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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PADI4 Gene

protein-coding   GIFtS: 62
GCID: GC01P017634

Peptidyl Arginine Deiminase, Type IV

(Previous names: peptidyl arginine deiminase, type V)
(Previous symbol: PADI5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidyl Arginine Deiminase, Type IV1 2     PAD2 5
PADI51 2 3 5     PAD42
Peptidyl Arginine Deiminase, Type V1 2     PDI42
Protein-Arginine Deiminase Type IV2 3     PADI-H Protein2
PDI52 3     Protein-Arginine Deiminase Type-42
HL-60 PAD2 3     Peptidylarginine Deiminase IV3
EC 3.5.3.153 8     

External Ids:    HGNC: 183681   Entrez Gene: 235692   Ensembl: ENSG000001593397   OMIM: 6053475   UniProtKB: Q9UM073   

Export aliases for PADI4 gene to outside databases

Previous GC identifers: GC00U991184 GC01P016675 GC01P017015 GC01P017379 GC01P017507 GC01P015882


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PADI4 Gene:
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues
to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to
inflammation and immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for PADI4 Gene: 
PADI4 (peptidyl arginine deiminase, type IV) is a protein-coding gene. Diseases associated with PADI4 include palindromic rheumatism, and chronic graft versus host disease. GO annotations related to this gene include protein-arginine deiminase activity and calcium ion binding. An important paralog of this gene is PADI2.

UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07
Function: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at
'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1
and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with
NCOA2/GRIP1

Gene Wiki entry for PADI4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PADI4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPADI4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PADI4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PADI4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

PADI4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PADI4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P017634:  view genomic region     (about GC identifiers)

Start:
17,634,690 bp from pter      End:
17,690,499 bp from pter
Size:
55,810 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07 (See protein sequence)
Recommended Name: Protein-arginine deiminase type-4  
Size: 663 amino acids; 74079 Da
Cofactor: Binds 5 calcium ions per subunit
Subcellular location: Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and
neutrophils
6/12 PDB 3D structures from and Proteopedia for PADI4 (see all 12):
1WD8 (3D)        1WD9 (3D)        1WDA (3D)        2DEW (3D)        2DEX (3D)        2DEY (3D)    
Secondary accessions: Q5VTZ8 Q70SX4

Explore the universe of human proteins at neXtProt for PADI4: NX_Q9UM07

Explore proteomics data for PADI4 at MOPED 

Post-translational modifications:

  • UniProtKB: Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UM07

  • 4/10 DME Specific Peptides for PADI4 (Q9UM07) (see all 10)
     VSPPVTV  APWIMTP  PTHAVCV  VNMLVLGK 

    PADI4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PADI4 Protein Expression
    REFSEQ proteins: NP_036519.2  
    ENSEMBL proteins: 
     ENSP00000364602   ENSP00000364597  

    Human Recombinant Protein Products for PADI4: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--

    PADI4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PADI: Peptidyl arginine deiminases

    5/6 InterPro protein domains (see all 6):
     IPR013733 Prot_Arg_deaminase_cen_dom
     IPR013732 PAD_N
     IPR008972 Cupredoxin
     IPR004303 PAD
     IPR016296 Protein-arginine_deiminase_sub

    Graphical View of Domain Structure for InterPro Entry Q9UM07

    ProtoNet protein and cluster: Q9UM07

    1 Blocks protein domain: IPB004303 Protein-arginine deiminase

    UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07
    Similarity: Belongs to the protein arginine deiminase family


    PADI4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PADI4_HUMAN, Q9UM07
    Function: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at
    'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1
    and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with
    NCOA2/GRIP1
    Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)
    Biophysicochemical properties: Kinetic parameters: KM=0.055 mM for fibrinogen; KM=0.064 mM for filaggrin;
    Vmax=33.2 umol/h/mg enzyme toward fibrinogen; Vmax=8.0 umol/h/mg enzyme toward filaggrin; pH dependence: Optimum
    pH is 6.5-9.0;

         Enzyme Number (IUBMB): EC 3.5.3.151 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004668protein-arginine deiminase activity IEA--
    GO:0005509calcium ion binding IEA--
         
    PADI4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Padi4):
     growth/size  immune system  mortality/aging  normal 

    PADI4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PADI4: Padi4tm1.1Ywan Padi4tm1.1Kmow

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PADI4 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PADI4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1protein citrullination
    protein citrullination


    1 BioSystems Pathway for PADI4
        protein citrullination



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PADI4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/24 Interacting proteins for PADI4 (Q9UM073 ENSP000003645974) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006464cellular protein modification process TAS10488123
    GO:0016568chromatin modification IEA--
    GO:0018101protein citrullination IEA--

    PADI4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PADI4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PADI4

    5 HMDB Compounds for PADI4    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--
    Citrulline(2S)-2-amino-5-(carbamoylamino)pentanoic acid (see all 55)372-75-8--
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for PADI4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--15345777 16271291 16412378 16146736 16355400
    N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE-- --target--10592235

    6 Novoseek inferred chemical compound relationships for PADI4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    citrulline 91 35 10027703 (2), 16539813 (2), 12586539 (1), 17216583 (1) (see all 27)
    acpa 83.8 2 18476880 (2)
    arginine 74.6 33 15832289 (2), 15339660 (2), 19246161 (2), 12586539 (1) (see all 29)
    baee 71.7 3 11017707 (2)
    fibrinogen 26.3 2 16892136 (1), 20450789 (1)
    calcium 11.2 4 12586539 (1), 16892136 (1), 15625577 (1), 19004619 (1)

    Search CenterWatch for drugs/clinical trials and news about PADI4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PADI4 gene: 
    NM_012387.2  

    Unigene Cluster for PADI4:

    Peptidyl arginine deiminase, type IV
    Hs.522969  [show with all ESTs]
    Unigene Representative Sequence: BC025718
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375453 ENST00000375448(uc009vpc.2 uc001baj.2) ENST00000468945
    ENST00000487048 ENST00000467001
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB017919.1 AF229067.1 AK290507.1 AK309637.1 AK314839.1 BC025718.1 

    6 DOTS entries:

    DT.200682  DT.92424921  DT.91944157  DT.95154884  DT.95097226  DT.95218477 

    24/56 AceView cDNA sequences (see all 56):

    CB241171 BM676574 BF942697 BM713957 BX280830 BI910127 BI752751 BI019938 
    AA682801 BU502414 BI836729 BC025718 BI020543 BX492929 BU600065 BX492994 
    BI025762 AB017919 BI905950 CB146134 BX493079 BI021411 AI766115 NM_012387 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PADI4 expression in normal human tissues (normalized intensities)      PADI4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCCTGAG
    PADI4 Expression
    About this image


    PADI4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 9 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone Marrow CD33+ Cells   
             neutrophils   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Umbilical Cord (Extraembryonic Tissues)
             Cord Blood Monocytes (CD14+)   
     
     Spleen (Hematopoietic System)
             spleen ; cells in red pulp   

    See PADI4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PADI4

    SOURCE GeneReport for Unigene cluster: Hs.522969

    UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07
    Tissue specificity: Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PADI4 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Padi41 , 5 peptidyl arginine deiminase, type IV1, 5 79.96(n)1
    73.56(a)1
      4 (72.34 cM)5
    186021  NM_011061.21  NP_035191.21 
     1407458655 
    chicken
    (Gallus gallus)
    Aves PADI16
    PADI36
    protein-arginine deiminase type-3
    57(a)
    55(a)
    many ↔ many
    many ↔ many
    21(138391-148124)
    21(129323-135282)
    lizard
    (Anolis carolinensis)
    Reptilia PADI36
    Uncharacterized protein
    43(a)
    1 → many
    GL344803.1(6947-18633)
    zebrafish
    (Danio rerio)
    Actinopterygii padi26
    peptidyl arginine deiminase, type II
    46(a)
    1 → many
    6(47784349-47806450)


    ENSEMBL Gene Tree for PADI4 (if available)
    TreeFam Gene Tree for PADI4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PADI4 gene
    PADI22  PADI12  PADI32  
    4 SIMAP similar genes for PADI4 using alignment to 9 protein entries:     PADI4_HUMAN (see all proteins):
    PADI1    PADI3    PADI6    PADI2

    PADI4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PADI4
    PGOHUM00000251109


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1683 SNPs in PADI4 are shown (see all 1683)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0274014
    ----see VAR_0274012 D N mis40--------
    rs1912609361,2
    --15878986(+) CAAACA/CAAAAG 1 -- us2k10--------
    rs1388985851,2
    --15879021(+) CCACTG/TTGTTC 1 -- us2k10--------
    rs1841840951,2
    --15879031(+) CACAGC/TGTATC 1 -- us2k10--------
    rs1885603791,2
    --15879226(+) TTGGGA/GTAGAG 1 -- us2k10--------
    rs750033931,2
    F--15879233(+) AGAGGC/ACAGCC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1489727261,2
    --15879415(+) TCATGA/CGGTCA 1 -- us2k10--------
    rs1140888771,2
    C,F--15879473(+) ATGCGT/ACAGAA 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs168251141,2
    C,F--15879482(+) AACGTC/TGGACC 1 -- us2k14Minor allele frequency- T:0.02NA WA 258
    rs1471205301,2
    --15879509(+) TGCTGG/TTACAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PADI4 (17634690 - 17690499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for PADI4 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv4441CNV Deletion18987735
    esv2744586CNV Deletion23290073
    dgv23e199CNV Deletion23128226
    esv2744574CNV Deletion23290073
    esv2674909CNV Deletion23128226
    esv2668971CNV Deletion23128226
    esv2744563CNV Deletion23290073
    nsv511142CNV Loss21212237
    esv21592CNV Loss19812545
    nsv511681CNV Loss21212237


    Human Gene Mutation Database (HGMD): PADI4
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for PADI4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605347   
    OMIM disorders: 180300  
    UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex
    genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial
    membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal
    tissues, and by atrophy and rarefaction of bony structures. Note=The gene represented in this entry may be
    involved in disease pathogenesis. It could play a role in increasing citrullination of proteins in rheumatoid
    arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides
    processed and presented in the appropriate HLA context

  • 20/23 diseases for PADI4 (see all 23):    About MalaCards
    palindromic rheumatism    chronic graft versus host disease    rheumatic disease    rheumatoid arthritis
    graft versus host disease    papilloma    sjogren's syndrome    arthritis
    multiple sclerosis    spondylitis    basal cell carcinoma    lupus erythematosus
    acute leukemia    ulcerative colitis    periodontitis    type 1 diabetes
    systemic lupus erythematosus    schizophrenia    alzheimer's disease    melanoma

    1 disease from the University of Copenhagen DISEASES database for PADI4:
    Rheumatoid arthritis

    PADI4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for PADI4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 80.4 41 15485997 (4), 17216583 (2), 15077293 (2), 15814578 (2) (see all 26)
    rheumatic diseases 57.3 2 17968335 (1), 16134727 (1)
    autoimmunity 50.7 2 18645041 (2)
    autoimmune diseases 46.2 2 17868046 (1), 19892302 (1)
    multiple sclerosis 36.2 5 16828881 (2), 19540364 (1), 15080264 (1), 18476880 (1)
    lupus erythematosus systemic 35.7 2 17968335 (1), 15080264 (1)
    osteoarthritis 30.5 2 17968929 (1)
    inflammation 28.8 4 16245073 (2), 15814578 (1), 18645041 (1)
    arthritis 4.84 3 17968929 (2)
    leukemia 0 3 17216583 (1), 16502257 (1)

    Genetic Association Database (GAD): PADI4
    Human Genome Epidemiology (HuGE) Navigator: PADI4 (41 documents)

    Export disorders for PADI4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PADI4 gene, integrated from 9 sources (see all 155):
    (articles sorted by number of sources associating them with PADI4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High variability of peptidylarginine deiminase 4 (PADI4) in a healthy white population: characterization of six new variants of PADI4 exons 2-4 by a novel haplotype-specific sequencing-based approach. (PubMed id 15338034)1, 2, 4, 9 Hoppe B....Salama A. (2004)
    2. Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3). (PubMed id 10488123)1, 2, 3, 9 Nakashima K.... Yamada M. (1999)
    3. Human PAD4 regulates histone arginine methylation levels via demethylimination. (PubMed id 15345777)1, 2, 7 Wang Y.... Coonrod S.A. (2004)
    4. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. (PubMed id 12833157)1, 2, 4 Suzuki A.... Yamamoto K. (2003)
    5. PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. (PubMed id 17265154)1, 4, 9 Lee Y.H....Song G.G. (2007)
    6. Genetic and genomic studies of PADI4 in rheumatoid arthritis. (PubMed id 15814578)1, 4, 9 Harney S.M....Brown M.A. (2005)
    7. Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population. (PubMed id 17980669)1, 4, 9 Chen C.C....Tsukamoto K. (2008)
    8. A functional haplotype of PADI4 gene in rheumatoid arthritis: positive correlation in a French population. (PubMed id 19332633)1, 4, 9 Gandjbakhch F....Solau-Gervais E. (2009)
    9. Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis. (PubMed id 17469103)1, 4, 9 Cha S....Bae S.C. (2007)
    10. A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans. (PubMed id 16385500)1, 4, 9 Kang C.P....Bae S.C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23569 HGNC: 18368 AceView: PADI4 Ensembl:ENSG00000159339 euGenes: HUgn23569
    ECgene: PADI4 H-InvDB: PADI4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PADI4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PADI4 gene:
    Search GeneIP for patents involving PADI4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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