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PAGE2B Gene

protein-coding   GIFtS: 37

GC0XP055118
P antigen family, member 2B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
GAGEE3 2, 3
OTTHUMP00000023392 2
PAGE-2B 3
Descriptions
G antigen, family E, 3 2
P antigen family, member 2B 2
Prostate-associated gene 2B protein 3
External Ids
HGNC: 318051
Entrez Gene: 3898602
UniProtKB: Q5JRK93
Ensembl: ENSG000001877617
Search outside databases for aliases for PAGE2B gene

Previous GC identifer: GC0XP054985

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PAGE2B gene  

Entrez Gene cytogenetic band: Xp11.21   Ensembl cytogenetic band:  Xp11.21   HGNC cytogenetic band: Xp11.22

PAGE2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP055118:     (about GC identifiers)

Start:
55,118,221 bp from pter
End:
55,122,067 bp from pter
Size:
3,847 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011630.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GGEE3_HUMAN, Q5JRK9 (See protein sequence)
Recommended Name: Putative G antigen family E member 3  
Size: 111 amino acids; 12041 Da
Secondary accessions: A1L414

REFSEQ proteins: NP_001015038.1  

ENSEMBL proteins: 
ENSP00000364110 ENSP00000364113 


Human Recombinant Proteins 
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Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for PAGE2B: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for PAGE2B

Assays for PAGE2B: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR008625 GAGE


   GeneDecks  PAGE2B for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q5JRK9

ProtoNet protein and cluster: Q5JRK9

1 Blocks protein family: IPB008625 GAGE

UniProtKB/Swiss-Prot: GGEE3_HUMAN, Q5JRK9
Similarity: Belongs to the GAGE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001015038

              Applied Biosystems Silencer® siRNAs for PAGE2B

              Sigma-Aldrich siRNA for PAGE2B  
                     Sigma-Aldrich shRNA for PAGE2B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001015038
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001015038
                                 untagged cDNA clone in CMV expression vector: NM_001015038 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001015038

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAGE2B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001015038

              Sigma-Aldrich siRNA for PAGE2B  
                     Sigma-Aldrich shRNA for PAGE2B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001015038  

REFSEQ mRNAs for PAGE2B gene: 

NM_001015038.1   


              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001015038
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001015038
                                 untagged cDNA clone in CMV expression vector: NM_001015038 

Additional cDNA sequence: BC130359.1 

1 DOTS entry:

DT.444522 

18 AceView cDNA sequences:

AA927353 BM782405 BM782748 AA976812 AA909141 AW236993 AW002915 AI125278 
BG150356 BV204624 AI968054 AI969761 BV200118 BM821844 AW025812 AW628855 
BM740184 AA905990 

highest scoring ESTs for PAGE2B:

AA976812 AA909141 AA927353 AI968054 AI969761 AW002915 AW025812 AW236993 BG150356 BM740184 

Unigene Cluster for PAGE2B:

P antigen family, member 2B
Hs.293317  [show with all ESTs]
Unigene Representative Sequence: EL735845


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PAGE2B

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1:              -                                             
SP2:              -                 -     -                     
SP3:                                                            

About this scheme

ECgene alternative splicing isoforms for PAGE2B

2 Ensembl transcripts including schematic representations:
ENST00000374971  ENST00000374974  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAGE2B expression in normal and diseased human tissues

1 / 2 / 3

5 probe-sets matching PAGE2B gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

51721_at2, 3 U95-C 5 1.00 0.42 0.41 0.35 AA815378 0.20 0.25 0.23 2

57322_at2, 3 U95-C 4 1.00 0.38 0.47 0.19 AA976812 0.60 0.62 0.61 1
54512_s_at2, 3 U95-C 4 1.00 0.25 1.00 1.00 AA824398 0.20 0.08 0.15 2

231307_at2, 3 U133-B 2 0.73 0.50 -- -- AW002915 0.40 0.67 0.55 1

231307_at2 U133Plus2 2 0.73 0.50 -- -- -- -- -- -- --
GeneDecks  PAGE2B for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.293317
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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ENSEMBL Gene Tree for PAGE2B
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for PAGE2B gene
PAGE21 2  PAGE52  PAGE32  PAGE42  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/34 NCBI SNPs in PAGE2B are shown (see all 34 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 2)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs78784671,2
A,C,F,H55116774(+) aaattT/Gccctg 1 -- ng514Minor allele frequency- G:0.11EU EA WA 418
--
rs11322101,2
H55119829(+) CTGCCG/TTTCAA 1 V/F mis1 ese34Minor allele frequency- T:0.00EU EA WA 406
--
rs24984451,2
C55117406(+) aacagG/Taatat 1 -- ng510--------
--
rs10523671,2
A,C,F,H55120642(+) GAGGGT/GATTAT 1 G/G syn1 ese3 trp34Minor allele frequency- G:0.12EU EA WA 418
--
rs19653201,2
A,C55120504(+) TTCCTT/CGTTCA 1 -- int13Minor allele frequency- C:0.01NA 117
--
rs32047291,2
--55119733(+) TCCAGC/GAGCCC 1 E/Q mis10--------
--
rs78917621,2
--55117130(+) ggtttC/Gcaaac 1 -- ng510--------
--
rs734904661,2
--55118124(+) CACTTC/GTCTGT 1 -- ng510--------
--
rs24984471,2
--55117864(+) AACAGA/GTATTA 1 -- ng51 tfbs30--------
--
rs734904561,2
--55116313(+) CTGCCC/TGAACA 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for PAGE2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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2 PubMed articles for PAGE2B gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 389860 HGNC: 31805 AceView: LOC389860 Ensembl:ENSG00000187761 euGenes: HUgn389860
ECgene: PAGE2B H-InvDB: PAGE2B
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for PAGE2B:
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PAGE2B-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for PAGE2B Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for PAGE2B Browse small molecules at Sigma-Aldrich
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