PADI4 Gene
protein-coding GIFtS: 61
GCID: GC01P017634
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|
peptidyl arginine deiminase, type IV(Previous names: peptidyl arginine deiminase, type V )
(Previous symbol: PADI5)
| |
Aliases
for PADI4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Peptidyl Arginine Deiminase, Type IV1 2 | | HL-60 PAD2 3 | | PADI51 2 3 5 | | EC 3.5.3.153 8 | | PDI51 2 3 | | PAD42 | | PAD1 2 5 | | PADI-H Protein2 | | PDI41 2 | | Protein-Arginine Deiminase Type-42 | | Peptidyl Arginine Deiminase, Type V1 2 | | Peptidylarginine Deiminase IV3 | | Protein-Arginine Deiminase Type IV2 3 | | |
Export aliases for PADI4 gene to outside databasesPrevious GC identifers: GC00U991184 GC01P016675 GC01P017015 GC01P017379 GC01P017507 GC01P015882 |
Summaries
for PADI4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PADI4:
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues tocitrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation andimmune response. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07Function: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 andrepresses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1
Gene Wiki entry for PADI4
|
Genomic Views
for PADI4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PADI4 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PADI4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PADI4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13PADI4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P017634: view genomic region
(about GC identifiers)
Start:
|
17,634,690 bp from pter |
End:
|
17,690,499 bp from pter |
Size:
|
55,810 bases |
Orientation:
|
plus strand |
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Proteins
for PADI4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07 (See
protein sequence)Recommended Name: Protein-arginine deiminase type-4 Size: 663 amino acids; 74079 Da
Cofactor: Binds 5 calcium ions per subunit
Subcellular location: Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and neutrophils
6/12 PDB 3D structures from  and Proteopedia  for PADI4 (see all 12):1WD8 (3D)
1WD9 (3D)
1WDA (3D)
2DEW (3D)
2DEX (3D)
2DEY (3D)
Secondary accessions: Q5VTZ8 Q70SX4Explore the universe of human proteins at neXtProt for PADI4: NX_Q9UM07
Post-translational modifications:
Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UM07
4/10 DME Specific Peptides for PADI4 (Q9UM07) (see all 10)
PADI4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036519.2
ENSEMBL proteins: ENSP00000364602 ENSP00000364597
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PADI4 for ontologies About GeneDecksing
PADI4 Antibody Products:
Assay Products for PADI4: |
Protein
Domains /
Families
for PADI4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PADI4 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9UM07ProtoNet protein and cluster: Q9UM07 1 Blocks protein family: IPB004303 Protein-arginine deiminase
UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07Similarity: Belongs to the protein arginine deiminase family |
Function
for PADI4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07Function: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 andrepresses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)Biophysicochemical properties: Kinetic parameters: KM=0.055 mM for fibrinogen; KM=0.064 mM for filaggrin; Vmax=33.2umol/h/mg enzyme toward fibrinogen; Vmax=8.0 umol/h/mg enzyme toward filaggrin; pH dependence: Optimum pH is 6.5-9.0;Enzyme Number (IUBMB): EC 3.5.3.151 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PADI4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PADI4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PADI4 (NM_012387) | |  | Sino Biological Human cDNA Clone for PADI4 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PADI4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004668 | protein-arginine deiminase activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- |
PADI4 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for PADI4: Padi4tm1.1Ywan Padi4tm1.1Kmow
4 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Padi4):
PADI4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PADI4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | protein citrullination | |
1  BioSystems Pathway for PADI4
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PADI4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/24 Interacting proteins for PADI4 (Q9UM073 ENSP000003645974) via UniProtKB, MINT, STRING, and/or I2D (see all 24)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006464 | cellular protein modification process |
TAS | 10488123 | | GO:0016568 | chromatin modification |
IEA | -- | | GO:0018101 | peptidyl-citrulline biosynthetic process from peptidyl-arginine |
IEA | -- |
PADI4 for ontologies About GeneDecksing
|
Drugs & Compounds
for PADI4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PADI4 for compounds About GeneDecksing
 Browse Tocris compounds for PADI4
5 HMDB Compounds for PADI4 About this table
2 DrugBank Compounds for PADI4 About this table
6 Novoseek chemical compound relationships for PADI4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| citrulline |
91 |
35 |
10027703 (2), 16539813 (2), 12586539 (1), 17216583 (1) (see all 27) |
| acpa |
83.8 |
2 |
18476880 (2) |
| arginine |
74.6 |
33 |
15832289 (2), 15339660 (2), 19246161 (2), 12586539 (1) (see all 29) |
| baee |
71.7 |
3 |
11017707 (2) |
| fibrinogen |
26.3 |
2 |
16892136 (1), 20450789 (1) |
| calcium |
11.2 |
4 |
12586539 (1), 16892136 (1), 15625577 (1), 19004619 (1) |
Search CenterWatch for drugs/clinical trials and news about PADI4
|
Transcripts
for PADI4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PADI4 gene: NM_012387.2 Unigene Cluster for PADI4: Peptidyl arginine deiminase, type IV Hs.522969 [show with all ESTs]Unigene Representative Sequence: BC0257185 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375453 ENST00000375448(uc009vpc.2 uc001baj.2) ENST00000468945
ENST00000487048 ENST00000467001
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PADI4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PADI4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PADI4 (NM_012387) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PADI4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI4 |
Additional cDNA sequence: AB017919.1 AF229067.1 AK290507.1 AK309637.1 AK314839.1 BC025718.1 6 DOTS entries: DT.200682 DT.92424921 DT.91944157 DT.95154884 DT.95097226 DT.95218477 24/56 AceView cDNA sequences (see all 56): CB241171 BM713957 BX280830 BM676574 BF942697 AI766115 BI905950 BU502414 BX492929 BI019938 AA682801 BI021411 BU600065 BX493079 AB017919 BI836729 BI025762 BI752751 BI020543 BC025718 BI910127 AW467231 CB146134 NM_012387
GeneLoc Exon Structure
|
Expression
for PADI4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PADI4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCCCTGAG
About this image
See PADI4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PADI4
SOURCE GeneReport for Unigene cluster: Hs.522969
UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07Tissue specificity: Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes
SABiosciences Custom PCR Arrays for PADI4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PADI4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PADI4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PADI4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PADI4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI4 |
Orthologs
for PADI4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PADI4 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for PADI4 (if available)
TreeFam Gene Tree for PADI4 (if available) |
Paralogs
for PADI4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PADI4 gene
- PADI22 PADI12 PADI32
4 SIMAP similar genes for PADI4 using alignment to 9 protein entries: PADI4_HUMAN (see all proteins):PADI1 PADI3 PADI6 PADI2
PADI4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PADI4
PGOHUM00000251109
|
Genomic Variants
for PADI4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PADI4 (17634690 - 17690499 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for PADI4
4 CNVs: 68142 43389 68143 6799 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PADI4 |
|
Disorders
/ Diseases
for PADI4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PADI4 for disorders About GeneDecksing
OMIM gene information: 605347
OMIM disorders: 180300
UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07
Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is asystemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects thejoints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespreadfibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bonystructures. Note=Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullinationof proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance tocitrullinated peptides processed and presented in the appropriate HLA context
20/23  diseases for PADI4 (see all 23): About MalaCardsgraft versus host disease palindromic rheumatism rheumatoid arthritis lupus erythematosus
systemic lupus erythematosus basal cell carcinoma multiple sclerosis ulcerative colitis
arthritis sjogren's syndrome osteoarthritis papilloma
spondylitis acute leukemia alzheimer's disease periodontitis
leukemia lung cancer breast cancer schizophrenia
1 disease from the University of Copenhagen DISEASES database for PADI4:Rheumatoid arthritis 10 Novoseek disease relationships for PADI4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rheumatoid arthritis |
80.4 |
41 |
15485997 (4), 17216583 (2), 15077293 (2), 15814578 (2) (see all 26) |
| rheumatic diseases |
57.3 |
2 |
17968335 (1), 16134727 (1) |
| autoimmunity |
50.7 |
2 |
18645041 (2) |
| autoimmune diseases |
46.2 |
2 |
17868046 (1), 19892302 (1) |
| multiple sclerosis |
36.2 |
5 |
16828881 (2), 19540364 (1), 15080264 (1), 18476880 (1) |
| lupus erythematosus systemic |
35.7 |
2 |
17968335 (1), 15080264 (1) |
| osteoarthritis |
30.5 |
2 |
17968929 (1) |
| inflammation |
28.8 |
4 |
16245073 (2), 15814578 (1), 18645041 (1) |
| arthritis |
4.84 |
3 |
17968929 (2) |
| leukemia |
0 |
3 |
17216583 (1), 16502257 (1) |
Genetic Association Database (GAD): PADI4
Human Genome Epidemiology (HuGE) Navigator: PADI4 (41 documents)
Export disorders for PADI4 gene to outside databases
|
Publications
for PADI4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PADI4 gene, integrated from 9 sources (see all 148):
(articles sorted by number of sources associating them with PADI4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- High variability of peptidylarginine deiminase 4 (PADI4) in a healthy white population: characterization of six new variants of PADI4 exons 2-4 by a novel haplotype-specific sequencing-based approach. (PubMed id 15338034)1, 2, 4, 9 Hoppe B....Salama A. (2004)
- Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3). (PubMed id 10488123)1, 2, 3, 9 Nakashima K.... Yamada M. (1999)
- Human PAD4 regulates histone arginine methylation levels via demethylimination. (PubMed id 15345777)1, 2, 7 Wang Y.... Coonrod S.A. (2004)
- Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. (PubMed id 12833157)1, 2, 4 Suzuki A.... Yamamoto K. (2003)
- Genetic and genomic studies of PADI4 in rheumatoid arthritis. (PubMed id 15814578)1, 4, 9 Harney S.M....Brown M.A. (2005)
- A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans. (PubMed id 16385500)1, 4, 9 Kang C.P....Bae S.C. (2006)
- Association between PADI4 and rheumatoid arthritis: a replication study. (PubMed id 16200584)1, 4, 9 Ikari K....Kamatani N. (2005)
- Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis. (PubMed id 15731287)1, 4, 9 Barton A....Silman A. (2005)
- Histone deimination antagonizes arginine methylation. (PubMed id 15339660)1, 2, 9 Cuthbert G.L.... Kouzarides T. (2004)
- A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population. (PubMed id 15077293)1, 4, 9 Barton A....Worthington J. (2004)
|
External Searches for PADI4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PADI4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PADI4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PADI4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PADI4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PADI4 gene:
Search GeneIP for patents involving PADI4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PADI4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for PADI4 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PADI4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PADI4 | | | OriGene Protein Over-expression Lysate for PADI4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PADI4 | | OriGene 3'-UTR Clone for PADI4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PADI4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PADI4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PADI4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PADI4 | | OriGene Custom Protein Services for PADI4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PADI4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PADI4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PADI4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PADI4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PADI4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PADI4 |
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| | | | Search Tocris compounds for PADI4 |
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 | | | PADI4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI4 |
|  |  |  | | | | ThermoFisher Antibody for PADI4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI4 |
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