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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PAGE5 Gene

protein-coding   GIFtS: 45
GCID: GC0XP055263

P Antigen Family, Member 5 (Prostate Associated)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
P Antigen Family, Member 5 (Prostate Associated)1 2     Member 11
Cancer/Testis Antigen 16.12 3     Member 21
G Antigen Family E Member 12 3     CT162
Prostate-Associated Gene 5 Protein2 3     CT16.22
CT16.12 3     Cancer/Testis Antigen Family 16, Member 12
GAGEE12 3     Cancer/Testis Antigen Family 16, Member 22
PAGE-52 3     G Antigen, Family E, 12
Cancer/Testis Antigen Family 161     P Antigen Family Member 52

External Ids:    HGNC: 299921   Entrez Gene: 907372   Ensembl: ENSG000001586397   UniProtKB: Q96GU13   

Export aliases for PAGE5 gene to outside databases

Previous GC identifers: GC0XP055130 GC0XP052295


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PAGE5 Gene:
This gene is a member of the GAGE family, which is expressed in a variety of tumors and in some fetal and
reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE
proteins. It may also belong to a family of CT (cancer-testis) antigens. Multiple alternatively spliced
transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some
variants have not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for PAGE5 Gene: 
PAGE5 (P antigen family, member 5 (prostate associated)) is a protein-coding gene. Diseases associated with PAGE5 include hepatocellular fibrolamellar carcinoma, and prostatitis. An important paralog of this gene is PAGE2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011630.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PAGE5
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAGE5 promoter sequence
   Search SABiosciences Chromatin IP Primers for PAGE5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAGE5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.21   Ensembl cytogenetic band:  Xp11.21   HGNC cytogenetic band: Xp11.22

PAGE5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAGE5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP055263:  view genomic region     (about GC identifiers)

Start:
55,246,788 bp from pter      End:
55,250,541 bp from pter
Size:
3,754 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAGE5_HUMAN, Q96GU1 (See protein sequence)
Recommended Name: P antigen family member 5  
Size: 130 amino acids; 14046 Da
Secondary accessions: Q2NL97 Q5JUL0 Q8WWL9
Alternative splicing: 2 isoforms:  Q96GU1-1   Q96GU1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PAGE5: NX_Q96GU1

Explore proteomics data for PAGE5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GU1

  • PAGE5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PAGE5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001013453.1  NP_569734.2  

    ENSEMBL proteins: 
     ENSP00000289619   ENSP00000364093   ENSP00000364090  

    Human Recombinant Protein Products for PAGE5: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008625 GAGE

    Graphical View of Domain Structure for InterPro Entry Q96GU1

    ProtoNet protein and cluster: Q96GU1

    1 Blocks protein domain: IPB008625 GAGE

    UniProtKB/Swiss-Prot: PAGE5_HUMAN, Q96GU1
    Similarity: Belongs to the GAGE family


    PAGE5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for PAGE5:
     Decreased viability after Chla  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PAGE5 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PAGE5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PAGE5 (ENSP000002896194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POT1ENSP000003502494STRING: ENSP00000350249
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PAGE5

    Search CenterWatch for drugs/clinical trials and news about PAGE5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PAGE5 gene (2 alternative transcripts): 
    NM_001013435.1  NM_130467.3  

    Unigene Cluster for PAGE5:

    P antigen family, member 5 (prostate associated)
    Hs.668491  [show with all ESTs]
    Unigene Representative Sequence: BF026248
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289619(uc004duj.3) ENST00000374955(uc004duk.3) ENST00000374952

    miRNA
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    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for PAGE5
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAGE5
    Sirion Biotech Customized lentivirus for stable overexpression of PAGE5 
                         Customized lentivirus expression plasmids for stable overexpression of PAGE5 
    Primer
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    OriGene qPCR primer pairs and template standards for PAGE5
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAGE5

    Additional mRNA sequence: 

    AJ344352.1 BC009230.2 BC110803.1 

    2 DOTS entries:

    DT.92420663  DT.92420665 

    24/25 AceView cDNA sequences (see all 25):

    BF062128 AW135330 BQ437151 BX088870 BE896256 BF026605 AA824398 BE386042 
    AW205230 BC009230 BE386043 NM_130467 BE408094 BQ425920 BF026249 AJ344352 
    BP429046 BF026248 BG477487 BE896742 BU156217 BE410403 BG333836 CB159986 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PAGE5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACAAGATC
    PAGE5 Expression
    About this image


    See PAGE5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PAGE5

    SOURCE GeneReport for Unigene cluster: Hs.668491
        SABiosciences Custom PCR Arrays for PAGE5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAGE5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for PAGE5 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia PAGE51 P antigen family, member 5 (prostate associated) 99.23(n)
    97.69(a)
      465659  XM_521084.4  XP_521084.3 


    ENSEMBL Gene Tree for PAGE5 (if available)
    TreeFam Gene Tree for PAGE5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PAGE5 gene
    PAGE22  PAGE2B2  PAGE32  
    7 SIMAP similar genes for PAGE5 using alignment to 2 protein entries:     PAGE5_HUMAN (see all proteins):
    PAGE2B    PAGE2    PAGE3    XAGE5    XAGE2    XAGE2B
    XAGE3

    PAGE5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PAGE5
    PGOHUM00000241796


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/119 SNPs in PAGE5 are shown (see all 119)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59137971,2
    C,H--55262014(+) gaggtG/Ttgcag 1 -- us2k17Minor allele frequency- T:0.00NA WA CSA 10
    rs1387884131,2
    --55262383(+) TGTTTC/TGTAGT 1 -- us2k10--------
    rs1419687281,2
    C--55262457(+) TGGCAA/GTTGTG 1 -- us2k10--------
    rs1463155121,2
    --55262474(+) ATTGTA/GTTTCT 1 -- us2k10--------
    rs1486841121,2
    C--55262551(+) GTATCC/TGGAAA 1 -- us2k10--------
    rs1831081861,2
    C--55262725(+) ATGCCC/TAATAA 1 -- us2k10--------
    rs48263781,2
    C,F,A,H--55262900(+) TAATAA/CCTAGT 1 -- us2k112Minor allele frequency- C:0.14NS EA NA WA 560
    rs1878536001,2
    C--55262965(+) AGACAA/GATGTG 1 -- us2k10--------
    rs1915833821,2
    --55263197(+) CAAATA/GATGTA 1 -- us2k10--------
    rs59137981,2
    C,F,A,H--55263245(+) TTTTTG/TTTTGt 1 -- us2k1 tfbs3 trp32Minor allele frequency- T:0.40NA 5

    HapMap Linkage Disequilibrium report for PAGE5 (55246788 - 55250541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PAGE5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740175CNV Deletion23290073
    nsv435891CNV Deletion17901297
    esv2740181CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for PAGE5:    About MalaCards
    hepatocellular fibrolamellar carcinoma    prostatitis    sarcoma    melanoma

    1 disease from the University of Copenhagen DISEASES database for PAGE5:
    Hepatocellular fibrolamellar carcinoma

    PAGE5 for disorders           About GeneDecksing


    Export disorders for PAGE5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PAGE5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PAGE5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2, 3 Zendman A.J.W....van Muijen G.N.P. (2002)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of cancer/testis genes by database mining and mRNA expression analysis. (PubMed id 11920606)1, 3 Scanlan M.J....Old L.J. (2002)
    5. Melanoma-associated cancer-testis antigen 16 (CT16) re gulates the expression of apoptotic and antiapoptotic genes and promotes cell su rvival. (PubMed id 23028975)1 Nylund C....Heino J. (2012)
    6. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90737 HGNC: 29992 AceView: PAGE-5 Ensembl:ENSG00000158639 euGenes: HUgn90737
    ECgene: PAGE5 H-InvDB: PAGE5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PAGE5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PAGE5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PAGE5 gene:
    Search GeneIP for patents involving PAGE5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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