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PAGE1 Gene

protein-coding   GIFtS: 48
GCID: GC0XM049452

P Antigen Family, Member 1 (Prostate Associated)

(Previous names: G antigen, family B, 1 (prostate associated))
(Previous symbol: GAGEB1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
P Antigen Family, Member 1 (Prostate Associated)1 2     G Antigen 92 3
GAGEB11 2 3 5     G Antigen Family B Member 12 3
G Antigen, Family B, 1 (Prostate Associated)1 2     CT16.32
Prostate-Associated Gene 1 Protein2 3     P Antigen Family Member 12
AL52 3     Prostate Associated Gene 12
GAGE-92 3     GAGE93
PAGE-12 3     

External Ids:    HGNC: 41071   Entrez Gene: 87122   Ensembl: ENSG000000689857   OMIM: 3002885   UniProtKB: O754593   

Export aliases for PAGE1 gene to outside databases

Previous GC identifers: GC0XM049156 GC0XM049339 GC0XM046922


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PAGE1 Gene:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except
for the testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is
presently known about the function of this protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for PAGE1 Gene:
PAGE1 (P antigen family, member 1 (prostate associated)) is a protein-coding gene. An important paralog of this gene is GAGE2D.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAGE1 gene promoter:
         C/EBPalpha   CHOP-10   POU2F1   CP2   POU2F1b   POU2F1a   HFH-1   STAT3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAGE1 promoter sequence
   Search Chromatin IP Primers for PAGE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAGE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

PAGE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAGE1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM049452:  view genomic region     (about GC identifiers)

Start:
49,452,053 bp from pter      End:
49,460,596 bp from pter
Size:
8,544 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAGE1_HUMAN, O75459 (See protein sequence)
Recommended Name: P antigen family member 1  
Size: 146 amino acids; 16150 Da
Miscellaneous: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal
tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree
of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain
either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE
members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644
presented a new GAGE gene nomenclature based on the identified genes and their products
Secondary accessions: Q6FGM3 Q9BSS7

Explore the universe of human proteins at neXtProt for PAGE1: NX_O75459

Explore proteomics data for PAGE1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PAGE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003776.2  
    ENSEMBL proteins: 
     ENSP00000365320  

    PAGE1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008625 GAGE

    Graphical View of Domain Structure for InterPro Entry O75459

    ProtoNet protein and cluster: O75459

    1 Blocks protein domain: IPB008625 GAGE

    UniProtKB/Swiss-Prot: PAGE1_HUMAN, O75459
    Similarity: Belongs to the GAGE family


    Find genes that share domains with PAGE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAGE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAGE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAGE1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PAGE1
    Interactions:

        Search GeneGlobe Interaction Network for PAGE1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PAGE1 (ENSP000003653204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS9651357

    Find genes that share ontologies with PAGE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PAGE1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PAGE1 gene: 
    NM_003785.3  

    Unigene Cluster for PAGE1:

    P antigen family, member 1 (prostate associated)
    Hs.128231  [show with all ESTs]
    Unigene Representative Sequence: BU941413
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000376150(uc004dom.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat PAGE1

    Additional mRNA sequence: 

    AF058989.1 BC004861.2 CR542084.1 

    1 DOTS entry:

    DT.40127333 

    15 AceView cDNA sequences:

    BC004861 CR542084 NM_003785 BU941413 BE727633 AA972716 BG163711 BU633662 
    BG333742 BF029740 AF058989 BF031437 AI795903 BE727945 BG198960 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PAGE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PAGE1 Expression
    About this image

    PAGE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAGE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128231

    UniProtKB/Swiss-Prot: PAGE1_HUMAN, O75459
    Tissue specificity: Isolated from prostate cancer cell lines; expression associated with progression to androgen
    insensitive phenotype. Expressed in normal testis and at lower level in normal placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for PAGE1 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia PAGE11 P antigen family, member 1 (prostate associated) 99.32(n)
    97.95(a)
      739464  XM_001142536.3  XP_001142536.1 


    ENSEMBL Gene Tree for PAGE1 (if available)
    TreeFam Gene Tree for PAGE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PAGE1 gene
    GAGE2D2  XAGE32  GAGE12H2  GAGE102  GAGE12I2  XAGE52  XAGE2B2  GAGE12C2  
    GAGE12E2  GAGE12D2  GAGE2E2  GAGE12  GAGE2C2  GAGE12F2  GAGE132  XAGE22  
    GAGE12G2  GAGE2B2  GAGE2A2  GAGE12J2  
    7 SIMAP similar genes for PAGE1 using alignment to 1 protein entry:     PAGE1_HUMAN:
    XAGE5    GAGE1    GAGE3    GAGE5    GAGE6    XAGE3
    GAGE4

    Find genes that share paralogs with PAGE1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PAGE1 (see all 265)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012932001,2
    --49454529(+) TATAT-/AGGGTGTA 2 -- int10--------
    rs3733051001,2
    C--49454530(+) TATAT-/GGGTGT 2 -- int10--------
    rs1135810921,2
    F--49455066(+) CAGGGG/ATAAGA 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs59525561,2
    C--49455169(+) AggccA/Gggcgc 1 -- ds50010--------
    rs1453693831,2
    C--49455254(+) ACAAAC/TTGGGC 1 -- ds50010--------
    rs1907845451,2
    --49455283(+) GTCTAC/TAAAAA 1 -- ds50010--------
    rs1383762951,2
    --49455312(+) AAAAAA/CGTGGC 1 -- ds50010--------
    rs603660731,2
    C,F--49455345(+) AAAGAT/CGATAT 1 -- ds50011Minor allele frequency- C:0.00WA 2
    rs1830883601,2
    --49455402(+) GAATTA/CATAAG 1 -- ds50010--------
    rs1864701711,2
    C--49455739(+) ACCCAA/GAAGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PAGE1 (49452053 - 49460596 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PAGE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6901CNV Insertion18451855
    esv1069714CNV Insertion17803354

    Locus Specific Mutation Databases (LSDB): PAGE1

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    DNA2.0 Custom Variant and Variant Library Synthesis for PAGE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300288    OMIM disorders: --


    Find genes that share disorders with PAGE1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: PAGE1 (1 document)

    Export disorders for PAGE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PAGE1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with PAGE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PubMed id 9651357)1, 2, 3 Chen M.E.... Sikes R.A. (J. Biol. Chem. 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PubMed id 9724777)1, 3 Brinkmann U....Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    4. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    6. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    7. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)2 Gjerstorff M.F. and Ditzel H.J. (Tissue Antigens 2008)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (J. Proteome Res. 2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8712 HGNC: 4107 AceView: GAGEB1 Ensembl:ENSG00000068985 euGenes: HUgn8712
    ECgene: PAGE1 H-InvDB: PAGE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PAGE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PAGE1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PAGE1 gene:
    Search GeneIP for patents involving PAGE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PAGE1   OriGene Custom Protein Services for PAGE1  

     
     
     Block miRNA regulation of human, mouse, rat PAGE1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PAGE1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAGE1 Predesigned siRNA for gene silencing in human, mouse, rat PAGE1
     QuantiFast Probe-based Assays in human, mouse, rat PAGE1 QuantiTect SYBR Green Assays in human, mouse, rat PAGE1
     Custom PCR Arrays for PAGE1 Search Chromatin IP Primers for PAGE1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PAGE1  Search GeneGlobe Interaction Network for PAGE1
     Regulatory tfbs in PAGE1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PAGE1 GenScript cDNA clones with any tag delivered in your preferred vector for PAGE1
     GenScript Custom Assay Services for PAGE1 GenScript Custom overexpressing Cell Line Services for PAGE1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PAGE1
     Browse Sino Biological Proteins
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     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Search for Antibodies for PAGE1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PAGE1
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     Abcam protocols and scientific support
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     Browse ESI BIO Cell Lines and PureStem Progenitors for PAGE1
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAGE1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAGE1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAGE1
     LSBio Antibodies in human, mouse, rat for PAGE1
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     Browse compounds at ApexBio
     Search Addgene for plasmids for PAGE1
      Search eBioscience for proteins for PAGE1
      Search eBioscience for elisas for PAGE1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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