Aliases for PAGR1 Gene
- PAXIP1 Associated Glutamate Rich Protein 1 2 3
- PAXIP1 Associated Glutamate-Rich Protein 1 2 3 5
- Glutamate-Rich Coactivator Interacting With SRC1/NCOA1 2 3
- Glutamate-Rich Coactivator Interacting With SRC1 3 4
- Glutamate-Rich Coactivator Associated With SRC1 2 3
- PAXIP1-Associated Protein 1 3 4
- PTIP-Associated 1 Protein 2 3
External Ids for PAGR1 Gene
Previous HGNC Symbols for PAGR1 Gene
Previous GeneCards Identifiers for PAGR1 Gene
C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008]
GeneCards Summary for PAGR1 Gene
PAGR1 (PAXIP1 Associated Glutamate Rich Protein 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is ENSG00000281348.
UniProtKB/Swiss-Prot for PAGR1 Gene
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582).