Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PADI6 Gene

RNA gene   GIFtS: 47
GCID: GC01P017698

Peptidyl Arginine Deiminase, Type VI

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Subcategory (RNA class): processed_transcript

Quality score for this RNA gene is 3

Aliases
Peptidyl Arginine Deiminase, Type VI1 2     Peptidylarginine Deiminase Type 62
Peptidyl Arginine Deiminase-Like Protein2 3     Protein-Arginine Deiminase Type-62
hPADVI2 3     Peptidylarginine Deiminase VI3
EC 3.5.3.153 8     Protein-Arginine Deiminase Type VI3

External Ids:    HGNC: 204491   Entrez Gene: 3532382   Ensembl: ENSG000002560497   OMIM: 6103635   UniProtKB: Q6TGC43   

Export aliases for PADI6 gene to outside databases

Previous GC identifers: GC00U911624 GC01U901038 GC01P017444 GC01P017571 GC01P015944


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PADI6 Gene:
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the
post-translational deimination of proteins by converting arginine residues into citrullines in the presence of
calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns.
This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. (provided
by RefSeq, Sep 2012)

GeneCards Summary for PADI6 Gene:
PADI6 (peptidyl arginine deiminase, type VI) is an RNA gene, and is affiliated with the processed_transcript RNA class. GO annotations related to this gene include protein-arginine deiminase activity and calcium ion binding.

UniProtKB/Swiss-Prot: PADI6_HUMAN, Q6TGC4
Function: Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal
reorganization in the egg and early embryo (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PADI6 gene promoter:
         CUTL1   HNF-4alpha2   GATA-2   C/EBPalpha   HNF-4alpha1   CHOP-10   CBF-A   POU2F1   POU2F1a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPADI6 promoter sequence
   Search Chromatin IP Primers for PADI6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PADI6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

PADI6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PADI6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P017698:  view genomic region     (about GC identifiers)

Start:
17,698,691 bp from pter      End:
17,728,195 bp from pter
Size:
29,505 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PADI6_HUMAN, Q6TGC4 (See protein sequence)
Recommended Name: Protein-arginine deiminase type-6  
Size: 694 amino acids; 77727 Da
Cofactor: Calcium (By similarity)
2 PDB 3D structures from and Proteopedia for PADI6:
4DAT (3D)        4DAU (3D)    
Secondary accessions: Q330K5 Q70SX3

Explore the universe of human proteins at neXtProt for PADI6: NX_Q6TGC4

Explore proteomics data for PADI6 at MOPED

4 DME Specific Peptides for PADI6 (Q6TGC4)
 LASPSAC  AQQVQAPV  GKEYPLGR  LGIPKPFGP 


See PADI6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_997304.3  

PADI6 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for PADI6
OriGene Protein Over-expression Lysate for PADI6
OriGene Custom MassSpec
OriGene Custom Protein Services for PADI6
GenScript Custom Purified and Recombinant Proteins Services for PADI6
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for PADI6

 
Search eBioscience for Proteins for PADI6 

 
antibodies-online proteins for PADI6 (2 products) 

 
antibodies-online peptides for PADI6

PADI6 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for PADI6
Novus Biologicals PADI6 Antibody
Abcam antibodies for PADI6
Cloud-Clone Corp. Antibodies for PADI6
Search ThermoFisher Antibodies for PADI6
antibodies-online antibodies for PADI6 (11 products) 

PADI6 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for PADI6
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for PADI6
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for PADI6
Cloud-Clone Corp. CLIAs for PADI6
Search eBioscience for ELISAs for PADI6 
antibodies-online kits for PADI6 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
PADI: Peptidyl arginine deiminases

Selected InterPro protein domains (see all 6):
 IPR013733 Prot_Arg_deaminase_cen_dom
 IPR013732 PAD_N
 IPR008972 Cupredoxin
 IPR004303 PAD
 IPR016296 Protein-arginine_deiminase_sub

Graphical View of Domain Structure for InterPro Entry Q6TGC4

ProtoNet protein and cluster: Q6TGC4

1 Blocks protein domain: IPB004303 Protein-arginine deiminase

UniProtKB/Swiss-Prot: PADI6_HUMAN, Q6TGC4
Similarity: Belongs to the protein arginine deiminase family


Find genes that share domains with PADI6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PADI6_HUMAN, Q6TGC4
Function: Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal
reorganization in the egg and early embryo (By similarity)
Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)

     Enzyme Number (IUBMB): EC 3.5.3.151 2

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004668protein-arginine deiminase activity IEA--
GO:0005509calcium ion binding IEA--
     
Find genes that share ontologies with PADI6           About GenesLikeMe


Phenotypes:
     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Padi6):
 embryogenesis  no phenotypic analysis  reproductive system 

Find genes that share phenotypes with PADI6           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Padi6tm1.1Jgo for PADI6

   genOway: Develop your customized and physiologically relevant rodent model for PADI6

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat PADI6 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate PADI6
SwitchGear 3'UTR luciferase reporter plasmidPADI6 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for PADI6
Predesigned siRNA for gene silencing in human, mouse, rat PADI6

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for PADI6

Clone
Products:
     
OriGene clones in human, mouse for PADI6 (see all 6)
OriGene ORF clones in mouse, rat for PADI6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PADI6 (NM_207421)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PADI6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI6

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for PADI6
Browse ESI BIO Cell Lines and PureStem Progenitors for PADI6 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
PADI6_HUMAN, Q6TGC4: Cytoplasm (By similarity). Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus2
plasma membrane2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005737cytoplasm IEA--

Find genes that share ontologies with PADI6           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for PADI6 About    
See pathways by source

SuperPathContained pathways About
1protein citrullination
protein citrullination


1 BioSystems Pathway for PADI6
    protein citrullination


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PADI6
Interactions:

    Search GeneGlobe Interaction Network for PADI6

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0018101protein citrullination IEA--

Find genes that share ontologies with PADI6           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PADI6

1 HMDB Compound for PADI6    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

1 DrugBank Compound for PADI6    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--17139284 17016423



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for PADI6 gene: 
NM_207421.4  

Unigene Cluster for PADI6:

Peptidyl arginine deiminase, type VI
Hs.531598  [show with all ESTs]
Unigene Representative Sequence: AY443100
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000434762(processed_transcript) ENST00000358481(processed_transcript)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat PADI6 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate PADI6
SwitchGear 3'UTR luciferase reporter plasmidPADI6 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for PADI6
Predesigned siRNA for gene silencing in human, mouse, rat PADI6
Clone
Products:
     
OriGene clones in human, mouse for PADI6 (see all 6)
OriGene ORF clones in mouse, rat for PADI6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PADI6 (NM_207421)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PADI6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI6
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for PADI6
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PADI6
  QuantiTect SYBR Green Assays in human, mouse, rat PADI6
  QuantiFast Probe-based Assays in human, mouse, rat PADI6

Additional mRNA sequence: 

AY422079.1 AY443100.1 

2 DOTS entries:

DT.102819972  DT.121442582 

2 AceView cDNA sequences:

AY422079 NM_207421 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

Expression evidence for PADI6:none

PADI6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTCTTTGCC
PADI6 Expression
About this image


PADI6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Ovary (Reproductive System)    fully expand to see all 3 entries
         Pre-Granulosa Cells Primordial Follicle
         Secondary follicles
PADI6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PADI6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.531598

UniProtKB/Swiss-Prot: PADI6_HUMAN, Q6TGC4
Tissue specificity: Ovary, testis and peripheral blood leukocytes

    Custom PCR Arrays for PADI6
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for PADI6
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PADI6
QuantiTect SYBR Green Assays in human, mouse, rat PADI6
QuantiFast Probe-based Assays in human, mouse, rat PADI6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of human and mouse.

Orthologs for PADI6 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Padi61 , 5 peptidyl arginine deiminase, type VI1, 5 74.54(n)1
67.74(a)1
  4 (72.26 cM)5
2427261  NM_153106.21  NP_694746.21 
 1407273555 


ENSEMBL Gene Tree for PADI6 (if available)
TreeFam Gene Tree for PADI6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for PADI6 gene
4 SIMAP similar genes for PADI6 using alignment to 1 protein entry:     PADI6_HUMAN:
PADI3    PADI4    PADI1    PADI2

Find genes that share paralogs with PADI6           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for PADI6 (see all 1128)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1995116101,2
C--15949372(+) TTGTT-/TTGT  
  TTTGTC
TTGTT
1 -- int10--------
rs1430828331,2
--15949379(+) GTTTT-/GTCTTGTT 1 -- int10--------
rs66643211,2
C--15953762(+) ACCCCC/TGACAC 1 -- int10--------
rs67033921,2
C,F,A,H--15953763(+) CCCCCG/CACACC 1 -- int16Minor allele frequency- C:0.29WA NA EA 366
rs2018772411,2
--15953763(+) CCCCC-/GACACC 1 -- int10--------
rs768864471,2
C--15966697(+) GGGGGA/GGGGGA 1 -- int10--------
rs106904731,2
C--17699379(+) AGCAA-/ACACACA 1 -- int11Minor allele frequency- AC:0.50CSA 2
rs716726131,2
C--17699380(+) GCAAA-/ACCACAG 1 -- int10--------
rs23082301,2
C--17699509(-) AACAC-/CAC   
  T
/TCAC
CTTCT
1 -- int15EU NA EA CSA 344
rs717205861,2
C--17699510(+) GAAGG-/GTGA  
        
TGTTT
1 -- int10--------

HapMap Linkage Disequilibrium report for PADI6 (17698691 - 17728195 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for PADI6:    About this table    
Variant IDTypeSubtypePubMed ID
esv2214804CNV Deletion18987734
esv2590404CNV Deletion19546169
esv2626551CNV Deletion19546169

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing PADI6
DNA2.0 Custom Variant and Variant Library Synthesis for PADI6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 610363    OMIM disorders: --


Find genes that share disorders with PADI6           About GenesLikeMe

Genetic Association Database (GAD): PADI6
Human Genome Epidemiology (HuGE) Navigator: PADI6 (1 document)

Export disorders for PADI6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for PADI6 gene integrated from 10 sources:
(articles sorted by number of sources associating them with PADI6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PubMed id 15087120)1, 2, 3, 9 Chavanas S.... Simon M. (Gene 2004)
  2. cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI. (PubMed id 15625577)1, 2, 9 Zhang J.... Mao Y. (Acta Biochim. Pol. 2004)
  3. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PubMed id 18849993)1, 4 Stacey S.N....Stefansson K. (Nat. Genet. 2008)
  4. Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study. (PubMed id 22364592)1 Giles J.T....Halushka M.K. (amp 2012)
  5. Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. (PubMed id 22634725)1 Rose R....Ottmann C. (J. Struct. Biol. 2012)
  6. Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis. (PubMed id 23164236)1 Too C.L....Padyukov L. (amp 2012)
  7. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
  8. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
  9. PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. (PubMed id 14579251)1 Vossenaar E.R....Pruijn G.J. (Bioessays 2003)
  10. Use of proteomics to identify highly abundant maternal factors that drive the egg-to-embryo transition. (PubMed id 20106898)9 Yurttas P....Coonrod S.A. (Reproduction 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 353238 HGNC: 20449 AceView: PADI6 Ensembl:ENSG00000256049 euGenes: HUgn353238
ECgene: PADI6 H-InvDB: PADI6

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for PADI6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for PADI6 gene:
Search GeneIP for patents involving PADI6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PADI6  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PADI6  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for PADI6  
 OriGene qSTAR qPCR primer pairs in human, mouse for PADI6   OriGene Purified Protein for PADI6  
 OriGene ORF clones in mouse, rat for PADI6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for PADI6   OriGene Custom Protein Services for PADI6  

 
 
 Block miRNA regulation of human, mouse, rat PADI6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PADI6
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PADI6 Predesigned siRNA for gene silencing in human, mouse, rat PADI6
 QuantiFast Probe-based Assays in human, mouse, rat PADI6 QuantiTect SYBR Green Assays in human, mouse, rat PADI6
 Custom PCR Arrays for PADI6 Search Chromatin IP Primers for PADI6
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PADI6  Search GeneGlobe Interaction Network for PADI6
 Regulatory tfbs in PADI6 promoter
 GenScript Custom Purified and Recombinant Proteins Services for PADI6 GenScript cDNA clones with any tag delivered in your preferred vector for PADI6
 GenScript Custom Assay Services for PADI6 GenScript Custom overexpressing Cell Line Services for PADI6
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for PADI6
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 PADI6 antibodies
 Antibodies for PADI6
 See all of Abcam's Antibodies, Kits and Proteins for PADI6
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for PADI6
 Antibodies for PADI6
 ELISAs for PADI6
 CLIAs for PADI6



 Browse ESI BIO Cell Lines and PureStem Progenitors for PADI6
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI6
 SwitchGear 3'UTR luciferase reporter plasmids for PADI6
 SwitchGear Promoter luciferase reporter plasmids for PADI6
 Search ThermoFisher Antibodies for PADI6
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI6
 Browse compounds at ApexBio
 Search Addgene for plasmids for PADI6
  Search eBioscience for proteins for PADI6
  Search eBioscience for elisas for PADI6
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for PADI6
 antibodies-online antibodies for PADI6 (11 products)
 antibodies-online kits for PADI6 (6 products)
 antibodies-online peptides for PADI6
 antibodies-online proteins for PADI6 (2 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      PADI6 gene at Home site.
Version: 3.12.250 16 Nov 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4