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PAIP1 Gene

protein-coding GIFtS: 56

GC05M043562

poly(A) binding protein interacting protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC12360 ^²
PAIP-1 ^³

Descriptions
PABC1-interacting protein 1 ^²
PABP-interacting protein 1 ^³
Poly(A)-binding protein-interacting protein 1 ^³
poly(A) binding protein interacting protein 1 ^²
polyadenylate binding protein-interacting protein 1 ^²

External Ids
HGNC: 16945¹
Entrez Gene: 10605²
UniProtKB: Q9H074³
Ensembl: ENSG00000172239⁷

Search outside databases for aliases for PAIP1 gene

Previous GC identifers: GC05M043835 GC05M044703 GC05M043526 GC05M043571

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAIP1:

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding

complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression

of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and

three transcript variants encoding three distinct isoforms have been identified. [provided by

RefSeq]

UniProtKB/Swiss-Prot: PAIP1_HUMAN, Q9H074

Function: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing

mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with

PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between

mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other

RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS

mRNA mediated by the major coding-region determinant of instability (mCRD) domain

Gene Wiki entry for PAIP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PAIP1 gene

Entrez Gene cytogenetic band: 5p12 Ensembl cytogenetic band: 5p12 HGNC cytogenetic band: 5p12

PAIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M043562: (about GC identifiers)

Start:	43,562,126 bp from pter
End:	43,593,244 bp from pter
Size:	31,119 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_006576.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PAIP1_HUMAN, Q9H074 (See protein sequence)

Recommended Name: Polyadenylate-binding protein-interacting protein 1

Size: 479 amino acids; 53525 Da

Subunit: Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry.

Interacts with EIF4A

Subcellular location: Cytoplasm (Probable)

PDB structures from and Proteopedia :

1JH4 (3D)

Secondary accessions: O60455 Q96B61 Q9BS63

Alternative splicing: 2 isoforms: Q9H074-1 Q9H074-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_006442.2 NP_877590.1 NP_899152.1

ENSEMBL proteins:

ENSP00000302768 ENSP00000370958 ENSP00000339622

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PAIP1)
	Human Recombinant Proteins from Abnova (PAIP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9548260

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Antibodies for PAIP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PAIP1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PAIP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PAIP1)
	Novus Biologicals Antibodies for PAIP1

Assays for PAIP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H074

ProtoNet protein and cluster: Q9H074

1 Blocks protein family: IPB009818 Ataxin-2

UniProtKB/Swiss-Prot: PAIP1_HUMAN, Q9H074

Domain: Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation

Similarity: Contains 1 MIF4G domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAIP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAIP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006451

Applied Biosystems Silencer® siRNAs for PAIP1

Sigma-Aldrich siRNA for PAIP1

Sigma-Aldrich shRNA for PAIP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PAIP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_006451
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_006451
untagged cDNA clones in CMV expression vector (see all 5): NM_006451

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006451

UniProtKB/Swiss-Prot: PAIP1_HUMAN, Q9H074

Function: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing

mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with

PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between

mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other

RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS

mRNA mediated by the major coding-region determinant of instability (mCRD) domain

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	TAS	9548260
GO:0005515	protein binding	IPI	9548260 10970864 11997512
GO:0008494	translation activator activity	IDA	9548260

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for PAIP1

5/17 Interacting proteins for PAIP1 (ENSP00000302768³ Q9H074^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PABPCP5	P11940¹^,²	STRING (score=.998) EBI-81519, EBI-81531 MINT-18204 MINT-18203 MINT-18202 MINT-18201
PABPC1	P11940¹^,²	EBI-81519, EBI-81531 MINT-18204 MINT-18203 MINT-18202 MINT-18201 EBI-81519, EBI-81531 MINT-18204 MINT-18203 MINT-18202 MINT-18201
PABPC1	P11940¹^,²	EBI-81519, EBI-81531 MINT-18204 MINT-18203 MINT-18202 MINT-18201 EBI-81519, EBI-81531 MINT-18204 MINT-18203 MINT-18202 MINT-18201
EIF4A1	ENSP00000369881³	STRING (score=.984)
HNRNPD	ENSP00000313199³	STRING (score=.943)
PAIP2	ENSP00000265192³	STRING (score=.942)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006413	translational initiation	TAS	9548260
GO:0006417	regulation of translation	IEA	--
GO:0016070	RNA metabolic process	IEA	--
GO:0048255	mRNA stabilization	TAS	11997512

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAIP1
1 Novoseek chemical compound relationship for PAIP1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pabc	95.98	3	11287632 (1), 14685257 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAIP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAIP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006451

Sigma-Aldrich siRNA for PAIP1

Sigma-Aldrich shRNA for PAIP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006451 NM_182789 NM_183323

REFSEQ mRNAs for PAIP1 gene (3 alternative transcripts):

NM_006451.4 NM_182789.3 NM_183323.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006451 NM_182789 NM_183323

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_006451
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_006451
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_006451

Additional cDNA sequence:

AF013758.2 AK308270.1 AL136920.1 BC005295.1 BC015937.2 CR594937.1 CR599012.1 CR600281.1

CR601652.1 CR607203.1 CR609051.1 CR609577.1 CR611090.1 CR614417.1 CR617943.1 CR623640.1

CR624807.1 CR625180.1 CR626272.1 DQ786248.1 DQ786326.1

19 DOTS entries:

DT.100812925 DT.316904 DT.92029035 DT.99986203 DT.100812933 DT.95075866 DT.92444677 DT.120862609

DT.102838137 DT.120862617 DT.95225834 DT.92444689 DT.95225879 DT.100000856 DT.100698936 DT.100715828

DT.100812923 DT.120862635 DT.95225854

24/270 AceView cDNA sequences (see all 270 ):

AL548163 CR625180 NM_006451 BQ217727 BM795272 CB114557 CR600281 CR611090

BX420716 CR594937 CB215025 AA367274 BM723289 CR609577 CR609051 CR623640

CD517438 BM928166 BM782103 CR601652 CR607203 CR624807 NM_182789 BM763148

highest scoring ESTs for PAIP1:

AF013758 BG719757 BG719787 CB148103 CB215025 AA043823 AA126598 AA209236 AA211941 AA367274

Unigene Cluster for PAIP1:

Poly(A) binding protein interacting protein 1

Hs.482038 [show with all ESTs]

Unigene Representative Sequence: NM_006451

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000306846 ENST00000381546 ENST00000338972

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAIP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAIP1

¹ / ² / ³

11 probe-sets matching PAIP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38978_at²^{, 3}	U95-A	2	1.00	0.50	1.00	1.00	AF013758	0.80	1.00	0.91	1
208051_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_006451	0.60	1.00	0.82	1
209064_x_at²^{, 3}	U133-A	2	1.00	0.50	--	--	AL136920	0.60	1.00	0.82	1
209063_x_at²^{, 3}	U133-A	6	1.00	0.35	--	--	BF248165	0.40	0.50	0.45	1
213754_s_at²^{, 3}	U133-A	6	1.00	0.33	--	--	AW613203	0.60	0.75	0.68	1
210283_x_at²^{, 3}	U133-A	6	1.00	0.33	--	--	BC005295	0.60	1.00	0.82	1
208051_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
209064_x_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
209063_x_at²	U133Plus2	6	1.00	0.35	--	--	--	--	--	--	--
213754_s_at²	U133Plus2	6	1.00	0.33	--	--	--	--	--	--	--
210283_x_at²	U133Plus2	6	1.00	0.33	--	--	--	--	--	--	--

GeneDecks PAIP1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAACTTCAAC

SOURCE GeneReport for Unigene cluster: Hs.482038
Expression variation in blood from EXPOLDB for PAIP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAIP1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PAIP1¹	--	poly(A) binding protein interacting protein 1	93.79(n) 97.45(a)	479343 XM_536482.2 XP_536482.1
cow (Bos taurus)	PAIP1¹	--	poly(A) binding protein interacting protein 1	94.29(n) 96.45(a)	510246 XM_587371.3 XP_587371.2
rat (Rattus norvegicus)	Paip1¹	--	poly(A) binding protein interacting protein 1	90.92(n) 94.08(a)	365684 XM_345160.3 XP_345161.3
mouse (Mus musculus)	Paip1^{1, 5}	13⁵	polyadenylate binding protein-interacting protein 1^{1, 5}	92.86(n)¹ 97.96(a)¹	218693¹ NM_145457.3¹ NP_663432.1¹ AA415200⁵ AA655308⁵ (see all 20)
zebrafish (Danio rerio)	wufb53g01²	--	wufb53g01	74.66(n)	322227 CK236314.1

About this table Species with no ortholog for PAIP1

ENSEMBL Gene Tree for PAIP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/218 NCBI SNPs in PAIP1 are shown (see all 218 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11738733^1,2	C,F,H	43595033(+)	`TAACAC/ACTGGG`	1	--	ng3¹		4		EU EA WA	420
--	rs12521249^1,2	A,C	43594386(+)	`TGTTTC/TAAGCA`	3	--	ng3¹		0	--	--	--	--
--	rs13360902^1,2	C	43593162(+)	`GGCTGC/GAGGGG`	3	--	ng3¹ int¹		0	--	--	--	--
--	rs13189484^1,2	A	43593791(+)	`cagccA/Tgacca`	3	--	ng3¹		0	--	--	--	--
--	rs9885481^1,2	C	43593163(+)	`GCTGGA/GGGGGA`	3	--	ng3¹ int¹		0	--	--	--	--
--	rs9632397^1,2	C	43562892(+)	`CCAGAA/CGAAGA`	3	--	ut3¹ ese³		0	--	--	--	--
	rs4535459^1,2	A,C,F,H	43587339(+)	`ATAAAA/GTTGTG`	3	--	int¹		4		EU EA WA	410
	rs6890419^1,2	A,C,F,H	43580349(+)	`TTCAAC/AAGTTT`	3	--	int¹		8		EU EA WA	838
	rs10941640^1,2	A,C,F,H	43571715(+)	`AGCAGA/GACTTT`	3	--	int¹		4		EU EA WA	414
	rs10058558^1,2	A,C,F,H	43575625(+)	`CCTACA/GAGGTA`	3	--	int¹		6		EU EA WA NA	594

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HapMap Linkage Disequilibrium images for PAIP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605184

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/19 PubMed articles for PAIP1 gene (see all 19 ):

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{2, 3, 4} Wiemann S.... Poustka A. (2001)
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. (PubMed id 9548260)^{2, 3, 4} Craig A.W.B.... Sonenberg N. (1998)
Paip1 interacts with poly(A) binding protein through two independent binding motifs. (PubMed id 11997512)^{1, 3, 4} Roy G.... Sonenberg N. (2002)
Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PubMed id 11172725)^{1, 3, 4} Khaleghpour K.... Sonenberg N. (2001)
A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. (PubMed id 11051545)^{1, 3, 4} Grosset C....Shyu A.-B. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Multiple portions of poly(A)-binding protein stimulate translation in vivo. (PubMed id 10970864)^{3, 4} Gray N.K.... Wickens M. (2000)
Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. (PubMed id 18725400)^{1, 3} Martineau Y....Sonenberg N. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450)³ Fortna A....Sikela J.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10605	HGNC: 16945	AceView: PAIP1	Ensembl:ENSG00000172239	euGenes: HUgn10605
ECgene: PAIP1	H-InvDB: PAIP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for PAIP1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PAIP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAIP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAIP1		Antibodies for PAIP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PAIP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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PAIP1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for PAIP1

Summaries
for PAIP1

Genomic Location
for PAIP1

Proteins
for PAIP1

Protein Domains/
Families
for PAIP1

Gene Function
for PAIP1

Pathways & Interactions
for PAIP1

Drugs & Compounds
for PAIP1

Transcripts
for PAIP1

Expression
for PAIP1

Orthologs
for PAIP1

Paralogs
for PAIP1

SNPs/Variants
for PAIP1

Disorders & Mutations
for PAIP1

Medical News
for PAIP1

Publications
for PAIP1

Search for PAIP1

Genome Databases showing PAIP1

Other Databases showing PAIP1

Specialized Databases showing PAIP1

Licensable Technologies
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Services
for PAIP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAIP1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor PAIP1

Summariesfor PAIP1

Genomic Locationfor PAIP1

Proteinsfor PAIP1

Protein Domains/Familiesfor PAIP1

Gene Functionfor PAIP1

Pathways & Interactionsfor PAIP1

Drugs & Compoundsfor PAIP1

Transcriptsfor PAIP1

Expression for PAIP1

Orthologsfor PAIP1

Paralogsfor PAIP1

SNPs/Variantsfor PAIP1

Disorders & Mutationsfor PAIP1

Medical Newsfor PAIP1

Publicationsfor PAIP1

Search for PAIP1

Genome Databases showing PAIP1

Other Databases showing PAIP1

Specialized Databases showing PAIP1

Licensable Technologiesfor PAIP1

Servicesfor PAIP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAIP1

Summaries
for PAIP1

Genomic Location
for PAIP1

Proteins
for PAIP1

Protein Domains/
Families
for PAIP1

Gene Function
for PAIP1

Pathways & Interactions
for PAIP1

Drugs & Compounds
for PAIP1

Transcripts
for PAIP1

Expression
for PAIP1

Orthologs
for PAIP1

Paralogs
for PAIP1

SNPs/Variants
for PAIP1

Disorders & Mutations
for PAIP1

Medical News
for PAIP1

Publications
for PAIP1

Licensable Technologies
for PAIP1

Services
for PAIP1