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Aliases for PAGE4 Gene

Aliases for PAGE4 Gene

  • PAGE Family Member 4 2 3 5
  • P Antigen Family, Member 4 (Prostate Associated) 2 3
  • G Antigen Family C Member 1 3 4
  • PAGE-1 3 4
  • GAGEC1 3 4
  • PAGE-4 3 4
  • Prostate-Associated Gene Protein 4 3
  • G Antigen, Family C, 1 2
  • GAGE-9 3
  • CT16.7 3
  • JM-27 3
  • JM27 3

External Ids for PAGE4 Gene

Previous HGNC Symbols for PAGE4 Gene

  • GAGEC1

Previous GeneCards Identifiers for PAGE4 Gene

  • GC0XP049297
  • GC0XP049481
  • GC0XP049593
  • GC0XP047063

Summaries for PAGE4 Gene

Entrez Gene Summary for PAGE4 Gene

  • This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for PAGE4 Gene

PAGE4 (PAGE Family Member 4) is a Protein Coding gene. Diseases associated with PAGE4 include Testicular Cancer and Prostate Cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAGE4 Gene

Genomics for PAGE4 Gene

Regulatory Elements for PAGE4 Gene

Enhancers for PAGE4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PAGE4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAGE4 Gene

49,829,260 bp from pter
49,834,037 bp from pter
4,778 bases
Plus strand

Genomic View for PAGE4 Gene

Genes around PAGE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAGE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAGE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAGE4 Gene

Proteins for PAGE4 Gene

  • Protein details for PAGE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P antigen family member 4
    Protein Accession:
    Secondary Accessions:
    • B2R529
    • D3DX68
    • Q6IBI1

    Protein attributes for PAGE4 Gene

    102 amino acids
    Molecular mass:
    11153 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PAGE4 Gene

Proteomics data for PAGE4 Gene at MOPED

Post-translational modifications for PAGE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAGE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PAGE4 Gene

Domains & Families for PAGE4 Gene

Protein Domains for PAGE4 Gene


Suggested Antigen Peptide Sequences for PAGE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with PAGE4: view

No data available for Gene Families for PAGE4 Gene

Function for PAGE4 Gene

Molecular function for PAGE4 Gene

GENATLAS Biochemistry:
prostate associated gene 4,expressed in normal and neoplastic prostate,testis and uteris,fallopian tube and placenta,homolog to a family of MAGE/GAGE-like proteins

Phenotypes for PAGE4 Gene

genes like me logo Genes that share phenotypes with PAGE4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAGE4 Gene

Localization for PAGE4 Gene

Subcellular locations from

Jensen Localization Image for PAGE4 Gene COMPARTMENTS Subcellular localization image for PAGE4 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PAGE4 Gene

Pathways & Interactions for PAGE4 Gene

SuperPathways for PAGE4 Gene

No Data Available

Interacting Proteins for PAGE4 Gene

Gene Ontology (GO) - Biological Process for PAGE4 Gene


No data available for Pathways by source and SIGNOR curated interactions for PAGE4 Gene

Drugs & Compounds for PAGE4 Gene

No Compound Related Data Available

Transcripts for PAGE4 Gene

Unigene Clusters for PAGE4 Gene

P antigen family, member 4 (prostate associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAGE4 Gene

No ASD Table

Relevant External Links for PAGE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PAGE4 Gene

mRNA expression in normal human tissues for PAGE4 Gene

mRNA differential expression in normal tissues according to GTEx for PAGE4 Gene

This gene is overexpressed in Prostate (x33.2), Fallopian Tube (x6.9), and Uterus (x5.5).

Protein differential expression in normal tissues from HIPED for PAGE4 Gene

This gene is overexpressed in Placenta (55.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PAGE4 Gene

SOURCE GeneReport for Unigene cluster for PAGE4 Gene Hs.441038

mRNA Expression by UniProt/SwissProt for PAGE4 Gene

Tissue specificity: Preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus, and placenta, as well as in prostate cancer, testicular cancer, and uterine cancer.
genes like me logo Genes that share expression patterns with PAGE4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for PAGE4 Gene

Orthologs for PAGE4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PAGE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PAGE4 35
  • 100 (n)
  • 100 (a)
PAGE4 36
  • 100 (a)
(Bos Taurus)
Mammalia PAGE4 36
  • 55 (a)
Species with no ortholog for PAGE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAGE4 Gene

Gene Tree for PAGE4 (if available)
Gene Tree for PAGE4 (if available)

Paralogs for PAGE4 Gene

(5) SIMAP similar genes for PAGE4 Gene using alignment to 1 proteins: Pseudogenes for PAGE4 Gene

genes like me logo Genes that share paralogs with PAGE4: view

No data available for Paralogs for PAGE4 Gene

Variants for PAGE4 Gene

Sequence variations from dbSNP and Humsavar for PAGE4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1802956 -- 49,832,598(+) TCTGA(C/T)GTAAA reference, synonymous-codon
rs2280892 -- 49,829,161(+) GCAGG(C/T)CCTTC upstream-variant-2KB
rs2280893 -- 49,829,533(+) CCAAG(A/G)TGCTG intron-variant
rs5906881 -- 49,828,296(+) gacat(C/T)acctg upstream-variant-2KB
rs6520467 -- 49,832,310(+) TAGAT(C/T)GTGAA intron-variant

Variation tolerance for PAGE4 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PAGE4 Gene

Disorders for PAGE4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PAGE4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
testicular cancer
  • childhood neoplasm of the testis
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search PAGE4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAGE4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PAGE4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAGE4 Gene

Publications for PAGE4 Gene

  1. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PMID: 9724777) Brinkmann U. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers. (PMID: 12489849) Iavarone C. … Bera T.K. (Mol. Cancer Ther. 2002) 3 23
  3. Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen. (PMID: 26242913) He Y. … Orban J. (J. Biol. Chem. 2015) 3
  4. The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation. (PMID: 24263171) Rajagopalan K. … Kulkarni P. (Biochim. Biophys. Acta 2014) 3
  5. Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway. (PMID: 24559171) Mooney S.M. … Weninger K.R. (Biochemistry 2014) 3

Products for PAGE4 Gene

Sources for PAGE4 Gene