PAGE1 Gene
protein-coding GIFtS: 46
GCID: GC0XM049452
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P antigen family, member 1 (prostate associated)(Previous names: G antigen, family B, 1 (prostate associated) )
(Previous symbol: GAGEB1)
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Aliases
for PAGE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| P Antigen Family, Member 1 (Prostate Associated)1 2 | | Prostate-Associated Gene 1 Protein2 3 | | GAGEB11 2 3 5 | | AL52 3 | | GAGE-91 2 3 | | G Antigen 92 3 | | PAGE-11 2 3 | | G Antigen Family B Member 12 | | CT16.31 2 | | Prostate Associated Gene 12 | | G Antigen, Family B, 1 (Prostate Associated)1 2 | | GAGE93 |
Export aliases for PAGE1 gene to outside databasesPrevious GC identifers: GC0XM049156 GC0XM049339 GC0XM046922 |
Summaries
for PAGE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PAGE1:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except forthe testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is presentlyknown about the function of this protein. (provided by RefSeq, Jul 2008)
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Genomic Views
for PAGE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_086939.3
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PAGE1 gene promoter:
C/EBPalpha CHOP-10 POU2F1 CP2 POU2F1b POU2F1a HFH-1 STAT3 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for PAGE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAGE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23PAGE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM049452: view genomic region
(about GC identifiers)
Start:
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49,452,053 bp from pter |
End:
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49,460,596 bp from pter |
Size:
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8,544 bases |
Orientation:
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minus strand |
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Proteins
for PAGE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAGB1_HUMAN, O75459 (See
protein sequence)Recommended Name: G antigen family B member 1 Size: 146 amino acids; 16150 Da
Miscellaneous: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normaltissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree ofpredicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain eitherthe antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE membersmade impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGEgene nomenclature based on the identified genes and their products
Secondary accessions: Q6FGM3 Q9BSS7Explore the universe of human proteins at neXtProt for PAGE1: NX_O75459
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75459
PAGE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003776.2
ENSEMBL proteins: ENSP00000365320
Human Recombinant Protein Products:
PAGE1 Antibody Products:
Assay Products for PAGE1: |
Protein
Domains /
Families
for PAGE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PAGE1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75459ProtoNet protein and cluster: O75459 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAGB1_HUMAN, O75459Similarity: Belongs to the GAGE family |
Function
for PAGE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PAGE1 (NM_003785) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAGE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAGE1 |
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Pathways & Interactions
for PAGE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PAGE1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PAGE1 (ENSP000003653204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006968 | cellular defense response |
TAS | 9651357 |
PAGE1 for ontologies About GeneDecksing
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Drugs & Compounds
for PAGE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PAGE1
Search CenterWatch for drugs/clinical trials and news about PAGE1 / GAGB1
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Transcripts
for PAGE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for PAGE1 gene: NM_003785.3 Unigene Cluster for PAGE1: P antigen family, member 1 (prostate associated) Hs.128231 [show with all ESTs]Unigene Representative Sequence: BU9414131 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000376150(uc004dom.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PAGE1 (NM_003785) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PAGE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAGE1 |
Additional cDNA sequence: AF058989.1 BC004861.2 CR542084.1 1 DOTS entry: DT.40127333 15 AceView cDNA sequences: BC004861 CR542084 BG333742 NM_003785 BU633662 BG163711 BE727633 AA972716 BU941413 BF031437 AF058989 BF029740 AI795903 BE727945 BG198960
GeneLoc Exon Structure
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Expression
for PAGE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PAGE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PAGE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PAGE1
SOURCE GeneReport for Unigene cluster: Hs.128231
UniProtKB/Swiss-Prot: GAGB1_HUMAN, O75459Tissue specificity: Isolated from prostate cancer cell lines; expression associated with progression to androgeninsensitive phenotype. Expressed in normal testis and at lower level in normal placenta
SABiosciences Custom PCR Arrays for PAGE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAGE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PAGE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAGE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAGE1 |
Orthologs
for PAGE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for PAGE1 (if available)
TreeFam Gene Tree for PAGE1 (if available) |
Paralogs
for PAGE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PAGE1 gene
- PAGE22 GAGE2D2 GAGE42 XAGE32 GAGE102 GAGE12H2 GAGE12I2 PAGE32
- XAGE52 XAGE2B2 PAGE52 GAGE12C2 GAGE12E2 GAGE12D2 PAGE2B2 GAGE12
- GAGE2E2 GAGE2C2 GAGE12F2 GAGE132 XAGE22 GAGE12G2 GAGE2A2 GAGE2B2
- PAGE42 GAGE12J2
7 SIMAP similar genes for PAGE1 using alignment to 1 protein entry: GAGB1_HUMAN:XAGE5 GAGE1 GAGE3 GAGE5 GAGE6 XAGE3
GAGE4
PAGE1 for paralogs About GeneDecksing
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Genomic Variants
for PAGE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PAGE1 (49452053 - 49460596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for PAGE1
6 Indels: 83514 83515 96673 96670 96672 96671
Locus Specific Mutation Databases (LSDB): PAGE1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAGE1 |
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Disorders
/ Diseases
for PAGE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PAGE1 for disorders About GeneDecksing
OMIM gene information: 300288
OMIM disorders: --
6  diseases for PAGE1: About MalaCardsprostatitis prostate cancer, progression of hepatitis b prostate cancer
hepatitis melanoma
Human Genome Epidemiology (HuGE) Navigator: PAGE1 (1 document)
Export disorders for PAGE1 gene to outside databases
|
Publications
for PAGE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PAGE1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with PAGE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PubMed id 9651357)1, 2, 3 Chen M.E.... Sikes R.A. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PubMed id 9724777)1, 3 Brinkmann U....Pastan I. (1998)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)2 Gjerstorff M.F. and Ditzel H.J. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
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External Searches for PAGE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PAGE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing PAGE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PAGE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PAGE1 gene:
Search GeneIP for patents involving PAGE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PAGE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PAGE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAGE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PAGE1 | | | OriGene Protein Over-expression Lysate for PAGE1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PAGE1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PAGE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PAGE1 | | OriGene Custom Protein Services for PAGE1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PAGE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PAGE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAGE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAGE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAGE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAGE1 |
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| | | | Search Tocris compounds for PAGE1 |
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 | | | PAGE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for PAGE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAGE1 |
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