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Aliases for PAGE3 Gene

Aliases for PAGE3 Gene

  • PAGE Family Member 3 2 3 5
  • P Antigen Family, Member 3 (Prostate Associated) 2 3
  • Prostate-Associated Gene 3 Protein 3 4
  • G Antigen Family D Member 1 3 4
  • G Antigen, Family D, 1 2 3
  • GAGED1 3 4
  • PAGE-3 3 4
  • P Antigen Family Member 3 3
  • CT16.6 3

External Ids for PAGE3 Gene

Previous HGNC Symbols for PAGE3 Gene

  • GAGED1

Previous GeneCards Identifiers for PAGE3 Gene

  • GC0XM055168
  • GC0XM052334

Summaries for PAGE3 Gene

Entrez Gene Summary for PAGE3 Gene

  • This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2015]

GeneCards Summary for PAGE3 Gene

PAGE3 (PAGE Family Member 3) is a Protein Coding gene. An important paralog of this gene is XAGE5.

Additional gene information for PAGE3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAGE3 Gene

Genomics for PAGE3 Gene

GeneHancer (GH) Regulatory Elements for PAGE3 Gene

Promoters and enhancers for PAGE3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI055264 Promoter 0.5 EPDnew 550.1 +198.5 198523 0.1 PAGE3 LOC100421746 PAGE5 GC0XP055190
GH0XI055265 Promoter 0.5 EPDnew 550.1 +198.8 198750 0.1 PAGE3 LOC100421746 PAGE5 GC0XP055190
GH0XI055450 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 0.4 +11.1 11132 3 MXI1 PKNOX1 MAX E4F1 ZBTB40 RAD21 E2F1 ZNF316 POLR2A ETV6 MAGEH1 MIR4536-1 MIR4536-2 KLF8 PAGE3
GH0XI055487 Enhancer 0.3 ENCODE 0.3 -23.6 -23632 0.1 RFX1 LOC101928692 USP51 PAGE3
GH0XI055456 Enhancer 0.2 Ensembl 0.4 +7.4 7351 0.2 MAGEH1 PAGE3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PAGE3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PAGE3 gene promoter:

Genomic Locations for PAGE3 Gene

Genomic Locations for PAGE3 Gene
chrX:55,258,412-55,463,452
(GRCh38/hg38)
Size:
205,041 bases
Orientation:
Minus strand
chrX:55,284,848-55,291,279
(GRCh37/hg19)

Genomic View for PAGE3 Gene

Genes around PAGE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAGE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAGE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAGE3 Gene

Proteins for PAGE3 Gene

  • Protein details for PAGE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JUK9-PAGE3_HUMAN
    Recommended name:
    P antigen family member 3
    Protein Accession:
    Q5JUK9
    Secondary Accessions:
    • A5D6Y1

    Protein attributes for PAGE3 Gene

    Size:
    113 amino acids
    Molecular mass:
    12480 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PAGE3 Gene

Post-translational modifications for PAGE3 Gene

No Post-translational modifications

Other Protein References for PAGE3 Gene

No data available for DME Specific Peptides for PAGE3 Gene

Domains & Families for PAGE3 Gene

Gene Families for PAGE3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PAGE3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PAGE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JUK9

UniProtKB/Swiss-Prot:

PAGE3_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with PAGE3: view

Function for PAGE3 Gene

Gene Ontology (GO) - Molecular Function for PAGE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PAGE3: view
genes like me logo Genes that share phenotypes with PAGE3: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAGE3 Gene

Localization for PAGE3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAGE3 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PAGE3 Gene

Pathways & Interactions for PAGE3 Gene

SuperPathways for PAGE3 Gene

No Data Available

Interacting Proteins for PAGE3 Gene

Gene Ontology (GO) - Biological Process for PAGE3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAGE3 Gene

Drugs & Compounds for PAGE3 Gene

No Compound Related Data Available

Transcripts for PAGE3 Gene

mRNA/cDNA for PAGE3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAGE3 Gene

P antigen family, member 3 (prostate associated):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAGE3 Gene

No ASD Table

Relevant External Links for PAGE3 Gene

GeneLoc Exon Structure for
PAGE3
ECgene alternative splicing isoforms for
PAGE3

Expression for PAGE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAGE3 Gene

mRNA differential expression in normal tissues according to GTEx for PAGE3 Gene

This gene is overexpressed in Testis (x52.7).

NURSA nuclear receptor signaling pathways regulating expression of PAGE3 Gene:

PAGE3

SOURCE GeneReport for Unigene cluster for PAGE3 Gene:

Hs.163473
genes like me logo Genes that share expression patterns with PAGE3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAGE3 Gene

Orthologs for PAGE3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PAGE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAGE3 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 44 (a)
ManyToMany
Species where no ortholog for PAGE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAGE3 Gene

ENSEMBL:
Gene Tree for PAGE3 (if available)
TreeFam:
Gene Tree for PAGE3 (if available)

Paralogs for PAGE3 Gene

Paralogs for PAGE3 Gene

(9) SIMAP similar genes for PAGE3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PAGE3 Gene

genes like me logo Genes that share paralogs with PAGE3: view

Variants for PAGE3 Gene

Sequence variations from dbSNP and Humsavar for PAGE3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001866243 -- 55,258,168(-) C/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1002530504 -- 55,262,621(-) A/T intron_variant
rs1003576119 -- 55,262,885(-) A/C intron_variant
rs1003614296 -- 55,257,905(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1003942673 -- 55,260,004(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PAGE3 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv2740181 CNV deletion 23290073
nsv435891 CNV deletion 17901297

Variation tolerance for PAGE3 Gene

Gene Damage Index Score: 0.97; 19.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAGE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAGE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAGE3 Gene

Disorders for PAGE3 Gene

Additional Disease Information for PAGE3

No disorders were found for PAGE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAGE3 Gene

Publications for PAGE3 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PMID: 9724777) Brinkmann U … Pastan I (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 58
  3. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  4. Genome-wide association study of smoking behaviours among Bangladeshi adults. (PMID: 24665060) Argos M … Ahsan H (Journal of medical genetics 2014) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for PAGE3 Gene

Sources for PAGE3 Gene

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