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PAK1 Gene

protein-coding GIFtS: 74

GC11M076710

p21 protein (Cdc42/Rac)-activated kinase 1
(Previous names: p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related), p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
Alpha-PAK ^³
EC 2.7.11.1 ^³
MGC130000 ^²
MGC130001 ^²
PAK-1 ^³
PAKalpha ^²
p65-PAK ^³

Descriptions
STE20 homolog, yeast ^²
p21 protein (Cdc42/Rac)-activated kinase 1 ^²
p21-activated kinase 1 ^², ³
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) ^¹, ²
p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) ^¹, ²

External Ids
HGNC: 8590¹
Entrez Gene: 5058²
UniProtKB: Q13153³
Ensembl: ENSG00000149269⁷

Search outside databases for aliases for PAK1 gene

Previous GC identifers: GC11M079360 GC11M078573 GC11M077255 GC11M076760

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAK1:

PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear

signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2,

PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac

and have been implicated in a wide range of biological activities. PAK1 regulates cell motility

and morphology. Alternativelt spliced transcript variants encoding different isoforms have been

found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: PAK1_HUMAN, Q13153

Function: The activated kinase acts on a variety of targets. Likely to be the GTPase effector that

links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved

in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of

microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing

apoptosis, potentially due to binding of CDC2L1 and CDC2L2

Gene Wiki entry for PAK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PAK1 gene

Entrez Gene cytogenetic band: 11q13-q14 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q13-q14

PAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M076710: (about GC identifiers)

Start:	76,710,708 bp from pter
End:	76,862,581 bp from pter
Size:	151,874 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033927.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PAK1_HUMAN, Q13153 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase PAK 1

Size: 545 amino acids; 60647 Da

Cofactor: Magnesium

Subunit: Homodimer in its autoinhibited state. Active as monomer. Interacts tightly with GTP-bound

but not GDP-bound CDC42/P21 and RAC1. Binds to the caspase-cleaved p110 isoform of CDC2L1 and

CDC2L2, p110C, but not the full-length proteins. Component of cytoplasmic complexes, which also

contain PXN, ARHGEF6 and GIT1. Interacts with ARHGEF7. Also interacts with CRIPAK. Interacts with

NISCH (By similarity)

Subcellular location: Cytoplasm. Cell junction, focal adhesion. Note=Recruited to focal adhesions

upon activation

PDB structures from and Proteopedia :

1F3M (3D)

1YHV (3D)

1YHW (3D)

1ZSG (3D)

2HY8 (3D)

2QME (3D)

3DVP (3D)

3FXZ (3D)

3FY0 (3D)

Secondary accessions: O75561 Q13567 Q32M53 Q32M54 Q86W79

Alternative splicing: 2 isoforms: Q13153-1 Q13153-2

Post-translational modifications:

Autophosphorylated when activated by CDC42/p21 and RAC1¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001122092.1 NP_002567.3

ENSEMBL proteins:

ENSP00000348696 ENSP00000278568

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PAK1
	Millipore Purified and/or Recombinant PAK1 Protein
	Sigma-Aldrich Proteins for PAK1
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PAK1
	Recombinant Proteins from Abcam (PAK1 + PAK2 + PAK3, PAK1, PAK1 + PAK2)
	Human Recombinant Proteins from Abnova (PAK1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	16278681
GO:0005794	Golgi apparatus	IDA	18029348
GO:0005886	plasma membrane	IDA	16278681
GO:0030054	cell junction	IEA	--

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Antibodies for PAK1:

	Invitrogen Antibodies for PAK1
	Millipore Mono- and Polyclonal Antibodies for the study of PAK1
	Sigma-Aldrich Antibody Arrays and Antibodies for PAK1
	R&D Systems Antibodies for PAK1 (PAK)
	Cell Signaling Technology (CST) Antibodies for PAK1
	Antibodies from Abcam (PAK1 + PAK2 + PAK3, PAK1, PAK1 + PAK2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PAK1)
	Novus Biologicals Antibodies for PAK1

Assays for PAK1:

	Invitrogen Assays for PAK1
	Millipore Kits and Assays for the Analysis of PAK1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13153

ProtoNet protein and cluster: Q13153

1 Blocks protein family: IPB000095 PAK-box/P21-Rho-binding

UniProtKB/Swiss-Prot: PAK1_HUMAN, Q13153

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20

subfamily

Similarity: Contains 1 CRIB domain

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAK1)
		Millipore RNAi Products for the Analysis of PAK1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PAK1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001128620

Applied Biosystems Silencer® siRNAs for PAK1

Sigma-Aldrich siRNA and siRNA Panels for PAK1

Sigma-Aldrich shRNA Panels and shRNA for PAK1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001128620
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001128620
untagged cDNA clones in CMV expression vector (see all 2): NM_001128620

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001128620

UniProtKB/Swiss-Prot: PAK1_HUMAN, Q13153

Function: The activated kinase acts on a variety of targets. Likely to be the GTPase effector that

links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved

in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of

microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing

apoptosis, potentially due to binding of CDC2L1 and CDC2L2

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the

autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of

Thr-423 and allows the kinase domain to adopt an active structure. Also activated by binding to

GTP-bound CDC42, independent of the phosphorylation state of Thr-423. Phosphorylation of Thr-84 by

OXSR1 inhibits this activation (By similarity)

Enzyme Number (IUBMB): EC 2.7.11.1

Genatlas biochemistry entry for PAK1:

p21/Cdc42/Rac1-activated kinase 1,S cerevisiae Ste20 related,expressed in brain,downstream effector

linking Rho,GTPases to actin cytoskeleton,potentially involved in the regulation of a subset of

cytoskeletal dynamics initiated by chemoattractant and phagocytic stimuli in human neutrophils

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Pak1):

immune system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	TAS	16278681
GO:0005518	collagen binding	IPI	12189148
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/26 Sigma-Aldrich "Your Favorite Gene" Pathways for PAK1 (Your Favorite Gene powered by Ingenuity) (see all 26 )

LPS-stimulated MAPK Signaling
Integrin Signaling
Axonal Guidance Signaling
Semaphorin Signaling in Neurons
Natural Killer Cell Signaling

GeneDecks PAK1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PAK1

5/109 Interacting proteins for PAK1 (ENSP00000278568³ Q13153^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 109 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC42P2	P60953¹^,²	STRING (score=.999) EBI-1307, EBI-81752 MINT-24772 MINT-14490 MINT-14030 MINT-14489
RHOU	Q7L0Q8¹	STRING (score=.961) EBI-1307, EBI-1638043
NCK1	P16333²	STRING (score=.999) MINT-16498 MINT-61476
ARHGEF7	Q14155²	STRING (score=.996) MINT-1953612
CTTN	Q14247²	STRING (score=.71) MINT-6541935
GIT1	Q9Y2X7²	STRING (score=.982) MINT-1953519

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	NOT MAPKKK cascade	IDA	8805275
GO:0006915	apoptosis	IEA	--
GO:0006984	ER-nuclear signaling pathway	TAS	16278681
GO:0007010	cytoskeleton organization	TAS	16278681
GO:0043507	positive regulation of JUN kinase activity	IMP	8805275

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for PAK1 available from Tocris Bioscience

Compound	Action	CAS number
IPA 3	Group I p21-activated kinase (PAK) inhibitor	[42521-82-4]

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10/18 Novoseek chemical compound relationships for PAK1 gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	68.54	15	18283314 (2), 10559936 (1), 9032259 (1), 9234703 (1) (see all 14)
phosphatidylinositol	42.91	14	9298982 (1), 18448666 (1), 14575865 (1), 11134074 (1) (see all 9)
sphingosine	37.59	12	9525917 (3), 10551809 (2), 11345898 (1)
gtp	37.26	4	18160398 (1), 7493928 (1), 9535855 (1), 15544329 (1)
gdp	36.42	1	14583477 (1)
guanosine	36.38	2	15514010 (1), 18006760 (1)
phosphoinositide	33.65	4	15066181 (1), 16472257 (1), 12733988 (1)
tyrosine	28.02	14	11382770 (2), 9755165 (2), 14575865 (1), 14760089 (1) (see all 8)
wortmannin	22.59	3	9298982 (1), 11438654 (1), 10496324 (1)
nadph	21.30	9	18160398 (4), 16330715 (1), 14694110 (1), 15271797 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAK1)
		Millipore RNAi Products for the Analysis of PAK1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PAK1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001128620

Sigma-Aldrich siRNA and siRNA Panels for PAK1

Sigma-Aldrich shRNA Panels and shRNA for PAK1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001128620 NM_002576

REFSEQ mRNAs for PAK1 gene (2 alternative transcripts):

NM_001128620.1 NM_002576.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001128620 NM_002576

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001128620
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001128620
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001128620

Additional cDNA sequence:

AF071884.1 AK055228.1 AK293098.1 AK295344.1 AK296006.1 BC050377.1 BC109298.1 BC109299.1

U24152.1 U51120.1

21 DOTS entries:

DT.95277840 DT.95277838 DT.91774669 DT.312772 DT.40312730 DT.95277841 DT.40114491 DT.40306989

DT.99950332 DT.99996370 DT.100702944 DT.91774656 DT.87016177 DT.91675204 DT.91931838 DT.95277819

DT.95286724 DT.97797412 DT.120705372 DT.91774663 DT.95277839

24/286 AceView cDNA sequences (see all 286 ):

AW192064 AU138249 AI189401 BG220809 BP344789 AI391481 BI054455 BM670367

AK055228 BM783494 AI307281 BQ687963 AW169475 BM766008 AA912798 AI075189

AW590160 NM_002576 AA253953 BE501896 BG680536 T17247 AL709241 BM765805

highest scoring ESTs for PAK1:

U24152 AA912798 AI307281 AI693712 AL709241 AL709860 AW015360 BE501896 BG943375 BM451179

Unigene Cluster for PAK1:

P21 protein (Cdc42/Rac)-activated kinase 1

Hs.435714 [show with all ESTs]

Unigene Representative Sequence: NM_001128620

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000356341 ENST00000278568

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PAK1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAK1

¹ / ² / ³

10 probe-sets matching PAK1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
43053_g_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.24	AW025012	0.40	1.00	0.76	1
1558_g_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.78	U24152	1.00	1.00	1.00	1
1557_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.63	U24152	1.00	1.00	1.00	1
43052_at²^{, 3}	U95-B	1	1.00	1.00	0.96	1.14	AW025012	0.40	1.00	0.76	1
60859_at²^{, 3}	U95-C	2	1.00	0.97	0.94	1.23	AI693712	0.80	1.00	0.91	1
226507_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU154408	0.60	1.00	0.82	1
209615_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U51120	0.80	1.00	0.91	1
226507_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209615_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1565772_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

GeneDecks PAK1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCTGAGGTA

SOURCE GeneReport for Unigene cluster: Hs.435714
Expression variation in blood from EXPOLDB for PAK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for PAK1 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PAK1¹	--	p21 protein (Cdc42/Rac)-activated kinase 1	93.69(n) 96.87(a)	607885 XM_844558.1 XP_849651.1
chimpanzee (Pan troglodytes)	PAK1¹	--	p21 protein (Cdc42/Rac)-activated kinase 1	95.46(n) 95.52(a)	451439 XM_508657.2 XP_508657.2
cow (Bos taurus)	PAK1¹	--	p21 protein (Cdc42/Rac)-activated kinase 1	93.32(n) 99.26(a)	533729 NM_001076898.1 NP_001070366.1
rat (Rattus norvegicus)	Pak1¹	--	p21 (CDKN1A)-activated kinase 1	92.46(n) 99.08(a)	29431 NM_017198.1 NP_058894.1
mouse (Mus musculus)	Pak1^{1, 5}	7 (46.50 cM)⁵	p21 protein (Cdc42/Rac)-activated kinase 1⁵ p21 (CDKN1A)-activated kinase 1¹	92.34(n)¹ 99.26(a)¹	18479¹ NM_011035.2¹ NP_035165.2¹ AF082077⁵ AJ133881⁵ (see all 18)

About this table Species with no ortholog for PAK1

ENSEMBL Gene Tree for PAK1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PAK1 gene

PAK3² PAK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/849 NCBI SNPs in PAK1 are shown (see all 849 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 249)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2729762^1,2	A,C,F,H,O	76711347(-)	`CCCAAT/CAGTGT`	2	--	ut3¹ ese³		8	NA EU EA WA	700
	rs7109645^1,2	A,C,F,H	76863971(+)	`CCTAAA/CTATTT`	1	--	ng3¹		5	EU EA WA	592
	rs11237200^1,2	A,C,F,H	76863650(+)	`TGCTTG/AAAATC`	1	--	ng3¹		4	EU EA WA	378
	rs11237199^1,2	A,C,F,H	76863127(+)	`TCGGTC/GCGCTG`	1	--	ng3¹		4	EU EA WA	360
	rs2844337^1,2	A,C,F,H	76711356(-)	`GGACCT/GTGACC`	2	--	ut3¹ ese³		4	EU EA WA	412
	rs35345144^1,2	C,F	76721431(+)	`TAGCAG/CCTCTT`	2	V/L	mis¹		4	EU EA WA	420
--	rs1048522^1,2	H	76744423(-)	`GACCCG/TGAATA`	2	R/L	mis¹ ese³		5	MN EU EA WA	560
	rs2729775^1,2	A,C,F,H,O	76771065(+)	`ttcccA/Gcctcc`	1	--	int¹		8	EU EA WA NA	712
	rs2853090^1,2	A,C,F,H,O	76761295(-)	`CAGAAG/AAGTGG`	1	--	int¹		8	EU EA WA NA	742
	rs2853084^1,2	A,C,F,H,O	76789966(-)	`TCAGCA/CAATTC`	1	--	int¹		6	EU EA NA	440

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HapMap Linkage Disequilibrium images for PAK1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602590

10/18 Novoseek disease relationships for PAK1 gene (see all 18 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	42.62	38	18283314 (4), 16082189 (4), 12151336 (2), 11382770 (2) (see all 22)
neurofibromatosis	25.15	2	16082189 (1), 16540233 (1)
tumors	22.45	45	17533742 (4), 16705121 (3), 18006760 (3), 12937139 (2) (see all 20)
squamous cell cancer	20.08	1	12700278 (1)
cancer	16.67	25	14760089 (4), 18922890 (3), 12700278 (2), 15000491 (1) (see all 17)
ovarian carcinoma	16.16	7	17533742 (4), 12937139 (2)
mammary tumor	13.11	3	16331248 (3)
immunodeficiency	3.57	3	14585966 (1), 11160719 (1), 14694110 (1)
breast carcinoma	3.23	3	18411304 (2), 15713627 (1)
necrosis	0.00	1	10779525 (1)

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1 PharmGKB disease relationship for PAK1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Genetic Association Database: PAK1
Human Genome Epidemiology Navigator: PAK1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/355 PubMed articles for PAK1 gene (see all 355 ):

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. (PubMed id 8805275)^{2, 3, 4} Brown J.L.... Chant J. (1996)
CRIPak, a novel endogenous Pak1 inhibitor. (PubMed id 16278681)^{1, 3, 4} Talukder A.H....Kumar R. (2006)
The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. (PubMed id 12624090)^{1, 3, 4} Chen S.... Gu J. (2003)
Differential effects of PAK1-activating mutations reveal activity- dependent and -independent effects on cytoskeletal regulation. (PubMed id 9774440)^{1, 3, 4} Frost J.A.... Cobb M.H. (1998)
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. (PubMed id 9395435)^{1, 3, 4} Sells M.A....Chernoff J. (1997)
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. (PubMed id 11804587)^{1, 3, 4} Parrini M.C.... Mayer B.J. (2002)
A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. (PubMed id 9528787)^{1, 3, 4} Zhao Z.S.... Lim L. (1998)
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. (PubMed id 10551809)^{1, 3, 4} Zenke F.T.... Bokoch G.M. (1999)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The active conformation of the PAK1 kinase domain. (PubMed id 15893667)^{3, 4} Lei M.... Harrison S.C. (2005)

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Entrez Gene: 5058	HGNC: 8590	AceView: PAK1	Ensembl:ENSG00000149269	euGenes: HUgn5058
ECgene: PAK1	H-InvDB: PAK1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for PAK1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PAK1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
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Products for PAK1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAK1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAK1		Antibodies for PAK1
	Explore super-pooled esiRNAs		Proteins for PAK1
	Lentivirus-delivered shRNAs for PAK1		Browse small molecules at Sigma-Aldrich
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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Mouse Mab
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Antibodies & Assays for PAK1

	Recombinant Proteins (PAK1 + PAK2 + PAK3, PAK1, PAK1 + PAK2)
	Antibodies (PAK1 + PAK2 + PAK3, PAK1, PAK1 + PAK2)

Search OriGene for PAK1

Tocris compounds for PAK1

	Proteins for PAK1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PAK1

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PAK1 Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for PAK1

Summaries
for PAK1

Genomic Location
for PAK1

Proteins
for PAK1

Protein Domains/
Families
for PAK1

Gene Function
for PAK1

Pathways & Interactions
for PAK1

Drugs & Compounds
for PAK1

Transcripts
for PAK1

Expression
for PAK1

Orthologs
for PAK1

Paralogs
for PAK1

SNPs/Variants
for PAK1

Disorders & Mutations
for PAK1

Medical News
for PAK1

Publications
for PAK1

Search for PAK1

Genome Databases showing PAK1

Other Databases showing PAK1

Specialized Databases showing PAK1

Licensable Technologies
for PAK1

Services
for PAK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAK1 Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor PAK1

Summariesfor PAK1

Genomic Locationfor PAK1

Proteinsfor PAK1

Protein Domains/Familiesfor PAK1

Gene Functionfor PAK1

Pathways & Interactionsfor PAK1

Drugs & Compoundsfor PAK1

Transcriptsfor PAK1

Expression for PAK1

Orthologsfor PAK1

Paralogsfor PAK1

SNPs/Variantsfor PAK1

Disorders & Mutationsfor PAK1

Medical Newsfor PAK1

Publicationsfor PAK1

Search for PAK1

Genome Databases showing PAK1

Other Databases showing PAK1

Specialized Databases showing PAK1

Licensable Technologiesfor PAK1

Servicesfor PAK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAK1

Summaries
for PAK1

Genomic Location
for PAK1

Proteins
for PAK1

Protein Domains/
Families
for PAK1

Gene Function
for PAK1

Pathways & Interactions
for PAK1

Drugs & Compounds
for PAK1

Transcripts
for PAK1

Expression
for PAK1

Orthologs
for PAK1

Paralogs
for PAK1

SNPs/Variants
for PAK1

Disorders & Mutations
for PAK1

Medical News
for PAK1

Publications
for PAK1

Licensable Technologies
for PAK1

Services
for PAK1