PAFAH1B1 Gene
protein-coding GIFtS: 72
GC17P002443
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platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa)
(Previous names: platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD), Miller-Dieker syndrome chromosome region, platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MDCR, MDS)
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Aliases &
Descriptions
for PAFAH1B1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| LIS-1 3 | | LIS1 1, 2, 3, 5 | | LIS2 2 | | MDCR 2, 3 | | MDS 2, 3 | | PAFAH 1, 2 | | PAFAHA 3 |
| | | Descriptions |
|---|
| Lissencephaly-1 protein 3 | | Miller-Dieker syndrome chromosome region 1 | | PAF acetylhydrolase 45 kDa subunit 3 | | PAF-AH 45 kDa subunit 3 | | PAF-AH alpha 3 | | PAFAH alpha 3 | | lissencephaly 1 protein 2 | platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit 2 | platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit (45kD) 1 | platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit 45kDa 1, 2 | platelet-activating factor acetylhydrolase, isoform Ib,
subunit 1 (45kDa) 2 |
|
| |
Search outside databases for aliases for PAFAH1B1 genePrevious GC identifers: GC17P002810 GC17P002447 GC17P002703 |
Summaries
for PAFAH1B1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PAFAH1B1:
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly
associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha
subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a
heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2
position of platelet-activating factor (identified as
1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular
platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a
single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided
by RefSeq]
UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034Function: Required for proper activation of Rho GTPases and actin polymerization at the leading
edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium
influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which
inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By
similarity). Positively regulates the activity of the minus-end directed microtubule motor protein
dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule
plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance
of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the
nucleus and centrosome. Required during brain development for the proliferation of neuronal
precursors and the migration of newly formed neurons from the ventricular/subventricular zone
toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby
migrating cells extend an anterior process into which the nucleus subsequently translocates.
During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the
centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of
cell locomotion including the migration of fibroblasts during wound healingGene Wiki entry for PAFAH1B1 |
Genomic Location
for PAFAH1B1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the PAFAH1B1 gene 
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3PAFAH1B1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P002443:
(about GC identifiers)
Start:
|
2,443,686 bp from pter |
End:
|
2,535,638 bp from pter |
Size:
|
91,953 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010718.15
| Proteins
for PAFAH1B1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034 (See
protein sequence)Recommended Name: Platelet-activating factor acetylhydrolase IB subunit alpha Size: 410 amino acids; 46638 Da
Subunit: Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta)
and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the
enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Interacts
with IQGAP1, KATNB1 and NUDC. Interacts with DAB1 when DAB1 is phosphorylated in response to
RELN/reelin signaling (By similarity). Can self-associate. Interacts with DCX, dynein, dynactin,
NDE1, NDEL1 and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1
Subcellular location: Cytoplasm, cytoskeleton. Spindle (By similarity). Nucleus membrane
(Potential). Centrosome. Note=Redistributes to axons during neuronal development. Also localizes
to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in
spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome.
May localize to the nuclear membrane
Sequence caution: Sequence=AAA02882.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
Secondary accessions: Q8WZ88 Q8WZ89Alternative splicing: 2 isoforms: P43034-1 P43034-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_000421.1
ENSEMBL proteins: ENSP00000380377 ENSP00000380378 ENSP00000006951
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5/16 Gene Ontology (GO) cellular component terms (links to tree view) (see all 16
): About this table
Antibodies for PAFAH1B1:
Assays for PAFAH1B1: | Protein
Domains/
Families
for PAFAH1B1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P43034
ProtoNet protein and cluster: P43034 2 Blocks protein families: IPB001680 G-protein beta WD-40 repeat signature IPB006594 Lissencephaly type-1-like homology motif
UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034Domain: Dimerization mediated by the LisH domain may be required to activate dynein (By similarity)Similarity: Belongs to the WD repeat LIS1/nudF familySimilarity: Contains 1 LisH domainSimilarity: Contains 7 WD repeats | Gene Function
for PAFAH1B1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000430
 Applied Biosystems Silencer® siRNAs for PAFAH1B1
 Sigma-Aldrich siRNA and siRNA Panels for PAFAH1B1
Sigma-Aldrich shRNA Panels and shRNA for PAFAH1B1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_000430
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000430
untagged cDNA clone in CMV expression vector: NM_000430
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_000430
UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034Function: Required for proper activation of Rho GTPases and actin polymerization at the leading
edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium
influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which
inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By
similarity). Positively regulates the activity of the minus-end directed microtubule motor protein
dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule
plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance
of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the
nucleus and centrosome. Required during brain development for the proliferation of neuronal
precursors and the migration of newly formed neurons from the ventricular/subventricular zone
toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby
migrating cells extend an anterior process into which the nucleus subsequently translocates.
During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the
centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of
cell locomotion including the migration of fibroblasts during wound healingGenatlas biochemistry entry for PAFAH1B1:platelet activating factor acetylhydrolase,microtubule associated protein,plasma isoform 1b,non
catalytic alpha subunit ,component of overlapping but distinct signal pathways including DCX that
promotes neuronal migration,expressed in fetal brain,regulated by phosphorylation,required for
ordered neuronal migration in the cortex,deleted or mutated in isolated lissencephaly,also deleted
in Miller-Dieker syndrome7 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Pafah1b1):
5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
): About this table | Pathways & Interactions
for PAFAH1B1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for PAFAH1B1 (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for PAFAH1B1
5/209 Interacting proteins for PAFAH1B1 (ENSP000000069513 P430342) via UniProtKB, MINT, and/or STRING (see all 209
)About this table
5/27 Gene Ontology (GO) biological process terms (links to tree view) (see all 27
): About this table
|
Drugs & Compounds
for PAFAH1B1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PAFAH1B1
10  Novoseek chemical compound relationships for PAFAH1B1 gene
About this table
|
Transcripts
for PAFAH1B1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000430
Sigma-Aldrich siRNA and siRNA Panels for PAFAH1B1
Sigma-Aldrich shRNA Panels and shRNA for PAFAH1B1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_000430 REFSEQ mRNAs for PAFAH1B1 gene: NM_000430.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000430
OriGene GFP tagged cDNA clone in CMV expression vector: NM_000430
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000430
untagged cDNA clone in CMV expression vector: NM_000430
Additional cDNA sequence: AF208835.1 AF208836.1 AF208837.1 AF208838.1 AF400434.1 AK293918.1 AK303015.1 AK308937.1 AK313078.1 BC064638.1 BX538346.1 CR594061.1 CR599910.1 CR608859.1 CR622803.1 CR624292.1 L13385.1 L13386.1 L13387.1 L13388.1 L25107.1 S81396.1 24/28 DOTS entries (see all 28
): DT.95198247 DT.448229 DT.100844382 DT.95265405 DT.95265403 DT.100844368 DT.120975397 DT.95232261 DT.99951065 DT.100832160 DT.100844370 DT.100893741 DT.120975390 DT.120975423 DT.120975457 DT.75100670 DT.95265406 DT.100719152 DT.102836560 DT.120975398 DT.120975429 DT.120975524 DT.99949047 DT.100704991 24/1840 AceView cDNA sequences (see all 1840
):AI270436 BM760170 BG677248 CR619511 AA976438 AA367853 AA189010 CK824060 AA724377 M78473 BM449638 BU153036 W49810 BE784239 BQ773238 BU155913 AK128785 BM806418 CA412610 BM762925 BQ439862 CR617332 AA737919 BM721057
 highest scoring ESTs for PAFAH1B1:L25107 L13385 AA013270 AA056313 AA059318 AA059337 AA216709 AA218588 AA253159 AA309766 Unigene Cluster for PAFAH1B1: Platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa) Hs.77318 [show with all ESTs]Unigene Representative Sequence: NM_000430
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PAFAH1B1 (see all 8
)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | - | | | | - | | | | - | | | | | | - | | - | | - | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PAFAH1B1
3 Ensembl transcripts including schematic representations: ENST00000397193
ENST00000397195
ENST00000006951
|
Expression
for PAFAH1B1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PAFAH1B1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PAFAH1B1
1 / 2 / 3 10 probe-sets matching PAFAH1B1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTTTCTGCAT
SOURCE GeneReport for Unigene cluster: Hs.77318
Expression variation in blood from EXPOLDB for PAFAH1B1 UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034Tissue specificity: Fairly ubiquitous expression in both the frontal and occipital areas of the
brain |
Orthologs
for PAFAH1B1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PAFAH1B1 gene from 5/17 species (see all 17
)
About this table Species with no ortholog for PAFAH1B1
ENSEMBL Gene Tree for PAFAH1B1 | Paralogs
for PAFAH1B1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PAFAH1B1 gene
- WDR692
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants
for PAFAH1B1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PAFAH1B1 (up to first 250kb)
|
Disorders & Mutations
for PAFAH1B1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601545 UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034
Defects in PAFAH1B1 are the cause of lissencephaly type 1 (LIS1) [MIM:607432]; also known
as classic lissencephaly. LIS1 is characterized by agyria or pachgyria and disorganization of the
clear neuronal lamination of normal six-layered cortex. The cortex is abnormally thick and poorly
organized with 4 primitive layers. LIS1 is associated with enlarged and dysmorphic ventricles and
often hypoplasia of the corpus callosum Defects in PAFAH1B1 are the cause of subcortical band heterotopia (SBH) [MIM:607432]. SBH
is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and
symmetric ribbons of gray matter found in the central white matter between the cortex and the
ventricular surface Defects in PAFAH1B1 are a cause of Miller-Dieker lissencephaly syndrome (MDLS)
[MIM:247200]. MDLS is a contiguous gene deletion syndrome of chromosome 17p13.3, characterized by
classical lissencephaly and distinct facial features. Additional congenital malformations can be
part of the condition10/21 Novoseek disease relationships for PAFAH1B1 gene (see all 21
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lissencephaly sequence, isolated |
97.12 |
30 |
17664403 (2), 10541472 (2), 16814084 (2), 11115846 (1) (see all 18) |
| agyria |
92.19 |
1 |
11502906 (1) |
| lissencephaly, x-linked |
90.96 |
2 |
17571022 (1), 10826984 (1) |
| periventricular nodular heterotopia |
89.00 |
1 |
16538086 (1) |
| miller-dieker lissencephaly syndrome |
88.94 |
2 |
17850624 (1) |
| cerebellar hypoplasia |
84.85 |
3 |
17664403 (2), 16538086 (1) |
| infantile spasms |
65.76 |
3 |
11579436 (1), 15921228 (1), 16724181 (1) |
| developmental disabilities |
50.54 |
1 |
10541472 (1) |
| developmental delay |
49.43 |
4 |
11579436 (1), 15921228 (1), 16724181 (1), 19136950 (1) |
| trisomy |
27.67 |
2 |
12390976 (1), 10406660 (1) |
About this table
GeneTests: PAFAH1B1
LIS1-Associated Lissencephaly/Subcortical Band Heterotopia
Human Gene Mutation Database: PAFAH1B1
Genetic Association Database: PAFAH1B1
Human Genome Epidemiology Navigator: PAFAH1B1 (12 documents)
|
Medical News
for PAFAH1B1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PAFAH1B1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/223 PubMed articles for PAFAH1B1 gene (see all 223
):- Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome. (PubMed id 9063735)1, 2, 3, 4 Lo Nigro C....Ledbetter D.H. (1997)
- Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats. (PubMed id 8355785)2, 3, 4 Reiner O.... Ledbetter D.H. (1993)
- Interaction between LIS1 and doublecortin, two lissencephaly gene products. (PubMed id 11001923)1, 3, 4 Caspi M.... Reiner O. (2000)
- Mosaic mutations of the LIS1 gene cause subcortical band heterotopia. (PubMed id 14581661)1, 3, 4 Sicca F....Guerrini R. (2003)
- LIS1 missense mutations cause milder lissencephaly phenotypes including a child with normal IQ. (PubMed id 11502906)1, 3, 4 Leventer R.J.... Dobyns W.B. (2001)
- LIS1, CLIP-170's key to the dynein/dynactin pathway. (PubMed id 11940666)1, 3, 4 Coquelle F.M.... Reiner O. (2002)
- Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis. (PubMed id 15081260)1, 3, 6 Osoegawa M....Kira J. (2004)
- Subcortical band heterotopia in rare affected males can be caused by missense mutations in DCX (XLIS) or LIS1. (PubMed id 10441340)1, 3, 4 Pilz D.T.... Ledbetter D.H. (1999)
- Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein. (PubMed id 14970193)1, 3, 4 Liang Y.... Zhu X. (2004)
- Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration. (PubMed id 15173193)1, 3, 4 Tanaka T....Gleeson J.G. (2004)
|
Search for PAFAH1B1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PAFAH1B1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PAFAH1B1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PAFAH1B1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| GeneReviews | http://www.genetests.org/query?gene=PAFAH1B1 |
|
| | | About This Section
| --
| Services
for PAFAH1B1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for PAFAH1B1:
 | |
 | | | | |
 |
 |  |  | |
|  | Recombinant Proteins
(LIS1) | | | Antibodies (LIS1) |
| |
|
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 | | |
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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