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PAICS Gene

protein-coding GIFtS: 62

GC04P056996

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PAIS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ADE2 ^², ³
ADE2H1 ^¹, ²
AIRC ^¹, ², ³, ⁵
DKFZp781N1372 ^²
MGC1343 ^²
MGC5024 ^²
PAIS ^², ³

Descriptions
AIR carboxylase ^²
SAICAR synthetase ^²
multifunctional protein ADE2 ^²
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase ^²

External Ids
HGNC: 8587¹
Entrez Gene: 10606²
UniProtKB: P22234³
Ensembl: ENSG00000128050⁷

Search outside databases for aliases for PAICS gene

Previous GC identifers: GC04P057105 GC04P057263 GC04P057217 GC04P057143

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAICS:

This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase

activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase

in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely

linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and

transcription of the two genes is coordinately regulated. The human genome contains several

pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found

for this gene. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PAICS gene

Entrez Gene cytogenetic band: 4q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4pter-q21

PAICS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P056996: (about GC identifiers)

Start:	56,996,672 bp from pter
End:	57,022,291 bp from pter
Size:	25,620 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_022853.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PUR6_HUMAN, P22234 (See protein sequence)

Recommended Name: Multifunctional protein ADE2

Size: 425 amino acids; 47079 Da

Subunit: Homooctamer

PDB structures from and Proteopedia :

2H31 (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001072992.1 NP_001072993.1 NP_006443.1

ENSEMBL proteins:

ENSP00000382595 ENSP00000264221

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PAICS)
	Human Recombinant Proteins from Abnova (PAICS)

OriGene Purified Recombinant Human Protein: PAICS

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009320	phosphoribosylaminoimidazole carboxylase complex	IEA	--

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Antibodies for PAICS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PAICS
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PAICS), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PAICS)
	Novus Biologicals Antibody for PAICS

Assays for PAICS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P22234

ProtoNet protein and cluster: P22234

2 Blocks protein families:

IPB000031 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase

IPB001636 SAICAR synthetase

UniProtKB/Swiss-Prot: PUR6_HUMAN, P22234

Similarity: In the N-terminal section; belongs to the SAICAR synthetase family

Similarity: In the C-terminal section; belongs to the AIR carboxylase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAICS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAICS)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006452

Applied Biosystems Silencer® siRNAs for PAICS

Sigma-Aldrich siRNA for PAICS

Sigma-Aldrich shRNA for PAICS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PAICS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001079524
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001079524
untagged cDNA clones in CMV expression vector (see all 3): NM_001079524

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001079525

UniProtKB/Swiss-Prot: PUR6_HUMAN, P22234

Catalytic activity: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate =

ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate

Catalytic activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate =

5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)

Genatlas biochemistry entry for PAICS:

lamino imidazole ribonucleotide (AIR) carboxylase (complementing Ade-D mutants in CHO cells) and

catalyzing respectively the sixth and seventh steps of the novo purine biosynthesis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004638	phosphoribosylaminoimidazole carboxylase activity	IEA	--
GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	TAS	2253271
GO:0005524	ATP binding	IEA	--
GO:0016829	lyase activity	IEA	--
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for PAICS (Your Favorite Gene powered by Ingenuity)

Purine Metabolism

GeneDecks PAICS for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: PUR6_HUMAN, P22234

Pathway: Purine metabolism; IMP biosynthesis via de novo pathway;

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from

N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 3/5

Pathway: Purine metabolism; IMP biosynthesis via de novo pathway;

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from

N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5

5/22 Interacting proteins for PAICS (P22234^{1, 2} ENSP00000264221³) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAICS	P22234¹^,²	EBI-712261, EBI-712261 MINT-63596 MINT-67536 EBI-712261, EBI-712261 MINT-63596 MINT-67536
DGKE	P52429¹	EBI-712261, EBI-1057499
EIF6	P56537¹	EBI-712261, EBI-372243
EPB41	P11171¹	EBI-712261, EBI-1050906
GNAS	P63092¹	EBI-712261, EBI-1047114

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006164	purine nucleotide biosynthetic process	IEA	--
GO:0006189	'de novo' IMP biosynthetic process	IEA	--
GO:0009113	purine base biosynthetic process	TAS	2253271

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAICS
4 Novoseek chemical compound relationships for PAICS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
saicar	94.84	13	2075724 (2), 7742366 (1), 2253271 (1), 19362848 (1) (see all 6)
aminoimidazole ribonucleotide	90.27	11	19095456 (4), 7742366 (1), 8976092 (1), 17224163 (1)
purine	74.75	9	15566465 (3), 10413613 (1), 8109174 (1), 17224163 (1)
prpp	62.82	1	15566465 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAICS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAICS)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006452

Sigma-Aldrich siRNA for PAICS

Sigma-Aldrich shRNA for PAICS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001079524 NM_001079525 NM_006452

REFSEQ mRNAs for PAICS gene (3 alternative transcripts):

NM_001079524.1 NM_001079525.1 NM_006452.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001079524 NM_001079525 NM_006452

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001079524
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001079524
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001079524

Additional cDNA sequence:

AK001163.1 AK054760.1 BX538303.1 CR620081.1

24/37 DOTS entries (see all 37 ):

DT.100846607 DT.446377 DT.95263338 DT.91779102 DT.100846618 DT.95263337 DT.100846611 DT.121267313

DT.101985474 DT.121489088 DT.121267442 DT.100846613 DT.121642403 DT.97815824 DT.100846617 DT.121267379

DT.121267434 DT.91677550 DT.100840978 DT.121267347 DT.121267372 DT.121267390 DT.121267403 DT.91779112

24/961 AceView cDNA sequences (see all 961 ):

CF593503 AA765418 N77356 BM458555 BE907759 CB143811 AW148890 BQ021257

CB136191 BI913538 AA736938 BU683496 BG577395 N47076 CA941062 BU153510

BC010273 CB142614 BX356417 AU077163 AI620852 BM551071 CA448034 AI369191

highest scoring ESTs for PAICS:

X53793 AA169611 AA211898 AA223257 AA233448 AA343674 AA564395 AA580499 AA588530 AA628861

Unigene Clusters for PAICS:

Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

Hs.518774 [show with all ESTs], Hs.709570 [show with all ESTs]

Unigene Representative Sequences: NM_006452, BX538303

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PAICS (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b
SP1:													-				-		-																				-
SP2:					-		-		-				-				-		-
SP3:							-		-				-				-		-
SP4:													-				-
SP5:																	-		-

About this scheme

ECgene alternative splicing isoforms for PAICS

2 Ensembl transcripts including schematic representations:

ENST00000399688 ENST00000264221

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAICS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAICS

¹ / ² / ³

5 probe-sets matching PAICS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39056_at²^{, 3}	U95-A	1	0.94	1.00	1.00	1.00	X53793	1.00	1.00	1.00	1
201013_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA902652	0.60	1.00	0.82	1
201014_s_at²^{, 3}	U133-A	4	1.00	0.67	--	--	NM_006452	0.60	1.00	0.82	1
201013_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201014_s_at²	U133Plus2	4	1.00	0.67	--	--	--	--	--	--	--

GeneDecks PAICS for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.518774 Hs.709570
Expression variation in blood from EXPOLDB for PAICS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAICS gene from 5/15 species (see all 15 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PAICS¹	--	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole more	93.02(n) 96.24(a)	475150 XM_532381.2 XP_532381.2
chimpanzee (Pan troglodytes)	PAICS¹	--	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole more	99.31(n) 98.84(a)	471236 XM_526618.2 XP_526618.2
cow (Bos taurus)	PAICS¹	--	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole more	91.69(n) 94.35(a)	404170 NM_205813.2 NP_991382.2
rat (Rattus norvegicus)	Paics¹	--	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole more	88.78(n) 96(a)	140946 NM_080910.3 NP_543186.1
mouse (Mus musculus)	Paics^{1, 5}	5⁵	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, more^{1, 5}	87.76(n)¹ 94.82(a)¹	67054¹ NM_025939.2¹ NP_080215.1¹ AK002669⁵ AK010462⁵ (see all 15)

About this table Species with no ortholog for PAICS

ENSEMBL Gene Tree for PAICS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/125 NCBI SNPs in PAICS are shown (see all 125 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 68)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs6584^1,2	A,C,F,H	57022162(+)	`TGTTAT/CGCTCT`	3	--	ut3¹		14		MN EA NA EU WA	1422
	rs7693436^1,2	C,F,H	57022370(+)	`TCTGTG/ACAGTA`	3	--	ng3¹		4		EU EA WA	408
	rs11549976^1,2	C,F,H	57009662(+)	`ACCAAA/CGAAAT`	3	K/N	mis¹		11		NA EU EA WA	968
	rs17051687^1,2	F,H	57021163(+)	`CTCATA/GAAAAA`	3	--	ut3¹ ese³		7		NA EU EA WA	548
	rs17086785^1,2	F,H	57022128(+)	`AGATGT/ACATTG`	3	--	ut3¹		7		NA EU EA WA	548
--	rs4132099^1,2	C	57020853(+)	`ctgtcC/Gcccag`	3	--	ut3¹		0	--	--	--	--
	rs6825812^1,2	H	57009743(+)	`GACAAA/TCAGGT`	3	K/N	mis¹		4		EU EA WA	406
	rs6816268^1,2	A,C,F,H	57007144(+)	`gtacaT/Ctcatc`	3	--	int¹		7		EU EA WA NA	558
	rs1356787^1,2	A,C,F,H	56999959(-)	`CAAGTA/GCCAAA`	3	--	int¹		8		EU EA WA NA	774
	rs10015221^1,2	A,C,F,H	57019865(+)	`GCAGAC/TAGAAA`	3	--	int¹		7		NA EU EA WA	538

About this table

HapMap Linkage Disequilibrium images for PAICS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 172439

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/55 PubMed articles for PAICS gene (see all 55 ):

Cloning and sequencing of a human cDNA coding for a multifunctional polypeptide of the purine pathway by complementation of the ade2-101 mutant in Saccharomyces cerevisiae. (PubMed id 2253271)^{1, 2, 3, 4} Minet M. and Lacroute F. (1990)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed. (PubMed id 8106516)^{2, 3} Brayton K.A....Zalkin H. (1994)
Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis. (PubMed id 17224163)^{1, 4} Li S.X....Bi R.C. (2007)
[Testing the activity of enzymes responsible for biosynthesis of purine nucleotides AIR-carboxylase and SAICAR-synthetase in human cell extracts] (PubMed id 2075724)^{1, 3} Alenin V.V....Domkin V.D. (1990)
Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations. (PubMed id 2183217)^{1, 3} Schild D.... Barr P.J. (1990)
Mapping of a locus correcting lack of phosphoribosylaminoimidazole carboxylase activity in Chinese hamster ovary cell Ade-D mutants to human chromosome 4. (PubMed id 2004782)^{1, 3} Barton J.W....Patterson D. (1991)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10606	HGNC: 8587	AceView: PAICSandSRP72	Ensembl:ENSG00000128050	euGenes: HUgn10606
ECgene: PAICS	H-InvDB: PAICS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PAICS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PAICS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAICS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAICS		Antibodies for PAICS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PAICS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PAICS)
	Antibodies (PAICS)
	Chimera RNAi (PAICS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PAICS)
	Antibodies (PAICS)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for PAICS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PAICS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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PAICS Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for PAICS

Summaries
for PAICS

Genomic Location
for PAICS

Proteins
for PAICS

Protein Domains/
Families
for PAICS

Gene Function
for PAICS

Pathways & Interactions
for PAICS

Drugs & Compounds
for PAICS

Transcripts
for PAICS

Expression
for PAICS

Orthologs
for PAICS

Paralogs
for PAICS

SNPs/Variants
for PAICS

Disorders & Mutations
for PAICS

Medical News
for PAICS

Publications
for PAICS

Search for PAICS

Genome Databases showing PAICS

Other Databases showing PAICS

Specialized Databases showing PAICS

Licensable Technologies
for PAICS

Services
for PAICS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAICS Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor PAICS

Summariesfor PAICS

Genomic Locationfor PAICS

Proteinsfor PAICS

Protein Domains/Familiesfor PAICS

Gene Functionfor PAICS

Pathways & Interactionsfor PAICS

Drugs & Compoundsfor PAICS

Transcriptsfor PAICS

Expression for PAICS

Orthologsfor PAICS

Paralogsfor PAICS

SNPs/Variantsfor PAICS

Disorders & Mutationsfor PAICS

Medical Newsfor PAICS

Publicationsfor PAICS

Search for PAICS

Genome Databases showing PAICS

Other Databases showing PAICS

Specialized Databases showing PAICS

Licensable Technologiesfor PAICS

Servicesfor PAICS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAICS

Summaries
for PAICS

Genomic Location
for PAICS

Proteins
for PAICS

Protein Domains/
Families
for PAICS

Gene Function
for PAICS

Pathways & Interactions
for PAICS

Drugs & Compounds
for PAICS

Transcripts
for PAICS

Expression
for PAICS

Orthologs
for PAICS

Paralogs
for PAICS

SNPs/Variants
for PAICS

Disorders & Mutations
for PAICS

Medical News
for PAICS

Publications
for PAICS

Licensable Technologies
for PAICS

Services
for PAICS