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Aliases for PAG1 Gene

Aliases for PAG1 Gene

  • Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1 2 3 5
  • Csk-Binding Protein 2 3 4
  • Phosphoprotein Associated With Glycosphingolipid Microdomains 1 2 3
  • Transmembrane Adaptor Protein PAG 2 3
  • Transmembrane Adapter Protein PAG 3 4
  • Transmembrane Phosphoprotein Cbp 3 4
  • CBP 3 4
  • PAG 3 4
  • Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1 3

External Ids for PAG1 Gene

Previous GeneCards Identifiers for PAG1 Gene

  • GC08M082049
  • GC08M081880
  • GC08M077369

Summaries for PAG1 Gene

Entrez Gene Summary for PAG1 Gene

  • The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAG1 Gene

PAG1 (Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1) is a Protein Coding gene. Among its related pathways are CXCR4-mediated signaling events and Immune System. GO annotations related to this gene include SH3/SH2 adaptor activity and SH2 domain binding.

UniProtKB/Swiss-Prot for PAG1 Gene

  • Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.

Gene Wiki entry for PAG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAG1 Gene

Genomics for PAG1 Gene

Regulatory Elements for PAG1 Gene

Enhancers for PAG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F081079 1.3 FANTOM5 Ensembl ENCODE 27.4 +30.4 30368 3.8 CEBPB PRDM10 ZNF558 PAG1 SNX16 ENSG00000254177
GH08F081080 0.2 Ensembl 22.6 +32.8 32768 0.6 PAG1 ENSG00000254177
GH08F081088 1.2 Ensembl ENCODE 21.9 +21.9 21880 2.8 HDGF PKNOX1 KLF17 FEZF1 ZNF2 RAD21 YY1 ZNF121 ZNF391 ZNF362 PAG1 ENSG00000254177
GH08F081071 0.8 Ensembl ENCODE 21 +37.6 37640 6.5 HDGF WRNIP1 FEZF1 EBF1 RELA ZFHX2 POLR2A EED CREM EGR2 PAG1 ENSG00000254177
GH08F081146 1.4 FANTOM5 Ensembl ENCODE 16.4 -36.4 -36448 4.2 ZNF664 ZNF316 EED ETV6 RAD21 NR2F2 TRIM28 PAG1 LOC105375924 PMP2 ZNF704 GC08M081130
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PAG1 on UCSC Golden Path with GeneCards custom track

Promoters for PAG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001395186 1368 3801 PKNOX1 SIN3A ZNF48 RAD21 YY1 CREM SMAD5 ZFP69B SMARCA4 ZNF341

Genomic Location for PAG1 Gene

Chromosome:
8
Start:
80,967,810 bp from pter
End:
81,112,068 bp from pter
Size:
144,259 bases
Orientation:
Minus strand

Genomic View for PAG1 Gene

Genes around PAG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAG1 Gene

Proteins for PAG1 Gene

  • Protein details for PAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWQ8-PHAG1_HUMAN
    Recommended name:
    Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
    Protein Accession:
    Q9NWQ8
    Secondary Accessions:
    • A8K1A3
    • Q2M1Z9
    • Q5BKU4
    • Q9NYK0

    Protein attributes for PAG1 Gene

    Size:
    432 amino acids
    Molecular mass:
    46981 Da
    Quaternary structure:
    • Interacts with FYN. When phosphorylated, interacts with CSK. Interacts with SLC9A3R1/EBP50. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Interacts with LYN on plasma membrane lipid rafts. Identified in a complex with LYN and STAT3.

neXtProt entry for PAG1 Gene

Post-translational modifications for PAG1 Gene

  • Palmitoylated.
  • Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAG1 Gene

Antibody Products

  • Abcam antibodies for PAG1

No data available for DME Specific Peptides for PAG1 Gene

Domains & Families for PAG1 Gene

Protein Domains for PAG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PAG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PAG1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PAG1 Gene

Function for PAG1 Gene

Molecular function for PAG1 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.

Gene Ontology (GO) - Molecular Function for PAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IBA --
GO:0005070 SH3/SH2 adaptor activity NAS 10790433
GO:0005515 protein binding IPI 10790433
GO:0042169 SH2 domain binding IDA 10790433
genes like me logo Genes that share ontologies with PAG1: view
genes like me logo Genes that share phenotypes with PAG1: view

Animal Models for PAG1 Gene

MGI Knock Outs for PAG1:

Animal Model Products

miRNA for PAG1 Gene

miRTarBase miRNAs that target PAG1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAG1 Gene

Localization for PAG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAG1 Gene

Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAG1 Gene COMPARTMENTS Subcellular localization image for PAG1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAG1: view

Pathways & Interactions for PAG1 Gene

genes like me logo Genes that share pathways with PAG1: view

Gene Ontology (GO) - Biological Process for PAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007165 signal transduction TAS 10790433
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PAG1: view

No data available for SIGNOR curated interactions for PAG1 Gene

Drugs & Compounds for PAG1 Gene

(3) Drugs for PAG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PAG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAG1: view

Transcripts for PAG1 Gene

Unigene Clusters for PAG1 Gene

Phosphoprotein associated with glycosphingolipid microdomains 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAG1 Gene

No ASD Table

Relevant External Links for PAG1 Gene

GeneLoc Exon Structure for
PAG1
ECgene alternative splicing isoforms for
PAG1

Expression for PAG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAG1 Gene

This gene is overexpressed in Whole Blood (x8.8).

Protein differential expression in normal tissues from HIPED for PAG1 Gene

This gene is overexpressed in Adrenal (19.4), Peripheral blood mononuclear cells (16.2), CD4 Tcells (10.2), and CD8 Tcells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAG1 Gene



Protein tissue co-expression partners for PAG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAG1 Gene:

PAG1

SOURCE GeneReport for Unigene cluster for PAG1 Gene:

Hs.266175

mRNA Expression by UniProt/SwissProt for PAG1 Gene:

Q9NWQ8-PHAG1_HUMAN
Tissue specificity: Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
genes like me logo Genes that share expression patterns with PAG1: view

Primer Products

Orthologs for PAG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAG1 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia PAG1 34 35
  • 84.61 (n)
cow
(Bos Taurus)
Mammalia PAG1 34 35
  • 81.56 (n)
rat
(Rattus norvegicus)
Mammalia Pag1 34
  • 80.79 (n)
mouse
(Mus musculus)
Mammalia Pag1 34 16 35
  • 80.16 (n)
oppossum
(Monodelphis domestica)
Mammalia PAG1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAG1 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAG1 34 35
  • 67.14 (n)
lizard
(Anolis carolinensis)
Reptilia PAG1 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pag1 34
  • 61.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15293 34
zebrafish
(Danio rerio)
Actinopterygii pag1 34 35
  • 52.67 (n)
Species where no ortholog for PAG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAG1 Gene

ENSEMBL:
Gene Tree for PAG1 (if available)
TreeFam:
Gene Tree for PAG1 (if available)

Paralogs for PAG1 Gene

No data available for Paralogs for PAG1 Gene

Variants for PAG1 Gene

Sequence variations from dbSNP and Humsavar for PAG1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086374 -- 81,016,168(+) TAAGA(C/T)GGCCC intron-variant
rs10086722 -- 81,019,469(+) atggc(A/G)ccctg intron-variant
rs10088860 -- 80,968,925(+) AAGTC(C/T)GAATT nc-transcript-variant, utr-variant-3-prime
rs10091879 -- 81,103,440(+) CCCAC(C/T)CATCT intron-variant
rs10093838 -- 80,996,742(+) TGTGT(C/T)GGTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PAG1 Gene

Variant ID Type Subtype PubMed ID
dgv2095e212 CNV loss 25503493
esv2658475 CNV deletion 23128226
esv2675037 CNV deletion 23128226
esv28663 CNV loss 19812545
esv34101 CNV loss 18971310
esv3543732 CNV deletion 23714750
esv3572855 CNV loss 25503493
esv3617787 CNV loss 21293372
esv3617788 CNV loss 21293372
esv3617789 CNV loss 21293372
esv3891422 CNV loss 25118596
nsv396304 CNV deletion 16902084
nsv824673 CNV loss 20364138
nsv831367 CNV gain 17160897

Variation tolerance for PAG1 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAG1 Gene

Disorders for PAG1 Gene

Relevant External Links for PAG1

Genetic Association Database (GAD)
PAG1
Human Genome Epidemiology (HuGE) Navigator
PAG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAG1

No disorders were found for PAG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAG1 Gene

Publications for PAG1 Gene

  1. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. (PMID: 10790433) Brdicka T. … Schraven B. (J. Exp. Med. 2000) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. (PMID: 18070987) Tauzin S. … Hoessli D.C. (Blood 2008) 3 4 64
  5. A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation. (PMID: 17389760) Smida M. … Lindquist J.A. (Blood 2007) 3 22 64

Products for PAG1 Gene

Sources for PAG1 Gene

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