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Aliases for PAIP2 Gene

Aliases for PAIP2 Gene

  • Poly(A) Binding Protein Interacting Protein 2 2 3 5
  • PABP-Interacting Protein 2 3 4
  • PAIP-2 3 4
  • PAIP2A 3 4
  • Poly(A)-Binding Protein-Interacting Protein 2 4
  • PolyA-Binding Protein-Interacting Protein 2 3
  • PABC1-Interacting Protein 2 3

External Ids for PAIP2 Gene

Previous GeneCards Identifiers for PAIP2 Gene

  • GC05P138553
  • GC05P138709
  • GC05P138754
  • GC05P138755
  • GC05P138706
  • GC05P133867
  • GC05P138677

Summaries for PAIP2 Gene

GeneCards Summary for PAIP2 Gene

PAIP2 (Poly(A) Binding Protein Interacting Protein 2) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway. GO annotations related to this gene include mRNA binding and translation repressor activity. An important paralog of this gene is PAIP2B.

UniProtKB/Swiss-Prot for PAIP2 Gene

  • Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.

Gene Wiki entry for PAIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAIP2 Gene

Genomics for PAIP2 Gene

Regulatory Elements for PAIP2 Gene

Promoters for PAIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAIP2 Gene

Chromosome:
5
Start:
139,341,587 bp from pter
End:
139,369,720 bp from pter
Size:
28,134 bases
Orientation:
Plus strand

Genomic View for PAIP2 Gene

Genes around PAIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAIP2 Gene

Proteins for PAIP2 Gene

  • Protein details for PAIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPZ3-PAIP2_HUMAN
    Recommended name:
    Polyadenylate-binding protein-interacting protein 2
    Protein Accession:
    Q9BPZ3
    Secondary Accessions:
    • B2RBI1
    • D3DQC6
    • Q49A06
    • Q9H0Y5
    • Q9P0Q8

    Protein attributes for PAIP2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14984 Da
    Quaternary structure:
    • Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry.

    Three dimensional structures from OCA and Proteopedia for PAIP2 Gene

neXtProt entry for PAIP2 Gene

Proteomics data for PAIP2 Gene at MOPED

Post-translational modifications for PAIP2 Gene

Other Protein References for PAIP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PAIP2 (PAIP2)

No data available for DME Specific Peptides for PAIP2 Gene

Domains & Families for PAIP2 Gene

Protein Domains for PAIP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PAIP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BPZ3

UniProtKB/Swiss-Prot:

PAIP2_HUMAN :
  • Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.
  • Belongs to the PAIP2 family.
Domain:
  • Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.
Family:
  • Belongs to the PAIP2 family.
genes like me logo Genes that share domains with PAIP2: view

No data available for Gene Families for PAIP2 Gene

Function for PAIP2 Gene

Molecular function for PAIP2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.

Gene Ontology (GO) - Molecular Function for PAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IEA --
genes like me logo Genes that share ontologies with PAIP2: view
genes like me logo Genes that share phenotypes with PAIP2: view

Animal Models for PAIP2 Gene

MGI Knock Outs for PAIP2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAIP2 Gene

Localization for PAIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAIP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAIP2 Gene COMPARTMENTS Subcellular localization image for PAIP2 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PAIP2 Gene

Pathways & Interactions for PAIP2 Gene

SuperPathways for PAIP2 Gene

Superpath Contained pathways
1 TGF-Beta Pathway
genes like me logo Genes that share pathways with PAIP2: view

Pathways by source for PAIP2 Gene

1 Qiagen pathway for PAIP2 Gene

Gene Ontology (GO) - Biological Process for PAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0007613 memory IEA --
GO:0045947 negative regulation of translational initiation IDA 11172725
genes like me logo Genes that share ontologies with PAIP2: view

No data available for SIGNOR curated interactions for PAIP2 Gene

Drugs & Compounds for PAIP2 Gene

(2) Additional Compounds for PAIP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAIP2: view

Transcripts for PAIP2 Gene

Unigene Clusters for PAIP2 Gene

Poly(A) binding protein interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for PAIP2 Gene

GeneLoc Exon Structure for
PAIP2
ECgene alternative splicing isoforms for
PAIP2

Expression for PAIP2 Gene

mRNA expression in normal human tissues for PAIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PAIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PAIP2 Gene



SOURCE GeneReport for Unigene cluster for PAIP2 Gene Hs.396644

mRNA Expression by UniProt/SwissProt for PAIP2 Gene

Q9BPZ3-PAIP2_HUMAN
Tissue specificity: Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.
genes like me logo Genes that share expression patterns with PAIP2: view

Protein tissue co-expression partners for PAIP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PAIP2 Gene

Orthologs for PAIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAIP2 35
  • 100 (n)
  • 100 (a)
PAIP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAIP2 36
  • 100 (a)
OneToOne
PAIP2 35
  • 97.58 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia PAIP2 35
  • 97.64 (n)
  • 98.43 (a)
PAIP2 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paip2 16
Paip2 36
  • 98 (a)
OneToOne
Paip2 35
  • 98.12 (n)
  • 98.39 (a)
oppossum
(Monodelphis domestica)
Mammalia PAIP2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAIP2 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paip2 35
  • 97.58 (n)
  • 98.39 (a)
chicken
(Gallus gallus)
Aves PAIP2 35
  • 90.29 (n)
  • 97.64 (a)
PAIP2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAIP2 36
  • 94 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3840 35
Species with no ortholog for PAIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAIP2 Gene

ENSEMBL:
Gene Tree for PAIP2 (if available)
TreeFam:
Gene Tree for PAIP2 (if available)

Paralogs for PAIP2 Gene

Paralogs for PAIP2 Gene

(1) SIMAP similar genes for PAIP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PAIP2: view

Variants for PAIP2 Gene

Sequence variations from dbSNP and Humsavar for PAIP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs951395 -- 139,342,968(+) AAGTA(A/G)ATGTT intron-variant
rs2352031 -- 139,361,034(-) GGAGG(A/C)CAAAG intron-variant
rs4509014 -- 139,364,588(-) AAGAA(A/C/G/T)AATTT nc-transcript-variant, reference, missense
rs5871696 -- 139,343,142(+) TTTTT(-/T)AATGA intron-variant
rs6882095 -- 139,347,807(+) GCTTA(A/G)AATGA intron-variant

Variation tolerance for PAIP2 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAIP2 Gene

HapMap Linkage Disequilibrium report
PAIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PAIP2 Gene

Disorders for PAIP2 Gene

Relevant External Links for PAIP2

Genetic Association Database (GAD)
PAIP2
Human Genome Epidemiology (HuGE) Navigator
PAIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAIP2

No disorders were found for PAIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAIP2 Gene

Publications for PAIP2 Gene

  1. Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PMID: 11172725) Khaleghpour K. … Sonenberg N. (Mol. Cell 2001) 2 3 4 23 67
  2. Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. (PMID: 16601676) Yoshida M. … Sonenberg N. (EMBO J. 2006) 3 23
  3. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. (PMID: 16804161) Berlanga J.J. … Sonenberg N. (RNA 2006) 2 3
  4. Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA. (PMID: 15175342) Onesto C. … PagA"s G. (J. Biol. Chem. 2004) 3 23
  5. Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. (PMID: 14685257) Kozlov G. … Gehring K. (EMBO J. 2004) 3 23

Products for PAIP2 Gene

Sources for PAIP2 Gene

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