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Aliases for PAGR1 Gene

Aliases for PAGR1 Gene

  • PAXIP1 Associated Glutamate-Rich Protein 1 2 3
  • C16orf53 3 4 6
  • PA1 3 4 6
  • Glutamate-Rich Coactivator Interacting With SRC1/NCOA1 2 3
  • Glutamate-Rich Coactivator Associated With SRC1 2 3
  • PAXIP1-Associated Protein 1 3 4
  • PTIP-Associated 1 Protein 2 3
  • PTIP-Associated Protein 1 3 4
  • PAXIP1-Associated Glutamate-Rich Protein 1 3
  • Chromosome 16 Open Reading Frame 53 2
  • GAS 3

External Ids for PAGR1 Gene

Previous HGNC Symbols for PAGR1 Gene

  • C16orf53

Previous GeneCards Identifiers for PAGR1 Gene

  • GC16P029845
  • GC16P029849
  • GC16P029856

Summaries for PAGR1 Gene

Entrez Gene Summary for PAGR1 Gene

  • C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008]

GeneCards Summary for PAGR1 Gene

PAGR1 (PAXIP1 Associated Glutamate-Rich Protein 1) is a Protein Coding gene. Among its related pathways are WNT Signaling and VEGF Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAGR1 Gene

Genomics for PAGR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PAGR1 Gene

Start:
29,816,207 bp from pter
End:
29,822,495 bp from pter
Size:
6,289 bases
Orientation:
Plus strand

Genomic View for PAGR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAGR1 Gene

No data available for Regulatory Elements for PAGR1 Gene

Proteins for PAGR1 Gene

  • Protein details for PAGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTK6-PAGR1_HUMAN
    Recommended name:
    PAXIP1-associated glutamate-rich protein 1
    Protein Accession:
    Q9BTK6
    Secondary Accessions:
    • A2ICR6

    Protein attributes for PAGR1 Gene

    Size:
    254 amino acids
    Molecular mass:
    27716 Da
    Quaternary structure:
    • Interacts with PAXIP1/PTIP; the interaction is direct and is required for the association with the rest of the PTIP complex. Component of the MLL2/MLL3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin.

neXtProt entry for PAGR1 Gene

Proteomics data for PAGR1 Gene at MOPED

Post-translational modifications for PAGR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAGR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PAGR1 Gene

Domains for PAGR1 Gene

Protein Domains for PAGR1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PAGR1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PAGR1 Gene

Function for PAGR1 Gene

Gene Ontology (GO) - Molecular Function for PAGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17178841
genes like me logo Genes that share ontologies with PAGR1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAGR1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PAGR1 Gene

Localization for PAGR1 Gene

Gene Ontology (GO) - Cellular Components for PAGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17500065
GO:0035097 histone methyltransferase complex IDA 17500065
genes like me logo Genes that share ontologies with PAGR1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for PAGR1 Gene

Pathways for PAGR1 Gene

SuperPathways for PAGR1 Gene

genes like me logo Genes that share pathways with PAGR1: view

Pathways by source for PAGR1 Gene

2 Qiagen pathways for PAGR1 Gene

Gene Ontology (GO) - Biological Process for PAGR1 Gene

None

Transcripts for PAGR1 Gene

mRNA/cDNA for PAGR1 Gene

(667) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAGR1 Gene

PAXIP1 associated glutamate-rich protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAGR1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAGR1 Gene

No ASD Table

Relevant External Links for PAGR1 Gene

GeneLoc Exon Structure for
PAGR1
ECgene alternative splicing isoforms for
PAGR1

Expression for PAGR1 Gene

mRNA expression in normal human tissues for PAGR1 Gene

mRNA differential expression in normal tissues according to GTEx for PAGR1 Gene

This gene is overexpressed in Brain - Cerebellum (5.1) and Brain - Cerebellar Hemisphere (4.2).

Protein differential expression in normal tissues for PAGR1 Gene

This gene is overexpressed in Blymphocyte (25.5), Fetal gut (14.8), Testis (12.0), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PAGR1 Gene

SOURCE GeneReport for Unigene cluster for PAGR1 Gene Hs.702841

genes like me logo Genes that share expressions with PAGR1: view

Expression partners for PAGR1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PAGR1 Gene

Orthologs for PAGR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAGR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAGR1 35
  • 90.65 (n)
  • 92.09 (a)
PAGR1 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PAGR1 35
  • 88.71 (n)
  • 89.76 (a)
-- 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pagr1a 35
  • 85.51 (n)
  • 87.75 (a)
Pagr1a 16
Pagr1a 36
  • 88 (a)
ManyToMany
Pagr1b 36
  • 95 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia PAGR1 35
  • 99.74 (n)
  • 99.61 (a)
-- 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pagr1 35
  • 65.94 (n)
  • 66.3 (a)
Str.16387 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.26428 35
zebrafish
(Danio rerio)
Actinopterygii pagr1 35
  • 57.8 (n)
  • 59.57 (a)
pagr1 36
  • 44 (a)
OneToMany
Species with no ortholog for PAGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAGR1 Gene

ENSEMBL:
Gene Tree for PAGR1 (if available)
TreeFam:
Gene Tree for PAGR1 (if available)

Paralogs for PAGR1 Gene

No data available for Paralogs for PAGR1 Gene

Variants for PAGR1 Gene

Sequence variations from dbSNP and Humsavar for PAGR1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs8058824 -- 29,817,389(+) CAGCT(C/G)CCACA intron-variant
rs11546677 -- 29,816,511(+) GGTCC(C/T)TGCCC utr-variant-5-prime
rs11546679 -- 29,816,655(+) CGGCC(A/G)GTAAG missense, reference
rs34508592 -- 29,816,587(-) CCCCT(-/T)CTTCA frameshift-variant, reference
rs34958455 -- 29,817,581(-) GGCAG(-/GAG)AATTG intron-variant

Relevant External Links for PAGR1 Gene

HapMap Linkage Disequilibrium report
PAGR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PAGR1 Gene

Disorders for PAGR1 Gene

No disorders were found for PAGR1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PAGR1 Gene

Publications for PAGR1 Gene

  1. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. (PMID: 17500065) Cho Y.-W. … Ge K. (J. Biol. Chem. 2007) 2 3 4
  2. GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. (PMID: 19039327) Liang J. … Shang Y. (EMBO Rep. 2009) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  5. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. (PMID: 17178841) Issaeva I. … Canaani E. (Mol. Cell. Biol. 2007) 3

Products for PAGR1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PAGR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PAGR1
    • Block miRNA regulation of PAGR1 using miScript Target Protectors
    • Addgene plasmids for PAGR1

    Sources for PAGR1 Gene

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