PAGE5 Gene
protein-coding GIFtS: 44
GCID: GC0XP055263
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P antigen family, member 5 (prostate associated)
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Aliases
for PAGE5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| P Antigen Family, Member 5 (Prostate Associated)1 2 | | GAGEE12 3 | | CT16.11 2 3 | | CT162 | | PAGE-51 2 3 | | Cancer/Testis Antigen Family 16, Member 12 | | CT16.21 2 | | Cancer/Testis Antigen Family 16, Member 22 | | Cancer/Testis Antigen 16.12 3 | | G Antigen Family E Member 12 | | Prostate-Associated Gene 5 Protein2 3 | | G Antigen, Family E, 12 |
Export aliases for PAGE5 gene to outside databasesPrevious GC identifers: GC0XP055130 GC0XP052295 |
Summaries
for PAGE5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PAGE5:
This gene is a member of the GAGE family, which is expressed in a variety of tumors and in some fetal and reproductivetissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. It may alsobelong to a family of CT (cancer-testis) antigens. Multiple alternatively spliced transcript variants encodingdistinct isoforms have been found for this gene, but the biological validity of some variants have not beendetermined. (provided by RefSeq, Jul 2008)
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Genomic Views
for PAGE5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PAGE5
Other transcription factors
Search SABiosciences Chromatin IP Primers for PAGE5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAGE5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.22PAGE5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP055263: view genomic region
(about GC identifiers)
Start:
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55,246,788 bp from pter |
End:
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55,250,541 bp from pter |
Size:
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3,754 bases |
Orientation:
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plus strand |
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Proteins
for PAGE5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GGEE1_HUMAN, Q96GU1 (See
protein sequence)Recommended Name: G antigen family E member 1 Size: 130 amino acids; 14046 Da
Secondary accessions: Q2NL97 Q5JUL0 Q8WWL9Alternative splicing: 2 isoforms: Q96GU1-1 Q96GU1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PAGE5: NX_Q96GU1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GU1
PAGE5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001013453.1 NP_569734.2
ENSEMBL proteins: ENSP00000289619 ENSP00000364093 ENSP00000364090
Human Recombinant Protein Products for PAGE5:
PAGE5 Antibody Products:
Assay Products for PAGE5: |
Protein
Domains /
Families
for PAGE5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PAGE5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96GU1ProtoNet protein and cluster: Q96GU1 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GGEE1_HUMAN, Q96GU1Similarity: Belongs to the GAGE family |
Function
for PAGE5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for PAGE5:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PAGE5 (NM_001013435) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAGE5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAGE5 |
|
Pathways & Interactions
for PAGE5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PAGE5
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PAGE5 (ENSP000002896194) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for PAGE5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PAGE5
Search CenterWatch for drugs/clinical trials and news about PAGE5 / GGEE1
|
Transcripts
for PAGE5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PAGE5 gene (2 alternative transcripts): NM_001013435.1 NM_130467.3 Unigene Cluster for PAGE5: P antigen family, member 5 (prostate associated) Hs.668491 [show with all ESTs]Unigene Representative Sequence: BF0262483 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000289619(uc004duj.3) ENST00000374955(uc004duk.3) ENST00000374952
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PAGE5 (NM_001013435) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAGE5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAGE5 |
Additional cDNA sequence: AJ344352.1 BC009230.2 BC110803.1 2 DOTS entries: DT.92420663 DT.92420665 24/25 AceView cDNA sequences (see all 25): BE896256 BX088870 AW135330 BF062128 BQ437151 BF026249 BP429046 NM_130467 BQ425920 BE386042 BF026605 AW205230 AJ344352 BC009230 BF026248 BE408094 BE386043 AA824398 BE896742 BE410403 BG333836 BG477487 BU156217 CB159986
GeneLoc Exon Structure
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Expression
for PAGE5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PAGE5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACAAGATC
About this image
See PAGE5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PAGE5
SOURCE GeneReport for Unigene cluster: Hs.668491
SABiosciences Custom PCR Arrays for PAGE5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAGE5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PAGE5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAGE5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAGE5 |
Orthologs
for PAGE5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for PAGE5 (if available)
TreeFam Gene Tree for PAGE5 (if available) |
Paralogs
for PAGE5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PAGE5 gene
- PAGE22 GAGE2D2 GAGE42 XAGE32 GAGE102 GAGE12H2 GAGE12I2 PAGE32
- XAGE52 XAGE2B2 GAGE12C2 GAGE12E2 GAGE12D2 GAGE12 PAGE2B2 GAGE2E2
- GAGE2C2 GAGE12F2 PAGE12 GAGE132 XAGE22 GAGE12G2 GAGE2A2 GAGE2B2
- PAGE42 GAGE12J2
8 SIMAP similar genes for PAGE5 using alignment to 2 protein entries: GGEE1_HUMAN (see all proteins):PAGE2B PAGE2 PAGE3 XAGE5 XAGE2 XAGE2B
XAGE3 PAGE4
PAGE5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PAGE5
PGOHUM00000241796
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Genomic Variants
for PAGE5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PAGE5 (55246788 - 55250541 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PAGE5
1 CNV: 23256 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAGE5 |
|
Disorders
/ Diseases
for PAGE5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PAGE5 for disorders About GeneDecksing
4  diseases for PAGE5: About MalaCardsprostatitis hepatocellular fibrolamellar carcinoma sarcoma melanoma
1 disease from the University of Copenhagen DISEASES database for PAGE5:Hepatocellular fibrolamellar carcinoma Export disorders for PAGE5 gene to outside databases
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Publications
for PAGE5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PAGE5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PAGE5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2, 3 Zendman A.J.W....van Muijen G.N.P. (2002)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of cancer/testis genes by database mining and mRNA expression analysis. (PubMed id 11920606)1, 3 Scanlan M.J....Old L.J. (2002)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for PAGE5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PAGE5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PAGE5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PAGE5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PAGE5 gene:
Search GeneIP for patents involving PAGE5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PAGE5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PAGE5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAGE5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAGE5 | | | OriGene Protein Over-expression Lysate for PAGE5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PAGE5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PAGE5 | | OriGene Custom Protein Services for PAGE5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PAGE5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAGE5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAGE5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAGE5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAGE5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAGE5 |
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 | | | PAGE5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for PAGE5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAGE5 |
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