Services
Jump to Section...
Aliases for PAIP2
Databases for PAIP2
Disorders for PAIP2
Domains/Families for PAIP2
Drugs/Compounds for PAIP2
Expression for PAIP2
Function for PAIP2
Location for PAIP2
Medical News for PAIP2
Orthologs for PAIP2
Paralogs for PAIP2
Pathways/Interactions for PAIP2
Proteins for PAIP2
Publications for PAIP2
SNPs for PAIP2
Search Box for PAIP2
Services for PAIP2
Summaries for PAIP2
Technologies for PAIP2
Transcripts for PAIP2
TOP
BOTTOM
Aliases & Descriptions for PAIP2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Aliases MGC72018 2 PAIP-2 3 PAIP2A 1 , 2 , 3 , 5
Descriptions PABC1-interacting protein 2 2 PABP-interacting protein 2 2 , 3 Poly(A)-binding protein-interacting protein 2 3 poly(A) binding protein interacting protein 2 2 polyA-binding protein-interacting protein 2 2 polyadenylate-binding protein-interacting protein 2 2
Search outside databases for aliases for PAIP2 genePrevious GC identifers: GC05P138553 GC05P139353 GC05P138709 GC05P138754 GC05P138755
Summaries for PAIP2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
UniProtKB/Swiss-Prot: PAIP2_HUMAN, Q9BPZ3 Function : Acts as a repressor in the regulation of translation initiation of poly(A)-containingmRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces theinteraction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Itsassociation with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structureorganization
Gene Wiki entry for PAIP2
Genomic Location for PAIP2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the PAIP2 gene Entrez Gene cytogenetic band: 5q31.2 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q32 PAIP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05P138706:
(about GC identifiers )
Start:
138,705,418 bp from pter
End:
138,733,308 bp from pter
Size:
27,891 bases
Orientation:
plus strand
Proteins for PAIP2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
UniProtKB/Swiss-Prot: PAIP2_HUMAN, Q9BPZ3 (See
protein sequence )Recommended Name: Polyadenylate-binding protein-interacting protein 2 Size : 127 amino acids; 14984 Da
Subunit : Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1stoichiometry
Subcellular location : Cytoplasm
PDB structures from and Proteopedia : 1JGN (3D)
 
Secondary accessions : Q49A06 Q9H0Y5 Q9P0Q8
REFSEQ proteins (2 alternative transcripts):
NP_001028284.1 NP_057564.3 ENSEMBL proteins: ENSP00000265192 ENSP00000378275 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: PAIP2 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for PAIP2: Assays for PAIP2:
Protein
Domains/ Families for PAIP2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Graphical View of Domain Structure for InterPro Entry Q9BPZ3 ProtoNet protein and cluster: Q9BPZ3
1 Blocks protein family : IPB009818 Ataxin-2 UniProtKB/Swiss-Prot: PAIP2_HUMAN, Q9BPZ3 Domain : Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A)RNA and translation initiation Similarity : Belongs to the PAIP2 family
Gene Function for PAIP2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_016480 Applied Biosystems Silencer ® siRNAs for PAIP2 Sigma-Aldrich siRNA for PAIP2 Sigma-Aldrich shRNA for PAIP2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001033112                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001033112                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001033112  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016480 UniProtKB/Swiss-Prot: PAIP2_HUMAN, Q9BPZ3 Function : Acts as a repressor in the regulation of translation initiation of poly(A)-containingmRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces theinteraction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Itsassociation with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structureorganization
2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for PAIP2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Gene Network CentralTM Interacting Genes and Proteins Network for PAIP2 5/11 Interacting proteins for PAIP2 (ENSP00000265192 3 Q9BPZ3 2 ) via UniProtKB, MINT, and/or STRING (see all 11
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006417 regulation of translation
IEA -- GO:0045947 negative regulation of translational initiation
IDA 11172725
About this table
Drugs & Compounds for PAIP2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Browse Tocris compounds for PAIP2 1 Novoseek chemical compound relationship for PAIP2 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
pabc
92.37
1
14685257 (1)
About this table
Transcripts for PAIP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_016480 Sigma-Aldrich siRNA for PAIP2 Sigma-Aldrich shRNA for PAIP2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001033112 NM_016480
REFSEQ mRNAs for PAIP2 gene (2 alternative transcripts): NM_001033112.1 NM_016480.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001033112 NM_016480
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001033112                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001033112                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001033112  
24/592 AceView cDNA sequences (see all 592
):AA376911 W00362 AA829902 AA962604 BF594808 BM702852 AJ346267 CA396521 BI793070 BM021103 AW875153 AW261815 BG393130 AA975210 BM722646 BM725811 BQ437316 BE893255 BU178944 W21553 AA934807 BI906320 BQ226222 BQ421901
highest scoring ESTs for PAIP2 :AI978983 AA022551 AA081656 AA193191 AA358425 AA376911 AA400451 AA412524 AA412568 AA486543 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for PAIP2 ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b SP1 :       -   -       -       SP2 :         -       -       SP3 :       -               SP4 :       -   -            
About this scheme ECgene alternative splicing isoforms for PAIP2 2 Ensembl transcripts including schematic representations : ENST00000265192
ENST00000394795
Expression for PAIP2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
PAIP2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for PAIP2 1 / 2 / 3
7 probe-sets matching PAIP2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCTTGATGTG
Orthologs for PAIP2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Orthologs for PAIP2 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for PAIP2 ENSEMBL Gene Tree for PAIP2 Paralogs for PAIP2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Paralogs for PAIP2 gene PAIP2B 2
SNPs/Variants for PAIP2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
HapMap Linkage Disequilibrium images for PAIP2 (up to first 250kb)
Disorders & Mutations for PAIP2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
OMIM: 605604 Human Genome Epidemiology Navigator: PAIP2 (1 document)
Medical News for PAIP2 (Possibly Related Articles in
Doctor's Guide )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Publications for PAIP2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
10/26 PubMed articles for PAIP2 gene (see all 26
): Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PubMed id 11172725) 1, 2, 3, 4 Khaleghpour K.... Sonenberg N. (2001) Dual interactions of the translational repressor Paip2 with poly(A) binding protein. (PubMed id 11438674) 1, 3, 4 Khaleghpour K.... Sonenberg N. (2001) Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. (PubMed id 16804161) 2, 3 Berlanga J.J....Sonenberg N. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Structure and function of the C-terminal PABC domain of human poly(A)-binding protein. (PubMed id 11287632) 3, 4 Kozlov G....Gehring K. (2001) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 3, 4 Wiemann S.... Poustka A. (2001) Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152) 3, 4 Zhang Q.H....Chen Z. (2000) Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. (PubMed id 16601676) 1, 3 Yoshida M....Sonenberg N. (2006) Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA. (PubMed id 15175342) 1, 3 Onesto C....Pages G. (2004) Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. (PubMed id 12820898) 1, 3 Gouyon F....Brot-Laroche E. (2003)
Search for PAIP2
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genome Databases showing PAIP2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Other Databases showing PAIP2
(According to HUGE )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Specialized Databases showing PAIP2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
-- Services for PAIP2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Products for PAIP2:
Search Tocris compounds for PAIP2
Jump to Section...
Aliases for PAIP2
Databases for PAIP2
Disorders for PAIP2
Domains/Families for PAIP2
Drugs/Compounds for PAIP2
Expression for PAIP2
Function for PAIP2
Location for PAIP2
Medical News for PAIP2
Orthologs for PAIP2
Paralogs for PAIP2
Pathways/Interactions for PAIP2
Proteins for PAIP2
Publications for PAIP2
SNPs for PAIP2
Search Box for PAIP2
Services for PAIP2
Summaries for PAIP2
Technologies for PAIP2
Transcripts for PAIP2
TOP
BOTTOM
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009