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Aliases for PAG1 Gene

Aliases for PAG1 Gene

  • Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1 2 3 5
  • Csk-Binding Protein 2 3 4
  • Phosphoprotein Associated With Glycosphingolipid Microdomains 1 2 3
  • Transmembrane Adaptor Protein PAG 2 3
  • Transmembrane Adapter Protein PAG 3 4
  • Transmembrane Phosphoprotein Cbp 3 4
  • CBP 3 4
  • PAG 3 4

External Ids for PAG1 Gene

Previous GeneCards Identifiers for PAG1 Gene

  • GC08M082049
  • GC08M081880
  • GC08M077369

Summaries for PAG1 Gene

Entrez Gene Summary for PAG1 Gene

  • The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAG1 Gene

PAG1 (Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include SH3/SH2 adaptor activity and SH2 domain binding.

UniProtKB/Swiss-Prot for PAG1 Gene

  • Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.

Gene Wiki entry for PAG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAG1 Gene

Genomics for PAG1 Gene

Regulatory Elements for PAG1 Gene

Promoters for PAG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAG1 Gene

Chromosome:
8
Start:
80,967,810 bp from pter
End:
81,112,068 bp from pter
Size:
144,259 bases
Orientation:
Minus strand

Genomic View for PAG1 Gene

Genes around PAG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAG1 Gene

Proteins for PAG1 Gene

  • Protein details for PAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWQ8-PHAG1_HUMAN
    Recommended name:
    Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
    Protein Accession:
    Q9NWQ8
    Secondary Accessions:
    • A8K1A3
    • Q2M1Z9
    • Q5BKU4
    • Q9NYK0

    Protein attributes for PAG1 Gene

    Size:
    432 amino acids
    Molecular mass:
    46981 Da
    Quaternary structure:
    • Interacts with FYN. When phosphorylated, interacts with CSK. Interacts with SLC9A3R1/EBP50. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Interacts with LYN on plasma membrane lipid rafts. Identified in a complex with LYN and STAT3.

neXtProt entry for PAG1 Gene

Proteomics data for PAG1 Gene at MOPED

Post-translational modifications for PAG1 Gene

  • Palmitoylated.
  • Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PAG1 Gene

Domains & Families for PAG1 Gene

Protein Domains for PAG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PAG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PAG1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PAG1 Gene

Function for PAG1 Gene

Molecular function for PAG1 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.

Gene Ontology (GO) - Molecular Function for PAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IBA --
genes like me logo Genes that share ontologies with PAG1: view
genes like me logo Genes that share phenotypes with PAG1: view

Animal Models for PAG1 Gene

MGI Knock Outs for PAG1:

Animal Model Products

miRNA for PAG1 Gene

miRTarBase miRNAs that target PAG1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAG1 Gene

Localization for PAG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAG1 Gene

Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAG1 Gene COMPARTMENTS Subcellular localization image for PAG1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 2
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for PAG1 Gene

Pathways & Interactions for PAG1 Gene

genes like me logo Genes that share pathways with PAG1: view

Gene Ontology (GO) - Biological Process for PAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0050863 regulation of T cell activation IDA 10790433
genes like me logo Genes that share ontologies with PAG1: view

No data available for SIGNOR curated interactions for PAG1 Gene

Drugs & Compounds for PAG1 Gene

(3) Drugs for PAG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PAG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAG1: view

Transcripts for PAG1 Gene

Unigene Clusters for PAG1 Gene

Phosphoprotein associated with glycosphingolipid microdomains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAG1 Gene

No ASD Table

Relevant External Links for PAG1 Gene

GeneLoc Exon Structure for
PAG1
ECgene alternative splicing isoforms for
PAG1

Expression for PAG1 Gene

mRNA expression in normal human tissues for PAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAG1 Gene

This gene is overexpressed in Whole Blood (x8.8).

Protein differential expression in normal tissues from HIPED for PAG1 Gene

This gene is overexpressed in Adrenal (19.4), Peripheral blood mononuclear cells (16.2), CD4 Tcells (10.2), and CD8 Tcells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAG1 Gene



SOURCE GeneReport for Unigene cluster for PAG1 Gene Hs.266175

mRNA Expression by UniProt/SwissProt for PAG1 Gene

Q9NWQ8-PHAG1_HUMAN
Tissue specificity: Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
genes like me logo Genes that share expression patterns with PAG1: view

Protein tissue co-expression partners for PAG1 Gene

Primer Products

In Situ Assay Products

Orthologs for PAG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAG1 35
  • 81.56 (n)
  • 82.18 (a)
PAG1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAG1 35
  • 84.61 (n)
  • 85.38 (a)
PAG1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pag1 35
  • 80.16 (n)
  • 80.24 (a)
Pag1 16
Pag1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAG1 35
  • 99.54 (n)
  • 99.07 (a)
PAG1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pag1 35
  • 80.79 (n)
  • 82.14 (a)
oppossum
(Monodelphis domestica)
Mammalia PAG1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAG1 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAG1 35
  • 67.14 (n)
  • 62.32 (a)
PAG1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAG1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pag1 35
  • 61.45 (n)
  • 55.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15293 35
zebrafish
(Danio rerio)
Actinopterygii pag1 35
  • 52.67 (n)
  • 44.92 (a)
pag1 36
  • 37 (a)
OneToOne
Species with no ortholog for PAG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAG1 Gene

ENSEMBL:
Gene Tree for PAG1 (if available)
TreeFam:
Gene Tree for PAG1 (if available)

Paralogs for PAG1 Gene

No data available for Paralogs for PAG1 Gene

Variants for PAG1 Gene

Sequence variations from dbSNP and Humsavar for PAG1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs11743 -- 80,967,861(-) ACTTA(C/T)CAAAT nc-transcript-variant, utr-variant-3-prime
rs737050 -- 80,993,614(+) ttttt(C/T)tttct intron-variant, upstream-variant-2KB
rs999450 -- 80,984,101(-) ACTTC(A/G)GGCAA intron-variant
rs999451 -- 80,983,562(-) AACAA(A/C)CCTAA intron-variant
rs895267 -- 80,993,298(-) CAGCT(C/T)TCTGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PAG1 Gene

Variant ID Type Subtype PubMed ID
esv34101 CNV Loss 18971310
nsv831367 CNV Gain 17160897
nsv891063 CNV Gain 21882294
nsv396304 CNV Loss 16902084
esv2675037 CNV Deletion 23128226
nsv824673 CNV Loss 20364138
esv2658475 CNV Deletion 23128226
esv28663 CNV Loss 19812545

Variation tolerance for PAG1 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAG1 Gene

HapMap Linkage Disequilibrium report
PAG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAG1 Gene

Disorders for PAG1 Gene

Relevant External Links for PAG1

Genetic Association Database (GAD)
PAG1
Human Genome Epidemiology (HuGE) Navigator
PAG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAG1

No disorders were found for PAG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAG1 Gene

Publications for PAG1 Gene

  1. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. (PMID: 10790433) Brdicka T. … Schraven B. (J. Exp. Med. 2000) 2 3 4 67
  2. A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation. (PMID: 17389760) Smida M. … Lindquist J.A. (Blood 2007) 3 23
  3. Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation. (PMID: 16636672) Jiang L.Q. … Chen Z. (Oncogene 2006) 3 23
  4. Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation. (PMID: 25684946) Zhou D. … Yang C. (World J. Gastroenterol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PAG1 Gene

Sources for PAG1 Gene

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