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PAIP2B Gene

protein-coding GIFtS: 43

GC02M071264

poly(A) binding protein interacting protein 2B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA1155 ^¹, ², ³
PAIP-2B ^³

Descriptions
PABP-interacting protein 2B ^³
Poly(A)-binding protein-interacting protein 2B ^³
poly(A) binding protein interacting protein 2B ^²

External Ids
HGNC: 29200¹
Entrez Gene: 400961²
UniProtKB: Q9ULR5³
Ensembl: ENSG00000124374⁷

Search outside databases for aliases for PAIP2B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for PAIP2B:

Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see

MIM 604679) enhances translation by circularizing mRNA through its interaction with the

translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding

proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and

PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed

17381337]).[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p13.3

PAIP2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M071264: (about GC identifiers)

Start:	71,263,376 bp from pter
End:	71,307,741 bp from pter
Size:	44,366 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PAI2B_HUMAN, Q9ULR5 (See protein sequence)

Recommended Name: Polyadenylate-binding protein-interacting protein 2B

Size: 123 amino acids; 14237 Da

REFSEQ proteins: NP_065192.1

ENSEMBL proteins:

ENSP00000244221

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IC	16804161

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Antibodies for PAIP2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Assays for PAIP2B:

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	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9ULR5

ProtoNet protein and cluster: Q9ULR5

1 Blocks protein family: IPB009818 Ataxin-2

UniProtKB/Swiss-Prot: PAI2B_HUMAN, Q9ULR5

Similarity: Belongs to the PAIP2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAIP2B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Applied Biosystems Silencer® siRNAs for PAIP2B

Sigma-Aldrich siRNA for PAIP2B

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020459
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020459
untagged cDNA clone in CMV expression vector: NM_020459

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020459

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000900	translation repressor activity, nucleic acid binding	IDA	16804161
GO:0005515	protein binding	IPI	16804161

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for PAIP2B (ENSP00000244221³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAIP1	ENSP00000302768³	STRING (score=.878)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045947	negative regulation of translational initiation	IDA	16804161

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAIP2B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAIP2B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Sigma-Aldrich siRNA for PAIP2B

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020459

REFSEQ mRNAs for PAIP2B gene:

NM_020459.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020459

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020459
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020459
                                 untagged cDNA clone in CMV expression vector: NM_020459

Additional cDNA sequence:

AB032981.1 AF090102.1 AL110211.1

7 DOTS entries:

DT.95365539 DT.121006839 DT.121006841 DT.40292599 DT.456357 DT.95365537 DT.92422601

24/124 AceView cDNA sequences (see all 124 ):

CB116896 AA194571 AA774903 AW182434 CK903044 CB128812 AI804731 T91597

BM715500 AL110211 AL596548 AA984623 H94462 BV204694 CF552802 BU931338

AW024082 T33809 BU845306 BX279890 BX499592 BE675182 F31446 BG696899

Unigene Cluster for PAIP2B:

Poly(A) binding protein interacting protein 2B

Hs.416735 [show with all ESTs]

Unigene Representative Sequence: NM_020459

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000244221

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAIP2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAIP2B

¹ / ²

6 probe-sets matching PAIP2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39526_at²	U95-A	1	1.00	1.00	0.94	0.94	--	--	--	--	--
60170_at²	U95-C	1	1.00	1.00	0.94	0.96	--	--	--	--	--
60114_r_at²	U95-C	1	1.00	1.00	-0.26	0.24	--	--	--	--	--
72923_at²	U95-E	1	0.94	1.00	0.95	1.11	--	--	--	--	--
221868_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
221868_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PAIP2B for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: CTACATTGGA

SOURCE GeneReport for Unigene cluster: Hs.416735

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAIP2B gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PAIP2B¹	--	poly(A) binding protein interacting protein 2B	91.87(n) 92.68(a)	475800 XM_533009.2 XP_533009.2
chimpanzee (Pan troglodytes)	PAIP2B¹	--	poly(A) binding protein interacting protein 2B	99.46(n) 100(a)	738296 XM_001139063.1 XP_001139063.1
rat (Rattus norvegicus)	Paip2b¹	--	poly(A) binding protein interacting protein 2B	89.16(n) 88.62(a)	312490 XM_232121.4 XP_232121.3
mouse (Mus musculus)	Paip2b^{1, 5}	6⁵	poly(A) binding protein interacting protein 2B^{1, 5}	89.16(n)¹ 87.8(a)¹	232164¹ NM_146169.1¹ NP_666281.2¹ AA413912⁵ AI662264⁵ (see all 20)
zebrafish (Danio rerio)	zgc:73265¹	--	zgc:73265	69.95(n) 65.57(a)	393739 NM_200766.1 NP_957060.1

About this table Species with no ortholog for PAIP2B

ENSEMBL Gene Tree for PAIP2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PAIP2B gene

PAIP2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/326 NCBI SNPs in PAIP2B are shown (see all 326 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 101)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs399251^1,2	A,C,F,H,O	71264837(+)	`GAAAGC/GTCAGT`	1	--	ut3¹		8	MN NA EU EA WA	742
	rs357781^1,2	A,C,F,H,O	71267279(+)	`TTAGAC/GGAAAC`	1	--	ut3¹ ese³		18	MN EA NA EU WA	2888
	rs3187463^1,2	A,C,F,H,O	71268153(-)	`TTAATT/CCCCTC`	1	--	ut3¹		8	MN EU EA WA NA	742
	rs187181^1,2	A,C,F,H	71265634(-)	`CAGGAA/GTCTAC`	1	--	ut3¹		7	NA EA EU WA	672
	rs429598^1,2	A,C,F,H	71264398(+)	`GTTGCC/TGGGGG`	1	--	ut3¹ ese³		9	MN EU EA WA	1010
	rs357780^1,2	C,F,H,O	71268987(+)	`AGTATC/TGTGAG`	1	--	ut3¹ ese³		16	NS EU EA WA NA	1080
	rs17742294^1,2	C,F,H	71308765(+)	`CCAATC/TTGCTT`	1	--	ng3¹		10	NA EU EA WA	830
--	rs4852249^1,2	C,F,H	71263085(+)	`TCTGTC/TGTTAT`	1	--	ng5¹		12	EU EA WA NA	1048
--	rs242597^1,2	A,C,F	71265953(+)	`cacttT/Agggag`	1	--	ut3¹ ese³		1	MN	184
	rs3821248^1,2	C,F,H	71267515(-)	`AGATTT/CAAAAT`	1	--	ut3¹		8	EA NA EU WA	2042

About this table

HapMap Linkage Disequilibrium images for PAIP2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611018

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for PAIP2B gene:

Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. (PubMed id 16804161)^{2, 3} Berlanga J.J....Sonenberg N. (2006)
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{3, 4} Hirosawa M....Ohara O. (1999)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Regulation of poly(A)-binding protein through PABP-interacting proteins. (PubMed id 17381337)³ Derry M.C....Sonenberg N. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 400961	HGNC: 29200	AceView: LOC400961	Ensembl:ENSG00000124374	euGenes: HUgn400961
ECgene: PAIP2B	H-InvDB: PAIP2B

(According to HUGE)
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HUGE: KIAA1155

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for PAIP2B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PAIP2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAIP2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAIP2B		Browse antibodies at Sigma-Aldrich
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PAIP2B Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for PAIP2B

Summaries
for PAIP2B

Genomic Location
for PAIP2B

Proteins
for PAIP2B

Protein Domains/
Families
for PAIP2B

Gene Function
for PAIP2B

Pathways & Interactions
for PAIP2B

Drugs & Compounds
for PAIP2B

Transcripts
for PAIP2B

Expression
for PAIP2B

Orthologs
for PAIP2B

Paralogs
for PAIP2B

SNPs/Variants
for PAIP2B

Disorders & Mutations
for PAIP2B

Medical News
for PAIP2B

Publications
for PAIP2B

Search for PAIP2B

Genome Databases showing PAIP2B

Other Databases showing PAIP2B

Specialized Databases showing PAIP2B

Licensable Technologies
for PAIP2B

Services
for PAIP2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAIP2B Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor PAIP2B

Summariesfor PAIP2B

Genomic Locationfor PAIP2B

Proteinsfor PAIP2B

Protein Domains/Familiesfor PAIP2B

Gene Functionfor PAIP2B

Pathways & Interactionsfor PAIP2B

Drugs & Compoundsfor PAIP2B

Transcriptsfor PAIP2B

Expression for PAIP2B

Orthologsfor PAIP2B

Paralogsfor PAIP2B

SNPs/Variantsfor PAIP2B

Disorders & Mutationsfor PAIP2B

Medical Newsfor PAIP2B

Publicationsfor PAIP2B

Search for PAIP2B

Genome Databases showing PAIP2B

Other Databases showing PAIP2B

Specialized Databases showing PAIP2B

Licensable Technologiesfor PAIP2B

Servicesfor PAIP2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAIP2B

Summaries
for PAIP2B

Genomic Location
for PAIP2B

Proteins
for PAIP2B

Protein Domains/
Families
for PAIP2B

Gene Function
for PAIP2B

Pathways & Interactions
for PAIP2B

Drugs & Compounds
for PAIP2B

Transcripts
for PAIP2B

Expression
for PAIP2B

Orthologs
for PAIP2B

Paralogs
for PAIP2B

SNPs/Variants
for PAIP2B

Disorders & Mutations
for PAIP2B

Medical News
for PAIP2B

Publications
for PAIP2B

Licensable Technologies
for PAIP2B

Services
for PAIP2B