V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

PAGE2 Gene

protein-coding GIFtS: 40

GC0XP055119

P antigen family, member 2 (prostate associated)
(Previous names: G antigen, family C, 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GAGEC2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GAGEC2 ^², ⁵
GAGEE2 ^², ³
MGC62094 ^¹, ²
OTTHUMP00000023395 ^²
PAGE-2 ^¹, ², ³

Descriptions
G antigen, family C, 2 ^¹, ²
G antigen, family E, 2 ^²
P antigen family, member 2 ^²
P antigen family, member 2 (prostate associated) ^²
Prostate-associated gene 2 protein ^³

External Ids
HGNC: 31804¹
Entrez Gene: 203569²
UniProtKB: Q7Z2X7³
Ensembl: ENSG00000221833⁷

Search outside databases for aliases for PAGE2 gene

Previous GC identifer: GC0XP054999

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.22

PAGE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP055119: (about GC identifiers)

Start:	55,132,210 bp from pter
End:	55,136,000 bp from pter
Size:	3,791 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011630.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GGEE2_HUMAN, Q7Z2X7 (See protein sequence)

Recommended Name: G antigen family E member 2

Size: 111 amino acids; 12090 Da

Sequence caution: Sequence=CAI39879.1; Type=Erroneous gene model prediction;

Secondary accessions: Q5JRK7 Q5JRK8

REFSEQ proteins: NP_997222.1

ENSEMBL proteins:

ENSP00000364104 ENSP00000364107

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for PAGE2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for PAGE2

Assays for PAGE2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q7Z2X7

ProtoNet protein and cluster: Q7Z2X7

1 Blocks protein family: IPB008625 GAGE

UniProtKB/Swiss-Prot: GGEE2_HUMAN, Q7Z2X7

Similarity: Belongs to the GAGE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_114723

Applied Biosystems Silencer® siRNAs for PAGE2

Sigma-Aldrich siRNA for PAGE2

Sigma-Aldrich shRNA for PAGE2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PAGE2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_207339
Myc/DDK tagged cDNA clone in CMV expression vector: NM_207339
untagged cDNA clone in CMV expression vector: NM_207339

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_207339

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for PAGE2 (ENSP00000364107³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAGE1	ENSP00000365320³	STRING (score=.732)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAGE2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_114723

Sigma-Aldrich siRNA for PAGE2

Sigma-Aldrich shRNA for PAGE2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_207339

REFSEQ mRNAs for PAGE2 gene:

NM_207339.2

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_207339
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_207339
                                 untagged cDNA clone in CMV expression vector: NM_207339

Additional cDNA sequence: BC054022.1

2 DOTS entries:

DT.100020517 DT.86853458

8 AceView cDNA sequences:

AI652066 AA437077 BX113994 AA815378 AA423978 NM_207339 BU598418 BC054022

highest scoring ESTs for PAGE2:

XM_114723 BC054022 BU598418 AA437077 AI652066 BU564995 BX113994 NM_207339 AA815378 AA905990

Unigene Cluster for PAGE2:

P antigen family, member 2 (prostate associated)

Hs.662489 [show with all ESTs]

Unigene Representative Sequence: BU564995

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000374965 ENST00000374968

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAGE2 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching PAGE2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
51721_at²^{, 3}	U95-C	5	1.00	0.42	0.41	0.35	AA815378	0.40	0.50	0.45	1
57322_at²^{, 3}	U95-C	4	1.00	0.38	0.47	0.19	AA976812	0.20	0.12	0.17	3
54512_s_at²^{, 3}	U95-C	4	1.00	0.25	1.00	1.00	AA824398	0.20	0.08	0.15	2
231307_at²	U133-B	2	0.73	0.50	--	--	--	--	--	--	--
231307_at²	U133Plus2	2	0.73	0.50	--	--	--	--	--	--	--

GeneDecks PAGE2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAGCTTTTC

SOURCE GeneReport for Unigene cluster: Hs.662489

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for PAGE2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PAGE2 gene

PAGE2B¹ ² PAGE5² PAGE3² PAGE4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/44 NCBI SNPs in PAGE2 are shown (see all 44 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 9)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1845444^1,2	C,F,H	55133191(+)	`AGCTTG/CTAAGA`	1	V/L	mis¹		10		NA EA EU WA	820
--	rs3736310^1,2	H	55133261(+)	`TGTGAT/CTGTGA`	1	T/I	mis¹		4		EU EA WA	418
--	rs2934730^1,2	--	55130987(+)	`ctctgC/Tgcttg`	1	--	ng5¹		0	--	--	--	--
--	rs2934731^1,2	--	55131028(+)	`tttttA/Gtacat`	1	--	ng5¹		0	--	--	--	--
--	rs2498446^1,2	--	55131671(+)	`GGGTGA/CAACAG`	1	--	ng5¹		0	--	--	--	--
--	rs2260572^1,2	--	55131401(+)	`CTAGTA/Gtctca`	1	--	ng5¹		0	--	--	--	--
--	rs2498455^1,2	--	55131789(+)	`TTGCAA/GTGGGT`	1	--	ng5¹		0	--	--	--	--
--	rs7064535^1,2	--	55131240(+)	`TGAATA/GTGAAG`	1	--	ng5¹		0	--	--	--	--
--	rs73214621^1,2	--	55132056(+)	`GAGGCA/GGGAAA`	1	--	ng5¹		0	--	--	--	--
--	rs2453228^1,2	--	55133747(+)	`AAAATC/GAAGCA`	1	Q/E	mis¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for PAGE2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300738

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for PAGE2 gene:

The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PubMed id 9724777)^{2, 3} Brinkmann U....Pastan I. (1998)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Leishmanial amastigote antigen P-2 induces major histocompatibility complex class II-dependent natural killer-cell reactivity in cells from healthy donors. (PubMed id 15030581)¹ Nylen S....Akuffo H. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 203569	HGNC: 31804	AceView: MGC62094	Ensembl:ENSG00000221833	euGenes: HUgn203569
ECgene: PAGE2	H-InvDB: PAGE2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PAGE2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PAGE2:

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAGE2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAGE2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PAGE2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for PAGE2

Search Tocris compounds for PAGE2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for PAGE2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PAGE2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

PAGE2 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for PAGE2

Summaries
for PAGE2

Genomic Location
for PAGE2

Proteins
for PAGE2

Protein Domains/
Families
for PAGE2

Gene Function
for PAGE2

Pathways & Interactions
for PAGE2

Drugs & Compounds
for PAGE2

Transcripts
for PAGE2

Expression
for PAGE2

Orthologs
for PAGE2

Paralogs
for PAGE2

SNPs/Variants
for PAGE2

Disorders & Mutations
for PAGE2

Medical News
for PAGE2

Publications
for PAGE2

Search for PAGE2

Genome Databases showing PAGE2

Other Databases showing PAGE2

Specialized Databases showing PAGE2

Licensable Technologies
for PAGE2

Services
for PAGE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAGE2 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor PAGE2

Summariesfor PAGE2

Genomic Locationfor PAGE2

Proteinsfor PAGE2

Protein Domains/Familiesfor PAGE2

Gene Functionfor PAGE2

Pathways & Interactionsfor PAGE2

Drugs & Compoundsfor PAGE2

Transcriptsfor PAGE2

Expression for PAGE2

Orthologsfor PAGE2

Paralogsfor PAGE2

SNPs/Variantsfor PAGE2

Disorders & Mutationsfor PAGE2

Medical Newsfor PAGE2

Publicationsfor PAGE2

Search for PAGE2

Genome Databases showing PAGE2

Other Databases showing PAGE2

Specialized Databases showing PAGE2

Licensable Technologiesfor PAGE2

Servicesfor PAGE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAGE2

Summaries
for PAGE2

Genomic Location
for PAGE2

Proteins
for PAGE2

Protein Domains/
Families
for PAGE2

Gene Function
for PAGE2

Pathways & Interactions
for PAGE2

Drugs & Compounds
for PAGE2

Transcripts
for PAGE2

Expression
for PAGE2

Orthologs
for PAGE2

Paralogs
for PAGE2

SNPs/Variants
for PAGE2

Disorders & Mutations
for PAGE2

Medical News
for PAGE2

Publications
for PAGE2

Licensable Technologies
for PAGE2

Services
for PAGE2