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PAEP Gene

protein-coding GIFtS: 57

GC09P137594

progestagen-associated endometrial protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GD ^¹, ², ³
GdA ^¹, ²
GdF ^¹, ²
GdS ^¹, ²
MGC138509 ^¹, ²
MGC142288 ^¹, ²
OTTHUMP00000022548 ^²
OTTHUMP00000022549 ^²
OTTHUMP00000022550 ^²
PAEG ^¹, ², ³
PEG ^³
PEP ^¹, ²
PP14 ^¹, ², ³, ⁵
glycodelin ^²
glycodelin-A ^²
glycodelin-F ^²
glycodelin-S ^²

Descriptions
PP14 protein (placental protein 14) ^²
Placental protein 14 ^³
Pregnancy-associated endometrial alpha-2 globulin ^³
Progesterone-associated endometrial protein ^², ³
alpha uterine protein ^²
pregnancy-associated endometrial alpha-2-globulin ^²
progestagen-associated endometrial protein ^², ³

External Ids
HGNC: 8573¹
Entrez Gene: 5047²
UniProtKB: P09466³
Ensembl: ENSG00000122133⁷

Search outside databases for aliases for PAEP gene

Previous GC identifers: GC09P129603 GC09P130225 GC09P131976 GC09P133892 GC09P135679

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PAEP:

This gene is a member of the kernel lipocalin superfamily whose members share relatively low

sequence similarity but have highly conserved exon/intron structure and three-dimensional protein

folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein

has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental

protein 14, and glycodelin, but has been officially named progestagen-associated endometrial

protein. Three distinct forms, with identical protein backbones but different glycosylation

profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive

system. These glycoproteins have distinct and essential roles in regulating a uterine environment

suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in

the fertilization process. A number of alternatively spliced transcript variants have been

observed at this locus, but the full-length nature of only two, each encoding the same protein,

has been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: PAEP_HUMAN, P09466

Function: This protein is, quantitatively, the main protein synthesized and secreted in the

endometrium from mid-luteal phase of the menstrual cycle and during the first semester of

pregnancy

Gene Wiki entry for PAEP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PAEP gene

Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34

PAEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P137594: (about GC identifiers)

Start:	137,593,425 bp from pter
End:	137,598,622 bp from pter
Size:	5,198 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_019501.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PAEP_HUMAN, P09466 (See protein sequence)

Recommended Name: Glycodelin precursor

Size: 180 amino acids; 20624 Da

Subunit: Homodimer

Secondary accessions: Q5T6T1 Q9UG92

Alternative splicing: 3 isoforms: P09466-1 P09466-2 P09466-3

Post-translational modifications:

At least two differentially glycosylated forms are found. Glycodelin-A (GdA) (amniotic fluid) with

contraceptive and immunosuppressive activities and glycodelin-S (Gds) (seminal plasma) whose role

is not yet known. The gender-specific glycosylation may serve to regulate key process involved in

human reproduction¹

REFSEQ proteins (2 alternative transcripts):

NP_001018059.1 NP_002562.2

ENSEMBL proteins:

ENSP00000277508 ENSP00000360832 ENSP00000360833 ENSP00000360831 ENSP00000343572

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Placental Protein 14 / Glycodelin A)
	Human Recombinant Proteins from Abnova (PAEP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for PAEP:

	Invitrogen Antibodies for PAEP
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PAEP
	R&D Systems Antibodies for PAEP (PP14)
	Antibodies from Abcam (Placental Protein 14 / Glycodelin A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PAEP)
	Novus Biologicals Antibodies for PAEP

Assays for PAEP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P09466

ProtoNet protein and cluster: P09466

2 Blocks protein families:

IPB002345 Lipocalin signature

IPB002447 Beta-lactoglobulin signature

UniProtKB/Swiss-Prot: PAEP_HUMAN, P09466

Similarity: Belongs to the calycin superfamily. Lipocalin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAEP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAEP)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002571

Applied Biosystems Silencer® siRNAs for PAEP

Sigma-Aldrich siRNA for PAEP

Sigma-Aldrich shRNA Panels and shRNA for PAEP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PAEP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001018049
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001018049
untagged cDNA clones in CMV expression vector (see all 2): NM_001018049

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002571

UniProtKB/Swiss-Prot: PAEP_HUMAN, P09466

Function: This protein is, quantitatively, the main protein synthesized and secreted in the

endometrium from mid-luteal phase of the menstrual cycle and during the first semester of

pregnancy

Genatlas biochemistry entry for PAEP:

progestagen-associated endometrial protein (lipocalin family,Kernel group),mainly expressed by the

secretory glandular epithelium of the endometrium and decidua,also expressed by the placenta and

by hematopoietic cells of the megakaryocytic lineage,present at high concentration in ammiotic

fluid,uterine luminal fluid,demonstrating potential immunosuppresive properties

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0005488	binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for PAEP

5/24 Interacting proteins for PAEP (ENSP00000360833³ P09466²) via UniProtKB, MINT, and/or STRING (see all 24 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD3	P84022²	MINT-51257
TNFRSF14	ENSP00000347948³	STRING (score=.985)
CADM3	ENSP00000357106³	STRING (score=.967)
GYPC	ENSP00000259254³	STRING (score=.953)
PVRL1	ENSP00000264025³	STRING (score=.953)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0007275	multicellular organismal development	TAS	3194393

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PAEP
10/19 Novoseek chemical compound relationships for PAEP gene (see all 19 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pp-12	90.30	18	2318953 (6), 2298862 (3), 1840727 (2), 7694434 (1) (see all 6)
lacdinac	80.54	4	7592613 (1), 15852231 (1), 16033064 (1), 17649829 (1)
progesterone	76.12	164	8498438 (6), 1730302 (4), 8288762 (4), 2380618 (3) (see all 62)
pregnanediol	55.29	1	15222384 (1)
progestins	45.46	6	10764460 (2), 11299967 (1), 16622300 (1), 17339403 (1)
estradiol	45.37	5	17649829 (2), 1442957 (1), 9062493 (1), 1619035 (1)
estradiol valerate	35.29	1	1555688 (1)
steroid	33.82	17	7593493 (2), 12820358 (2), 17068141 (2), 17720699 (2) (see all 9)
isocitrate	30.41	3	1400926 (1), 8497343 (1), 1532445 (1)
ribonucleic acid	21.97	2	9166287 (1), 16823513 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PAEP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PAEP)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002571

Sigma-Aldrich siRNA for PAEP

Sigma-Aldrich shRNA Panels and shRNA for PAEP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001018049 NM_002571

REFSEQ mRNAs for PAEP gene (2 alternative transcripts):

NM_001018049.1 NM_002571.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001018049 NM_002571

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001018049
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001018049
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001018049

Additional cDNA sequence:

AK304657.1 AK309965.1 AK309983.1 AK311007.1 AK311730.1 AK311731.1 AK311813.1 BC069451.1

BC069562.1 BC112304.1 BC113728.1 CR598196.1 CR606504.1 DQ884407.1 J04129.1 M61886.1

11 DOTS entries:

DT.102821925 DT.75103603 DT.100738506 DT.121162152 DT.86853781 DT.95156051 DT.121162144 DT.121162145

DT.121162157 DT.97777817 DT.40267411

24/93 AceView cDNA sequences (see all 93 ):

AA479874 CR598196 AA854990 AA477016 CB216464 CR606504 AI092114 BC069451

AA293479 AA433965 AL050169 CB216948 AI474212 AI865541 BQ216754 M61886

AI597661 BF589533 BC069562 BM978054 BF509153 AA478226 AA434011 AI420208

highest scoring ESTs for PAEP:

J04129 AA235001 AA252967 AA291495 AA293088 AA293479 AA402723 AA402883 AA421247 AA421417

Unigene Cluster for PAEP:

Progestagen-associated endometrial protein

Hs.532325 [show with all ESTs]

Unigene Representative Sequence: AK311730

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PAEP (see all 9 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	·	4e	^	5a	·	5b	^	6	^	7a	·	7b
SP1:							-								-		-						-		-		-		-
SP2:							-		-						-		-		-		-		-		-		-
SP3:							-								-		-		-
SP4:															-		-		-
SP5:							-								-		-

About this scheme

ECgene alternative splicing isoforms for PAEP

5 Ensembl transcripts including schematic representations:

ENST00000277508 ENST00000371767 ENST00000371768 ENST00000371766 ENST00000344007

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PAEP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PAEP

¹ / ² / ³

4 probe-sets matching PAEP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37634_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.82	M61886	0.80	1.00	0.91	1
37633_s_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.20	J04129	1.00	1.00	1.00	1
206859_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002571	0.60	1.00	0.82	1
206859_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PAEP for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.532325
Expression variation in blood from EXPOLDB for PAEP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAEP gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	PAEP¹	--	progestagen-associated endometrial protein	98.81(n) 97.86(a)	748128 XM_001159832.1 XP_001159832.1
mouse (Mus musculus)	Paep⁵	2 (73.00 cM)	progestagen-associated endometrial protein	--	-

About this table Species with no ortholog for PAEP

ENSEMBL Gene Tree for PAEP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/66 NCBI SNPs in PAEP are shown (see all 66 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 55)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs705661^1,2	A,C,F,H	137592790(-)	`ACTTTA/GTAACT`	2	--	ng5¹		11	EU EA WA NA	1058
	rs3748212^1,2	A,C,F,H	137598391(+)	`GGCTGC/TTCCCT`	2	--	ut3¹ ese³		4	EU EA WA	418
	rs10858123^1,2	A,C,F,H	137591847(+)	`GCCTTG/AACATG`	2	--	ng5¹		8	EU EA WA	838
	rs783773^1,2	C,F,H,O	137598601(-)	`CTTTTA/GTTTTG`	2	--	ng3¹ ese³		7	EU EA WA NA	560
	rs3748205^1,2	A,C,F,H	137593462(+)	`ACAGCC/TGCAGC`	2	--	ut5¹ ese³		2	EA EU	1424
	rs783772^1,2	A,C,F,H	137598922(-)	`TTTCCC/TGGGTG`	2	--	ng3¹		14	EU EA WA NA	1236
	rs4841882^1,2	A,C,F,H	137592793(+)	`TACAAA/GGTGAT`	2	--	ng5¹		4	EU EA WA	412
	rs3748211^1,2	C,F,H	137598283(+)	`GACTTC/TCTCCT`	2	--	ut3¹		4	EU EA WA	418
--	rs3748210^1,2	A,C,F	137595976(+)	`GCCTAC/AAGGAC`	2	K/Q	mis¹ ese³		2	EA NA	1574
	rs3748204^1,2	F,H	137593355(+)	`ACATGG/ACGAGG`	2	--	ng5¹		3	EA WA	298

About this table

HapMap Linkage Disequilibrium images for PAEP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 173310

10/37 Novoseek disease relationships for PAEP gene (see all 37 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
miscarriage recurrent	66.12	20	9853880 (5), 8567792 (4), 17049713 (2), 7890064 (2) (see all 5)
infertility	53.06	15	8458460 (4), 16417092 (1), 8485609 (1), 9886514 (1) (see all 9)
endometrial carcinoma	51.52	11	16123169 (2), 16325596 (2), 11369448 (2), 9804252 (2) (see all 6)
endometriosis	49.62	18	1531465 (4), 8452641 (2), 10027629 (1), 16417092 (1) (see all 11)
pregnancy ectopic	44.15	7	7947525 (3), 12781411 (2), 1551949 (1), 16055453 (1)
spontaneous abortion	42.47	11	17049713 (2), 8485609 (2), 1551949 (1), 7947525 (1) (see all 7)
pregnancy tubal	37.13	1	7498715 (1)
endometrial cancer	34.73	2	16325596 (1), 17068141 (1)
hydatidiform mole	32.19	1	12820349 (1)
turners syndrome	31.79	4	2351706 (1), 7540180 (1), 8473472 (1), 1555688 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/268 PubMed articles for PAEP gene (see all 268 ):

Glycodelin from seminal plasma is a differentially glycosylated form of contraceptive glycodelin-A. (PubMed id 9239694)^{1, 3, 4} Koistinen H.... Seppala M. (1996)
Purification and characterization of an immunomodulatory endometrial protein, glycodelin. (PubMed id 11278680)^{1, 3, 4} Vigne J.-L.... Taylor R.N. (2001)
Gender-specific glycosylation of human glycodelin affects its contraceptive activity. (PubMed id 8943270)^{1, 3, 4} Morris H.R.... Clark G.F. (1996)
The human placental protein 14 (PP14) gene is localized on chromosome 9q34. (PubMed id 2016092)^{1, 2, 3} Van Cong N....Bernheim A. (1991)
Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities. (PubMed id 7592613)^{1, 3, 4} Dell A.... Clark G.F. (1995)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Multiple forms of mRNA encoding human pregnancy-associated endometrial alpha 2-globulin, a beta-lactoglobulin homologue. (PubMed id 2006183)^{3, 4} Garde J.... Eperon I.C. (1991)
Human placental protein 14 gene: sequence and characterization of a short duplication. (PubMed id 2206398)^{3, 4} Vaisse C.... Milgrom E. (1990)
Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta- lactoglobulins. (PubMed id 3194393)^{3, 4} Julkunen M.... Janne O.A. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5047	HGNC: 8573	AceView: PAEP	Ensembl:ENSG00000122133	euGenes: HUgn5047
ECgene: PAEP	H-InvDB: PAEP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PAEP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PAEP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PAEP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAEP		Antibodies for PAEP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PAEP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PAEP)
	Antibodies (PAEP)
	Chimera RNAi (PAEP)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Placental Protein 14 / Glycodelin A)
	Antibodies (Placental Protein 14 / Glycodelin A)

Search OriGene for PAEP

Search Tocris compounds for PAEP

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PAEP

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PAEP Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for PAEP

Summaries
for PAEP

Genomic Location
for PAEP

Proteins
for PAEP

Protein Domains/
Families
for PAEP

Gene Function
for PAEP

Pathways & Interactions
for PAEP

Drugs & Compounds
for PAEP

Transcripts
for PAEP

Expression
for PAEP

Orthologs
for PAEP

Paralogs
for PAEP

SNPs/Variants
for PAEP

Disorders & Mutations
for PAEP

Medical News
for PAEP

Publications
for PAEP

Search for PAEP

Genome Databases showing PAEP

Other Databases showing PAEP

Specialized Databases showing PAEP

Licensable Technologies
for PAEP

Services
for PAEP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PAEP (Gene Symbol)
GD
GdA
GdF
GdS
MGC138509
MGC142288
OTTHUMP00000022548
OTTHUMP00000022549
OTTHUMP00000022550
PAEG
PEG
PEP
PP14
glycodelin
glycodelin-A
glycodelin-F
glycodelin-S
PP14 protein (placental protein 14)
Placental protein 14
Pregnancy-associated endometrial alpha-2 globulin
Progesterone-associated endometrial protein
alpha uterine protein
pregnancy-associated endometrial alpha-2-globulin
progestagen-associated endometrial protein

PAEP Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor PAEP

Summariesfor PAEP

Genomic Locationfor PAEP

Proteinsfor PAEP

Protein Domains/Familiesfor PAEP

Gene Functionfor PAEP

Pathways & Interactionsfor PAEP

Drugs & Compoundsfor PAEP

Transcriptsfor PAEP

Expression for PAEP

Orthologsfor PAEP

Paralogsfor PAEP

SNPs/Variantsfor PAEP

Disorders & Mutationsfor PAEP

Medical Newsfor PAEP

Publicationsfor PAEP

Search for PAEP

Genome Databases showing PAEP

Other Databases showing PAEP

Specialized Databases showing PAEP

Licensable Technologiesfor PAEP

Servicesfor PAEP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PAEP

Summaries
for PAEP

Genomic Location
for PAEP

Proteins
for PAEP

Protein Domains/
Families
for PAEP

Gene Function
for PAEP

Pathways & Interactions
for PAEP

Drugs & Compounds
for PAEP

Transcripts
for PAEP

Expression
for PAEP

Orthologs
for PAEP

Paralogs
for PAEP

SNPs/Variants
for PAEP

Disorders & Mutations
for PAEP

Medical News
for PAEP

Publications
for PAEP

Licensable Technologies
for PAEP

Services
for PAEP