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Aliases for PAEP Gene

Aliases for PAEP Gene

  • Progestagen Associated Endometrial Protein 2 3
  • Progesterone-Associated Endometrial Protein 2 3 4
  • Progestagen-Associated Endometrial Protein 2 4 5
  • Pregnancy-Associated Endometrial Alpha-2-Globulin 2 3
  • Pregnancy-Associated Endometrial Alpha-2 Globulin 3 4
  • PP14 Protein (Placental Protein 14) 2 3
  • Alpha Uterine Protein 2 3
  • Placental Protein 14 3 4
  • Glycodelin-A 2 3
  • Glycodelin-S 2 3
  • Glycodelin-F 2 3
  • PAEG 3 4
  • PP14 3 4
  • PEG 3 4
  • GD 3 4
  • Progestagen-Associated Endometrial Protein (Placental Protein 14, Pregnancy-Associated Endometrial A 3
  • Glycodelin 2
  • GdA 3
  • GdF 3
  • GdS 3
  • PEP 3

External Ids for PAEP Gene

Previous GeneCards Identifiers for PAEP Gene

  • GC09P129603
  • GC09P130225
  • GC09P131976
  • GC09P133892
  • GC09P135679
  • GC09P137594
  • GC09P138453
  • GC09P107915

Summaries for PAEP Gene

Entrez Gene Summary for PAEP Gene

  • This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

GeneCards Summary for PAEP Gene

PAEP (Progestagen Associated Endometrial Protein) is a Protein Coding gene. Diseases associated with PAEP include endometriosis and endometrial cancer. GO annotations related to this gene include small molecule binding.

UniProtKB/Swiss-Prot for PAEP Gene

  • This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy.

Gene Wiki entry for PAEP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAEP Gene

Genomics for PAEP Gene

Regulatory Elements for PAEP Gene

Genomic Location for PAEP Gene

Chromosome:
9
Start:
135,561,754 bp from pter
End:
135,566,955 bp from pter
Size:
5,202 bases
Orientation:
Plus strand

Genomic View for PAEP Gene

Genes around PAEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAEP Gene

Proteins for PAEP Gene

  • Protein details for PAEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09466-PAEP_HUMAN
    Recommended name:
    Glycodelin
    Protein Accession:
    P09466
    Secondary Accessions:
    • Q5T6T1
    • Q9UG92

    Protein attributes for PAEP Gene

    Size:
    180 amino acids
    Molecular mass:
    20624 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAA60147.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43305.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PAEP Gene

    Alternative splice isoforms for PAEP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAEP Gene

Proteomics data for PAEP Gene at MOPED

Post-translational modifications for PAEP Gene

  • At least two differentially glycosylated forms are found. Glycodelin-A (GdA) (amniotic fluid) with contraceptive and immunosuppressive activities and glycodelin-S (Gds) (seminal plasma) whose role is not yet known. The gender-specific glycosylation may serve to regulate key process involved in human reproduction.
  • Glycosylation at Asn 46 and Asn 81
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PAEP (PP14/Glycodelin)

No data available for DME Specific Peptides for PAEP Gene

Domains & Families for PAEP Gene

Gene Families for PAEP Gene

Graphical View of Domain Structure for InterPro Entry

P09466

UniProtKB/Swiss-Prot:

PAEP_HUMAN :
  • Belongs to the calycin superfamily. Lipocalin family.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with PAEP: view

Function for PAEP Gene

Molecular function for PAEP Gene

GENATLAS Biochemistry:
progestagen-associated endometrial protein (lipocalin family,Kernel group),mainly expressed by the secretory glandular epithelium of the endometrium and decidua,also expressed by the placenta and by hematopoietic cells of the megakaryocytic lineage,present at high concentration in ammiotic fluid,uterine luminal fluid,demonstrating potential immunosuppresive properties
UniProtKB/Swiss-Prot Function:
This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy.
genes like me logo Genes that share phenotypes with PAEP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAEP Gene

Localization for PAEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAEP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAEP Gene COMPARTMENTS Subcellular localization image for PAEP gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PAEP Gene

Pathways & Interactions for PAEP Gene

SuperPathways for PAEP Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 18996219
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA 19945098
GO:2000778 positive regulation of interleukin-6 secretion IDA 19945098
genes like me logo Genes that share ontologies with PAEP: view

No data available for Pathways by source and SIGNOR curated interactions for PAEP Gene

Drugs & Compounds for PAEP Gene

(24) Drugs for PAEP Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Experimental Pharma Target 191
12-Bromododecanoic Acid Experimental Pharma Target 0
Palmitic Acid Experimental Pharma Full agonist, Agonist, Target 20

(20) Additional Compounds for PAEP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAEP: view

Transcripts for PAEP Gene

Unigene Clusters for PAEP Gene

Progestagen-associated endometrial protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAEP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: -
SP8: - -
SP9: - - -

Relevant External Links for PAEP Gene

GeneLoc Exon Structure for
PAEP
ECgene alternative splicing isoforms for
PAEP

Expression for PAEP Gene

mRNA expression in normal human tissues for PAEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAEP Gene

This gene is overexpressed in Uterus (x22.1), Fallopian Tube (x12.9), and Cervix - Endocervix (x5.5).

Protein differential expression in normal tissues from HIPED for PAEP Gene

This gene is overexpressed in Cervix (41.3) and Fetal gut (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PAEP Gene



SOURCE GeneReport for Unigene cluster for PAEP Gene Hs.532325

genes like me logo Genes that share expression patterns with PAEP: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PAEP Gene

Orthologs for PAEP Gene

This gene was present in the common ancestor of mammals.

Orthologs for PAEP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAEP 35
  • 98.52 (n)
  • 97.22 (a)
PAEP 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 40 (a)
OneToMany
LGB 36
  • 43 (a)
OneToMany
PAEP 35
  • 65.87 (n)
  • 43.11 (a)
dog
(Canis familiaris)
Mammalia LOC491263 35
  • 73.26 (n)
  • 58.14 (a)
-- 36
  • 56 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
Species with no ortholog for PAEP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAEP Gene

ENSEMBL:
Gene Tree for PAEP (if available)
TreeFam:
Gene Tree for PAEP (if available)

Paralogs for PAEP Gene

Pseudogenes.org Pseudogenes for PAEP Gene

genes like me logo Genes that share paralogs with PAEP: view

No data available for Paralogs for PAEP Gene

Variants for PAEP Gene

Sequence variations from dbSNP and Humsavar for PAEP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3748210 - 135,564,309(+) GCCTA(A/C)AGGAC intron-variant, reference, missense
rs34284195 - 135,561,883(+) AGGAC(C/G)TGGAG reference, missense, utr-variant-5-prime
rs705661 -- 135,561,123(-) ACTTT(A/G)TAACT upstream-variant-2KB
rs783487 -- 135,564,477(-) AGAAA(A/G)AAAAA intron-variant
rs783488 -- 135,566,415(+) CCCCC(C/G)CTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAEP Gene

Variant ID Type Subtype PubMed ID
dgv8367n71 CNV Loss 21882294
nsv466656 CNV Gain 19166990
nsv6759 CNV Insertion 18451855

Variation tolerance for PAEP Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAEP Gene

HapMap Linkage Disequilibrium report
PAEP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAEP Gene

Disorders for PAEP Gene

MalaCards: The human disease database

(6) MalaCards diseases for PAEP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endometriosis
endometrial cancer
  • endometrial cancer, familial
proximal symphalangism
  • symphalangism, proximal, 1a
multiple synostoses syndrome
  • deafness-hermann type symphalangism syndrome
acromesomelic dysplasia
  • acromesomelic dwarfism
- elite association - COSMIC cancer census association via MalaCards
Search PAEP in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAEP

Genetic Association Database (GAD)
PAEP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAEP
genes like me logo Genes that share disorders with PAEP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAEP Gene

Publications for PAEP Gene

  1. Glycodelin from seminal plasma is a differentially glycosylated form of contraceptive glycodelin-A. (PMID: 9239694) Koistinen H. … Seppala M. (Mol. Hum. Reprod. 1996) 3 4 23 67
  2. The human placental protein 14 (PP14) gene is localized on chromosome 9q34. (PMID: 2016092) Van Cong N. … Bernheim A. (Hum. Genet. 1991) 2 3 23
  3. Correlation between symptoms of pain and peritoneal fluid inflammatory cytokine concentrations in endometriosis. (PMID: 19903048) Scholl B. … Mueller M.D. (Gynecol. Endocrinol. 2009) 3 23
  4. Glycodelin A, an immunomodulatory protein in the endometrium, inhibits proliferation and induces apoptosis in monocytic cells. (PMID: 18996219) Alok A. … Karande A.A. (Int. J. Biochem. Cell Biol. 2009) 3 23
  5. Glycodelin-A as a modulator of trophoblast invasion. (PMID: 19520712) Lam K.K. … Yeung W.S. (Hum. Reprod. 2009) 3 23

Products for PAEP Gene

Sources for PAEP Gene

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