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Aliases for PAGE3 Gene

Aliases for PAGE3 Gene

  • PAGE Family Member 3 2 3 5
  • P Antigen Family, Member 3 (Prostate Associated) 2 3
  • Prostate-Associated Gene 3 Protein 3 4
  • G Antigen Family D Member 1 3 4
  • G Antigen, Family D, 1 2 3
  • GAGED1 3 4
  • PAGE-3 3 4
  • P Antigen Family Member 3 3
  • CT16.6 3

External Ids for PAGE3 Gene

Previous HGNC Symbols for PAGE3 Gene

  • GAGED1

Previous GeneCards Identifiers for PAGE3 Gene

  • GC0XM055168
  • GC0XM052334

Summaries for PAGE3 Gene

Entrez Gene Summary for PAGE3 Gene

  • This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2015]

GeneCards Summary for PAGE3 Gene

PAGE3 (PAGE Family Member 3) is a Protein Coding gene. An important paralog of this gene is PAGE5.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAGE3 Gene

Genomics for PAGE3 Gene

Regulatory Elements for PAGE3 Gene

Enhancers for PAGE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG055450 0.8 ENCODE 0.4 +11.2 11249 2.7 PKNOX1 MXI1 CREB3L1 MAX RAD21 ZBTB40 E2F1 ZNF316 POLR2A KDM5B MAGEH1 KLF8 PAGE3
GH0XG055487 0.4 ENCODE 0.3 -23.6 -23632 0.1 RFX1 LOC101928692 PAGE3
GH0XG055456 0.2 Ensembl 0.4 +7.4 7352 0.2 MAGEH1 PAGE3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PAGE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAGE3 Gene

Chromosome:
X
Start:
55,258,412 bp from pter
End:
55,463,452 bp from pter
Size:
205,041 bases
Orientation:
Minus strand

Genomic View for PAGE3 Gene

Genes around PAGE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAGE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAGE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAGE3 Gene

Proteins for PAGE3 Gene

  • Protein details for PAGE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JUK9-PAGE3_HUMAN
    Recommended name:
    P antigen family member 3
    Protein Accession:
    Q5JUK9
    Secondary Accessions:
    • A5D6Y1

    Protein attributes for PAGE3 Gene

    Size:
    113 amino acids
    Molecular mass:
    12480 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PAGE3 Gene

Post-translational modifications for PAGE3 Gene

No Post-translational modifications

Other Protein References for PAGE3 Gene

No data available for DME Specific Peptides for PAGE3 Gene

Domains & Families for PAGE3 Gene

Protein Domains for PAGE3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PAGE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JUK9

UniProtKB/Swiss-Prot:

PAGE3_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with PAGE3: view

No data available for Gene Families for PAGE3 Gene

Function for PAGE3 Gene

Gene Ontology (GO) - Molecular Function for PAGE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PAGE3: view
genes like me logo Genes that share phenotypes with PAGE3: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAGE3 Gene

Localization for PAGE3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAGE3 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PAGE3 Gene

Pathways & Interactions for PAGE3 Gene

SuperPathways for PAGE3 Gene

No Data Available

Interacting Proteins for PAGE3 Gene

Gene Ontology (GO) - Biological Process for PAGE3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAGE3 Gene

Drugs & Compounds for PAGE3 Gene

No Compound Related Data Available

Transcripts for PAGE3 Gene

mRNA/cDNA for PAGE3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAGE3 Gene

P antigen family, member 3 (prostate associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAGE3 Gene

No ASD Table

Relevant External Links for PAGE3 Gene

GeneLoc Exon Structure for
PAGE3
ECgene alternative splicing isoforms for
PAGE3

Expression for PAGE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAGE3 Gene

mRNA differential expression in normal tissues according to GTEx for PAGE3 Gene

This gene is overexpressed in Testis (x52.7).

NURSA nuclear receptor signaling pathways regulating expression of PAGE3 Gene:

PAGE3

SOURCE GeneReport for Unigene cluster for PAGE3 Gene:

Hs.163473
genes like me logo Genes that share expression patterns with PAGE3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAGE3 Gene

Orthologs for PAGE3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PAGE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAGE3 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 44 (a)
ManyToMany
Species where no ortholog for PAGE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAGE3 Gene

ENSEMBL:
Gene Tree for PAGE3 (if available)
TreeFam:
Gene Tree for PAGE3 (if available)

Paralogs for PAGE3 Gene

Paralogs for PAGE3 Gene

(9) SIMAP similar genes for PAGE3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PAGE3 Gene

genes like me logo Genes that share paralogs with PAGE3: view

Variants for PAGE3 Gene

Sequence variations from dbSNP and Humsavar for PAGE3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1001866243 -- 55,258,168(+) AAAGG(C/G)AGACT downstream-variant-500B, utr-variant-3-prime
rs1002530504 -- 55,262,621(+) GACAC(A/T)ATCTC intron-variant
rs1003576119 -- 55,262,885(+) ACTCT(A/C)CGCAT intron-variant
rs1003614296 -- 55,257,905(+) ATCCT(A/G)TGATA utr-variant-3-prime
rs1003942673 -- 55,260,004(+) ATAAC(C/T)AATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAGE3 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv2740181 CNV deletion 23290073
nsv435891 CNV deletion 17901297

Variation tolerance for PAGE3 Gene

Gene Damage Index Score: 0.97; 19.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAGE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAGE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAGE3 Gene

Disorders for PAGE3 Gene

Relevant External Links for PAGE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAGE3

No disorders were found for PAGE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAGE3 Gene

Publications for PAGE3 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PMID: 9724777) Brinkmann U. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 64
  3. Genome-wide association study of smoking behaviours among Bangladeshi adults. (PMID: 24665060) Argos M. … Ahsan H. (J. Med. Genet. 2014) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for PAGE3 Gene

Sources for PAGE3 Gene

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