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Aliases for PADI6 Gene

Aliases for PADI6 Gene

  • Peptidyl Arginine Deiminase 6 2 3
  • Peptidyl Arginine Deiminase, Type VI 2 3 5
  • Peptidyl Arginine Deiminase-Like Protein 3 4
  • EC 4 63
  • HPADVI 3 4
  • Protein-Arginine Deiminase Type VI 4
  • Peptidylarginine Deiminase Type 6 3
  • Peptidylarginine Deiminase VI 4
  • PAD6 4

External Ids for PADI6 Gene

Previous GeneCards Identifiers for PADI6 Gene

  • GC00U911624
  • GC01U901038
  • GC01P017444
  • GC01P017571
  • GC01P017698
  • GC01P015944

Summaries for PADI6 Gene

Entrez Gene Summary for PADI6 Gene

  • This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012]

GeneCards Summary for PADI6 Gene

PADI6 (Peptidyl Arginine Deiminase 6) is a Protein Coding gene. Among its related pathways are Chromatin organization and protein citrullination. GO annotations related to this gene include calcium ion binding and protein-arginine deiminase activity. An important paralog of this gene is PADI3.

UniProtKB/Swiss-Prot for PADI6 Gene

  • Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PADI6 Gene

Genomics for PADI6 Gene

Regulatory Elements for PADI6 Gene

Enhancers for PADI6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PADI6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PADI6 Gene

17,372,196 bp from pter
17,401,699 bp from pter
29,504 bases
Plus strand

Genomic View for PADI6 Gene

Genes around PADI6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PADI6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PADI6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PADI6 Gene

Proteins for PADI6 Gene

  • Protein details for PADI6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-arginine deiminase type-6
    Protein Accession:
    Secondary Accessions:
    • Q330K5
    • Q70SX3

    Protein attributes for PADI6 Gene

    694 amino acids
    Molecular mass:
    77727 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PADI6 Gene

neXtProt entry for PADI6 Gene

Proteomics data for PADI6 Gene at MOPED

Selected DME Specific Peptides for PADI6 Gene

Post-translational modifications for PADI6 Gene

  • Phosphorylation at Ser-10, possibly by RSK-type kinases, and Ser-446 creates binding sites for 14-3-3 proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PADI6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PADI6 Gene

Gene Families for PADI6 Gene

Protein Domains for PADI6 Gene

Suggested Antigen Peptide Sequences for PADI6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein arginine deiminase family.
  • Belongs to the protein arginine deiminase family.
genes like me logo Genes that share domains with PADI6: view

Function for PADI6 Gene

Molecular function for PADI6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein L-arginine + H(2)O = protein L-citrulline + NH(3).
UniProtKB/Swiss-Prot Function:
Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo (By similarity).

Enzyme Numbers (IUBMB) for PADI6 Gene

Gene Ontology (GO) - Molecular Function for PADI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004668 protein-arginine deiminase activity IEA --
genes like me logo Genes that share ontologies with PADI6: view
genes like me logo Genes that share phenotypes with PADI6: view

Animal Models for PADI6 Gene

MGI Knock Outs for PADI6:

Animal Model Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PADI6 Gene

Localization for PADI6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PADI6 Gene

Cytoplasm. Nucleus.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PADI6 Gene

Pathways & Interactions for PADI6 Gene

genes like me logo Genes that share pathways with PADI6: view

Pathways by source for PADI6 Gene

1 BioSystems pathway for PADI6 Gene
2 Reactome pathways for PADI6 Gene

Interacting Proteins for PADI6 Gene

Gene Ontology (GO) - Biological Process for PADI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007028 cytoplasm organization IEA --
GO:0034613 cellular protein localization IEA --
genes like me logo Genes that share ontologies with PADI6: view

No data available for SIGNOR curated interactions for PADI6 Gene

Drugs & Compounds for PADI6 Gene

(3) Drugs for PADI6 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citrulline Approved Nutra Full agonist, Agonist, Target 0
ADI-PEG 20 Pharma inhibitor 0
calcium Nutra 0

(2) Additional Compounds for PADI6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with PADI6: view

Transcripts for PADI6 Gene

mRNA/cDNA for PADI6 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PADI6 Gene

Peptidyl arginine deiminase, type VI:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PADI6 Gene

No ASD Table

Relevant External Links for PADI6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PADI6 Gene

mRNA expression in normal human tissues for PADI6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PADI6 Gene

This gene is overexpressed in Ovary (x34.7) and Whole Blood (x11.1).

Protein differential expression in normal tissues from HIPED for PADI6 Gene

This gene is overexpressed in Fetal ovary (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PADI6 Gene

SOURCE GeneReport for Unigene cluster for PADI6 Gene Hs.531598

mRNA Expression by UniProt/SwissProt for PADI6 Gene

Tissue specificity: Ovary, testis and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with PADI6: view

Protein tissue co-expression partners for PADI6 Gene

Primer Products

Orthologs for PADI6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PADI6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PADI6 35
  • 77.13 (n)
  • 71.55 (a)
(Canis familiaris)
Mammalia PADI6 35
  • 81.22 (n)
  • 77.37 (a)
(Mus musculus)
Mammalia Padi6 35
  • 74.54 (n)
  • 67.74 (a)
Padi6 16
(Pan troglodytes)
Mammalia PADI6 35
  • 99.37 (n)
  • 99.42 (a)
(Rattus norvegicus)
Mammalia Padi6 35
  • 75.16 (n)
  • 70.13 (a)
Species with no ortholog for PADI6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PADI6 Gene

Gene Tree for PADI6 (if available)
Gene Tree for PADI6 (if available)

Paralogs for PADI6 Gene

Paralogs for PADI6 Gene

(4) SIMAP similar genes for PADI6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PADI6: view

Variants for PADI6 Gene

Sequence variations from dbSNP and Humsavar for PADI6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs942459 -- 17,372,842(-) CTACC(A/G)ACACT intron-variant
rs1204864 -- 17,377,198(-) ccagg(A/C)tgggc intron-variant
rs1204865 -- 17,376,539(-) AAAAA(A/T)TAGCC intron-variant
rs1204866 -- 17,374,220(-) TCCTG(C/T)AGGGT intron-variant
rs1204867 -- 17,373,379(-) CACTG(G/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PADI6 Gene

Variant ID Type Subtype PubMed ID
esv2590404 CNV Deletion 19546169
esv2214804 CNV Deletion 18987734
esv2626551 CNV Deletion 19546169

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for PADI6 Gene

Disorders for PADI6 Gene

Relevant External Links for PADI6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PADI6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PADI6 Gene

Publications for PADI6 Gene

  1. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PMID: 15087120) Chavanas S. … Simon M. (Gene 2004) 2 3 4 23 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI. (PMID: 15625577) Zhang J. … Mao Y. (Acta Biochim. Pol. 2004) 3 23
  5. Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. (PMID: 24403052) Stacey S.N. … Stefansson K. (Hum. Mol. Genet. 2014) 3

Products for PADI6 Gene

Sources for PADI6 Gene