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Aliases for PAIP1 Gene

Aliases for PAIP1 Gene

  • Poly(A) Binding Protein Interacting Protein 1 2 3 5
  • Poly(A)-Binding Protein-Interacting Protein 1 3 4
  • PABP-Interacting Protein 1 3 4
  • PAIP-1 3 4
  • Polyadenylate Binding Protein-Interacting Protein 1 3
  • PABC1-Interacting Protein 1 3

External Ids for PAIP1 Gene

Previous GeneCards Identifiers for PAIP1 Gene

  • GC05M043835
  • GC05M044703
  • GC05M043571
  • GC05M043562
  • GC05M043477

Summaries for PAIP1 Gene

Entrez Gene Summary for PAIP1 Gene

  • The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAIP1 Gene

PAIP1 (Poly(A) Binding Protein Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include RNA binding and translation activator activity.

UniProtKB/Swiss-Prot for PAIP1 Gene

  • Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Gene Wiki entry for PAIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAIP1 Gene

Genomics for PAIP1 Gene

Regulatory Elements for PAIP1 Gene

Promoters for PAIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAIP1 Gene

Chromosome:
5
Start:
43,526,267 bp from pter
End:
43,557,758 bp from pter
Size:
31,492 bases
Orientation:
Minus strand

Genomic View for PAIP1 Gene

Genes around PAIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAIP1 Gene

Proteins for PAIP1 Gene

  • Protein details for PAIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H074-PAIP1_HUMAN
    Recommended name:
    Polyadenylate-binding protein-interacting protein 1
    Protein Accession:
    Q9H074
    Secondary Accessions:
    • A6NKV8
    • O60455
    • Q96B61
    • Q9BS63

    Protein attributes for PAIP1 Gene

    Size:
    479 amino acids
    Molecular mass:
    53525 Da
    Quaternary structure:
    • Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A.

    Three dimensional structures from OCA and Proteopedia for PAIP1 Gene

    Alternative splice isoforms for PAIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAIP1 Gene

Proteomics data for PAIP1 Gene at MOPED

Post-translational modifications for PAIP1 Gene

  • Ubiquitination at Lys 368
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PAIP1 Gene

Domains & Families for PAIP1 Gene

Protein Domains for PAIP1 Gene

Suggested Antigen Peptide Sequences for PAIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H074

UniProtKB/Swiss-Prot:

PAIP1_HUMAN :
  • Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.
Domain:
  • Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.
  • Contains 1 MIF4G domain.
genes like me logo Genes that share domains with PAIP1: view

No data available for Gene Families for PAIP1 Gene

Function for PAIP1 Gene

Molecular function for PAIP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Gene Ontology (GO) - Molecular Function for PAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 9548260
GO:0008494 translation activator activity IDA 9548260
genes like me logo Genes that share ontologies with PAIP1: view
genes like me logo Genes that share phenotypes with PAIP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAIP1 Gene

Localization for PAIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAIP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAIP1 Gene COMPARTMENTS Subcellular localization image for PAIP1 gene
Compartment Confidence
cytosol 5
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for PAIP1 Gene

Pathways & Interactions for PAIP1 Gene

genes like me logo Genes that share pathways with PAIP1: view

Pathways by source for PAIP1 Gene

1 BioSystems pathway for PAIP1 Gene
1 KEGG pathway for PAIP1 Gene
1 Qiagen pathway for PAIP1 Gene

Gene Ontology (GO) - Biological Process for PAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006413 translational initiation TAS 9548260
GO:0045727 positive regulation of translation IDA 9548260
genes like me logo Genes that share ontologies with PAIP1: view

No data available for SIGNOR curated interactions for PAIP1 Gene

Drugs & Compounds for PAIP1 Gene

(2) Additional Compounds for PAIP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAIP1: view

Transcripts for PAIP1 Gene

Unigene Clusters for PAIP1 Gene

Poly(A) binding protein interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAIP1 Gene

No ASD Table

Relevant External Links for PAIP1 Gene

GeneLoc Exon Structure for
PAIP1
ECgene alternative splicing isoforms for
PAIP1

Expression for PAIP1 Gene

mRNA expression in normal human tissues for PAIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PAIP1 Gene

This gene is overexpressed in Skin (6.6) and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAIP1 Gene



SOURCE GeneReport for Unigene cluster for PAIP1 Gene Hs.482038

genes like me logo Genes that share expression patterns with PAIP1: view

Protein tissue co-expression partners for PAIP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PAIP1 Gene

Orthologs for PAIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAIP1 36
  • 100 (a)
OneToOne
PAIP1 35
  • 99.32 (n)
  • 99.74 (a)
cow
(Bos Taurus)
Mammalia PAIP1 35
  • 93.79 (n)
  • 96.94 (a)
-- 36
  • 85 (a)
OneToMany
PAIP1 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PAIP1 36
  • 93 (a)
OneToOne
PAIP1 35
  • 93.91 (n)
  • 96.85 (a)
mouse
(Mus musculus)
Mammalia Paip1 16
Paip1 36
  • 98 (a)
OneToOne
Paip1 35
  • 92.86 (n)
  • 97.96 (a)
oppossum
(Monodelphis domestica)
Mammalia PAIP1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAIP1 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paip1 35
  • 92.46 (n)
  • 98.37 (a)
chicken
(Gallus gallus)
Aves PAIP1 35
  • 76.31 (n)
  • 80 (a)
PAIP1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAIP1 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia paip1-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia paip1 35
  • 65.21 (n)
  • 64.8 (a)
Str.1486 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5680 35
zebrafish
(Danio rerio)
Actinopterygii paip1 35
  • 61.44 (n)
  • 61.03 (a)
wufb53g01 35
paip1 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011627 35
  • 41.63 (n)
  • 29.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8963 35
  • 42.37 (n)
  • 30 (a)
CG8963 36
  • 19 (a)
OneToOne
Species with no ortholog for PAIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAIP1 Gene

ENSEMBL:
Gene Tree for PAIP1 (if available)
TreeFam:
Gene Tree for PAIP1 (if available)

Paralogs for PAIP1 Gene

Pseudogenes.org Pseudogenes for PAIP1 Gene

genes like me logo Genes that share paralogs with PAIP1: view

No data available for Paralogs for PAIP1 Gene

Variants for PAIP1 Gene

Sequence variations from dbSNP and Humsavar for PAIP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs4367306 -- 43,540,522(+) GCAAT(A/G)TATGT intron-variant
rs4533897 -- 43,535,769(+) ATTAT(C/T)CTGTC intron-variant
rs4535459 -- 43,551,480(+) ATAAA(A/G)TTGTG intron-variant
rs4513704 -- 43,538,447(+) TAAAG(A/T)TATAA intron-variant
rs4866749 -- 43,548,116(+) CTGTT(C/T)AGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAIP1 Gene

Variant ID Type Subtype PubMed ID
dgv6043n71 CNV Gain 21882294
nsv830275 CNV Gain 17160897
nsv823062 CNV Gain 20364138
esv2550683 CNV Insertion 19546169
nsv512851 CNV Insertion 21212237
esv270544 CNV Insertion 20981092
esv273191 CNV Insertion 20981092
esv2660584 CNV Deletion 23128226
esv27940 CNV Loss 19812545

Variation tolerance for PAIP1 Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAIP1 Gene

HapMap Linkage Disequilibrium report
PAIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAIP1 Gene

Disorders for PAIP1 Gene

Relevant External Links for PAIP1

Genetic Association Database (GAD)
PAIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAIP1

No disorders were found for PAIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAIP1 Gene

Publications for PAIP1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1. (PMID: 19851022) Kanaan A.S. … Nagar B. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009) 3 23
  3. Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. (PMID: 18725400) Martineau Y. … Sonenberg N. (Mol. Cell. Biol. 2008) 3 23
  4. Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. (PMID: 14685257) Kozlov G. … Gehring K. (EMBO J. 2004) 3 23
  5. Paip1 interacts with poly(A) binding protein through two independent binding motifs. (PMID: 11997512) Roy G. … Sonenberg N. (Mol. Cell. Biol. 2002) 3 23

Products for PAIP1 Gene

Sources for PAIP1 Gene

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