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PAK1 Gene

protein-coding   GIFtS: 73
GCID: GC11M077033

P21 Protein (Cdc42/Rac)-Activated Kinase 1

(Previous names: p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related),...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
P21 Protein (Cdc42/Rac)-Activated Kinase 11 2     alpha-PAK2
P21/Cdc42/Rac1-Activated Kinase 1 (STE20 Homolog, Yeast)1 2     Serine/Threonine-Protein Kinase PAK 12
P21/Cdc42/Rac1-Activated Kinase 1 (Yeast Ste20-Related)1 2     STE20 Homolog, Yeast2
p65-PAK2 3     Alpha-PAK3
EC 2.7.11.13 8     PAK-13
STE20 Homolog1     P21-Activated Kinase 13
yeast1     EC 2.7.118
PAKalpha2     

External Ids:    HGNC: 85901   Entrez Gene: 50582   Ensembl: ENSG000001492697   OMIM: 6025905   UniProtKB: Q131533   

Export aliases for PAK1 gene to outside databases

Previous GC identifers: GC11M079360 GC11M078573 GC11M077255 GC11M076760 GC11M076710 GC11M073331


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PAK1 Gene:
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These
proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and
they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates
cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Apr 2010)

GeneCards Summary for PAK1 Gene:
PAK1 (p21 protein (Cdc42/Rac)-activated kinase 1) is a protein-coding gene. Diseases associated with PAK1 include neurofibromatosis, and bladder transitional cell carcinoma. GO annotations related to this gene include protein kinase binding and identical protein binding. An important paralog of this gene is PAK6.

UniProtKB/Swiss-Prot: PAK1_HUMAN, Q13153
Function: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type
kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation,
apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects
cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links
the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and
thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton,
actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays
a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in
the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that
contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the
formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially
due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339'
resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by
RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor
activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization.
Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the
up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake
and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3,
maybe through CFL1 phosphorylation and inactivation

Gene Wiki entry for PAK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAK1 gene promoter:
         C/EBPbeta   p53   Pax-2a   Egr-4   S8   POU2F1   POU2F1a   Chx10   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PAK1 promoter sequence
   Search Chromatin IP Primers for PAK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13-q14   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q13-q14

PAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAK1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M077033:  view genomic region     (about GC identifiers)

Start:
77,032,752 bp from pter      End:
77,185,680 bp from pter
Size:
152,929 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PAK1_HUMAN, Q13153 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase PAK 1  
Size: 545 amino acids; 60647 Da
Cofactor: Magnesium
Subunit: Homodimer in its autoinhibited state. Active as monomer. Component of cytoplasmic complexes, which also
contains PXN, ARHGEF6 and GIT1. Interacts with NISCH (By similarity). Interacts with DVL1; mediates the formation
of a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity). Binds to the
caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. Interacts with
ARHGEF7. Interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. Probably found in a ternary
complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM (via cytoplasmic domain); the interaction is
direct and enhanced in presence of RAC1. Interacts with SCRIB. Interacts with PDPK1. Interacts (via kinase
domain) with RAF1. Interacts with NCK1 and NCK2. Interacts with TBCB. Interacts with CRIPAK. Interacts with
BRSK2. Interacts with SNAI1. Interacts with CIB1 isoform 2
Selected PDB 3D structures from and Proteopedia for PAK1 (see all 14):
1F3M (3D)        1YHV (3D)        1YHW (3D)        1ZSG (3D)        2HY8 (3D)        2QME (3D)    
Secondary accessions: O75561 Q13567 Q32M53 Q32M54 Q86W79
Alternative splicing: 2 isoforms:  Q13153-1   Q13153-2   

Explore the universe of human proteins at neXtProt for PAK1: NX_Q13153

Explore proteomics data for PAK1 at MOPED

Post-translational modifications: 

  • Autophosphorylated in trans, meaning that in a dimer, one kinase molecule phosphorylates the other one. Activated
    by autophosphorylation at Thr-423 in response to a conformation change, triggered by interaction with GTP-bound
    CDC42 or RAC1. Activated by phosphorylation at Thr-423 by BRSK2 and by PDPK1. Phosphorylated by JAK2 in response
    to PRL; this increases PAK1 kinase activity. Phosphorylated at Ser-21 by PKB/AKT; this reduces interaction with
    NCK1 and association with focal adhesion sites1
  • Ubiquitination2 at Lys420
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PAK1 (Q13153) (see all 34)
     EGEPPYL  VLDVLEF  NEILVMR  GQEVAIK 


    See PAK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001122092.1  NP_002567.3  

    ENSEMBL proteins: 
     ENSP00000348696   ENSP00000433423   ENSP00000278568   ENSP00000433211   ENSP00000431906  
     ENSP00000431541   ENSP00000437261   ENSP00000433518   ENSP00000432477   ENSP00000433004  
     ENSP00000435983   ENSP00000433737  
    Reactome Protein details: Q13153

    PAK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PAK1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PAK1
    OriGene Protein Over-expression Lysate for PAK1
    OriGene MassSpec for PAK1
    OriGene Custom Protein Services for PAK1
    GenScript Custom Purified and Recombinant Proteins Services for PAK1
    Novus Biologicals PAK1 Proteins
    Novus Biologicals PAK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PAK1

    PAK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PAK1
    R&D Systems Antibodies for PAK1
    Cell Signaling Technology (CST) Antibodies for PAK1 
    OriGene Antibodies for PAK1
    OriGene Custom Antibody Services for PAK1
    Novus Biologicals PAK1 Antibodies
    Abcam antibodies for PAK1 (Q13153, Q13177, O75914)
    Cloud-Clone Corp. Antibodies for PAK1
    ThermoFisher Antibody for PAK1
    LSBio Antibodies in human, mouse, rat for PAK1

    PAK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PAK1
    Browse R&D Systems for biochemical assays
    GenScript PAK1-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PAK1
    Cloud-Clone Corp. CLIAs for PAK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: p21 protein (Cdc42/Rac)-activated kinase 1
    PAKA subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q13153

    ProtoNet protein and cluster: Q13153

    1 Blocks protein domain: IPB000095 PAK-box/P21-Rho-binding

    UniProtKB/Swiss-Prot: PAK1_HUMAN, Q13153
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 protein kinase domain


    PAK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAK1_HUMAN, Q13153
    Function: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type
    kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation,
    apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects
    cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links
    the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and
    thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton,
    actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays
    a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in
    the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that
    contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the
    formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially
    due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339'
    resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by
    RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor
    activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization.
    Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the
    up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake
    and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3,
    maybe through CFL1 phosphorylation and inactivation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation of Thr-84 by OXSR1 inhibits activation (By similarity). Activated by binding
    small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the
    autoinhibited dimer, and enables activation by phosphorylation of Thr-423

         Genatlas biochemistry entry for PAK1:
    p21/Cdc42/Rac1-activated kinase 1,S cerevisiae Ste20 related,expressed in brain,downstream effector linking
    Rho,GTPases to actin cytoskeleton,potentially involved in the regulation of a subset of cytoskeletal dynamics
    initiated by chemoattractant and phagocytic stimuli in human neutrophils

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA8805275
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515contributes to protein binding IPI11950598
         
    PAK1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PAK1:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased Salmonella enterica   Increased cell death HMECs cel 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pak1):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     muscle  normal  respiratory system 

    PAK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pak1tm1Cher for PAK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PAK1:
    hsa-mir-423-5p (MIRT038058), hsa-mir-7-5p (MIRT000668), mmu-mir-465a-5p (MIRT005336), hsa-mir-377-3p (MIRT000991), hsa-mir-320a (MIRT044750), hsa-let-7b-5p (MIRT051883), hsa-mir-26b-5p (MIRT029738), hsa-mir-122-5p (MIRT023312)

    Block miRNA regulation of human, mouse, rat PAK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAK1 (see all 18):
    hsa-miR-3678-3p hsa-miR-485-5p hsa-let-7d hsa-miR-1271 hsa-let-7c hsa-miR-221 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidPAK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PAK1
    Predesigned siRNA for gene silencing in human, mouse, rat PAK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PAK1

    Clone
    Products:
         
    OriGene clones in human, mouse for PAK1 (see all 11)
    OriGene ORF clones in mouse, rat for PAK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PAK1 (NM_002576)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAK1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PAK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PAK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAK1_HUMAN, Q13153: Cytoplasm. Cell junction, focal adhesion. Cell membrane. Note=Recruited to the cell membrane
    by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    golgi apparatus4
    nucleus4
    cytoskeleton3
    endosome1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA12912914
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA16278681
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol TAS--

    PAK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAK1 About   (see all 95)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    HGF Pathway0.34
    2Immune response IL 23 signaling pathway
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Angiopoietin-TIE2 Signaling0.36
    3Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    GDNF-Family Ligands and Receptor Interactions0.41
    Development GDNF family signaling0.45
    EGF Pathway0.39
    4EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    5Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PAK1 (see all 47)
        Caspase Cascade
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for PAK1
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for PAK1 (see all 32)
        Development A2A receptor signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development EGFR signaling pathway
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response CD28 signaling

    Selected BioSystems Pathways for PAK1 (see all 32)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    EGFR1 Signaling Pathway
    FAS pathway and Stress induction of HSP regulation

    Selected Reactome Pathways for PAK1 (see all 8)
        FCERI mediated MAPK activation
    CD28 dependent Vav1 pathway
    Activation of Rac
    DSCAM interactions
    Signal transduction by L1


    Selected Kegg Pathways  (Kegg details for PAK1) (see all 13):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Chemokine signaling pathway
    Axon guidance


    PAK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PAK1 (see all 7): 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PAK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PAK1 (Q131531, 2, 3 ENSP000002785684) via UniProtKB, MINT, STRING, and/or I2D (see all 935)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SORBS2O948752, 3, ENSP000002847764MINT-61474 MINT-61475 MINT-61478 MINT-61470 MINT-61473 MINT-61471 MINT-61477 MINT-61472 I2D: score=2 STRING: ENSP00000284776
    HIST1H4AP628053, ENSP000003529804I2D: score=3 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165NOT MAPK cascade IDA8805275
    GO:0000278NOT mitotic cell cycle IBA--
    GO:0001666response to hypoxia IEA--
    GO:0001934positive regulation of protein phosphorylation IMP--
    GO:0006468protein phosphorylation IDA9852149

    PAK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PAK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (5Z)-7-OxozeaenolPotent and selective TAK1 MAPKKK inhibitor[66018-38-0]
    GSK 650394Serum- and glucocorticoid-regulated kinase (SGK) inhibitor[890842-28-1]
    IPA 3Group I p21-activated kinase (PAK) inhibitor[42521-82-4]
    CGP 57380Selective inhibitor of Mnk1[522629-08-9]
    AZ 3146Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor[1124329-14-1]

    4 HMDB Compounds for PAK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected Novoseek inferred chemical compound relationships for PAK1 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 69 18 18283314 (2), 19557173 (1), 10559936 (1), 9032259 (1) (see all 16)
    serine 58.8 17 12189148 (1), 16611744 (1), 19557173 (1), 9032259 (1) (see all 16)
    depsipeptide 47.8 6 16418572 (2), 16082189 (2), 16540233 (1)
    phosphatidylinositol 46.3 15 9298982 (1), 18448666 (1), 20154149 (1), 14575865 (1) (see all 10)
    ly294002 40.6 5 15066181 (1), 15693023 (1), 17255101 (1)
    gtp 35.5 4 18160398 (1), 7493928 (1), 9535855 (1), 15544329 (1)
    sphingosine 35.4 12 9525917 (3), 10551809 (2), 11345898 (1)
    gdp 34.4 1 14583477 (1)
    guanosine 34.3 2 15514010 (1), 18006760 (1)
    methoctramine 34.1 2 12576304 (1)



    PAK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PAK1 gene (2 alternative transcripts): 
    NM_001128620.1  NM_002576.4  

    Unigene Cluster for PAK1:

    P21 protein (Cdc42/Rac)-activated kinase 1
    Hs.435714  [show with all ESTs]
    Unigene Representative Sequence: NM_001128620
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000356341(uc010rsn.2 uc010rso.2 uc001oyg.4 uc001oyh.4)
    ENST00000530617(uc001oyi.1) ENST00000278568 ENST00000528203 ENST00000527457
    ENST00000525542 ENST00000533285 ENST00000527535 ENST00000532991 ENST00000532711
    ENST00000530358 ENST00000526103 ENST00000533468 ENST00000533568 ENST00000526910
    ENST00000529248 ENST00000524847 ENST00000528592
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-3678-3p hsa-miR-485-5p hsa-let-7d hsa-miR-1271 hsa-let-7c hsa-miR-221 hsa-let-7g hsa-let-7a
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    Additional mRNA sequence: 

    AF071884.1 AK055228.1 AK293098.1 AK295344.1 AK296006.1 BC050377.1 BC109298.1 BC109299.1 
    U24152.1 U51120.1 

    20 DOTS entries:

    DT.95277840  DT.95277838  DT.91774669  DT.312772  DT.40312730  DT.95277841  DT.40114491  DT.40306989 
    DT.99996370  DT.100702944  DT.91774656  DT.87016177  DT.95277819  DT.97797412  DT.120705372  DT.91675204 
    DT.91774663  DT.91931838  DT.95277839  DT.99950332 

    Selected AceView cDNA sequences (see all 286):

    CK821030 AI189401 BC050377 AI307281 BM783626 AK055228 BG680536 BG220809 
    BI054455 T17247 AA283977 AI075189 BM783494 AI391481 BP429631 BI793123 
    AL709241 AW590160 AW192064 BP344789 AU121294 BE702625 AI862893 BM979411 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PAK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGAGGTA
    PAK1 Expression
    About this image


    PAK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PAK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435714
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PAK1 (see all 7): 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PAK1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pak11 , 5 p21 protein (Cdc42/Rac)-activated kinase 11, 5 92.34(n)1
    99.26(a)1
      7 (53.57 cM)5
    184791  NM_011035.21  NP_035165.21 
     978429355 
    chicken
    (Gallus gallus)
    Aves PAK11 p21 protein (Cdc42/Rac)-activated kinase 1 82.81(n)
    94.84(a)
      419083  NM_001162372.2  NP_001155844.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAK16
    p21 protein (Cdc42/Rac)-activated kinase 1
    92(a)
    1 ↔ 1
    GL343337.1(900298-994845)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.73952 Transcribed sequence with strong similarity to protein more 80.56(n)    AL873802.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044138.12   -- 78(n)   373103  BC044138.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pak1 , 3 axon guidance protein serine/threonine
    kinase3
    PAK-kinase1
    82(a)
    (best of 2)3
    65.35(n)1
    70.95(a)1
      3 83E43
    440391  NM_001275384.11  NP_001262313.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y38F1A.103
    pak-11
    Eukaryotic protein kinase domain3
    pak-11
    58(a)
    (best of 3)3
    58.65(n)1
    62.23(a)1
      II(13015261-13020425)3
    1808731  NM_001029207.21  NP_001024378.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE20(YHL007C)4
    STE201
    Cdc42p-activated signal transducing kinase of the PAK more4
    STE201
    55.53(n)1
    55.17(a)1
      8(97937-95118)4
    8563821, 4  NP_011856.11, 4 


    ENSEMBL Gene Tree for PAK1 (if available)
    TreeFam Gene Tree for PAK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAK1 gene
    PAK62  PAK32  PAK72  PAK42  PAK22  
    Selected SIMAP similar genes for PAK1 using alignment to 11 protein entries:     PAK1_HUMAN (see all proteins) (see all similar genes):
    PAK2    PAK3    PAK4    PAK6    DKFZp686J1430    STK25
    MST094    STK24    STK4    MST4    MAP4K3    OXSR1
    STK3    MAP4K2    MAP4K5    MAP3K2    MAP4K1    MAPK8

    PAK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAK1 (see all 2830)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113241431,2
    C--73333210(+) ATTCCT/-TTTTT 2 -- int1 trp31Minor allele frequency- -:0.50NA 2
    rs1429819451,2
    C--73333787(+) TGTAT-/ACACACA 2 -- int10--------
    rs112929711,2
    C,F--73340815(+) TTAAA-/AGTATA 2 -- int13Minor allele frequency- A:0.33NA CSA 6
    rs596593711,2
    C--73352570(+) AAAAA-/A/AA  
            
    TCAGA
    2 -- int11NA 2
    rs354878321,2
    C--73367641(+) TTCTCAA/-AGAGA 2 -- int12Minor allele frequency- -:0.00CSA 4
    rs106666671,2
    C--73379605(+) CCTCTCT/-GTTTC 2 -- int11Minor allele frequency- -:0.50NA 2
    rs346355261,2
    C--73379607(+) GTTCC-/CT/TC 
            
    TCTGT
    2 -- int10--------
    rs352165211,2
    C--73402572(+) AAAAA-/A/AG  
            
    AGAGA
    2 -- int11NA 2
    rs350410351,2
    C,F--73418410(+) AAAAAT/-TTTTT 2 -- int14Minor allele frequency- -:0.50NA CSA 8
    rs676047131,2
    C--73431868(+) AAAAA-/A/AA  
            
    GTCAC
    2 -- int11NA 2

    HapMap Linkage Disequilibrium report for PAK1 (77032752 - 77185680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PAK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744811CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing PAK1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    SeqTarget long-range PCR primers for resequencing PAK1
    DNA2.0 Custom Variant and Variant Library Synthesis for PAK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602590    OMIM disorders: --

    Selected diseases for PAK1 (see all 53):    
    About MalaCards
    neurofibromatosis    bladder transitional cell carcinoma    orofacial cleft    transitional cell carcinoma
    adenomyosis    wiskott-aldrich syndrome    myotonic dystrophy    papilloma
    type 1 diabetes mellitus    human t-cell leukemia virus type 1    type 1 diabetes    papillary thyroid carcinoma
    esophagitis    medulloblastoma    diabetes mellitus    esophageal cancer
    down syndrome    endometriosis    esophageal squamous cell carcinoma    influenza

    1 disease from the University of Copenhagen DISEASES database for PAK1:
    Breast cancer

    PAK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for PAK1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 44.6 48 20179234 (5), 18283314 (4), 16082189 (4), 12151336 (2) (see all 25)
    cancer 24.4 25 14760089 (4), 18922890 (3), 12700278 (2), 15000491 (1) (see all 17)
    tumors 23.1 60 20179234 (4), 17533742 (4), 16705121 (3), 18006760 (3) (see all 23)
    neurofibromatosis 22.9 2 16082189 (1), 16540233 (1)
    ovarian carcinoma 21 8 17533742 (4), 12937139 (2), 20213325 (1)
    squamous cell cancer 17.6 1 12700278 (1)
    mammary tumor 10.8 3 16331248 (3)
    immunodeficiency 1.06 3 14585966 (1), 11160719 (1), 14694110 (1)
    breast carcinoma 0.803 3 18411304 (2), 15713627 (1)
    leukemia 0 1 15378030 (1)

    Genetic Association Database (GAD): PAK1
    Human Genome Epidemiology (HuGE) Navigator: PAK1 (11 documents)

    Export disorders for PAK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAK1 gene, integrated from 10 sources (see all 496):
    (articles sorted by number of sources associating them with PAK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. (PubMed id 8805275)1, 2, 3 Brown J.L.... Chant J. (Curr. Biol. 1996)
    2. CRIPak, a novel endogenous Pak1 inhibitor. (PubMed id 16278681)1, 2, 9 Talukder A.H.... Kumar R. (Oncogene 2006)
    3. The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. (PubMed id 12624090)1, 2, 9 Chen S.... Gu J. (J. Biol. Chem. 2003)
    4. Pak1 phosphorylation of snail, a master regulator of epithelial-to- mesenchyme transition, modulates snail's subcellular localization and functions. (PubMed id 15833848)1, 2, 9 Yang Z.... Kumar R. (Cancer Res. 2005)
    5. Differential effects of PAK1-activating mutations reveal activity- dependent and -independent effects on cytoskeletal regulation. (PubMed id 9774440)1, 2, 9 Frost J.A.... Cobb M.H. (J. Biol. Chem. 1998)
    6. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. (PubMed id 9395435)1, 2, 9 Sells M.A....Chernoff J. (Curr. Biol. 1997)
    7. Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. (PubMed id 15611088)1, 2, 9 Zhou H. and Kramer R.H. (J. Biol. Chem. 2005)
    8. Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. (PubMed id 11733498)1, 2, 9 Zang M.... Luo Z. (J. Biol. Chem. 2002)
    9. Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. (PubMed id 11804587)1, 2, 9 Parrini M.C.... Mayer B.J. (Mol. Cell 2002)
    10. Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. (PubMed id 10551809)1, 2, 9 Zenke F.T.... Bokoch G.M. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5058 HGNC: 8590 AceView: PAK1 Ensembl:ENSG00000149269 euGenes: HUgn5058
    ECgene: PAK1 Kegg: 5058 H-InvDB: PAK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PAK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PAK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PAK1 gene:
    Search GeneIP for patents involving PAK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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