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Aliases for PAK2 Gene

Aliases for PAK2 Gene

  • P21 (RAC1) Activated Kinase 2 2 3 5
  • S6/H4 Kinase 2 3 4
  • P21 Protein (Cdc42/Rac)-Activated Kinase 2 2 3
  • P21 (CDKN1A)-Activated Kinase 2 2 3
  • P21-Activated Kinase 2 3 4
  • EC 2.7.11.1 4 58
  • Gamma-PAK 3 4
  • PAK-2 3 4
  • PAK65 3 4
  • P58 3 4
  • Serine/Threonine-Protein Kinase PAK 2 3
  • EC 2.7.11 58
  • PAKgamma 3

External Ids for PAK2 Gene

Previous GeneCards Identifiers for PAK2 Gene

  • GC15P018867
  • GC03P196858
  • GC03P197874
  • GC03P197793
  • GC03P197955
  • GC03P196466
  • GC03P193763

Summaries for PAK2 Gene

Entrez Gene Summary for PAK2 Gene

  • The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAK2 Gene

PAK2 (P21 (RAC1) Activated Kinase 2) is a Protein Coding gene. Diseases associated with PAK2 include Hiv-1. Among its related pathways are Focal Adhesion and CD28 co-stimulation. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is PAK3.

UniProtKB/Swiss-Prot for PAK2 Gene

  • Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.

Gene Wiki entry for PAK2 Gene

Additional gene information for PAK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK2 Gene

Genomics for PAK2 Gene

Regulatory Elements for PAK2 Gene

Enhancers for PAK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H197351 1.4 Ensembl ENCODE dbSUPER 5.3 +613.9 613875 4 HDGF PKNOX1 FOXA2 SIN3A RCOR1 RUNX3 SMARCA5 HMG20B SREBF1 ZNF217 MELTF-AS1 PAK2 LOC101926923 GC03M197355
GH03H196739 1.1 ENCODE 6.2 +1.0 1024 3 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 UBXN7 RPL36P7 SENP5 LOC220729 ENSG00000260261 UBXN7-AS1 SDHAP1 PAK2 PIGX GC03M196744
GH03H196983 1.3 ENCODE dbSUPER 5.2 +248.0 248034 7 HDGF PKNOX1 ATF1 FOXA2 ARNT TCF12 SLC30A9 ZNF766 GATA2 ELK1 NCBP2 NCBP2-AS1 PIGZ PAK2 RPSAP69 MELTF-AS1
GH03H196753 1.1 Ensembl ENCODE 6.1 +14.7 14651 2 ELF3 ZFP64 ARID4B SIN3A DMAP1 THRB GATA2 THAP11 MXD4 ELF1 RNU6-42P CEP19 PAK2 GC03P196755 RNU4-89P
GH03H196790 1.1 Ensembl ENCODE 5.8 +52.7 52731 5 FOXA2 NFIB SIN3A BRCA1 RAD21 ZBTB40 RFX5 RCOR1 FOS SMARCA5 CEP19 SENP5 NCBP2-AS1 NCBP2 MELTF-AS1 PIGX PAK2 SDHAP1 TCTEX1D2 GC03M196785
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PAK2 on UCSC Golden Path with GeneCards custom track

Promoters for PAK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164455 644 2200 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS SP3

Genomic Location for PAK2 Gene

Chromosome:
3
Start:
196,739,857 bp from pter
End:
196,832,647 bp from pter
Size:
92,791 bases
Orientation:
Plus strand

Genomic View for PAK2 Gene

Genes around PAK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAK2 Gene

Proteins for PAK2 Gene

  • Protein details for PAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13177-PAK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 2
    Protein Accession:
    Q13177
    Secondary Accessions:
    • Q13154
    • Q6ISC3

    Protein attributes for PAK2 Gene

    Size:
    524 amino acids
    Molecular mass:
    58043 Da
    Quaternary structure:
    • Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts with and activated by HIV-1 Nef. Interacts with SCRIB. Interacts with ARHGEF7 and GIT1. PAK-2p34 interacts with ARHGAP10.

    Three dimensional structures from OCA and Proteopedia for PAK2 Gene

neXtProt entry for PAK2 Gene

Selected DME Specific Peptides for PAK2 Gene

Q13177:
  • NEILVMK
  • QIAAVCRECLQAL
  • TGEFTGMP
  • PEQWARLLQTSNITK
  • FRDFLNRCLEMDV
  • GPKVDIW
  • NPQAVLD
  • DFGFCAQ
  • GTPYWMAPEVV
  • LQALEFLH
  • WSLGIMAIEM
  • APPVIAPRPDHTKSIYTRSVIDP
  • KLRTIVSIG
  • IHRDIKSDN
  • EGEPPYL
  • KLTDFGFCA
  • MAPEVVTR
  • KIGQGASG
  • GQEVAIK
  • NIVNFLDSYL
  • QPKKELI
  • FEHTIHVG
  • AKPLSSLTPL
  • GTPYWMAPE
  • GGSLTDV
  • KVDIWSLGIMA
  • ALYLIATNGTP

Post-translational modifications for PAK2 Gene

  • During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34.
  • Full length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate.
  • PAK-2p34 is myristoylated.
  • Ubiquitinated, leading to its proteasomal degradation.
  • Ubiquitination at Lys136, Lys278, and posLast=468468
  • Modification sites at PhosphoSitePlus

Other Protein References for PAK2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PAK2 (PAK2)

Domains & Families for PAK2 Gene

Gene Families for PAK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PAK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13177

UniProtKB/Swiss-Prot:

PAK2_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with PAK2: view

Function for PAK2 Gene

Molecular function for PAK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure (By similarity). Following caspase cleavage, autophosphorylated PAK-2p34 is constitutively active.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.

Enzyme Numbers (IUBMB) for PAK2 Gene

Phenotypes From GWAS Catalog for PAK2 Gene

Gene Ontology (GO) - Molecular Function for PAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004672 protein kinase activity IEA,TAS 10748018
GO:0004674 protein serine/threonine kinase activity TAS,IEA --
GO:0005515 protein binding IPI 10607567
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PAK2: view
genes like me logo Genes that share phenotypes with PAK2: view

Animal Models for PAK2 Gene

MGI Knock Outs for PAK2:

Animal Model Products

CRISPR Products

miRNA for PAK2 Gene

miRTarBase miRNAs that target PAK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PAK2
  • Applied Biological Materials Clones for PAK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAK2 Gene

Localization for PAK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK2 Gene

Serine/threonine-protein kinase PAK 2: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAK2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 25468996
GO:0005829 cytosol TAS,IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PAK2: view

Pathways & Interactions for PAK2 Gene

genes like me logo Genes that share pathways with PAK2: view

SIGNOR curated interactions for PAK2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IDA,IEA 11805089
GO:0006469 negative regulation of protein kinase activity TAS 10748018
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 7744004
genes like me logo Genes that share ontologies with PAK2: view

Drugs & Compounds for PAK2 Gene

(18) Drugs for PAK2 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
FRAX597 Pharma PAK inhibitor,potent and ATP-competitive 0

(5) Additional Compounds for PAK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PAK2 Gene

Compound Action Cas Number
FRAX597 PAK inhibitor,potent and ATP-competitive 1286739-19-2
genes like me logo Genes that share compounds with PAK2: view

Drug Products

Transcripts for PAK2 Gene

Unigene Clusters for PAK2 Gene

P21 protein (Cdc42/Rac)-activated kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PAK2
  • Applied Biological Materials Clones for PAK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PAK2 Gene

No ASD Table

Relevant External Links for PAK2 Gene

GeneLoc Exon Structure for
PAK2
ECgene alternative splicing isoforms for
PAK2

Expression for PAK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PAK2 Gene

This gene is overexpressed in Lymph node (7.4) and Lavage (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAK2 Gene



Protein tissue co-expression partners for PAK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PAK2 Gene:

PAK2

SOURCE GeneReport for Unigene cluster for PAK2 Gene:

Hs.518530

mRNA Expression by UniProt/SwissProt for PAK2 Gene:

Q13177-PAK2_HUMAN
Tissue specificity: Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.

Evidence on tissue expression from TISSUES for PAK2 Gene

  • Blood(4.4)
  • Liver(4.3)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with PAK2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAK2 Gene

Orthologs for PAK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAK2 33 34
  • 99.24 (n)
oppossum
(Monodelphis domestica)
Mammalia PAK2 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAK2 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAK2 33 34
  • 93.51 (n)
cow
(Bos Taurus)
Mammalia PAK2 33 34
  • 92.43 (n)
mouse
(Mus musculus)
Mammalia Pak2 33 16 34
  • 89.69 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910732 33
  • 89.38 (n)
chicken
(Gallus gallus)
Aves PAK2 33 34
  • 82.82 (n)
lizard
(Anolis carolinensis)
Reptilia PAK2 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pak2 33
  • 78.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia PAK2 33
zebrafish
(Danio rerio)
Actinopterygii pak2b 34
  • 82 (a)
OneToMany
pak2a 33 34
  • 75.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pak 35 34
  • 79 (a)
Pak3 35
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea Y38F1A.10 35
  • 57 (a)
pak-1 34
  • 52 (a)
OneToMany
C45B11.1a 35
  • 37 (a)
C45B11.1b 35
  • 37 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03894 33
  • 59.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3720 34
  • 59 (a)
OneToMany
Species where no ortholog for PAK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAK2 Gene

ENSEMBL:
Gene Tree for PAK2 (if available)
TreeFam:
Gene Tree for PAK2 (if available)

Paralogs for PAK2 Gene

Paralogs for PAK2 Gene

Pseudogenes.org Pseudogenes for PAK2 Gene

genes like me logo Genes that share paralogs with PAK2: view

Variants for PAK2 Gene

Sequence variations from dbSNP and Humsavar for PAK2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000006892 -- 196,750,004(+) TTTTT(G/T)AAACA intron-variant
rs1000065325 -- 196,754,925(+) TCTGA(A/G)TCTCC intron-variant
rs1000109617 -- 196,746,561(+) TATCC(C/T)AGCAC intron-variant
rs1000118324 -- 196,740,188(+) CGGGA(C/T)GCAGG intron-variant
rs1000208072 -- 196,764,710(+) AATAG(C/T)GTCTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PAK2 Gene

Variant ID Type Subtype PubMed ID
dgv1445e212 CNV loss 25503493
dgv1446e212 CNV loss 25503493
dgv5035n100 CNV gain 25217958
dgv5036n100 CNV gain 25217958
dgv852n67 CNV gain 20364138
esv1008888 CNV insertion 20482838
esv2102177 CNV deletion 18987734
esv2670483 CNV deletion 23128226
esv2678966 CNV deletion 23128226
esv2763775 CNV gain+loss 21179565
esv29668 CNV gain+loss 19812545
esv3401219 CNV insertion 20981092
esv3406839 CNV duplication 20981092
esv3599293 CNV gain 21293372
esv3599294 CNV loss 21293372
esv3599295 CNV loss 21293372
esv3599296 CNV loss 21293372
esv3599297 CNV loss 21293372
esv999373 CNV loss 20482838
nsv1001045 CNV gain 25217958
nsv1003135 CNV gain 25217958
nsv1009975 CNV gain 25217958
nsv1014692 CNV gain 25217958
nsv10391 CNV gain+loss 18304495
nsv4184 CNV insertion 18451855
nsv508979 CNV insertion 20534489
nsv510945 OTHER complex 20534489
nsv515003 CNV gain 21397061
nsv829829 CNV loss 17160897

Variation tolerance for PAK2 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK2 Gene

Disorders for PAK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PAK2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PAK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAK2

Genetic Association Database (GAD)
PAK2
Human Genome Epidemiology (HuGE) Navigator
PAK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAK2
genes like me logo Genes that share disorders with PAK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAK2 Gene

Publications for PAK2 Gene

  1. Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration. (PMID: 19923322) Hsu RM … Yu JS (Molecular biology of the cell 2010) 3 4 22 60
  2. Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. (PMID: 16617111) Vilas GL … Berthiaume LG (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 60
  3. Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. (PMID: 15471851) Koeppel MA … Jakobi R (The Journal of biological chemistry 2004) 3 4 22 60
  4. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. (PMID: 15234964) Orton KC … Traugh JA (The Journal of biological chemistry 2004) 3 4 22 60
  5. Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation. (PMID: 12853446) Jakobi R … Stringer DK (The Journal of biological chemistry 2003) 3 4 22 60

Products for PAK2 Gene

  • Addgene plasmids for PAK2

Sources for PAK2 Gene

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