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Aliases for PAK1 Gene

Aliases for PAK1 Gene

  • P21 Protein (Cdc42/Rac)-Activated Kinase 1 2 3 5
  • P21/Cdc42/Rac1-Activated Kinase 1 (STE20 Homolog, Yeast) 2 3
  • P21/Cdc42/Rac1-Activated Kinase 1 (Yeast Ste20-Related) 2 3
  • EC 2.7.11.1 4 63
  • Alpha-PAK 3 4
  • P65-PAK 3 4
  • P21-Activated Kinase 1 4
  • STE20 Homolog, Yeast 3
  • STE20 Homolog 2
  • EC 2.7.11 63
  • PAKalpha 3
  • Yeast 2
  • PAK-1 4

External Ids for PAK1 Gene

Previous GeneCards Identifiers for PAK1 Gene

  • GC11M079360
  • GC11M078573
  • GC11M076760
  • GC11M076710
  • GC11M077033
  • GC11M073331

Summaries for PAK1 Gene

Entrez Gene Summary for PAK1 Gene

  • This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

GeneCards Summary for PAK1 Gene

PAK1 (P21 Protein (Cdc42/Rac)-Activated Kinase 1) is a Protein Coding gene. Diseases associated with PAK1 include gastric cancer and gastroesophageal junction adenocarcinoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PAK7.

UniProtKB/Swiss-Prot for PAK1 Gene

  • Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at Ser-338 and Ser-339 resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at Ser-246 promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321).

Tocris Summary for PAK1 Gene

Gene Wiki entry for PAK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK1 Gene

Genomics for PAK1 Gene

Regulatory Elements for PAK1 Gene

Promoters for PAK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAK1 Gene

Chromosome:
11
Start:
77,321,551 bp from pter
End:
77,474,635 bp from pter
Size:
153,085 bases
Orientation:
Minus strand

Genomic View for PAK1 Gene

Genes around PAK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAK1 Gene

Proteins for PAK1 Gene

  • Protein details for PAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13153-PAK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 1
    Protein Accession:
    Q13153
    Secondary Accessions:
    • O75561
    • Q13567
    • Q32M53
    • Q32M54
    • Q86W79

    Protein attributes for PAK1 Gene

    Size:
    545 amino acids
    Molecular mass:
    60647 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer in its autoinhibited state. Active as monomer. Component of cytoplasmic complexes, which also contains PXN, ARHGEF6 and GIT1. Interacts with NISCH (By similarity). Interacts with DVL1; mediates the formation of a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity). Binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. Interacts with ARHGEF7. Interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM (via cytoplasmic domain); the interaction is direct and enhanced in presence of RAC1. Interacts with SCRIB. Interacts with PDPK1. Interacts (via kinase domain) with RAF1. Interacts with NCK1 and NCK2. Interacts with TBCB. Interacts with CRIPAK. Interacts with BRSK2. Interacts with SNAI1. Interacts with CIB1 isoform 2. Interacts with CIB1 (via N-terminal region); the interaction is direct, promotes PAK1 activity and occurs in a calcium-dependent manner.

    Three dimensional structures from OCA and Proteopedia for PAK1 Gene

    Alternative splice isoforms for PAK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAK1 Gene

Proteomics data for PAK1 Gene at MOPED

Post-translational modifications for PAK1 Gene

  • Autophosphorylated in trans, meaning that in a dimer, one kinase molecule phosphorylates the other one. Activated by autophosphorylation at Thr-423 in response to a conformation change, triggered by interaction with GTP-bound CDC42 or RAC1. Activated by phosphorylation at Thr-423 by BRSK2 and by PDPK1. Phosphorylated by JAK2 in response to PRL; this increases PAK1 kinase activity. Phosphorylated at Ser-21 by PKB/AKT; this reduces interaction with NCK1 and association with focal adhesion sites.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PAK1 Gene

Gene Families for PAK1 Gene

Suggested Antigen Peptide Sequences for PAK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13153

UniProtKB/Swiss-Prot:

PAK1_HUMAN :
  • Contains 1 CRIB domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 CRIB domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with PAK1: view

Function for PAK1 Gene

Molecular function for PAK1 Gene

GENATLAS Biochemistry:
p21/Cdc42/Rac1-activated kinase 1,S cerevisiae Ste20 related,expressed in brain,downstream effector linking Rho,GTPases to actin cytoskeleton,potentially involved in the regulation of a subset of cytoskeletal dynamics initiated by chemoattractant and phagocytic stimuli in human neutrophils
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation of Thr-84 by OXSR1 inhibits activation (By similarity). Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, and enables activation by phosphorylation of Thr-423.
UniProtKB/Swiss-Prot Function:
Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at Ser-338 and Ser-339 resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at Ser-246 promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321).

Enzyme Numbers (IUBMB) for PAK1 Gene

Gene Ontology (GO) - Molecular Function for PAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 8805275
genes like me logo Genes that share ontologies with PAK1: view
genes like me logo Genes that share phenotypes with PAK1: view

Animal Models for PAK1 Gene

MGI Knock Outs for PAK1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAK1 Gene

Localization for PAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK1 Gene

Cytoplasm. Cell junction, focal adhesion. Cell membrane. Cell projection, ruffle membrane. Cell projection, invadopodium. Note=Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321). Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. {ECO:0000269 PubMed:25766321}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAK1 Gene COMPARTMENTS Subcellular localization image for PAK1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytoskeleton 2
endosome 1

Gene Ontology (GO) - Cellular Components for PAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,TAS --
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA,ISS --
GO:0031965 nuclear membrane IEA,ISS --
GO:0032587 ruffle membrane IEA --
genes like me logo Genes that share ontologies with PAK1: view

Pathways & Interactions for PAK1 Gene

genes like me logo Genes that share pathways with PAK1: view

SIGNOR curated interactions for PAK1 Gene

Gene Ontology (GO) - Biological Process for PAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 NOT MAPK cascade IDA 8805275
GO:0001666 response to hypoxia IEA --
GO:0001934 positive regulation of protein phosphorylation IMP 23633677
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA,IDA 9852149
genes like me logo Genes that share ontologies with PAK1: view

Drugs & Compounds for PAK1 Gene

(24) Drugs for PAK1 Gene - From: HMDB, Novoseek, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0
FRAX597 Pharma PAK inhibitor,potent and ATP-competitive 0
IPA-3 Pharma Non-ATP competitive Pak1 inhibitor 0
Magnesium Nutra 0

(17) Additional Compounds for PAK1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
DCA
2156-56-1
ML 202
1221186-52-2
PD 407824
622864-54-4

(5) Tocris Compounds for PAK1 Gene

Compound Action Cas Number
DCA Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor 2156-56-1
ML 202 Pyruvate kinase M2 activator 1221186-52-2
Necrostatin-1 RIPK1 inhibitor; inhibits necroptosis 4311-88-0
NH 125 CaM kinase III (eEF-2 kinase) inhibitor 278603-08-0
PD 407824 Selective inhibitor of Chk1 and Wee1 622864-54-4

(2) ApexBio Compounds for PAK1 Gene

Compound Action Cas Number
FRAX597 PAK inhibitor,potent and ATP-competitive 1286739-19-2
IPA-3 Non-ATP competitive Pak1 inhibitor 42521-82-4
genes like me logo Genes that share compounds with PAK1: view

Transcripts for PAK1 Gene

Unigene Clusters for PAK1 Gene

P21 protein (Cdc42/Rac)-activated kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAK1 Gene

No ASD Table

Relevant External Links for PAK1 Gene

GeneLoc Exon Structure for
PAK1
ECgene alternative splicing isoforms for
PAK1

Expression for PAK1 Gene

mRNA expression in normal human tissues for PAK1 Gene

mRNA differential expression in normal tissues according to GTEx for PAK1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9), Brain - Cortex (x4.5), and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for PAK1 Gene

This gene is overexpressed in Liver (17.1) and Frontal cortex (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAK1 Gene



SOURCE GeneReport for Unigene cluster for PAK1 Gene Hs.435714

mRNA Expression by UniProt/SwissProt for PAK1 Gene

Q13153-PAK1_HUMAN
Tissue specificity: Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321).
genes like me logo Genes that share expression patterns with PAK1: view

Protein tissue co-expression partners for PAK1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PAK1 Gene

Orthologs for PAK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAK1 35
  • 93.32 (n)
  • 99.26 (a)
PAK1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAK1 35
  • 93.69 (n)
  • 96.87 (a)
PAK1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pak1 35
  • 92.34 (n)
  • 99.26 (a)
Pak1 16
Pak1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAK1 35
  • 94.1 (n)
  • 93.46 (a)
PAK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pak1 35
  • 92.46 (n)
  • 99.08 (a)
oppossum
(Monodelphis domestica)
Mammalia PAK1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAK1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAK1 35
  • 82.81 (n)
  • 94.84 (a)
PAK1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAK1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7395 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
pak1 35
  • 76.22 (n)
  • 87.99 (a)
pak1 36
  • 88 (a)
OneToMany
pak1 36
  • 75 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9895 35
fruit fly
(Drosophila melanogaster)
Insecta Pak 37
  • 82 (a)
Pak3 37
  • 59 (a)
Pak 35
  • 65.35 (n)
  • 70.95 (a)
Pak 36
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002986 35
  • 63.27 (n)
  • 68.85 (a)
worm
(Caenorhabditis elegans)
Secernentea C45B11.1a 37
  • 38 (a)
C45B11.1b 37
  • 38 (a)
Y38F1A.10 37
  • 58 (a)
pak-1 35
  • 58.65 (n)
  • 62.23 (a)
pak-1 36
  • 53 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE20 35
  • 55.53 (n)
  • 55.17 (a)
STE20 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes shk1 35
  • 52.41 (n)
  • 53.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3720 36
  • 59 (a)
OneToMany
Species with no ortholog for PAK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAK1 Gene

ENSEMBL:
Gene Tree for PAK1 (if available)
TreeFam:
Gene Tree for PAK1 (if available)

Paralogs for PAK1 Gene

Paralogs for PAK1 Gene

genes like me logo Genes that share paralogs with PAK1: view

Variants for PAK1 Gene

Sequence variations from dbSNP and Humsavar for PAK1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35345144 - 77,332,738(+) TAGCA(C/G)CTCTT reference, missense
rs51500 -- 77,340,775(-) TATCT(A/G)TATTC intron-variant
rs98703 -- 77,390,839(+) GGAAG(G/T)GAAGG intron-variant
rs475376 -- 77,432,683(-) ctgtg(A/T)atata intron-variant
rs476258 -- 77,386,748(+) tctgg(A/G)tggaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAK1 Gene

Variant ID Type Subtype PubMed ID
esv2744811 CNV Deletion 23290073

Variation tolerance for PAK1 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAK1 Gene

HapMap Linkage Disequilibrium report
PAK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK1 Gene

Disorders for PAK1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PAK1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
gastroesophageal junction adenocarcinoma
  • adenocarcinoma of cardioesophageal junction
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search PAK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAK1

Genetic Association Database (GAD)
PAK1
Human Genome Epidemiology (HuGE) Navigator
PAK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAK1
genes like me logo Genes that share disorders with PAK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAK1 Gene

Publications for PAK1 Gene

  1. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. (PMID: 8805275) Brown J.L. … Chant J. (Curr. Biol. 1996) 2 3 4 67
  2. Estrogen receptor-alpha phosphorylation at serine 305, nuclear p21-activated kinase 1 expression, and response to tamoxifen in postmenopausal breast cancer. (PMID: 20179234) Bostner J. … StAYl O. (Clin. Cancer Res. 2010) 3 23
  3. LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. (PMID: 20400510) Deguchi A. … Taketo M.M. (J. Biol. Chem. 2010) 3 23
  4. p21-Activated kinase-1 promotes aggressive phenotype, cell proliferation, and invasion in gestational trophoblastic disease. (PMID: 20413688) Siu M.K. … Cheung A.N. (Am. J. Pathol. 2010) 3 23
  5. A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1. (PMID: 20417602) Say E. … Manser E. (Mol. Cell 2010) 3 23

Products for PAK1 Gene

  • Addgene plasmids for PAK1

Sources for PAK1 Gene

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