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Aliases & Descriptions for PAK1IP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ20624 1, 2 | | MAK11 1, 2 | | OTTHUMP00000016022 2 | | PIP1 1, 2, 3, 5 | | RP11-421M1.5 2 | | WDR84 1, 2, 3 | | bA421M1.5 1, 2 | | hPIP1 1, 2, 3 |
| | | Descriptions |
|---|
| PAK/PLC-interacting protein 1 2, 3 | | PAK1 interacting protein 1 2 | | PAK1-interacting protein 2 | | PAK1-interacting protein 1 3 | | WD repeat-containing protein 84 3 |
|
| | Search outside databases for aliases for PAK1IP1 genePrevious GC identifer: GC06P010757 |
Summaries for PAK1IP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: PK1IP_HUMAN, Q9NWT1Function: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42Gene Wiki entry for PAK1IP1 |
Genomic Location for PAK1IP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PAK1IP1 gene 
Entrez Gene cytogenetic band: 6p24.2 Ensembl cytogenetic band: 6p24.2 HGNC cytogenetic band: 6p24.1PAK1IP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P010803:
(about GC identifiers)
Start:
|
10,803,174 bp from pter |
End:
|
10,817,958 bp from pter |
Size:
|
14,785 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14
| Proteins for PAK1IP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PK1IP_HUMAN, Q9NWT1 (See
protein sequence)Recommended Name: p21-activated protein kinase-interacting protein 1 Size: 392 amino acids; 43964 Da
Subunit: Interacts with PAK1
Subcellular location: Nucleus, nucleolus
Secondary accessions: Q5T4J2 Q96QJ8 Q96T87Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060376.2
ENSEMBL proteins: ENSP00000368887
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: PAK1IP1 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for PAK1IP1: Assays for PAK1IP1: | Protein
Domains/ Families for PAK1IP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NWT1
ProtoNet protein and cluster: Q9NWT1 UniProtKB/Swiss-Prot: PK1IP_HUMAN, Q9NWT1Similarity: Contains 5 WD repeats | Gene Function for PAK1IP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017906
Applied Biosystems Silencer® siRNAs for PAK1IP1
Sigma-Aldrich siRNA for PAK1IP1  Sigma-Aldrich shRNA for PAK1IP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017906                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017906                                  untagged cDNA clones in CMV expression vector (see all 2): NM_017906 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_017906
UniProtKB/Swiss-Prot: PK1IP_HUMAN, Q9NWT1Function: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42 | Pathways & Interactions for PAK1IP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for PAK1IP1 
5/237 Interacting proteins for PAK1IP1 (Q9NWT12 ENSP000003688873) via UniProtKB, MINT, and/or STRING (see all 237
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009968 | negative regulation of signal transduction |
IEA | -- | About this table
|
Drugs & Compounds for PAK1IP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PAK1IP1
|
Transcripts for PAK1IP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017906
Sigma-Aldrich siRNA for PAK1IP1  Sigma-Aldrich shRNA for PAK1IP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_017906 REFSEQ mRNAs for PAK1IP1 gene: NM_017906.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_017906               OriGene GFP tagged cDNA clone in CMV expression vector: NM_017906                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017906                                  untagged cDNA clones in CMV expression vector (see all 2): NM_017906  Additional cDNA sequence: AF283303.1 AK000631.1 AK225516.1 BC010907.1 7 DOTS entries: DT.412342 DT.95168625 DT.100814008 DT.121391295 DT.86855075 DT.121391278 DT.75102633 24/127 AceView cDNA sequences (see all 127
):AW117624 BI545887 AI393969 N53359 BU181468 H62065 AI537089 AI872448 BQ226963 BU618231 CD557340 AW592352 AI141270 BE504340 BM973899 BU177530 BM756293 BU677437 AA236103 AA953892 BU629319 AA679804 AI632312 BQ216070
highest scoring ESTs for PAK1IP1:AI521868 AA126597 AA157015 AA228341 AA534957 AA564151 AA640001 AA679804 AF283303 AI141270 Unigene Cluster for PAK1IP1: PAK1 interacting protein 1 Hs.310231 [show with all ESTs]Unigene Representative Sequence: AK000631
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for PAK1IP1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for PAK1IP1
1 Ensembl transcript including schematic representation: ENST00000379568
|
Expression for PAK1IP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PAK1IP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PAK1IP1
1 / 2 / 3 3 probe-sets matching PAK1IP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAATTTTTAC
SOURCE GeneReport for Unigene cluster: Hs.310231 UniProtKB/Swiss-Prot: PK1IP_HUMAN, Q9NWT1Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus |
Orthologs for PAK1IP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PAK1IP1 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for PAK1IP1
ENSEMBL Gene Tree for PAK1IP1 | Paralogs for PAK1IP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for PAK1IP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PAK1IP1 (up to first 250kb)
|
Disorders & Mutations for PAK1IP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607811
|
Medical News for PAK1IP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PAK1IP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for PAK1IP1 gene (see all 11
):- Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1. (PubMed id 11371639)1, 2, 3, 4 Xia C.... Liu M. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)3, 4 Scherl A.... Diaz J.-J. (2002)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)3 Suzuki Y.... Sugano S. (1997)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)3 Maruyama K. and Sugano S. (1994)
|
Search for PAK1IP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PAK1IP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PAK1IP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PAK1IP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PAK1IP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PAK1IP1:

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| | | | Search Tocris compounds for PAK1IP1 |
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Incremental update: 13 Oct 2009
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