PAK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAK2 Gene

ENSEMBL:
Gene Tree for PAK2 (if available)
TreeFam:
Gene Tree for PAK2 (if available)

Paralogs for PAK2 Gene

Paralogs for PAK2 Gene

Pseudogenes.org Pseudogenes for PAK2 Gene

genes like me logo Genes that share paralogs with PAK2: view

Variants for PAK2 Gene

Sequence variations from dbSNP and Humsavar for PAK2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10433651 -- 196,741,299(+) CAATA(A/G/T)AATAA intron-variant
rs10433652 -- 196,741,343(+) GAATA(A/G)TAATT intron-variant
rs10440165 -- 196,784,999(+) cttca(C/T)gaatt intron-variant
rs10446496 -- 196,819,503(+) CTCAA(A/G)AAATG intron-variant
rs10446497 -- 196,819,658(+) GGGTT(G/T)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAK2 Gene

Variant ID Type Subtype PubMed ID
dgv1445e212 CNV loss 25503493
dgv1446e212 CNV loss 25503493
dgv5035n100 CNV gain 25217958
dgv5036n100 CNV gain 25217958
dgv852n67 CNV gain 20364138
esv1008888 CNV insertion 20482838
esv2102177 CNV deletion 18987734
esv2670483 CNV deletion 23128226
esv2678966 CNV deletion 23128226
esv2763775 CNV gain+loss 21179565
esv29668 CNV gain+loss 19812545
esv3401219 CNV insertion 20981092
esv3406839 CNV duplication 20981092
esv3599293 CNV gain 21293372
esv3599294 CNV loss 21293372
esv3599295 CNV loss 21293372
esv3599296 CNV loss 21293372
esv3599297 CNV loss 21293372
esv999373 CNV loss 20482838
nsv1001045 CNV gain 25217958
nsv1003135 CNV gain 25217958
nsv1009975 CNV gain 25217958
nsv1014692 CNV gain 25217958
nsv10391 CNV gain+loss 18304495
nsv4184 CNV insertion 18451855
nsv508979 CNV insertion 20534489
nsv510945 OTHER complex 20534489
nsv515003 CNV gain 21397061
nsv829829 CNV loss 17160897

Variation tolerance for PAK2 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK2 Gene

Disorders for PAK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PAK2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PAK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAK2

Genetic Association Database (GAD)
PAK2
Human Genome Epidemiology (HuGE) Navigator
PAK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAK2
genes like me logo Genes that share disorders with PAK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAK2 Gene

Publications for PAK2 Gene

  1. Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration. (PMID: 19923322) Hsu R.M. … Yu J.S. (Mol. Biol. Cell 2010) 3 4 22 64
  2. Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. (PMID: 16617111) Vilas G.L. … Berthiaume L.G. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 22 64
  3. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. (PMID: 15234964) Orton K.C. … Traugh J.A. (J. Biol. Chem. 2004) 3 4 22 64
  4. Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. (PMID: 15471851) Koeppel M.A. … Jakobi R. (J. Biol. Chem. 2004) 3 4 22 64
  5. Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation. (PMID: 12853446) Jakobi R. … Stringer D.K. (J. Biol. Chem. 2003) 3 4 22 64

Products for PAK2 Gene

  • Addgene plasmids for PAK2

Sources for PAK2 Gene

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