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PAGE5 Gene

protein-coding GIFtS: 38

GC0XP055263

P antigen family, member 5 (prostate associated)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CT16.1 ^³
GAGEE1 ^², ³
OTTHUMP00000023398 ^²
OTTHUMP00000023399 ^²
PAGE-5 ^¹, ², ³

Descriptions
Cancer/testis antigen 16.1 ^³
G antigen, family E, 1 ^²
P antigen family, member 5 ^²
P antigen family, member 5 (prostate associated) ^²
Prostate-associated gene 5 protein ^³

External Ids
HGNC: 29992¹
Entrez Gene: 90737²
UniProtKB: Q96GU1³
Ensembl: ENSG00000158639⁷

Search outside databases for aliases for PAGE5 gene

Previous GC identifer: GC0XP055130

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAGE5:

This gene is a member of the GAGE family, which is expressed in a variety of tumors and in some

fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with

other GAGE/PAGE proteins. It may also belong to a family of CT (cancer-testis) antigens. Multiple

alternatively spliced transcript variants encoding distinct isoforms have been found for this

gene, but the biological validity of some variants have not been determined. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.22

PAGE5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP055263: (about GC identifiers)

Start:	55,263,515 bp from pter
End:	55,267,266 bp from pter
Size:	3,752 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011630.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GGEE1_HUMAN, Q96GU1 (See protein sequence)

Recommended Name: G antigen family E member 1

Size: 130 amino acids; 14046 Da

Secondary accessions: Q8WWL9

REFSEQ proteins (2 alternative transcripts):

NP_001013453.1 NP_569734.2

ENSEMBL proteins:

ENSP00000289619 ENSP00000379481 ENSP00000364093 ENSP00000364090

Human Recombinant Proteins

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OriGene Purified Recombinant Human Protein: PAGE5

Antibodies for PAGE5:

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Assays for PAGE5:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96GU1

ProtoNet protein and cluster: Q96GU1

1 Blocks protein family: IPB008625 GAGE

UniProtKB/Swiss-Prot: GGEE1_HUMAN, Q96GU1

Similarity: Belongs to the GAGE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAGE5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001013435

Applied Biosystems Silencer® siRNAs for PAGE5

Sigma-Aldrich siRNA for PAGE5

Sigma-Aldrich shRNA for PAGE5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PAGE5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001013435
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001013435
untagged cDNA clones in CMV expression vector (see all 2): NM_001013435

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_130467

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAGE5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAGE5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001013435

Sigma-Aldrich siRNA for PAGE5

Sigma-Aldrich shRNA for PAGE5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001013435 NM_130467

REFSEQ mRNAs for PAGE5 gene (2 alternative transcripts):

NM_001013435.1 NM_130467.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_130467

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001013435
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001013435
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001013435

Additional cDNA sequence:

AJ344352.1 BC009230.2 BC110803.1

2 DOTS entries:

DT.92420663 DT.92420665

24/25 AceView cDNA sequences (see all 25 ):

AW135330 BQ437151 BE896256 BF062128 BX088870 AA824398 BQ425920 BE386042

BP429046 BC009230 AJ344352 AW205230 BF026249 NM_130467 BE408094 BF026248

BF026605 BE386043 BE896742 BG477487 BG333836 BU156217 BE410403 BF026873

highest scoring ESTs for PAGE5:

AJ344352 BC009230 BE386042 BE408094 BF026248 BF026293 BF026605 AW135330 AW205230 BE386043

Unigene Cluster for PAGE5:

P antigen family, member 5 (prostate associated)

Hs.668491 [show with all ESTs]

Unigene Representative Sequence: BF026248

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000289619 ENST00000396178 ENST00000374955 ENST00000374952

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PAGE5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAGE5

¹ / ² / ³

3 probe-sets matching PAGE5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54512_s_at²^{, 3}	U95-C	4	1.00	0.25	1.00	1.00	AA824398	0.80	0.83	0.82	1
236152_at²^{, 3}	U133-B	4	1.00	0.82	--	--	AW135330	0.60	1.00	0.82	1
236152_at²	U133Plus2	4	1.00	0.82	--	--	--	--	--	--	--

GeneDecks PAGE5 for binary patterns associated with the probe-sets selected above

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About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAACAAGATC

SOURCE GeneReport for Unigene cluster: Hs.668491

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAGE5 gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	PAGE5¹	--	P antigen family, member 5 (prostate associated)	97.64(n) 94.69(a)	465659 XM_521084.2 XP_521084.2

About this table Species with no ortholog for PAGE5

ENSEMBL Gene Tree for PAGE5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PAGE5 gene

PAGE2² PAGE2B² PAGE3² PAGE4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/24 NCBI SNPs in PAGE5 are shown (see all 24 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 6)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs4826378^1,2	A,C,F,H	55262421(+)	`TAATAA/CCTAGT`	2	--	ng5¹		7		EU EA WA NA	530
	rs5914273^1,2	A,C,F,H	55263755(+)	`AGGTCG/CTGATG`	2	--	ut5¹ int¹		7		EU EA WA NA	528
	rs4826379^1,2	C,F,H	55263267(+)	`TTGTCT/CGAAAC`	2	--	ng5¹		4		EU EA WA	396
--	rs5913798^1,2	A,C	55262766(+)	`TTTTTG/TTTTGt`	2	--	ng5¹ tfbs³ trp³		0	--	--	--	--
--	rs5913799^1,2	A,C	55262783(+)	`gttttG/Tttttt`	2	--	ng5¹ tfbs³		0	--	--	--	--
--	rs5914272^1,2	A	55263690(+)	`GGTCCC/TGTGGC`	2	--	int¹ ut5¹ ese³		0	--	--	--	--
--	rs5913797^1,2	C	55261535(+)	`gaggtG/Ttgcag`	2	--	ng5¹		0	--	--	--	--
--	rs2148982^1,2	A,C,F,H,O	55265774(-)	`CCTTAA/GAGATA`	2	--	int¹		10		NA EA EU WA	809
--	rs5914275^1,2	A,C,F,H	55265101(+)	`GTGACA/GTACCA`	2	--	int¹		7		EU EA WA NA	562
--	rs4826274^1,2	A,C,F,H	55264815(+)	`TCTCTA/CTATAT`	2	--	int¹ trp³		4		EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for PAGE5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for PAGE5 gene:

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)^{3, 4} Zendman A.J.W....van Muijen G.N.P. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 90737	HGNC: 29992	AceView: PAGE-5	Ensembl:ENSG00000158639	euGenes: HUgn90737
ECgene: PAGE5	H-InvDB: PAGE5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PAGE5	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PAGE5
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PAGE5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAGE5-related products

	Millipore Custom Antibody & Bulk Services
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PAGE5 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for PAGE5

Summaries
for PAGE5

Genomic Location
for PAGE5

Proteins
for PAGE5

Protein Domains/
Families
for PAGE5

Gene Function
for PAGE5

Pathways & Interactions
for PAGE5

Drugs & Compounds
for PAGE5

Transcripts
for PAGE5

Expression
for PAGE5

Orthologs
for PAGE5

Paralogs
for PAGE5

SNPs/Variants
for PAGE5

Disorders & Mutations
for PAGE5

Medical News
for PAGE5

Publications
for PAGE5

Search for PAGE5

Genome Databases showing PAGE5

Other Databases showing PAGE5

Specialized Databases showing PAGE5

Licensable Technologies
for PAGE5

Services
for PAGE5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAGE5 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor PAGE5

Summariesfor PAGE5

Genomic Locationfor PAGE5

Proteinsfor PAGE5

Protein Domains/Familiesfor PAGE5

Gene Functionfor PAGE5

Pathways & Interactionsfor PAGE5

Drugs & Compoundsfor PAGE5

Transcriptsfor PAGE5

Expression for PAGE5

Orthologsfor PAGE5

Paralogsfor PAGE5

SNPs/Variantsfor PAGE5

Disorders & Mutationsfor PAGE5

Medical Newsfor PAGE5

Publicationsfor PAGE5

Search for PAGE5

Genome Databases showing PAGE5

Other Databases showing PAGE5

Specialized Databases showing PAGE5

Licensable Technologiesfor PAGE5

Servicesfor PAGE5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAGE5

Summaries
for PAGE5

Genomic Location
for PAGE5

Proteins
for PAGE5

Protein Domains/
Families
for PAGE5

Gene Function
for PAGE5

Pathways & Interactions
for PAGE5

Drugs & Compounds
for PAGE5

Transcripts
for PAGE5

Expression
for PAGE5

Orthologs
for PAGE5

Paralogs
for PAGE5

SNPs/Variants
for PAGE5

Disorders & Mutations
for PAGE5

Medical News
for PAGE5

Publications
for PAGE5

Licensable Technologies
for PAGE5

Services
for PAGE5