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Aliases for PAIP2B Gene

Aliases for PAIP2B Gene

  • Poly(A) Binding Protein Interacting Protein 2B 2 3 5
  • Poly(A)-Binding Protein-Interacting Protein 2B 3 4
  • PABP-Interacting Protein 2B 3 4
  • PAIP-2B 3 4
  • KIAA1155 4

External Ids for PAIP2B Gene

Previous GeneCards Identifiers for PAIP2B Gene

  • GC02M071264
  • GC02M071409
  • GC02M071146

Summaries for PAIP2B Gene

Entrez Gene Summary for PAIP2B Gene

  • Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PAIP2B Gene

PAIP2B (Poly(A) Binding Protein Interacting Protein 2B) is a Protein Coding gene. GO annotations related to this gene include translation repressor activity, nucleic acid binding. An important paralog of this gene is PAIP2.

UniProtKB/Swiss-Prot for PAIP2B Gene

  • Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAIP2B Gene

Genomics for PAIP2B Gene

Regulatory Elements for PAIP2B Gene

Promoters for PAIP2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAIP2B on UCSC Golden Path with GeneCards custom track

Genomic Location for PAIP2B Gene

Chromosome:
2
Start:
71,182,738 bp from pter
End:
71,227,114 bp from pter
Size:
44,377 bases
Orientation:
Minus strand

Genomic View for PAIP2B Gene

Genes around PAIP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAIP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAIP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAIP2B Gene

Proteins for PAIP2B Gene

  • Protein details for PAIP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULR5-PAI2B_HUMAN
    Recommended name:
    Polyadenylate-binding protein-interacting protein 2B
    Protein Accession:
    Q9ULR5

    Protein attributes for PAIP2B Gene

    Size:
    123 amino acids
    Molecular mass:
    14237 Da
    Quaternary structure:
    • Interacts (via central acidic portion and C-terminus) with PABPC1 (via the second and third RRM domains and the C-terminus).
    SequenceCaution:
    • Sequence=BAA86469.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PAIP2B Gene

Proteomics data for PAIP2B Gene at MOPED

Post-translational modifications for PAIP2B Gene

Other Protein References for PAIP2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PAIP2B Gene

Domains & Families for PAIP2B Gene

Protein Domains for PAIP2B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PAIP2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULR5

UniProtKB/Swiss-Prot:

PAI2B_HUMAN :
  • Belongs to the PAIP2 family.
Family:
  • Belongs to the PAIP2 family.
genes like me logo Genes that share domains with PAIP2B: view

No data available for Gene Families for PAIP2B Gene

Function for PAIP2B Gene

Molecular function for PAIP2B Gene

UniProtKB/Swiss-Prot Function:
Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.
genes like me logo Genes that share phenotypes with PAIP2B: view

Animal Models for PAIP2B Gene

MGI Knock Outs for PAIP2B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAIP2B Gene

Localization for PAIP2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAIP2B Gene COMPARTMENTS Subcellular localization image for PAIP2B gene
Compartment Confidence
nucleus 3
cytoskeleton 2
mitochondrion 2
cytosol 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PAIP2B Gene

Pathways & Interactions for PAIP2B Gene

SuperPathways for PAIP2B Gene

No Data Available

Interacting Proteins for PAIP2B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244221%0d%0a9606.ENSP00000313007%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000244221 Q9ULR5-PAI2B_HUMAN for PAIP2B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PAIP2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAIP2B Gene

Drugs & Compounds for PAIP2B Gene

No Compound Related Data Available

Transcripts for PAIP2B Gene

mRNA/cDNA for PAIP2B Gene

Unigene Clusters for PAIP2B Gene

Poly(A) binding protein interacting protein 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAIP2B Gene

No ASD Table

Relevant External Links for PAIP2B Gene

GeneLoc Exon Structure for
PAIP2B
ECgene alternative splicing isoforms for
PAIP2B

Expression for PAIP2B Gene

mRNA expression in normal human tissues for PAIP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAIP2B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.6), Brain - Substantia nigra (x5.2), Brain - Amygdala (x4.6), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for PAIP2B Gene

This gene is overexpressed in Skin (57.1) and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PAIP2B Gene



SOURCE GeneReport for Unigene cluster for PAIP2B Gene Hs.416735

mRNA Expression by UniProt/SwissProt for PAIP2B Gene

Q9ULR5-PAI2B_HUMAN
Tissue specificity: Expressed in brain, cervix, heart, liver, ovary, kidney, prostate and testis.
genes like me logo Genes that share expression patterns with PAIP2B: view

Protein tissue co-expression partners for PAIP2B Gene

Primer Products

In Situ Assay Products

Orthologs for PAIP2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAIP2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAIP2B 35
  • 93.22 (n)
  • 93.5 (a)
PAIP2B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475800 35
  • 91.87 (n)
  • 92.68 (a)
PAIP2B 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paip2b 35
  • 89.16 (n)
  • 87.8 (a)
Paip2b 16
Paip2b 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAIP2B 35
  • 99.46 (n)
  • 100 (a)
PAIP2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paip2b 35
  • 89.16 (n)
  • 88.62 (a)
oppossum
(Monodelphis domestica)
Mammalia PAIP2B 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAIP2B 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia paip2b 35
  • 78.59 (n)
  • 80.49 (a)
zebrafish
(Danio rerio)
Actinopterygii paip2b 35
  • 69.95 (n)
  • 65.57 (a)
paip2b 36
  • 51 (a)
OneToOne
Species with no ortholog for PAIP2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAIP2B Gene

ENSEMBL:
Gene Tree for PAIP2B (if available)
TreeFam:
Gene Tree for PAIP2B (if available)

Paralogs for PAIP2B Gene

Paralogs for PAIP2B Gene

(1) SIMAP similar genes for PAIP2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PAIP2B: view

Variants for PAIP2B Gene

Sequence variations from dbSNP and Humsavar for PAIP2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs187181 -- 71,184,996(-) CAGGA(A/G)TCTAC utr-variant-3-prime
rs357761 -- 71,202,761(+) ATCCA(C/T)ATCCT intron-variant
rs357762 -- 71,201,061(+) TGTGT(C/T)TCTGC intron-variant
rs357763 -- 71,200,644(+) CTACT(C/G)AGGAG intron-variant
rs357764 -- 71,200,218(+) GGTAC(A/C)TGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAIP2B Gene

Variant ID Type Subtype PubMed ID
nsv834256 CNV Gain 17160897
esv2720185 CNV Deletion 23290073
nsv508148 CNV Loss 20534489

Variation tolerance for PAIP2B Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAIP2B Gene

HapMap Linkage Disequilibrium report
PAIP2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAIP2B Gene

Disorders for PAIP2B Gene

Relevant External Links for PAIP2B

Genetic Association Database (GAD)
PAIP2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAIP2B

No disorders were found for PAIP2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAIP2B Gene

Publications for PAIP2B Gene

  1. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. (PMID: 16804161) Berlanga J.J. … Sonenberg N. (RNA 2006) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Regulation of poly(A)-binding protein through PABP-interacting proteins. (PMID: 17381337) Derry M.C. … Sonenberg N. (Cold Spring Harb. Symp. Quant. Biol. 2006) 3
  5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3

Products for PAIP2B Gene

Sources for PAIP2B Gene

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