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Aliases for PADI6 Gene

Aliases for PADI6 Gene

  • Peptidyl Arginine Deiminase, Type VI 2 3
  • Peptidyl Arginine Deiminase-Like Protein 3 4
  • EC 3.5.3.15 4 63
  • HPADVI 3 4
  • Protein-Arginine Deiminase Type VI 4
  • Peptidylarginine Deiminase Type 6 3
  • Protein-Arginine Deiminase Type-6 3
  • Peptidylarginine Deiminase VI 4

External Ids for PADI6 Gene

Previous GeneCards Identifiers for PADI6 Gene

  • GC00U911624
  • GC01U901038
  • GC01P017444
  • GC01P017571
  • GC01P017698
  • GC01P015944

Summaries for PADI6 Gene

Entrez Gene Summary for PADI6 Gene

  • This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012]

GeneCards Summary for PADI6 Gene

PADI6 (Peptidyl Arginine Deiminase, Type VI) is a Protein Coding gene. Among its related pathways are protein citrullination. GO annotations related to this gene include calcium ion binding and protein-arginine deiminase activity.

UniProtKB/Swiss-Prot for PADI6 Gene

  • Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PADI6 Gene

Genomics for PADI6 Gene

Regulatory Elements for PADI6 Gene

Genomic Location for PADI6 Gene

Start:
17,372,196 bp from pter
End:
17,401,699 bp from pter
Size:
29,504 bases
Orientation:
Plus strand

Genomic View for PADI6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PADI6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PADI6 Gene

Proteins for PADI6 Gene

  • Protein details for PADI6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6TGC4-PADI6_HUMAN
    Recommended name:
    Protein-arginine deiminase type-6
    Protein Accession:
    Q6TGC4
    Secondary Accessions:
    • Q330K5
    • Q70SX3

    Protein attributes for PADI6 Gene

    Size:
    694 amino acids
    Molecular mass:
    77727 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PADI6 Gene

neXtProt entry for PADI6 Gene

Proteomics data for PADI6 Gene at MOPED

Selected DME Specific Peptides for PADI6 Gene

Post-translational modifications for PADI6 Gene

  • Phosphorylation at Ser-10, possibly by RSK-type kinases, and Ser-446 creates binding sites for 14-3-3 proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PADI6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PADI6 Gene

Gene Families for PADI6 Gene

HGNC:
  • PADI :Peptidyl arginine deiminases

Protein Domains for PADI6 Gene

Suggested Antigen Peptide Sequences for PADI6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6TGC4

UniProtKB/Swiss-Prot:

PADI6_HUMAN :
  • Q6TGC4
Family:
  • Belongs to the protein arginine deiminase family.
genes like me logo Genes that share domains with PADI6: view

Function for PADI6 Gene

Molecular function for PADI6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein L-arginine + H(2)O = protein L-citrulline + NH(3)
UniProtKB/Swiss-Prot Function:
Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo (By similarity).

Enzyme Numbers (IUBMB) for PADI6 Gene

Gene Ontology (GO) - Molecular Function for PADI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004668 protein-arginine deiminase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PADI6: view
genes like me logo Genes that share phenotypes with PADI6: view

Animal Models for PADI6 Gene

MGI Knock Outs for PADI6:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PADI6

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PADI6 Gene

Localization for PADI6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PADI6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PADI6 Gene COMPARTMENTS Subcellular localization image for PADI6 gene
Compartment Confidence
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PADI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0045111 intermediate filament cytoskeleton IEA --
genes like me logo Genes that share ontologies with PADI6: view

Pathways for PADI6 Gene

SuperPathways for PADI6 Gene

Superpath Contained pathways
1 protein citrullination
genes like me logo Genes that share pathways with PADI6: view

Pathways by source for PADI6 Gene

1 BioSystems pathway for PADI6 Gene

Interacting Proteins for PADI6 Gene

Gene Ontology (GO) - Biological Process for PADI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007028 cytoplasm organization IEA --
GO:0018101 protein citrullination IEA --
GO:0034613 cellular protein localization --
GO:0043143 regulation of translation by machinery localization IEA --
genes like me logo Genes that share ontologies with PADI6: view

Compounds for PADI6 Gene

(1) HMDB Compounds for PADI6 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for PADI6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Citrulline
  • 2-Amino-5-uredovaleric acid
372-75-8 target
genes like me logo Genes that share compounds with PADI6: view

Transcripts for PADI6 Gene

mRNA/cDNA for PADI6 Gene

(2) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PADI6 Gene

Peptidyl arginine deiminase, type VI:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PADI6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PADI6 Gene

No ASD Table

Relevant External Links for PADI6 Gene

GeneLoc Exon Structure for
PADI6
ECgene alternative splicing isoforms for
PADI6

Expression for PADI6 Gene

mRNA expression in normal human tissues for PADI6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PADI6 Gene

This gene is overexpressed in Ovary (34.7) and Whole Blood (11.1).

Protein differential expression in normal tissues for PADI6 Gene

This gene is overexpressed in Fetal ovary (67.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PADI6 Gene

SOURCE GeneReport for Unigene cluster for PADI6 Gene Hs.531598

mRNA Expression by UniProt/SwissProt for PADI6 Gene

Q6TGC4-PADI6_HUMAN
Tissue specificity: Ovary, testis and peripheral blood leukocytes.
genes like me logo Genes that share expressions with PADI6: view

Expression partners for PADI6 Gene

In Situ Assay Products

Orthologs for PADI6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PADI6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PADI6 35
  • 77.13 (n)
  • 71.55 (a)
dog
(Canis familiaris)
Mammalia PADI6 35
  • 81.22 (n)
  • 77.37 (a)
mouse
(Mus musculus)
Mammalia Padi6 35
  • 74.54 (n)
  • 67.74 (a)
Padi6 16
chimpanzee
(Pan troglodytes)
Mammalia PADI6 35
  • 99.37 (n)
  • 99.42 (a)
rat
(Rattus norvegicus)
Mammalia Padi6 35
  • 75.16 (n)
  • 70.13 (a)
Species with no ortholog for PADI6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PADI6 Gene

ENSEMBL:
Gene Tree for PADI6 (if available)
TreeFam:
Gene Tree for PADI6 (if available)

Paralogs for PADI6 Gene

Selected SIMAP similar genes for PADI6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PADI6: view

No data available for Paralogs for PADI6 Gene

Variants for PADI6 Gene

Sequence variations from dbSNP and Humsavar for PADI6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs942459 -- 17,372,842(-) CTACC(A/G)ACACT intron-variant
rs1204864 -- 17,377,198(-) ccagg(A/C)tgggc intron-variant
rs1204865 -- 17,376,539(-) AAAAA(A/T)TAGCC intron-variant
rs1204866 -- 17,374,220(-) TCCTG(C/T)AGGGT intron-variant
rs1204867 -- 17,373,379(-) CACTG(G/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PADI6 Gene

Variant ID Type Subtype PubMed ID
esv2590404 CNV Deletion 19546169
esv2214804 CNV Deletion 18987734
esv2626551 CNV Deletion 19546169

Relevant External Links for PADI6 Gene

HapMap Linkage Disequilibrium report
PADI6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PADI6 Gene

Disorders for PADI6 Gene

Relevant External Links for PADI6

Genetic Association Database (GAD)
PADI6
Human Genome Epidemiology (HuGE) Navigator
PADI6

No disorders were found for PADI6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PADI6 Gene

Publications for PADI6 Gene

  1. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PMID: 15087120) Chavanas S. … Simon M. (Gene 2004) 2 3 4 23
  2. cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI. (PMID: 15625577) Zhang J. … Mao Y. (Acta Biochim. Pol. 2004) 3 4 23
  3. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PMID: 18849993) Stacey S.N. … Stefansson K. (Nat. Genet. 2008) 3 48
  4. Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. (PMID: 22634725) Rose R. … Ottmann C. (J. Struct. Biol. 2012) 3 4
  5. Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis. (PMID: 23164236) Too C.L. … Padyukov L. (Arthritis Res. Ther. 2012) 3

Products for PADI6 Gene

Sources for PADI6 Gene

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