V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

PAGE1 Gene

protein-coding GIFtS: 50

GC0XM049339

P antigen family, member 1 (prostate associated)
(Previous names: G antigen, family B, 1 (prostate associated) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GAGEB1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AL5 ^³
GAGE-9 ^¹, ², ³
GAGE9 ^³
GAGEB1 ^², ³, ⁵
OTTHUMP00000032034 ^²
PAGE-1 ^¹, ², ³

Descriptions
G antigen, family B, 1 (prostate associated) ^¹, ²
P antigen family, member 1 ^²
P antigen family, member 1 (prostate associated) ^²
Prostate-associated gene 1 protein ^³
prostate associated gene 1 ^²

External Ids
HGNC: 4107¹
Entrez Gene: 8712²
UniProtKB: O75459³
Ensembl: ENSG00000068985⁷

Search outside databases for aliases for PAGE1 gene

Previous GC identifer: GC0XM049156

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAGE1:

This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal

tissues, except for the testis. Unlike the other gene family members, this gene does not encode an

antigenic peptide. Nothing is presently known about the function of this protein. [provided by

RefSeq]

UniProtKB/Swiss-Prot: GAGB1_HUMAN, O75459

Function: Unknown

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PAGE1 gene

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23

PAGE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM049339: (about GC identifiers)

Start:	49,339,007 bp from pter
End:	49,347,307 bp from pter
Size:	8,301 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_086939.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GAGB1_HUMAN, O75459 (See protein sequence)

Recommended Name: G antigen family B member 1

Size: 146 amino acids; 16150 Da

Secondary accessions: Q6FGM3 Q9BSS7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003776.2

ENSEMBL proteins:

ENSP00000365320

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PAGE1)
	Human Recombinant Proteins from Abnova (PAGE1)

OriGene Purified Recombinant Human Protein: PAGE1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005730	nucleolus	IDA	18029348
GO:0005856	cytoskeleton	IDA	18029348

About this table

Antibodies for PAGE1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PAGE1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PAGE1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PAGE1)
	Novus Biologicals Antibodies for PAGE1

Assays for PAGE1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O75459

ProtoNet protein and cluster: O75459

1 Blocks protein family: IPB008625 GAGE

UniProtKB/Swiss-Prot: GAGB1_HUMAN, O75459

Similarity: Belongs to the GAGE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAGE1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003785

Applied Biosystems Silencer® siRNAs for PAGE1

Sigma-Aldrich siRNA for PAGE1

Sigma-Aldrich shRNA for PAGE1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PAGE1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003785
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003785
untagged cDNA clone in CMV expression vector: NM_003785

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003785

UniProtKB/Swiss-Prot: GAGB1_HUMAN, O75459

Function: Unknown

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for PAGE1 (ENSP00000365320³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAGE2	ENSP00000364107³	STRING (score=.732)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006968	cellular defense response	TAS	9651357

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAGE1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAGE1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003785

Sigma-Aldrich siRNA for PAGE1

Sigma-Aldrich shRNA for PAGE1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003785

REFSEQ mRNAs for PAGE1 gene:

NM_003785.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003785

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003785
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003785
                                 untagged cDNA clone in CMV expression vector: NM_003785

Additional cDNA sequence:

AF058989.1 BC004861.2 CR542084.1

1 DOTS entry:

DT.40127333

15 AceView cDNA sequences:

CR542084 BC004861 NM_003785 AA972716 BE727633 BG163711 BG333742 BU633662

BU941413 BF031437 BF029740 AF058989 BE727945 AI795903 BG198960

highest scoring ESTs for PAGE1:

AF058989 AI795903 BC004861 BE727633 BE727945 BF029740 BF031437 BG163711 BG333742 AA972716

Unigene Cluster for PAGE1:

P antigen family, member 1 (prostate associated)

Hs.128231 [show with all ESTs]

Unigene Representative Sequence: BU941413

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000376150

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAGE1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAGE1

¹ / ² / ³

3 probe-sets matching PAGE1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32997_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	AF058989	1.00	1.00	1.00	1
206897_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_003785	0.60	1.00	0.82	1
206897_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.128231
Expression variation in blood from EXPOLDB for PAGE1
UniProtKB/Swiss-Prot: GAGB1_HUMAN, O75459
Tissue specificity: Isolated from prostate cancer cell lines; expression associated with
progression to androgen insensitive phenotype. Expressed in normal testis and at lower level in
normal placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAGE1 gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	PAGE1¹	--	P antigen family, member 1 (prostate associated)	99.32(n) 97.95(a)	739464 XM_001142536.1 XP_001142536.1

About this table Species with no ortholog for PAGE1

ENSEMBL Gene Tree for PAGE1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PAGE1 gene

XAGE3² GAGE2D² GAGE10² GAGE12H² ENSG00000169164² XAGE5² XAGE2B² GAGE12C²

GAGE12E² GAGE2E² GAGE1² GAGE2C² GAGE12F² GAGE13² XAGE2² GAGE12G²

GAGE2B² GAGE2A² GAGE12J²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/77 NCBI SNPs in PAGE1 are shown (see all 77 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 25)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6610019^1,2	A,C,F,H	49348271(+)	`ttctcC/Accaaa`	1	--	ng3¹		4		EU EA WA	418
	rs5906865^1,2	A,C,F,H	49348692(+)	`atgtcC/Aagcat`	1	--	ng3¹		4		EU EA WA	418
	rs6610018^1,2	H	49348082(+)	`tcacgC/Tgactg`	1	--	ng3¹		4		EU EA WA	414
--	rs12837499^1,2	H	49340992(+)	`TTTTCA/CCCTCC`	1	V/G	mis¹ ese³		4		EU EA WA	404
--	rs1055197^1,2	H	49342624(-)	`TGAGCT/CTGGAG`	1	P/L	mis¹		4		EU EA WA	406
--	rs6610020^1,2	A	49348543(+)	`aggcaA/Ggagga`	1	--	ng3¹		0	--	--	--	--
--	rs6610017^1,2	A,C,F,H	49343763(+)	`agagaC/Tatgaa`	1	--	int¹		8		EU EA WA	626
	rs4824800^1,2	A,C,F,H	49339263(+)	`TTATAG/ACCAAG`	1	--	int¹		8		EU EA WA NA	634
	rs17173960^1,2	F,H	49341789(+)	`GACTCT/CTACAT`	1	--	int¹		7		NA EU EA WA	526
--	rs7884377^1,2	A,C	49341131(+)	`aaaaaA/TaTAta`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for PAGE1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300288

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

8 PubMed articles for PAGE1 gene:

Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PubMed id 9651357)^{2, 3, 4} Chen M.E.... Sikes R.A. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PubMed id 9724777)^{2, 3} Brinkmann U....Pastan I. (1998)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PubMed id 10397259)³ De Backer O.... van der Bruggen P. (1999)
A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PubMed id 7544395)³ van den Eynde B....Boon T. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8712	HGNC: 4107	AceView: GAGEB1	Ensembl:ENSG00000068985	euGenes: HUgn8712
ECgene: PAGE1	H-InvDB: PAGE1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PAGE1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PAGE1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PAGE1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAGE1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAGE1		Antibodies for PAGE1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PAGE1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PAGE1)
	Antibodies (PAGE1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PAGE1)
	Antibodies (PAGE1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for PAGE1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PAGE1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PAGE1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

PAGE1 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for PAGE1

Summaries
for PAGE1

Genomic Location
for PAGE1

Proteins
for PAGE1

Protein Domains/
Families
for PAGE1

Gene Function
for PAGE1

Pathways & Interactions
for PAGE1

Drugs & Compounds
for PAGE1

Transcripts
for PAGE1

Expression
for PAGE1

Orthologs
for PAGE1

Paralogs
for PAGE1

SNPs/Variants
for PAGE1

Disorders & Mutations
for PAGE1

Medical News
for PAGE1

Publications
for PAGE1

Search for PAGE1

Genome Databases showing PAGE1

Other Databases showing PAGE1

Specialized Databases showing PAGE1

Licensable Technologies
for PAGE1

Services
for PAGE1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAGE1 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor PAGE1

Summariesfor PAGE1

Genomic Locationfor PAGE1

Proteinsfor PAGE1

Protein Domains/Familiesfor PAGE1

Gene Functionfor PAGE1

Pathways & Interactionsfor PAGE1

Drugs & Compoundsfor PAGE1

Transcriptsfor PAGE1

Expression for PAGE1

Orthologsfor PAGE1

Paralogsfor PAGE1

SNPs/Variantsfor PAGE1

Disorders & Mutationsfor PAGE1

Medical Newsfor PAGE1

Publicationsfor PAGE1

Search for PAGE1

Genome Databases showing PAGE1

Other Databases showing PAGE1

Specialized Databases showing PAGE1

Licensable Technologiesfor PAGE1

Servicesfor PAGE1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAGE1

Summaries
for PAGE1

Genomic Location
for PAGE1

Proteins
for PAGE1

Protein Domains/
Families
for PAGE1

Gene Function
for PAGE1

Pathways & Interactions
for PAGE1

Drugs & Compounds
for PAGE1

Transcripts
for PAGE1

Expression
for PAGE1

Orthologs
for PAGE1

Paralogs
for PAGE1

SNPs/Variants
for PAGE1

Disorders & Mutations
for PAGE1

Medical News
for PAGE1

Publications
for PAGE1

Licensable Technologies
for PAGE1

Services
for PAGE1