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PAIP1 Gene

protein-coding   GIFtS: 56
GCID: GC05M043526

Poly(A) Binding Protein Interacting Protein 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poly(A) Binding Protein Interacting Protein 11 2     PABC1-Interacting Protein 12
Poly(A)-Binding Protein-Interacting Protein 12 3     Polyadenylate Binding Protein-Interacting Protein 12
PAIP-12 3     Polyadenylate-Binding Protein-Interacting Protein 12
PABP-Interacting Protein 12 3     

External Ids:    HGNC: 169451   Entrez Gene: 106052   Ensembl: ENSG000001722397   OMIM: 6051845   UniProtKB: Q9H0743   

Export aliases for PAIP1 gene to outside databases

Previous GC identifers: GC05M043835 GC05M044703 GC05M043571 GC05M043562 GC05M043477


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PAIP1 Gene:
The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It
is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells
stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three
distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PAIP1 Gene:
PAIP1 (poly(A) binding protein interacting protein 1) is a protein-coding gene. Diseases associated with PAIP1 include malaria. GO annotations related to this gene include RNA binding and translation activator activity.

UniProtKB/Swiss-Prot: PAIP1_HUMAN, Q9H074
Function: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its
stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to
PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved
in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic
deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant
of instability (mCRD) domain

Gene Wiki entry for PAIP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAIP1 gene promoter:
         Spz1   Sp1   Pax-6   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAIP1 promoter sequence
   Search Chromatin IP Primers for PAIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5p12

PAIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAIP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M043526:  view genomic region     (about GC identifiers)

Start:
43,526,369 bp from pter      End:
43,557,860 bp from pter
Size:
31,492 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PAIP1_HUMAN, Q9H074 (See protein sequence)
Recommended Name: Polyadenylate-binding protein-interacting protein 1  
Size: 479 amino acids; 53525 Da
Subunit: Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with
EIF4A
3 PDB 3D structures from and Proteopedia for PAIP1:
1JH4 (3D)        3NTW (3D)        3RK6 (3D)    
Secondary accessions: A6NKV8 O60455 Q96B61 Q9BS63
Alternative splicing: 3 isoforms:  Q9H074-1   Q9H074-2   Q9H074-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PAIP1: NX_Q9H074

Explore proteomics data for PAIP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys368
  • Modification sites at PhosphoSitePlus

  • See PAIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_006442.2  NP_877590.1  NP_899152.1  

    ENSEMBL proteins: 
     ENSP00000302768   ENSP00000387729   ENSP00000426089   ENSP00000339622   ENSP00000425084  
     ENSP00000422084   ENSP00000425675   ENSP00000425736   ENSP00000427410   ENSP00000425406  
    Reactome Protein details: Q9H074

    PAIP1 Human Recombinant Protein Products:

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    Novus Biologicals PAIP1 Proteins
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    Cloud-Clone Corp. CLIAs for PAIP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003890 MIF4G-like_typ-3
     IPR009818 Ataxin-2_C
     IPR016021 MIF4-like_typ_1/2/3
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H074

    ProtoNet protein and cluster: Q9H074

    1 Blocks protein domain: IPB009818 Ataxin-2

    UniProtKB/Swiss-Prot: PAIP1_HUMAN, Q9H074
    Domain: Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation
    Similarity: Contains 1 MIF4G domain


    PAIP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAIP1_HUMAN, Q9H074
    Function: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its
    stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to
    PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved
    in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic
    deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant
    of instability (mCRD) domain

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI10970864
    GO:0008494translation activator activity IDA9548260
         
    PAIP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAIP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAIP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAIP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PAIP1:
    hsa-mir-760 (MIRT036793), hsa-mir-20a-5p (MIRT050527), hsa-mir-17-5p (MIRT050840), hsa-mir-30a-5p (MIRT028550)

    Block miRNA regulation of human, mouse, rat PAIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAIP1 (see all 40):
    hsa-miR-142-5p hsa-miR-25 hsa-miR-628-3p hsa-miR-3916 hsa-miR-548l hsa-miR-3148 hsa-miR-92b hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmidPAIP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PAIP1
    Predesigned siRNA for gene silencing in human, mouse, rat PAIP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PAIP1

    Clone
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    OriGene clones in human, mouse for PAIP1 (see all 20)
    OriGene ORF clones in mouse, rat for PAIP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PAIP1 (NM_183323)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAIP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAIP1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PAIP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAIP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAIP1_HUMAN, Q9H074: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9548260
    GO:0005829cytosol TAS--

    PAIP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PAIP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    2TGF-Beta Pathway
    Regulation of eIF4 and p70S6K0.43
    3Gene Expression
    Gene Expression0.40
    4Translation Factors
    Translation Factors
    5RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PAIP1
        Regulation of eIF4 and p70S6K

    1 BioSystems Pathway for PAIP1
        Translation Factors

    1 Reactome Pathway for PAIP1
        Deadenylation of mRNA


    1 Kegg Pathway  (Kegg details for PAIP1):
        RNA transport


    PAIP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PAIP1
    Interactions:

        GeneGlobe Interaction Network for PAIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PAIP1 (Q9H0741, 2, 3 ENSP000003027684) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119401, 2, 3, ENSP000003130074EBI-81519,EBI-81531 MINT-18204 MINT-18203 MINT-18202 MINT-18201 I2D: score=5 STRING: ENSP00000313007
    UBR5O950713, ENSP000002209594I2D: score=2 STRING: ENSP00000220959
    USP12O753173, ENSP000002823444I2D: score=2 STRING: ENSP00000282344
    EIF4A1P608423, ENSP000002938314I2D: score=3 STRING: ENSP00000293831
    CNOT1ENSP000003209494STRING: ENSP00000320949
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006413translational initiation TAS9548260
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    PAIP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PAIP1

    2 Novoseek inferred chemical compound relationships for PAIP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pabc 94.9 3 11287632 (1), 14685257 (1)
    adenylate 60.8 2 11997512 (1), 11051545 (1)



    PAIP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PAIP1 gene (3 alternative transcripts): 
    NM_006451.4  NM_182789.3  NM_183323.2  

    Unigene Cluster for PAIP1:

    Poly(A) binding protein interacting protein 1
    Hs.482038  [show with all ESTs]
    Unigene Representative Sequence: NM_006451
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306846(uc003joa.3 uc003job.3 uc003joc.3) ENST00000436644
    ENST00000514816 ENST00000338972 ENST00000514514 ENST00000504639 ENST00000511321
    ENST00000508537 ENST00000504075 ENST00000515338
    miRNA
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    Block miRNA regulation of human, mouse, rat PAIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAIP1 (see all 40):
    hsa-miR-142-5p hsa-miR-25 hsa-miR-628-3p hsa-miR-3916 hsa-miR-548l hsa-miR-3148 hsa-miR-92b hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmidPAIP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PAIP1
    Predesigned siRNA for gene silencing in human, mouse, rat PAIP1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PAIP1 (NM_183323)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAIP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAIP1
    Primer
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    OriGene qPCR primer pairs and template standards for PAIP1
    OriGene qSTAR qPCR primer pairs in human, mouse for PAIP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAIP1
      QuantiTect SYBR Green Assays in human, mouse, rat PAIP1
      QuantiFast Probe-based Assays in human, mouse, rat PAIP1

    Additional mRNA sequence: 

    AF013758.2 AK308270.1 AL136920.1 BC005295.1 BC015937.2 DQ786248.1 DQ786326.1 

    19 DOTS entries:

    DT.100812925  DT.316904  DT.92029035  DT.99986203  DT.100812933  DT.95075866  DT.92444677  DT.102838137 
    DT.120862609  DT.92444689  DT.95225834  DT.95225879  DT.100000856  DT.100698936  DT.100715828  DT.100812923 
    DT.120862617  DT.120862635  DT.95225854 

    Selected AceView cDNA sequences (see all 270):

    BQ221855 CR625180 BM928166 BP368961 BG180314 CB114557 CR611090 AW513266 
    BM782103 BQ217727 CR594937 AL548163 CR609051 NM_183323 NM_182789 BM795272 
    CR624807 CR600281 BM723289 CR607203 CR626272 AA367274 CR601652 CR599012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PAIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACTTCAAC
    PAIP1 Expression
    About this image


    PAIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    PAIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482038
        Custom PCR Arrays for PAIP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PAIP1
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    QuantiFast Probe-based Assays in human, mouse, rat PAIP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PAIP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Paip11 , 5 polyadenylate binding protein-interacting protein 11, 5 92.86(n)1
    97.96(a)1
      13 (67.22 cM)5
    2186931  NM_145457.41  NP_663432.11 
     1194286015 
    chicken
    (Gallus gallus)
    Aves PAIP11 poly(A) binding protein interacting protein 1 76.31(n)
    80(a)
      427195  XM_003642935.2  XP_003642983.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAIP16
    poly(A) binding protein interacting protein 1
    73(a)
    1 ↔ 1
    2(6011909-6037800)
    African clawed frog
    (Xenopus laevis)
    Amphibia paip1-pending-prov2 polyadenylate binding protein-interacting protein 1 78.54(n)    BC043861.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb53g012 wufb53g01 74.66(n)   322227  CK236314.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89631 CG8963 42.37(n)
    30(a)
      36913  NM_001259451.1  NP_001246380.1 


    ENSEMBL Gene Tree for PAIP1 (if available)
    TreeFam Gene Tree for PAIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAIP1 gene

    PAIP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PAIP1
    PGOHUM00000237264 PGOHUM00000250173


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAIP1 (see all 708)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339235821,2
    C--43525886(+) GGTAG-/CTACTGTG 3 -- ds50010--------
    rs2004560801,2
    C--43525890(-) CTCACA/GGTAGC 3 -- ds50010--------
    rs1859572931,2
    --43525907(+) AGTAGC/TTGGTG 3 -- ds50010--------
    rs1147189621,2
    C,F--43526157(+) AATTAC/TGTACA 3 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1896271551,2
    --43526407(+) AAAGTC/TTAATT 3 -- ut310--------
    rs1387224581,2
    C--43526791(+) TCTAGC/GCTTTA 3 -- ut310--------
    rs1811076501,2
    --43526899(+) GTTCAA/CCAAGT 3 -- ut310--------
    rs48667471,2
    C--43527033(+) TTTGAT/AATTCA 3 -- ut311Minor allele frequency- A:0.50NA 2
    rs1854512001,2
    --43527107(+) TGCTAC/TATTTT 3 -- ut310--------
    rs10534931,2
    C--43527134(-) CTTCGT/CCTGGA 3 -- ut31 ese31Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for PAIP1 (43526369 - 43557860 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PAIP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660584CNV Deletion23128226
    nsv512851CNV Insertion21212237
    esv270544CNV Insertion20981092
    esv273191CNV Insertion20981092
    esv2550683CNV Insertion19546169
    esv27940CNV Loss19812545
    nsv830275CNV Gain17160897
    nsv823062CNV Gain20364138
    dgv6043n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605184    OMIM disorders: --

    1 disease for PAIP1:    
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    malaria


    PAIP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PAIP1

    Export disorders for PAIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAIP1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with PAIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. (PubMed id 9548260)1, 2, 3 Craig A.W.B.... Sonenberg N. (Nature 1998)
    3. Paip1 interacts with poly(A) binding protein through two independent binding motifs. (PubMed id 11997512)1, 2, 9 Roy G.... Sonenberg N. (Mol. Cell. Biol. 2002)
    4. Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PubMed id 11172725)1, 2, 9 Khaleghpour K.... Sonenberg N. (Mol. Cell 2001)
    5. A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. (PubMed id 11051545)1, 2, 9 Grosset C....Shyu A.-B. (Cell 2000)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Multiple portions of poly(A)-binding protein stimulate translation in vivo. (PubMed id 10970864)1, 2 Gray N.K.... Wickens M. (EMBO J. 2000)
    8. Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1. (PubMed id 19851022)1, 9 Kanaan A.S....Nagar B. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009)
    9. Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. (PubMed id 18725400)1, 9 Martineau Y....Sonenberg N. (Mol. Cell. Biol. 2008)
    10. Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. (PubMed id 14685257)1, 9 Kozlov G....Gehring K. (EMBO J. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10605 HGNC: 16945 AceView: PAIP1 Ensembl:ENSG00000172239 euGenes: HUgn10605
    ECgene: PAIP1 Kegg: 10605 H-InvDB: PAIP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PAIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PAIP1 gene:
    Search GeneIP for patents involving PAIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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