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PAIP2 Gene

protein-coding   GIFtS: 50

GC05P138706
poly(A) binding protein interacting protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
MGC72018 2
PAIP-2 3
PAIP2A 1, 2, 3, 5
Descriptions
PABC1-interacting protein 2 2
PABP-interacting protein 2 2, 3
Poly(A)-binding protein-interacting protein 2 3
poly(A) binding protein interacting protein 2 2
polyA-binding protein-interacting protein 2 2
polyadenylate-binding protein-interacting protein 2 2
External Ids
HGNC: 179701
Entrez Gene: 512472
UniProtKB: Q9BPZ33
Ensembl: ENSG000001207277
Search outside databases for aliases for PAIP2 gene

Previous GC identifers: GC05P138553 GC05P139353 GC05P138709 GC05P138754 GC05P138755

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PAIP2_HUMAN, Q9BPZ3
Function: Acts as a repressor in the regulation of translation initiation of poly(A)-containing
mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the
interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its
association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure
organization

Gene Wiki entry for PAIP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PAIP2 gene  

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q32

PAIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P138706:     (about GC identifiers)

Start:
138,705,418 bp from pter
End:
138,733,308 bp from pter
Size:
27,891 bases
Orientation:
plus strand
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PAIP2_HUMAN, Q9BPZ3 (See protein sequence)
Recommended Name: Polyadenylate-binding protein-interacting protein 2  
Size: 127 amino acids; 14984 Da
Subunit: Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1
stoichiometry
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
1JGN (3D)    
Secondary accessions: Q49A06 Q9H0Y5 Q9P0Q8

REFSEQ proteins (2 alternative transcripts): 
NP_001028284.1  NP_057564.3  


ENSEMBL proteins: 
ENSP00000265192 ENSP00000378275 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (PAIP2)
Browse Abnova for Human Recombinant Proteins
              OriGene Purified Recombinant Human Protein: PAIP2 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IDA11172725
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Antibodies for PAIP2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for PAIP2
Browse R&D Systems for Antibodies
Antibodies from Abcam (PAIP2), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for PAIP2

Assays for PAIP2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR009818 Ataxin-2_C


   GeneDecks  PAIP2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9BPZ3

ProtoNet protein and cluster: Q9BPZ3

1 Blocks protein family: IPB009818 Ataxin-2

UniProtKB/Swiss-Prot: PAIP2_HUMAN, Q9BPZ3
Domain: Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A)
RNA and translation initiation
Similarity: Belongs to the PAIP2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PAIP2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016480

              Applied Biosystems Silencer® siRNAs for PAIP2

              Sigma-Aldrich siRNA for PAIP2  
                     Sigma-Aldrich shRNA for PAIP2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for PAIP2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001033112
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001033112
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001033112 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_016480

UniProtKB/Swiss-Prot: PAIP2_HUMAN, Q9BPZ3
Function: Acts as a repressor in the regulation of translation initiation of poly(A)-containing
mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the
interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its
association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure
organization

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IPI11172725
GO:0030371 translation repressor activity IDA11172725
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Cell Signaling Technology (CST) Pathway for PAIP2: 
 Translational Control: Regulation of eIF2

   GeneDecks  PAIP2 for the pathways selected above  
About GeneDecksing

 Gene Network CentralTM Interacting Genes and Proteins Network for  PAIP2 


5/11 Interacting proteins for PAIP2 (ENSP000002651923 Q9BPZ32) via UniProtKB, MINT, and/or STRING (see all 11 )
InteractantInteraction Details
GeneCardExternal ID(s)
PABPCP5P119402STRING (score=.998) MINT-1899153
UBR5O950712MINT-1899264 MINT-1899175 MINT-1899242 MINT-1899220 MINT-1899195
PABPC1P119402MINT-1899153
ELAVL1ENSP000002640733STRING (score=.986)
PAIP1ENSP000003027683STRING (score=.942)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006417 regulation of translation IEA--
GO:0045947 negative regulation of translational initiation IDA11172725
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAIP2
1 Novoseek chemical compound relationship for PAIP2 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
pabc 92.37 1 14685257 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PAIP2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016480

              Sigma-Aldrich siRNA for PAIP2  
                     Sigma-Aldrich shRNA for PAIP2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001033112  NM_016480  

REFSEQ mRNAs for PAIP2 gene (2 alternative transcripts): 

NM_001033112.1   NM_016480.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001033112  NM_016480  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001033112
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001033112
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001033112 

24/592 AceView cDNA sequences (see all 592 ):

AA376911 W00362 AA829902 AA962604 BF594808 BM702852 AJ346267 CA396521 
BI793070 BM021103 AW875153 AW261815 BG393130 AA975210 BM722646 BM725811 
BQ437316 BE893255 BU178944 W21553 AA934807 BI906320 BQ226222 BQ421901 

highest scoring ESTs for PAIP2:

AI978983 AA022551 AA081656 AA193191 AA358425 AA376911 AA400451 AA412524 AA412568 AA486543 


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for PAIP2

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1:                    -     -                 -               
SP2:                          -                 -               
SP3:                    -                                       
SP4:                    -     -                                 

About this scheme

ECgene alternative splicing isoforms for PAIP2

2 Ensembl transcripts including schematic representations:
ENST00000265192  ENST00000394795  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAIP2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for PAIP2

1 / 2 / 3

7 probe-sets matching PAIP2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

56399_at2, 3 U95-B 1 1.00 1.00 0.99 1.02 AI792631 0.80 1.00 0.91 1

43855_at2, 3 U95-B 1 1.00 1.00 0.99 0.98 AI978983 1.00 1.00 1.00 1

222984_at2, 3 U133-B 1 1.00 1.00 -- -- AF151052 0.80 1.00 0.91 1

222983_s_at2, 3 U133-B 1 1.00 1.00 -- -- BC001716 0.80 1.00 0.91 1

1560065_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

222984_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

222983_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GCTTGATGTG
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for PAIP2 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
PAIP21   -- poly(A) binding protein interacting protein 2 98.12(n)
99.19(a)
478024  XM_535206.2  XP_535206.1 
chimpanzee
(Pan troglodytes)
PAIP21   -- poly(A) binding protein interacting protein 2 100(n)
100(a)
462103  XM_001172444.1  XP_001172444.1 
cow
(Bos taurus)
PAIP21   -- poly(A) binding protein interacting protein 2 97.58(n)
100(a)
536619  NM_001034636.1  NP_001029808.1 
rat
(Rattus norvegicus)
Paip21   -- poly(A) binding protein interacting protein 2 97.58(n)
98.39(a)
361309  NM_001014148.1  NP_001014170.1 
mouse
(Mus musculus)
Paip21, 5 185
polyadenylate-binding protein-interacting protein 21, 5 98.12(n)1
98.39(a)1
678691  NM_026420.21  NP_080696.11 
 AI8460785  AK0054625  (see all 18)
About this table        Species with no ortholog for PAIP2

ENSEMBL Gene Tree for PAIP2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for PAIP2 gene
PAIP2B2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/109 NCBI SNPs in PAIP2 are shown (see all 109 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 30)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 5 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs38981661,2
C,H138728221(-) ATGCTC/TTTTTT 2 E/K mis1 trp34Minor allele frequency- T:0.00EU EA WA 406
rs77033911,2
C,H138703916(+) TTCCTC/TCAGCC 1 -- ng514Minor allele frequency- T:0.00EU EA WA 416
--
rs115488401,2
H138727403(+) CTAGCC/GCAAGC 2 P/A mis1 ese34Minor allele frequency- G:0.00EU EA WA 400
rs10639101,2
H138728317(+) CTTCTC/ATGGAA 2 M/L mis1 ese35Minor allele frequency- A:0.00MN EU EA WA 584
--
rs115488391,2
H138728254(+) ATCTCC/ACACAA 2 T/P mis1 ese34Minor allele frequency- A:0.00EU EA WA 402
rs45090141,2
H138728176(+) AAGAAG/AAATTT 2 K/E mis1 trp34Minor allele frequency- A:0.00EU EA WA 414
--
rs77197881,2
A,F,H138721189(+) gctgaA/Ggcggg 2 -- int14Minor allele frequency- G:0.06EU EA WA 412
rs74489411,2
C,F,H138729466(+) ATACAA/GAAGTA 2 -- int18Minor allele frequency- G:0.02EU EA WA 838
--
rs68804431,2
A,F,H138721275(+) ttagcG/Agggca 2 -- int14Minor allele frequency- A:0.18EU EA WA 418
--
rs119510081,2
A,C138714226(+) AAAAAA/TAAATA 2 -- int10--------
About this table

HapMap Linkage Disequilibrium images for PAIP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605604

Human Genome Epidemiology Navigator: PAIP2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/26 PubMed articles for PAIP2 gene (see all 26 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 51247 HGNC: 17970 AceView: PAIP2 Ensembl:ENSG00000120727 euGenes: HUgn51247
ECgene: PAIP2 H-InvDB: PAIP2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for PAIP2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PAIP2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for PAIP2 Antibodies for PAIP2
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for PAIP2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for PAIP2




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for PAIP2

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