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Aliases & Descriptions for PAF1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| F23149_1 1, 2 | | FLJ11123 1, 2 | | PD2 1, 2, 3, 5 | | hPAF1 3 |
| | | Descriptions |
|---|
| Paf1, RNA polymerase II associated factor, homolog 2 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2 | | Pancreatic differentiation protein 2 3 |
|
| | Search outside databases for aliases for PAF1 gene |
Summaries for PAF1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PAF1: PAF1, parafibromin (CDC73; MIM 607393), LEO1 (MIM 610507), and CTR9 (MIM 609366) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]). The PAF complex also has a role in histone monoubiquitination (Zhu et al., 2005 [PubMed 16307923]).[supplied by OMIM] UniProtKB/Swiss-Prot: PAF1_HUMAN, Q8N7H5Function: The mammalian PAF1 complex is a multifunctional complex. The PAF1 complex interacts with RNA polymerase II and may be involved in both initiation and elongation, and in histone methylation and RNA processing. Has oncogenic activity in vivo and in vitro |
Genomic Location for PAF1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PAF1 gene 
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1PAF1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M044569:
(about GC identifiers)
Start:
|
44,568,109 bp from pter |
End:
|
44,573,586 bp from pter |
Size:
|
5,478 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for PAF1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PAF1_HUMAN, Q8N7H5 (See
protein sequence)Recommended Name: RNA polymerase II-associated factor 1 homolog Size: 531 amino acids; 59976 Da
Subunit: Component of the mammalian PAF1 complex, which consists of, at least, CDC73, PAF1, LEO1 and CTR9. Interacts directly with POLR2A/RNA polymerase II and CDC73
Subcellular location: Nucleus. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin
Sequence caution: Sequence=AAC25503.1; Type=Erroneous gene model prediction; Sequence=EAW56880.1; Type=Erroneous gene model prediction; Sequence=EAW56881.1; Type=Erroneous gene model prediction;
Secondary accessions: O75239 Q9H166 Q9NUU9Alternative splicing: 2 isoforms: Q8N7H5-1 Q8N7H5-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061961.2
ENSEMBL proteins: ENSP00000221265 ENSP00000221266
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for PAF1: Assays for PAF1: | Protein
Domains/ Families for PAF1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8N7H5
ProtoNet protein and cluster: Q8N7H5 UniProtKB/Swiss-Prot: PAF1_HUMAN, Q8N7H5Similarity: Belongs to the PAF1 family | Gene Function for PAF1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019088
Applied Biosystems Silencer® siRNAs for PAF1
Sigma-Aldrich siRNA for PAF1  Sigma-Aldrich shRNA for PAF1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019088                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_019088                                  untagged cDNA clone in CMV expression vector: NM_019088 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_019088
UniProtKB/Swiss-Prot: PAF1_HUMAN, Q8N7H5Function: The mammalian PAF1 complex is a multifunctional complex. The PAF1 complex interacts with RNA polymerase II and may be involved in both initiation and elongation, and in histone methylation and RNA processing. Has oncogenic activity in vivo and in vitro | Pathways & Interactions for PAF1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for PAF1 
5/25 Interacting proteins for PAF1 (ENSP000002212653) via UniProtKB, MINT, and/or STRING (see all 25
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for PAF1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PAF1
|
Transcripts for PAF1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019088
Sigma-Aldrich siRNA for PAF1  Sigma-Aldrich shRNA for PAF1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_019088 REFSEQ mRNAs for PAF1 gene: NM_019088.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_019088               OriGene GFP tagged cDNA clone in CMV expression vector: NM_019088                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_019088                                  untagged cDNA clone in CMV expression vector: NM_019088  Additional cDNA sequence: AF086555.1 AJ401156.1 AK001985.1 AK098423.1 AK294625.1 BC000017.2 BC013402.1 CR599585.1 CR604612.1 CR604698.1 CR616137.1 15 DOTS entries: DT.95178706 DT.455978 DT.121415717 DT.100797446 DT.100797444 DT.100797450 DT.100797438 DT.121415693 DT.92369367 DT.121415632 DT.92380018 DT.92453697 DT.99943256 DT.100797448 DT.91920931 24/381 AceView cDNA sequences (see all 381
):CB152089 AJ401156 CF131270 BQ687402 CA425897 CB153315 BQ899118 CD366275 BU078045 AA479050 BM829176 BX377783 CR616137 BE906392 BQ690679 BQ689832 BU859511 BE122816 BQ669339 BQ717923 BQ228096 AL710971 CB241112 BQ049720
highest scoring ESTs for PAF1:AI879164 AI929472 AJ401156 AK001985 AK098423 AL516414 AL543738 AL546687 AL551152 AL599054 Unigene Cluster for PAF1: Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) Hs.466714 [show with all ESTs]Unigene Representative Sequence: NM_019088
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PAF1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | |
| SP1: | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for PAF1
2 Ensembl transcripts including schematic representations: ENST00000221265
ENST00000221266
|
Expression for PAF1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PAF1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PAF1
1 / 2 / 3 3 probe-sets matching PAF1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATGAGAAGG
SOURCE GeneReport for Unigene cluster: Hs.466714
|
Orthologs for PAF1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PAF1 gene from 5/13 species (see all 13
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
PAF11 |
-- |
Paf1, RNA polymerase II associated factor, homolog more |
91.92(n) 99.24(a) |
476464 XM_533675.2 XP_533675.2 |
cow (Bos taurus) |
PAF11 |
-- |
Paf1, RNA polymerase II associated factor, homolog more |
91.7(n) 98.87(a) |
528744 NM_001046293.1 NP_001039758.1 |
rat (Rattus norvegicus) |
Paf11 |
-- |
Paf1, RNA polymerase II associated factor, homolog more |
90.33(n) 98.49(a) |
361531 NM_001024898.1 NP_001020069.1 |
mouse (Mus musculus) |
Paf11, 5 |
75
|
Paf1, RNA polymerase II associated factor, homolog more1, 5 |
90.27(n)1 98.87(a)1 |
546241 NM_019458.31 NP_062331.21 AA6750455 AB0416155 (see all 16) |
zebrafish (Danio rerio) |
paf1l1 |
-- |
paf1, RNA polymerase II associated factor, homolog more |
75.15(n) 79.56(a) |
553020 NM_001024453.1 NP_001019624.1 |
About this table Species with no ortholog for PAF1
ENSEMBL Gene Tree for PAF1 | Paralogs for PAF1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for PAF1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PAF1 (up to first 250kb)
|
Disorders & Mutations for PAF1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610506
|
Medical News for PAF1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PAF1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for PAF1 gene (see all 11
):- The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis. (PubMed id 16491129)1, 3, 4 Moniaux N....Batra S.K. (2006)
- The parafibromin tumor suppressor protein is part of a human Paf1 complex. (PubMed id 15632063)2, 3 Rozenblatt-Rosen O....Meyerson M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)4 Olsen J.V....Mann M. (2006)
- The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. (PubMed id 15923622)4 Yart A.... Krek W. (2005)
- Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)3 Zhu B.... Reinberg D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)4 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for PAF1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PAF1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PAF1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PAF1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PAF1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PAF1:

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