Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PAFAH1B1 Gene

protein-coding   GIFtS: 67
GCID: GC17P002496

Platelet-Activating Factor Acetylhydrolase 1b, Regulatory...

(Previous names: platelet-activating factor acetylhydrolase, isoform Ib,...)
(Previous symbols: MDCR, MDS)
  See PAFAH1B1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1
(45kDa)1 2
     PAF-AH Alpha2 3
MDCR1 2 3     PAFAH Alpha2 3
MDS1 2 3     Miller-Dieker Syndrome Chromosome Region1
LIS12 3 5     Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Alpha Subunit
45kDa1
Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Alpha Subunit
(45kD)1 2
     LIS22
Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Subunit 1 (45kDa)1 2     PAFAH2
Lissencephaly-1 Protein2 3     Lissencephaly 1 Protein2
LIS-12 3     Platelet-Activating Factor Acetylhydrolase IB Subunit Alpha2
PAF Acetylhydrolase 45 KDa Subunit2 3     PAFAHA3
PAF-AH 45 KDa Subunit2 3     

External Ids:    HGNC: 85741   Entrez Gene: 50482   Ensembl: ENSG000000071687   OMIM: 6015455   UniProtKB: P430343   

Export aliases for PAFAH1B1 gene to outside databases

Previous GC identifers: GC17P002810 GC17P002447 GC17P002703 GC17P002443


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PAFAH1B1 Gene:
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with
Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib
isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the
removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as
1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating
factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a
single-subunit isoform of this enzyme is found in serum. (provided by RefSeq, Apr 2009)

GeneCards Summary for PAFAH1B1 Gene:
PAFAH1B1 (platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)) is a protein-coding gene. Diseases associated with PAFAH1B1 include 17p13.3 microduplication syndrome, and lis1-associated lissencephaly/subcortical band heterotopia. GO annotations related to this gene include heparin binding and protein homodimerization activity. An important paralog of this gene is NLE1.

UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034
Function: Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting
cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA
receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF)
by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the
minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting
dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the
maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus
and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration
of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration
involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the
nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus
towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell
locomotion including the migration of fibroblasts during wound healing

Gene Wiki entry for PAFAH1B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PAFAH1B1 gene promoter:
         TBP   c-Fos   AML1a   AP-1   Nkx2-2   NF-kappaB   C/EBPalpha   TFIID   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PAFAH1B1 promoter sequence
   Search Chromatin IP Primers for PAFAH1B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAFAH1B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

PAFAH1B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAFAH1B1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P002496:  view genomic region     (about GC identifiers)

Start:
2,496,504 bp from pter      End:
2,588,909 bp from pter
Size:
92,406 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034 (See protein sequence)
Recommended Name: Platelet-activating factor acetylhydrolase IB subunit alpha  
Size: 410 amino acids; 46638 Da
Subunit: Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3
(gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed
solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Interacts with IQGAP1, KATNB1 and NUDC. Interacts
with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling (By similarity). Can self-associate.
Interacts with DCX, dynein, dynactin, NDE1, NDEL1 and RSN. Interacts with DISC1, and this interaction is enhanced
by NDEL1. Interacts with ASUN
Sequence caution: Sequence=AAA02882.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
Secondary accessions: B2R7Q7 Q8WZ88 Q8WZ89
Alternative splicing: 2 isoforms:  P43034-1   P43034-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PAFAH1B1: NX_P43034

Explore proteomics data for PAFAH1B1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PAFAH1B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000421.1  
    ENSEMBL proteins: 
     ENSP00000461087   ENSP00000380378   ENSP00000460258   ENSP00000460591   ENSP00000395628  
    Reactome Protein details: P43034

    PAFAH1B1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PAFAH1B1
    OriGene Protein Over-expression Lysate for PAFAH1B1
    OriGene MassSpec for PAFAH1B1
    OriGene Custom Protein Services for PAFAH1B1
    GenScript Custom Purified and Recombinant Proteins Services for PAFAH1B1
    Novus Biologicals PAFAH1B1 Proteins
    Novus Biologicals PAFAH1B1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PAFAH1B1

     
    Search eBioscience for Proteins for PAFAH1B1 

    PAFAH1B1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PAFAH1B1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PAFAH1B1 
    OriGene Antibodies for PAFAH1B1
    OriGene Custom Antibody Services for PAFAH1B1
    Novus Biologicals PAFAH1B1 Antibodies
    Search for Antibodies for PAFAH1B1 at Abcam
    Cloud-Clone Corp. Antibodies for PAFAH1B1
    ThermoFisher Antibodies for PAFAH1B1
    LSBio Antibodies in human, mouse, rat for PAFAH1B1

    PAFAH1B1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PAFAH1B1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PAFAH1B1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PAFAH1B1
    Cloud-Clone Corp. CLIAs for PAFAH1B1
    Search eBioscience for ELISAs for PAFAH1B1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 8):
     IPR017252 Dynein_regulator_LIS1
     IPR019775 WD40_repeat_CS
     IPR006594 LisH_dimerisation
     IPR013720 LisH_dimerisation_subgr
     IPR001680 WD40_repeat

    Graphical View of Domain Structure for InterPro Entry P43034

    ProtoNet protein and cluster: P43034

    2 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB006594 Lissencephaly type-1-like homology motif


    UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034
    Domain: Dimerization mediated by the LisH domain may be required to activate dynein (By similarity)
    Similarity: Belongs to the WD repeat LIS1/nudF family
    Similarity: Contains 1 LisH domain
    Similarity: Contains 7 WD repeats


    Find genes that share domains with PAFAH1B1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIS1_HUMAN, P43034
    Function: Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting
    cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA
    receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF)
    by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the
    minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting
    dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the
    maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus
    and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration
    of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration
    involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the
    nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus
    towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell
    locomotion including the migration of fibroblasts during wound healing

         Genatlas biochemistry entry for PAFAH1B1:
    platelet activating factor acetylhydrolase,microtubule associated protein,plasma isoform 1b,non catalytic alpha
    subunit ,component of overlapping but distinct signal pathways including DCX that promotes neuronal
    migration,expressed in fetal brain,regulated by phosphorylation,required for ordered neuronal migration in the
    cortex,deleted or mutated in isolated lissencephaly,also deleted in Miller-Dieker syndrome

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11163258
    GO:0008017microtubule binding ISS10729324
    GO:0008201heparin binding ISS8028668
    GO:0016787hydrolase activity ----
    GO:0032403protein complex binding ----
         
    Find genes that share ontologies with PAFAH1B1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PAFAH1B1:
     Cell cycle / mitosis defect  Decreased number of cells in m  Increased G2M DNA content  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Pafah1b1):
     behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     mortality/aging  nervous system  reproductive system 

    Find genes that share phenotypes with PAFAH1B1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PAFAH1B1: Pafah1b1tm1Awb Pafah1b1tm2.2Awb Pafah1b1tm1Or

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAFAH1B1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAFAH1B1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PAFAH1B1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PAFAH1B1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PAFAH1B1:
    hsa-mir-192-5p (MIRT026749), hsa-mir-375 (MIRT020051), hsa-mir-100-5p (MIRT048588), hsa-mir-101-3p (MIRT027380), hsa-mir-215-5p (MIRT024898), hsa-mir-18a-5p (MIRT031314)

    Block miRNA regulation of human, mouse, rat PAFAH1B1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAFAH1B1 (see all 99):
    hsa-miR-411* hsa-miR-3607-3p hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-4305 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidPAFAH1B1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PAFAH1B1
    Predesigned siRNA for gene silencing in human, mouse, rat PAFAH1B1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PAFAH1B1

    Clone
    Products:
         
    OriGene clones in human, mouse for PAFAH1B1 (see all 7)
    OriGene ORF clones in mouse, rat for PAFAH1B1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PAFAH1B1 (NM_000430)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAFAH1B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAFAH1B1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PAFAH1B1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PAFAH1B1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAFAH1B1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LIS1_HUMAN, P43034: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Cytoplasm, cytoskeleton, spindle (By similarity). Nucleus membrane (Potential). Note=Redistributes to axons
    during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to
    the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the
    centrosome. May localize to the nuclear membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    endosome1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000235astral microtubule IDA11940666
    GO:0000776kinetochore IDA11056532
    GO:0005634nucleus ----
    GO:0005635nuclear envelope IDA11940666
    GO:0005737cytoplasm ----

    Find genes that share ontologies with PAFAH1B1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PAFAH1B1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    5Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    Wnt Signaling Pathway and Pluripotency0.55


    Find genes that share SuperPaths with PAFAH1B1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PAFAH1B1
        Neuroscience
    Cytoskeletal Signaling

    4 BioSystems Pathways for PAFAH1B1
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Lissencephaly gene (LIS1) in neuronal migration and development
    Reelin signaling pathway

    Selected Reactome Pathways for PAFAH1B1 (see all 7)
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome


    2 Kegg Pathways  (Kegg details for PAFAH1B1):
        Ether lipid metabolism
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Array including PAFAH1B1: 
              Neurogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PAFAH1B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PAFAH1B1 (P430341, 2, 3 ENSP000003803784) via UniProtKB, MINT, STRING, and/or I2D (see all 300)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KARSQ150462, 3, ENSP000003254484MINT-65542 I2D: score=5 STRING: ENSP00000325448
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=1 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=1 STRING: ENSP00000291295
    DCTN1Q142033, ENSP000003547914I2D: score=4 STRING: ENSP00000354791
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000132establishment of mitotic spindle orientation IMP11056532
    GO:0000226microtubule cytoskeleton organization ISS10729324
    GO:0000278mitotic cell cycle TAS--
    GO:0001667ameboidal cell migration IEA--

    Find genes that share ontologies with PAFAH1B1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PAFAH1B1 (LIS1)

    5 HMDB Compounds for PAFAH1B1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    CalciumCa (see all 2)7440-70-2--
    LysoPC(O-18:0)1-Octadecyl-sn-glycero-3-phosphocholine;LysoPC(o-18:0)LysoPC(dm18:0);LysoPC(18:0e/0:0);LysoPC(o-18:0/0:0) (see all 2)----
    PC(18:1(9Z)e/2:0)(2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate;2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine;PC(o-18:1(9Z)/2:0) ----
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for PAFAH1B1 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    medroxyprogesterone 48.7 3 8460940 (2), 8233731 (1)
    phospholipid 14.8 4 10051281 (1), 15265050 (1), 12934648 (1), 1414232 (1)
    txb2 3.97 5 7938902 (4)
    leukotriene b4 3.96 5 7938902 (4)
    calcium 2.85 1 12934648 (1)
    endotoxin 0 1 8460940 (1)
    polyacrylamide 0 3 16761416 (1), 12821559 (1)
    arachidonic acid 0 2 7938902 (1)
    lipid 0 4 10722879 (1), 11168434 (1), 15942364 (1), 9349753 (1)
    steroid 0 2 8460940 (1), 8040619 (1)



    Find genes that share compounds with PAFAH1B1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PAFAH1B1 gene: 
    NM_000430.3  

    Unigene Cluster for PAFAH1B1:

    Platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
    Hs.77318  [show with all ESTs]
    Unigene Representative Sequence: NM_000430
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576586 ENST00000397195(uc010ckb.2 uc002fuw.4 uc010vqz.2)
    ENST00000575477 ENST00000572915 ENST00000570400 ENST00000571289 ENST00000574816
    ENST00000609078 ENST00000397193 ENST00000574468 ENST00000571495 ENST00000610190
    ENST00000574213 ENST00000451360
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PAFAH1B1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PAFAH1B1 (see all 99):
    hsa-miR-411* hsa-miR-3607-3p hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-4305 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidPAFAH1B1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PAFAH1B1
    Predesigned siRNA for gene silencing in human, mouse, rat PAFAH1B1
    Clone
    Products:
         
    OriGene clones in human, mouse for PAFAH1B1 (see all 7)
    OriGene ORF clones in mouse, rat for PAFAH1B1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PAFAH1B1 (NM_000430)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PAFAH1B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAFAH1B1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PAFAH1B1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAFAH1B1
      QuantiTect SYBR Green Assays in human, mouse, rat PAFAH1B1
      QuantiFast Probe-based Assays in human, mouse, rat PAFAH1B1

    Additional mRNA sequence: 

    AF208835.1 AF208836.1 AF208837.1 AF208838.1 AF400434.1 AK293918.1 AK303015.1 AK308937.1 
    AK313078.1 BC064638.1 BX538346.1 L13385.1 L13386.1 L13387.1 L13388.1 L25107.1 
    S81396.1 

    Selected DOTS entries (see all 28):

    DT.95198247  DT.448229  DT.100844382  DT.95265405  DT.95265403  DT.100844368  DT.120975397  DT.95232261 
    DT.99951065  DT.100832160  DT.100844370  DT.100719152  DT.100893741  DT.120975390  DT.120975423  DT.120975457 
    DT.95265406  DT.100704991  DT.120975398  DT.120975429  DT.120975524  DT.121007247  DT.75100670  DT.99949047 

    Selected AceView cDNA sequences (see all 1840):

    BM473686 BM972146 BQ432505 BM998232 AA718963 BQ019763 BQ021429 BP376361 
    AI471564 AA161462 H09905 BM015983 AW780133 BM670429 BQ019490 T98808 
    AW794783 BP371029 AA953175 BI222448 BG289065 BM759754 BM971903 CB130457 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PAFAH1B1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -           -                                   -                       -                                       
    SP2:                    -           -     -     -           -           -                 -     -     -     -     -     -               
    SP3:                                                                    -                                                               
    SP4:        -     -     -           -                                                                                                   
    SP5:                                -     -                                                                                             


    ECgene alternative splicing isoforms for PAFAH1B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PAFAH1B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTGCAT
    PAFAH1B1 Expression
    About this image


    PAFAH1B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    PAFAH1B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PAFAH1B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77318

    UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034
    Tissue specificity: Fairly ubiquitous expression in both the frontal and occipital areas of the brain

        Pathway & Disease-focused RT2 Profiler PCR Array including PAFAH1B1: 
              Neurogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PAFAH1B1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAFAH1B1
    QuantiTect SYBR Green Assays in human, mouse, rat PAFAH1B1
    QuantiFast Probe-based Assays in human, mouse, rat PAFAH1B1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAFAH1B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PAFAH1B1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pafah1b11 , 5 platelet-activating factor acetylhydrolase, isoform more1, 5 95.12(n)1
    99.76(a)1
      11 (45.76 cM)5
    184721  NM_013625.41  NP_038653.11 
     746739495 
    chicken
    (Gallus gallus)
    Aves PAFAH1B11 platelet-activating factor acetylhydrolase 1b, regulatory more 89.35(n)
    99.02(a)
      374224  NM_204324.1  NP_989655.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAFAH1B16
    platelet-activating factor acetylhydrolase 1b, reg...
    99(a)
    1 ↔ 1
    GL343731.1(29023-44889)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.53472 Xenopus laevis LIS1 mRNA, complete cds 84.68(n)    AY032881.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pafah1b1a2 platelet-activating factor acetylhydrolase, isoform more 82.39(n)   394246  BC053205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lis13 microtubule-based movement
    2-acetyl-1-alkylglycerophosphocholine
    more
    70(a)   52F5   --
    worm
    (Caenorhabditis elegans)
    Secernentea lis-11 , 3 WD domain, G-beta repeats (4 domains)3
    lis-11
    57(a)3
    59.47(n)1
    58.56(a)1
      III(13442945-13447923)3
    1767581  NM_067354.51  NP_499755.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSA46
    WD-repeat protein involved in ribosome biogenesis;...
    19(a)
    1 → many
    III(240805-242352) YCR072C
    corn
    (Zea mays)
    Liliopsida Zm.14342 Zea mays transcribed sequence 92.92(n)    BE049906.1 


    ENSEMBL Gene Tree for PAFAH1B1 (if available)
    TreeFam Gene Tree for PAFAH1B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PAFAH1B1 gene
    NLE12  WDR832  POC1B2  WDR52  ATG16L12  SNRNP402  WDR5B2  SMU12  
    DAW12  WDR382  ATG16L22  POC1A2  
    12 SIMAP similar genes for PAFAH1B1 using alignment to 5 protein entries:     LIS1_HUMAN (see all proteins):
    WSB1    PF20    FBXW7    POC1B    GNB5    PLRG1
    PAAF1    WDR5    WDR5B    WDR83    GNB2L1    DAW1

    Find genes that share paralogs with PAFAH1B1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PAFAH1B1
    PGOHUM00000240135 PGOHUM00000262449 PGOHUM00000262466


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PAFAH1B1 (see all 1968)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0102034
    Subcortical band heterotopia (SBH)4--see VAR_0102032 S P mis40--------
    VAR_0373014
    Lissencephaly 1 (LIS1)4--see VAR_0373012 H P mis40--------
    VAR_0153984
    Lissencephaly 1 (LIS1)4--see VAR_0153982 F S mis40--------
    rs289364111,2,4
    Subcortical band heterotopia (SBH)4--see VAR_0373002 mis40--------
    rs289366891,2,4
    Lissencephaly 1 (LIS1)4--see VAR_0154002 mis40--------
    rs289364101,2,4
    Lissencephaly 1 (LIS1)4--see VAR_0153992 mis40--------
    VAR_0077244
    Lissencephaly 1 (LIS1)4--see VAR_0077242 H R mis40--------
    rs66281,2
    C,F,A,Hnon-pathogenic12575351(+) TCGGCC/TCCTCC 1 -- ut31 ese3 trp38Minor allele frequency- T:0.21MN NA WA EA EU 1829
    rs1813836551,2
    --2485198(+) TCATCC/TTCCCC 1 -- us2k10--------
    rs1379312491,2
    --2485202(+) CCTCCC/TCAGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PAFAH1B1 (2496504 - 2588909 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PAFAH1B1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715502CNV Deletion23290073
    esv2660206CNV Deletion23128226
    esv2715503CNV Deletion23290073
    esv2664869CNV Deletion23128226
    dgv3037n71CNV Loss21882294
    nsv833339CNV Loss17160897
    nsv516756CNV Gain19592680
    esv275250CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): PAFAH1B1
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing PAFAH1B1:
    Intellectual Disability
    SeqTarget long-range PCR primers for resequencing PAFAH1B1
    DNA2.0 Custom Variant and Variant Library Synthesis for PAFAH1B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601545   
    OMIM disorders: 607432  
    UniProtKB/Swiss-Prot: LIS1_HUMAN, P43034
  • Lissencephaly 1 (LIS1) [MIM:607432]: A classical lissencephaly. It is characterized by agyria or
    pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. The cortex is
    abnormally thick and poorly organized with 4 primitive layers. Associated with enlarged and dysmorphic ventricles
    and often hypoplasia of the corpus callosum. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Subcortical band heterotopia (SBH) [MIM:607432]: SBH is a mild brain malformation of the lissencephaly
    spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central
    white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Miller-Dieker lissencephaly syndrome (MDLS) [MIM:247200]: A contiguous gene deletion syndrome of
    chromosome 17p13.3, characterized by classical lissencephaly and distinct facial features. Additional congenital
    malformations can be part of the condition. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 12 diseases for PAFAH1B1:    
    About MalaCards
    17p13.3 microduplication syndrome    lis1-associated lissencephaly/subcortical band heterotopia    subcortical laminar heterotopia    lissencephaly 1
    lissencephaly    platelet-activating factor acetylhydrolase deficiency    subcortical band heterotopia    miller-dieker syndrome
    lissencephaly x-linked    periventricular nodular heterotopia    pachygyria    schizophrenia

    5 diseases from the University of Copenhagen DISEASES database for PAFAH1B1:
    Lissencephaly     Periventricular nodular heterotopia     Intellectual disability     Microcephaly
    Focal epilepsy

    Find genes that share disorders with PAFAH1B1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PAFAH1B1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lissencephaly sequence, isolated 97.1 30 17664403 (2), 10541472 (2), 16814084 (2), 11115846 (1) (see all 18)
    agyria 92.8 2 19667223 (1), 11502906 (1)
    lissencephaly, x-linked 90.3 2 17571022 (1), 10826984 (1)
    periventricular nodular heterotopia 88.8 1 16538086 (1)
    miller-dieker lissencephaly syndrome 87.3 2 17850624 (1)
    cerebellar hypoplasia 84.7 3 17664403 (2), 16538086 (1)
    infantile spasms 64.3 3 11579436 (1), 15921228 (1), 16724181 (1)
    developmental delay 52.3 5 11579436 (1), 15921228 (1), 16724181 (1), 19136950 (1) (see all 5)
    epilepsy 51.6 10 19797046 (1), 20227246 (1)
    developmental disabilities 51.1 2 10541472 (1), 19864038 (1)

    GeneTests: PAFAH1B1
    GeneReviews: PAFAH1B1
    Genetic Association Database (GAD): PAFAH1B1
    Human Genome Epidemiology (HuGE) Navigator: PAFAH1B1 (25 documents)

    Export disorders for PAFAH1B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PAFAH1B1 gene, integrated from 10 sources (see all 288):
    (articles sorted by number of sources associating them with PAFAH1B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome. (PubMed id 9063735)1, 2, 3, 9 Lo Nigro C....Ledbetter D.H. (Hum. Mol. Genet. 1997)
    2. Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats. (PubMed id 8355785)1, 2, 3 Reiner O.... Ledbetter D.H. (Nature 1993)
    3. Interaction between LIS1 and doublecortin, two lissencephaly gene products. (PubMed id 11001923)1, 2, 9 Caspi M.... Reiner O. (Hum. Mol. Genet. 2000)
    4. Mosaic mutations of the LIS1 gene cause subcortical band heterotopia. (PubMed id 14581661)1, 2, 9 Sicca F....Guerrini R. (Neurology 2003)
    5. LIS1 missense mutations cause milder lissencephaly phenotypes including a child with normal IQ. (PubMed id 11502906)1, 2, 9 Leventer R.J.... Dobyns W.B. (Neurology 2001)
    6. LIS1, CLIP-170's key to the dynein/dynactin pathway. (PubMed id 11940666)1, 2, 9 Coquelle F.M.... Reiner O. (Mol. Cell. Biol. 2002)
    7. Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis. (PubMed id 15081260)1, 4, 9 Osoegawa M....Kira J. (J. Neuroimmunol. 2004)
    8. Subcortical band heterotopia in rare affected males can be caused by missense mutations in DCX (XLIS) or LIS1. (PubMed id 10441340)1, 2, 9 Pilz D.T.... Ledbetter D.H. (Hum. Mol. Genet. 1999)
    9. Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration. (PubMed id 15173193)1, 2, 9 Tanaka T....Gleeson J.G. (J. Cell Biol. 2004)
    10. Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. (PubMed id 14962739)1, 2, 9 Brandon N.J....Whiting P.J. (Mol. Cell. Neurosci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5048 HGNC: 8574 AceView: YWHAE Ensembl:ENSG00000007168 euGenes: HUgn5048
    ECgene: PAFAH1B1 Kegg: 5048 H-InvDB: PAFAH1B1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PAFAH1B1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PAFAH1B1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PAFAH1B1 gene:
    Search GeneIP for patents involving PAFAH1B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PAFAH1B1
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PAFAH1B1   OriGene RNAi products in human, mouse, rat for PAFAH1B1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PAFAH1B1  
     OriGene MassSpec something-or-other for PAFAH1B1   OriGene clones in human, mouse for PAFAH1B1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PAFAH1B1   OriGene Purified Protein for PAFAH1B1  
     OriGene ORF clones in mouse, rat for PAFAH1B1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PAFAH1B1   OriGene Custom Protein Services for PAFAH1B1  

     
     
     Block miRNA regulation of human, mouse, rat PAFAH1B1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PAFAH1B1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PAFAH1B1 Predesigned siRNA for gene silencing in human, mouse, rat PAFAH1B1
     QuantiFast Probe-based Assays in human, mouse, rat PAFAH1B1 QuantiTect SYBR Green Assays in human, mouse, rat PAFAH1B1
     PCR Arrays including human, mouse, rat PAFAH1B1 Search Chromatin IP Primers for PAFAH1B1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PAFAH1B1  GeneGlobe Interaction Network for PAFAH1B1
     Regulatory tfbs in PAFAH1B1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PAFAH1B1 GenScript cDNA clones with any tag delivered in your preferred vector for PAFAH1B1
     GenScript Custom Assay Services for PAFAH1B1 GenScript Custom overexpressing Cell Line Services for PAFAH1B1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for PAFAH1B1 

     Search Tocris compounds for PAFAH1B1 (LIS1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PAFAH1B1 antibodies
     PAFAH1B1 proteins
     PAFAH1B1 lysates
     Search for Antibodies for PAFAH1B1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PAFAH1B1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PAFAH1B1
     Antibodies for PAFAH1B1
     ELISAs for PAFAH1B1
     CLIAs for PAFAH1B1



     Browse ESI BIO Cell Lines and PureStem Progenitors for PAFAH1B1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAFAH1B1
     SwitchGear 3'UTR luciferase reporter plasmids for PAFAH1B1
     SwitchGear Promoter luciferase reporter plasmids for PAFAH1B1
     ThermoFisher Antibodies for PAFAH1B1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PAFAH1B1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PAFAH1B1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PAFAH1B1
     LSBio Antibodies in human, mouse, rat for PAFAH1B1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PAFAH1B1
      Search eBioscience for proteins for PAFAH1B1
      Search eBioscience for elisas for PAFAH1B1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PAFAH1B1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4