V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

PAG1 Gene

protein-coding GIFtS: 51

GC08M082049

phosphoprotein associated with glycosphingolipid microdomains 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CBP ^¹, ², ³
FLJ37858 ^²
MGC138364 ^²
PAG ^¹, ², ³

Descriptions
Csk-binding protein ^², ³
Transmembrane adapter protein PAG ^³
Transmembrane phosphoprotein Cbp ^³
phosphoprotein associated with glycosphingolipid microdomains 1 ^²
phosphoprotein associated with glycosphingolipid-enriched microdomains ^²

External Ids
HGNC: 30043¹
Entrez Gene: 55824²
UniProtKB: Q9NWQ8³
Ensembl: ENSG00000076641⁷

Search outside databases for aliases for PAG1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAG1:

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the

tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.

[provided by RefSeq]

UniProtKB/Swiss-Prot: PAG1_HUMAN, Q9NWQ8

Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and

FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes

CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits

immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be

involved in cell adhesion signaling

Gene Wiki entry for PAG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PAG1 gene

Entrez Gene cytogenetic band: 8q21.13 Ensembl cytogenetic band: 8q21.13 HGNC cytogenetic band: 8q21.13

PAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M082049: (about GC identifiers)

Start:	82,042,600 bp from pter
End:	82,186,858 bp from pter
Size:	144,259 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PAG1_HUMAN, Q9NWQ8 (See protein sequence)

Recommended Name: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Size: 432 amino acids; 46981 Da

Subunit: Interacts with FYN. When phosphorylated, interacts with CSK. Interacts with

SLC9A3R1/EBP50. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon

TCR activation

Subcellular location: Cell membrane; Single-pass type III membrane protein. Note=Present in lipid

rafts

Secondary accessions: Q2M1Z9 Q5BKU4 Q9NYK0

Post-translational modifications:

Palmitoylated¹

Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK.

Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be

dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060910.3

ENSEMBL proteins:

ENSP00000220597

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PAG)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	10790433
GO:0016021	integral to membrane	IEA	--
GO:0045121	membrane raft	IDA	10790433

About this table

Antibodies for PAG1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PAG1
	R&D Systems Antibodies for PAG1
	Antibodies from Abcam (PAG), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PAG1)
	Novus Biologicals Antibodies for PAG1

Assays for PAG1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9NWQ8

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAG1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018440

Applied Biosystems Silencer® siRNAs for PAG1

Sigma-Aldrich siRNA for PAG1

Sigma-Aldrich shRNA Panels and shRNA for PAG1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018440
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018440
untagged cDNA clones in CMV expression vector (see all 2): AK094546

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018440

UniProtKB/Swiss-Prot: PAG1_HUMAN, Q9NWQ8

Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and

FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes

CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits

immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be

involved in cell adhesion signaling

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pag1):

hematopoietic system

immune system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	NAS	10790433
GO:0005515	protein binding	IPI	10790433
GO:0042169	SH2 domain binding	IDA	10790433

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for PAG1 (Your Favorite Gene powered by Ingenuity)

B Cell Receptor Signaling
T Cell Receptor Signaling

GeneDecks PAG1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PAG1

5/36 Interacting proteins for PAG1 (ENSP00000220597³ Q9NWQ8²) via UniProtKB, MINT, and/or STRING (see all 36 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC9A3R1	O14745²	MINT-19912 MINT-19913
CSK	ENSP00000220003³	STRING (score=.985)
SRC	ENSP00000362659³	STRING (score=.967)
FYN	ENSP00000357656³	STRING (score=.964)
LCK	ENSP00000328213³	STRING (score=.955)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--
GO:0007242	intracellular signaling cascade	IDA	10790433
GO:0050868	negative regulation of T cell activation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAG1
3 Novoseek chemical compound relationships for PAG1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	65.29	8	10918051 (1), 17389760 (1), 1385560 (1), 15975665 (1) (see all 7)
lipid	28.31	4	19298372 (1), 18491059 (1), 11390365 (1), 18498747 (1)
cholesterol	0.00	1	1385560 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAG1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018440

Sigma-Aldrich siRNA for PAG1

Sigma-Aldrich shRNA Panels and shRNA for PAG1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018440

REFSEQ mRNAs for PAG1 gene:

NM_018440.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018440

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018440
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018440
                                 untagged cDNA clones in CMV expression vector (see all 2): AK094546

Additional cDNA sequence:

AF240634.1 AK000680.1 AK095177.1 AK289818.1 BC090931.1 BC112159.1

9 DOTS entries:

DT.444332 DT.40189891 DT.100667741 DT.100806130 DT.101957376 DT.95356468 DT.100750167 DT.91680522

DT.95257024

24/188 AceView cDNA sequences (see all 188 ):

AK095177 AA827154 AA622656 AA534901 AA905390 AA766638 BX418077 AW293853

CB133978 F13471 BF196863 NM_018440 AI686375 BQ016094 AI810567 AA651793

F08578 BX498308 AA278678 AA732661 BG286642 AW511238 BM681407 AA602328

highest scoring ESTs for PAG1:

AI809431 AI860212 AA045281 AA046562 AA220201 AA251143 AA278678 AA278686 AA281378 AA381289

Unigene Cluster for PAG1:

Phosphoprotein associated with glycosphingolipid microdomains 1

Hs.266175 [show with all ESTs]

Unigene Representative Sequence: NM_018440

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000220597

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAG1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAG1

¹ / ² / ³

13 probe-sets matching PAG1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65068_at²^{, 3}	U95-C	1	1.00	1.00	0.88	1.34	AI076356	0.60	1.00	0.82	1
61485_at²^{, 3}	U95-C	1	1.00	1.00	0.94	1.16	AI382057	0.60	1.00	0.82	1
59941_at²^{, 3}	U95-C	1	1.00	1.00	0.66	0.48	AI769545	0.60	1.00	0.82	1
80912_at²^{, 3}	U95-D	2	1.00	0.59	0.85	0.98	AI809431	0.80	1.00	0.91	1
84044_at²^{, 3}	U95-E	2	1.00	0.50	0.31	0.89	AL038841	0.60	1.00	0.82	1
57670_at²^{, 3}	U95-B	1	0.94	1.00	0.94	1.13	AI860212	0.80	1.00	0.91	1
53988_at²^{, 3}	U95-C	1	0.38	1.00	0.56	1.10	AA622656	0.60	1.00	0.82	1
225626_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK000680	0.60	1.00	0.82	1
225622_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI860212	0.80	1.00	0.91	1
227354_at²^{, 3}	U133-B	1	0.91	1.00	--	--	BF589359	0.40	1.00	0.76	1
225626_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225622_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227354_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks PAG1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAATAGCAG

SOURCE GeneReport for Unigene cluster: Hs.266175
UniProtKB/Swiss-Prot: PAG1_HUMAN, Q9NWQ8
Tissue specificity: Ubiquitously expressed. Present in germinal center B-cells, plasma cells,
T-cells, monocytes and platelets (at protein level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAG1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PAG1¹	--	phosphoprotein associated with glycosphingolipid microdomains more	84.61(n) 85.38(a)	610895 XM_848462.1 XP_853555.1
chimpanzee (Pan troglodytes)	PAG1¹	--	phosphoprotein associated with glycosphingolipid microdomains more	99.54(n) 99.07(a)	464253 XM_001168080.1 XP_001168080.1
cow (Bos taurus)	PAG1¹	--	phosphoprotein associated with glycosphingolipid microdomains more	81.56(n) 82.18(a)	614460 XM_865981.1 XP_871074.1
mouse (Mus musculus)	Pag1^{1, 5}	3⁵	phosphoprotein associated with glycosphingolipid microdomains more^{1, 5}	80.16(n)¹ 80.24(a)¹	94212¹ NM_053182.3¹ NP_444412.2¹ AF250192⁵ AI462872⁵ (see all 16)
chicken (Gallus gallus)	PAG1¹	--	phosphoprotein associated with glycosphingolipid microdomains more	68.49(n) 64.19(a)	420195 XM_418306.2 XP_418306.2

About this table Species with no ortholog for PAG1

ENSEMBL Gene Tree for PAG1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/739 NCBI SNPs in PAG1 are shown (see all 739 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 329)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1445560^1,2	A,C,F,H,O	82047632(-)	`TAGTGC/TGATGA`	1	--	ut3¹		12	EU EA WA NA	1052
	rs3739342^1,2	A,C,F,H	82045405(+)	`ACGGCA/GCTAAC`	1	--	ut3¹ ese³		13	EA EU WA	2748
	rs6984342^1,2	A,C,F,H	82046460(+)	`ACGCTT/CTTTAA`	1	--	ut3¹		8	EU EA WA	836
--	rs10088860^1,2	A,C,F,H	82043715(+)	`AAGTCT/CGAATT`	1	--	ut3¹ ese³		4	EU EA WA	412
	rs895267^1,2	A,C,F,H	82068088(-)	`CAGCTC/TTCTGC`	1	--	ut5¹ ese³		17	EA NA EU WA	2918
	rs7017984^1,2	A,C,F,H	82049241(+)	`CTAATC/ACAAGG`	1	--	ut3¹ ese³		4	EU EA WA	418
	rs3816314^1,2	A,C,F,H	82049070(-)	`TTGTGA/CATGCT`	1	--	ut3¹ ese³		4	EU EA WA	412
	rs1445564^1,2	A,C,F,H	82044517(-)	`TTAGAG/ATGTAA`	1	--	ut3¹		9	MN EU EA WA	1022
	rs11743^1,2	C,F,H	82042651(-)	`ACTTAT/CCAAAT`	1	--	ut3¹		13	MN EU EA WA	1442
--	rs12708112^1,2	C,F,H	82187424(+)	`ttgtgA/Ttgaga`	1	--	ng3¹		4	EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for PAG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605767

1 Novoseek disease relationship for PAG1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0.00	9	18538730 (2), 18498747 (2), 16636672 (1), 10343192 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/48 PubMed articles for PAG1 gene (see all 48 ):

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. (PubMed id 10790433)^{2, 3, 4} Brdicka T.... Schraven B. (2000)
Transmembrane adaptor molecules: a new category of lymphoid-cell markers. (PubMed id 16160011)^{3, 4} Tedoldi S....Horejsi V. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. (PubMed id 11684085)^{3, 4} Brdickova N.... Horejsi V. (2001)
Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation. (PubMed id 16636672)^{1, 3} Jiang L.Q....Chen Z. (2006)
A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation. (PubMed id 17389760)^{1, 3} Smida M....Lindquist J.A. (2007)
Regulation of FynT function by dual domain docking on PAG/Cbp. (PubMed id 18056706)³ Solheim S.A....Berge T. (2008)
Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. (PubMed id 18070987)³ Tauzin S....Hoessli D.C. (2008)
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)⁴ Rikova K....Comb M.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55824	HGNC: 30043	AceView: PAG	Ensembl:ENSG00000076641	euGenes: HUgn55824
ECgene: PAG1	H-InvDB: PAG1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PAG1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PAG1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAG1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAG1		Antibodies for PAG1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PAG1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (PAG1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PAG)
	Antibodies (PAG)

Search OriGene for PAG1

Search Tocris compounds for PAG1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PAG1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PAG1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

PAG1 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for PAG1

Summaries
for PAG1

Genomic Location
for PAG1

Proteins
for PAG1

Protein Domains/
Families
for PAG1

Gene Function
for PAG1

Pathways & Interactions
for PAG1

Drugs & Compounds
for PAG1

Transcripts
for PAG1

Expression
for PAG1

Orthologs
for PAG1

Paralogs
for PAG1

SNPs/Variants
for PAG1

Disorders & Mutations
for PAG1

Medical News
for PAG1

Publications
for PAG1

Search for PAG1

Genome Databases showing PAG1

Other Databases showing PAG1

Specialized Databases showing PAG1

Licensable Technologies
for PAG1

Services
for PAG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAG1 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor PAG1

Summariesfor PAG1

Genomic Locationfor PAG1

Proteinsfor PAG1

Protein Domains/Familiesfor PAG1

Gene Functionfor PAG1

Pathways & Interactionsfor PAG1

Drugs & Compoundsfor PAG1

Transcriptsfor PAG1

Expression for PAG1

Orthologsfor PAG1

Paralogsfor PAG1

SNPs/Variantsfor PAG1

Disorders & Mutationsfor PAG1

Medical Newsfor PAG1

Publicationsfor PAG1

Search for PAG1

Genome Databases showing PAG1

Other Databases showing PAG1

Specialized Databases showing PAG1

Licensable Technologiesfor PAG1

Servicesfor PAG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAG1

Summaries
for PAG1

Genomic Location
for PAG1

Proteins
for PAG1

Protein Domains/
Families
for PAG1

Gene Function
for PAG1

Pathways & Interactions
for PAG1

Drugs & Compounds
for PAG1

Transcripts
for PAG1

Expression
for PAG1

Orthologs
for PAG1

Paralogs
for PAG1

SNPs/Variants
for PAG1

Disorders & Mutations
for PAG1

Medical News
for PAG1

Publications
for PAG1

Licensable Technologies
for PAG1

Services
for PAG1