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PAGE3 Gene

protein-coding   GIFtS: 38

GC0XM055301
P antigen family, member 3 (prostate associated)
(Previous names: G antigen, family D, 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GAGED1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
GAGEC1 2, 5
GAGED1 2, 3
OTTHUMP00000037449 2
PAGE-3 1, 2, 3
Descriptions
G antigen, family D, 1 1, 2
P antigen family, member 3 (prostate associated) 2
Prostate-associated gene 3 protein 3
External Ids
HGNC: 41101
Entrez Gene: 1397932
UniProtKB: Q5JUK93
Ensembl: ENSG000002042797
Search outside databases for aliases for PAGE3 gene

Previous GC identifer: GC0XM055168

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PAGE3 gene  

Entrez Gene cytogenetic band: Xp11.21   Ensembl cytogenetic band:  Xp11.21   HGNC cytogenetic band: Xp11

PAGE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM055301:     (about GC identifiers)

Start:
55,301,573 bp from pter
End:
55,308,004 bp from pter
Size:
6,432 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011630.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GGED1_HUMAN, Q5JUK9 (See protein sequence)
Recommended Name: Putative G antigen family D member 1  
Size: 113 amino acids; 12480 Da

REFSEQ proteins: NP_001017931.1  

ENSEMBL proteins: 
ENSP00000364089 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for PAGE3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for PAGE3

Assays for PAGE3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR008625 GAGE


   GeneDecks  PAGE3 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q5JUK9

ProtoNet protein and cluster: Q5JUK9

1 Blocks protein family: IPB008625 GAGE

UniProtKB/Swiss-Prot: GGED1_HUMAN, Q5JUK9
Similarity: Belongs to the GAGE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PAGE3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_060054

              Applied Biosystems Silencer® siRNAs for PAGE3

              Sigma-Aldrich siRNA for PAGE3  
                     Sigma-Aldrich shRNA for PAGE3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017931
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017931
                                 untagged cDNA clone in CMV expression vector: NM_001017931 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001017931

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAGE3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PAGE3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_060054

              Sigma-Aldrich siRNA for PAGE3  
                     Sigma-Aldrich shRNA for PAGE3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001017931  

REFSEQ mRNAs for PAGE3 gene: 

NM_001017931.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001017931  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017931
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017931
                                 untagged cDNA clone in CMV expression vector: NM_001017931 

Additional cDNA sequence: 

BC140001.1 BC140741.1 BC144449.1 

2 DOTS entries:

DT.40245891  DT.100738252 

5 AceView cDNA sequences:

CD519391 BX104655 CD559036 AI392665 AA907594 

highest scoring ESTs for PAGE3:

AI392665 BX104655 AA907594 CD519391 CD559036 DB449522 DB514537 NM_001017931 

Unigene Cluster for PAGE3:

P antigen family, member 3 (prostate associated)
Hs.163473  [show with all ESTs]
Unigene Representative Sequence: CD559036


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000374951  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAGE3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for PAGE3

1 / 2 / 3

2 probe-sets matching PAGE3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

84491_f_at2, 3 U95-D 2 1.00 0.97 0.90 0.67 AI392665 0.60 1.00 0.82 1

84488_i_at2, 3 U95-D 2 1.00 0.96 0.67 1.34 AI392665 0.60 1.00 0.82 1
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CAGTCTTTAT

SOURCE GeneReport for Unigene cluster: Hs.163473
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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ENSEMBL Gene Tree for PAGE3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for PAGE3 gene
PAGE22  PAGE52  PAGE2B2  PAGE42  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/29 NCBI SNPs in PAGE3 are shown (see all 29 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 16)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs28876541,2
A,C,F,H55307893(+) CCGCAG/CGACCT 1 -- ut51 ese37Minor allele frequency- C:0.47EU EA WA NA 562
rs48263811,2
A,C,F,H55306499(+) GTCATC/TACTGG 1 N/D mis1 ese311Minor allele frequency- T:0.15EU EA WA NA 845
rs22968071,2
C,F,H55306445(+) TTGACC/TAGGTG 1 G/S mis1 ese38Minor allele frequency- T:0.03EU EA WA 732
rs37615601,2
A,C,F,H55303756(+) CCATCT/GCCACG 1 G/G syn111Minor allele frequency- G:0.27EU EA WA NA 770
rs21489811,2
A,C,F,H55306318(+) TATTGT/CTTTTT 1 -- int1 trp310Minor allele frequency- C:0.15NA EA EU WA 811
rs23701311,2
A,C,F,H55307422(+) CATTTC/ACCCCC 1 -- int14Minor allele frequency- A:0.16EU EA WA 418
rs37615591,2
A,C,F,H55303612(+) CAGTAG/TTGGTA 1 -- int14Minor allele frequency- T:0.32EU EA WA 402
--
rs66122831,2
C,F,H55305461(+) AATTAT/CACTGA 1 -- int17Minor allele frequency- C:0.34EU EA WA NA 562
rs59138071,2
C,F,H55304545(+) tataaG/Tagaat 1 -- int14Minor allele frequency- T:0.14EU EA WA 404
rs22968061,2
F,H55306366(+) ACATAC/TACCCC 1 -- int14Minor allele frequency- T:0.02EU EA WA 418
About this table

HapMap Linkage Disequilibrium images for PAGE3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300739

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

2 PubMed articles for PAGE3 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 139793 HGNC: 4110 AceView: LOC139793 Ensembl:ENSG00000204279 euGenes: HUgn139793
ECgene: PAGE3 H-InvDB: PAGE3
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for PAGE3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PAGE3-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for PAGE3 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for PAGE3 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search Tocris compounds for PAGE3




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for PAGE3

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