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Aliases for PAGE1 Gene

Aliases for PAGE1 Gene

  • P Antigen Family, Member 1 (Prostate Associated) 2 3
  • G Antigen, Family B, 1 (Prostate Associated) 2 3
  • Prostate-Associated Gene 1 Protein 3 4
  • G Antigen Family B Member 1 3 4
  • G Antigen 9 3 4
  • GAGE-9 3 4
  • PAGE-1 3 4
  • GAGEB1 3 4
  • AL5 3 4
  • Prostate Associated Gene 1 3
  • P Antigen Family Member 1 3
  • GAGEB1, 6
  • CT16.3 3
  • GAGE9 4

External Ids for PAGE1 Gene

Previous Symbols for PAGE1 Gene

  • GAGEB1

Summaries for PAGE1 Gene

Entrez Gene Summary for PAGE1 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is presently known about the function of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAGE1 Gene

PAGE1 (P Antigen Family, Member 1 (Prostate Associated)) is a Protein Coding gene. An important paralog of this gene is XAGE2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAGE1 Gene

Genomics for PAGE1 Gene

Genomic Location for PAGE1 Gene

Start:
49,687,450 bp from pter
End:
49,695,993 bp from pter
Size:
8,544 bases
Orientation:
Minus strand

Genomic View for PAGE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAGE1 Gene

Regulatory Elements for PAGE1 Gene

Proteins for PAGE1 Gene

  • Protein details for PAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75459-PAGE1_HUMAN
    Recommended name:
    P antigen family member 1
    Protein Accession:
    O75459
    Secondary Accessions:
    • Q6FGM3
    • Q9BSS7

    Protein attributes for PAGE1 Gene

    Size:
    146 amino acids
    Molecular mass:
    16150 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for PAGE1 Gene

Proteomics data for PAGE1 Gene at MOPED

Post-translational modifications for PAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAGE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PAGE1 Gene

Domains for PAGE1 Gene

Protein Domains for PAGE1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PAGE1_HUMAN
Family:
  • Belongs to the GAGE family.:
    • O75459
genes like me logo Genes that share domains with PAGE1: view

No data available for Gene Families for PAGE1 Gene

Function for PAGE1 Gene

Gene Ontology (GO) - Molecular Function for PAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PAGE1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PAGE1 Gene

Localization for PAGE1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAGE1 Gene COMPARTMENTS Subcellular localization image for PAGE1 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PAGE1 Gene

Pathways for PAGE1 Gene

SuperPathways for PAGE1 Gene

No Data Available

Interacting Proteins for PAGE1 Gene

Selected Interacting proteins: O75459-PAGE1_HUMAN for PAGE1 Gene via UniProtKB

Symbol External ID(s) Details
FAM9B

Gene Ontology (GO) - Biological Process for PAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9651357
genes like me logo Genes that share ontologies with PAGE1: view

No data available for Pathways by source for PAGE1 Gene

Transcripts for PAGE1 Gene

mRNA/cDNA for PAGE1 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAGE1 Gene

P antigen family, member 1 (prostate associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAGE1 Gene

No ASD Table

Relevant External Links for PAGE1 Gene

GeneLoc Exon Structure for
PAGE1
ECgene alternative splicing isoforms for
PAGE1

Expression for PAGE1 Gene

mRNA expression in normal human tissues for PAGE1 Gene

mRNA differential expression in normal tissues according to GTEx for PAGE1 Gene

This gene is overexpressed in Testis (52.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PAGE1 Gene

SOURCE GeneReport for Unigene cluster for PAGE1 Gene Hs.128231

mRNA Expression by UniProt/SwissProt for PAGE1 Gene

O75459-PAGE1_HUMAN
Tissue specificity: Isolated from prostate cancer cell lines; expression associated with progression to androgen insensitive phenotype. Expressed in normal testis and at lower level in normal placenta
genes like me logo Genes that share expressions with PAGE1: view

Orthologs for PAGE1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAGE1 36
  • 99.32 (n)
  • 97.95 (a)
PAGE1 37
  • 98 (a)
OneToOne
Species with no ortholog for PAGE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAGE1 Gene

ENSEMBL:
Gene Tree for PAGE1 (if available)
TreeFam:
Gene Tree for PAGE1 (if available)

Paralogs for PAGE1 Gene

Selected SIMAP similar genes for PAGE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PAGE1: view

Variants for PAGE1 Gene

Sequence variations from dbSNP and Humsavar for PAGE1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs909369 -- 49,692,901(+) TGATT(G/T)CACAG intron-variant
rs1055197 - 49,691,317(-) TGAGC(C/T)TGGAG missense, reference
rs2272705 -- 49,691,648(+) GATTG(C/T)CCTTA intron-variant
rs4824800 -- 49,687,706(+) TTATA(A/G)CCAAG intron-variant
rs5906865 -- 49,697,378(+) atgtc(A/C)agcat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PAGE1 Gene

Variant ID Type Subtype PubMed ID
nsv6901 CNV Insertion 18451855
esv1069714 CNV Insertion 17803354

Relevant External Links for PAGE1 Gene

HapMap Linkage Disequilibrium report
PAGE1
Locus Specific Mutation Databases (LSDB)
PAGE1

Disorders for PAGE1 Gene

Relevant External Links for PAGE1

Human Genome Epidemiology (HuGE) Navigator
PAGE1
genes like me logo Genes that share disorders with PAGE1: view

No data available for UniProtKB/Swiss-Prot for PAGE1 Gene

Publications for PAGE1 Gene

  1. Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PMID: 9651357) Chen M.E. … Sikes R.A. (J. Biol. Chem. 1998) 2 3 4
  2. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PMID: 9724777) Brinkmann U. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PMID: 18781797) Meierhofer D. … Kaiser P. (J. Proteome Res. 2008) 3

Products for PAGE1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate PAGE1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PAGE1
    • Block miRNA regulation of PAGE1 using miScript Target Protectors

    Sources for PAGE1 Gene

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