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Aliases for PAGE5 Gene

Aliases for PAGE5 Gene

  • PAGE Family Member 5 2 3 5
  • P Antigen Family, Member 5 (Prostate Associated) 2 3
  • Cancer/Testis Antigen Family 16, Member 1 2 3
  • Cancer/Testis Antigen Family 16, Member 2 2 3
  • Prostate-Associated Gene 5 Protein 3 4
  • G Antigen Family E Member 1 3 4
  • Cancer/Testis Antigen 16.1 3 4
  • CT16.1 3 4
  • GAGEE1 3 4
  • PAGE-5 3 4
  • P Antigen Family Member 5 3
  • CT16.2 3
  • CT16 3

External Ids for PAGE5 Gene

Previous GeneCards Identifiers for PAGE5 Gene

  • GC0XP055130
  • GC0XP052295

Summaries for PAGE5 Gene

Entrez Gene Summary for PAGE5 Gene

  • This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. The encoded protein may protect cells from programmed cell death. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jan 2015]

GeneCards Summary for PAGE5 Gene

PAGE5 (PAGE Family Member 5) is a Protein Coding gene. An important paralog of this gene is PAGE2B.

Additional gene information for PAGE5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAGE5 Gene

Genomics for PAGE5 Gene

Genomic Location for PAGE5 Gene

Chromosome:
X
Start:
55,220,347 bp from pter
End:
55,224,108 bp from pter
Size:
3,762 bases
Orientation:
Plus strand

Genomic View for PAGE5 Gene

Genes around PAGE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAGE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAGE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAGE5 Gene

No data available for Regulatory Elements for PAGE5 Gene

Proteins for PAGE5 Gene

  • Protein details for PAGE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GU1-PAGE5_HUMAN
    Recommended name:
    P antigen family member 5
    Protein Accession:
    Q96GU1
    Secondary Accessions:
    • Q2NL97
    • Q5JUL0
    • Q8WWL9

    Protein attributes for PAGE5 Gene

    Size:
    130 amino acids
    Molecular mass:
    14046 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PAGE5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAGE5 Gene

Post-translational modifications for PAGE5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAGE5 Gene

No data available for DME Specific Peptides for PAGE5 Gene

Domains & Families for PAGE5 Gene

Gene Families for PAGE5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PAGE5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PAGE5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GU1

UniProtKB/Swiss-Prot:

PAGE5_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with PAGE5: view

Function for PAGE5 Gene

Gene Ontology (GO) - Molecular Function for PAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with PAGE5: view
genes like me logo Genes that share phenotypes with PAGE5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PAGE5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAGE5 Gene

Localization for PAGE5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAGE5 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PAGE5 Gene

Pathways & Interactions for PAGE5 Gene

SuperPathways for PAGE5 Gene

No Data Available

Interacting Proteins for PAGE5 Gene

Selected Interacting proteins: Q96GU1-PAGE5_HUMAN for PAGE5 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for PAGE5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAGE5 Gene

Drugs & Compounds for PAGE5 Gene

No Compound Related Data Available

Transcripts for PAGE5 Gene

mRNA/cDNA for PAGE5 Gene

Unigene Clusters for PAGE5 Gene

P antigen family, member 5 (prostate associated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PAGE5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PAGE5 Gene

No ASD Table

Relevant External Links for PAGE5 Gene

GeneLoc Exon Structure for
PAGE5
ECgene alternative splicing isoforms for
PAGE5

Expression for PAGE5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAGE5 Gene

mRNA differential expression in normal tissues according to GTEx for PAGE5 Gene

This gene is overexpressed in Testis (x47.4).

Protein differential expression in normal tissues from HIPED for PAGE5 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PAGE5 Gene



Protein tissue co-expression partners for PAGE5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAGE5 Gene:

PAGE5

SOURCE GeneReport for Unigene cluster for PAGE5 Gene:

Hs.668491
genes like me logo Genes that share expression patterns with PAGE5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAGE5 Gene

Orthologs for PAGE5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PAGE5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAGE5 33 34
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 44 (a)
ManyToMany
Species where no ortholog for PAGE5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAGE5 Gene

ENSEMBL:
Gene Tree for PAGE5 (if available)
TreeFam:
Gene Tree for PAGE5 (if available)

Paralogs for PAGE5 Gene

Paralogs for PAGE5 Gene

(7) SIMAP similar genes for PAGE5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PAGE5 Gene

genes like me logo Genes that share paralogs with PAGE5: view

Variants for PAGE5 Gene

Sequence variations from dbSNP and Humsavar for PAGE5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000290960 -- 55,222,856(+) CATCT(A/G)AAGAT intron-variant
rs1001364645 -- 55,223,123(+) GGTTG(A/G)GCCGT intron-variant
rs1006110822 -- 55,224,286(+) CCTCT(A/G)TATCC downstream-variant-500B
rs1006367825 -- 55,221,172(+) AGGTG(A/T)TTTCT intron-variant
rs1007322454 -- 55,222,277(+) TTTAT(-/TAA)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAGE5 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv2740181 CNV deletion 23290073
nsv435891 CNV deletion 17901297

Variation tolerance for PAGE5 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAGE5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAGE5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAGE5 Gene

Disorders for PAGE5 Gene

Relevant External Links for PAGE5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAGE5

No disorders were found for PAGE5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAGE5 Gene

Publications for PAGE5 Gene

  1. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman AJ … Van Muijen GN (International journal of cancer 2002) 2 3 4 60
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Identification of cancer/testis genes by database mining and mRNA expression analysis. (PMID: 11920606) Scanlan MJ … Old LJ (International journal of cancer 2002) 2 3 60
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60

Products for PAGE5 Gene

Sources for PAGE5 Gene

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