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Aliases for PAGE1 Gene

Aliases for PAGE1 Gene

  • PAGE Family Member 1 2 3 5
  • P Antigen Family, Member 1 (Prostate Associated) 2 3
  • G Antigen, Family B, 1 (Prostate Associated) 2 3
  • Prostate-Associated Gene 1 Protein 3 4
  • G Antigen Family B Member 1 3 4
  • G Antigen 9 3 4
  • GAGEB1 3 4
  • GAGE-9 3 4
  • PAGE-1 3 4
  • AL5 3 4
  • Prostate Associated Gene 1 3
  • CT16.3 3
  • GAGE9 4

External Ids for PAGE1 Gene

Previous HGNC Symbols for PAGE1 Gene

  • GAGEB1

Previous GeneCards Identifiers for PAGE1 Gene

  • GC0XM049156
  • GC0XM049339
  • GC0XM049452
  • GC0XM046922

Summaries for PAGE1 Gene

Entrez Gene Summary for PAGE1 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is presently known about the function of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAGE1 Gene

PAGE1 (PAGE Family Member 1) is a Protein Coding gene. Diseases associated with PAGE1 include prostate cancer. An important paralog of this gene is XAGE5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAGE1 Gene

Genomics for PAGE1 Gene

Regulatory Elements for PAGE1 Gene

Enhancers for PAGE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PAGE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAGE1 Gene

Chromosome:
X
Start:
49,687,450 bp from pter
End:
49,696,017 bp from pter
Size:
8,568 bases
Orientation:
Minus strand

Genomic View for PAGE1 Gene

Genes around PAGE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAGE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAGE1 Gene

Proteins for PAGE1 Gene

  • Protein details for PAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75459-PAGE1_HUMAN
    Recommended name:
    P antigen family member 1
    Protein Accession:
    O75459
    Secondary Accessions:
    • Q6FGM3
    • Q9BSS7

    Protein attributes for PAGE1 Gene

    Size:
    146 amino acids
    Molecular mass:
    16150 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for PAGE1 Gene

Proteomics data for PAGE1 Gene at MOPED

Post-translational modifications for PAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAGE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PAGE1 Gene

Domains & Families for PAGE1 Gene

Protein Domains for PAGE1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PAGE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75459

UniProtKB/Swiss-Prot:

PAGE1_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with PAGE1: view

No data available for Gene Families for PAGE1 Gene

Function for PAGE1 Gene

genes like me logo Genes that share phenotypes with PAGE1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAGE1 Gene

Localization for PAGE1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAGE1 Gene COMPARTMENTS Subcellular localization image for PAGE1 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PAGE1 Gene

Pathways & Interactions for PAGE1 Gene

SuperPathways for PAGE1 Gene

No Data Available

Interacting Proteins for PAGE1 Gene

Selected Interacting proteins: O75459-PAGE1_HUMAN for PAGE1 Gene via UniProtKB

Symbol External ID(s) Details
FAM9B

Gene Ontology (GO) - Biological Process for PAGE1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAGE1 Gene

Drugs & Compounds for PAGE1 Gene

No Compound Related Data Available

Transcripts for PAGE1 Gene

mRNA/cDNA for PAGE1 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAGE1 Gene

P antigen family, member 1 (prostate associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAGE1 Gene

No ASD Table

Relevant External Links for PAGE1 Gene

GeneLoc Exon Structure for
PAGE1
ECgene alternative splicing isoforms for
PAGE1

Expression for PAGE1 Gene

mRNA expression in normal human tissues for PAGE1 Gene

mRNA differential expression in normal tissues according to GTEx for PAGE1 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for PAGE1 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PAGE1 Gene



SOURCE GeneReport for Unigene cluster for PAGE1 Gene Hs.128231

mRNA Expression by UniProt/SwissProt for PAGE1 Gene

O75459-PAGE1_HUMAN
Tissue specificity: Isolated from prostate cancer cell lines; expression associated with progression to androgen insensitive phenotype. Expressed in normal testis and at lower level in normal placenta.
genes like me logo Genes that share expression patterns with PAGE1: view

Protein tissue co-expression partners for PAGE1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PAGE1 Gene

Orthologs for PAGE1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAGE1 35
  • 99.32 (n)
  • 97.95 (a)
PAGE1 36
  • 98 (a)
OneToOne
Species with no ortholog for PAGE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAGE1 Gene

ENSEMBL:
Gene Tree for PAGE1 (if available)
TreeFam:
Gene Tree for PAGE1 (if available)

Paralogs for PAGE1 Gene

(7) SIMAP similar genes for PAGE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PAGE1: view

Variants for PAGE1 Gene

Sequence variations from dbSNP and Humsavar for PAGE1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1055197 - 49,691,317(-) TGAGC(A/C/T)TGGAG reference, missense
rs909369 -- 49,692,901(+) TGATT(G/T)CACAG intron-variant
rs2272705 -- 49,691,648(+) GATTG(C/T)CCTTA intron-variant
rs4824800 -- 49,687,706(+) TTATA(A/G)CCAAG intron-variant
rs5906865 -- 49,697,378(+) atgtc(A/C)agcat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PAGE1 Gene

Variant ID Type Subtype PubMed ID
nsv6901 CNV Insertion 18451855
esv1069714 CNV Insertion 17803354

Variation tolerance for PAGE1 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAGE1 Gene

HapMap Linkage Disequilibrium report
PAGE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAGE1 Gene

Disorders for PAGE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PAGE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search PAGE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAGE1

Human Genome Epidemiology (HuGE) Navigator
PAGE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAGE1
genes like me logo Genes that share disorders with PAGE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAGE1 Gene

Publications for PAGE1 Gene

  1. Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PMID: 9651357) Chen M.E. … Sikes R.A. (J. Biol. Chem. 1998) 2 3 4 67
  2. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PMID: 9724777) Brinkmann U. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for PAGE1 Gene

Sources for PAGE1 Gene

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