Aliases for PAGR1 Gene
- PAXIP1 Associated Glutamate Rich Protein 1 2 3
- PAXIP1 Associated Glutamate-Rich Protein 1 2 3 5
- Glutamate-Rich Coactivator Interacting With SRC1/NCOA1 2 3
- Glutamate-Rich Coactivator Interacting With SRC1 3 4
- Glutamate-Rich Coactivator Associated With SRC1 2 3
- PAXIP1-Associated Protein 1 3 4
- PTIP-Associated 1 Protein 2 3
External Ids for PAGR1 Gene
Previous HGNC Symbols for PAGR1 Gene
Previous GeneCards Identifiers for PAGR1 Gene
C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008]
GeneCards Summary for PAGR1 Gene
PAGR1 (PAXIP1 Associated Glutamate Rich Protein 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and VEGF Pathway (Qiagen). An important paralog of this gene is ENSG00000281348.
UniProtKB/Swiss-Prot for PAGR1 Gene
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582).