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PADI4 Gene

protein-coding GIFtS: 54

GC01P017507

peptidyl arginine deiminase, type IV
(Previous names: peptidyl arginine deiminase, type V )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PADI5)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.5.3.15 ^³
OTTHUMP00000002482 ^²
PAD ^¹, ², ⁵
PAD4 ^²
PADI5 ^², ³, ⁵
PDI4 ^¹, ²
PDI5 ^¹, ², ³

Descriptions
HL-60 PAD ^², ³
PADI-H protein ^²
Peptidylarginine deiminase IV ^³
Protein-arginine deiminase type IV ^³
peptidyl arginine deiminase, type IV ^²
peptidyl arginine deiminase, type V ^¹, ²
protein-arginine deiminase ^²

External Ids
HGNC: 18368¹
Entrez Gene: 23569²
UniProtKB: Q9UM07³
Ensembl: ENSG00000159339⁷

Search outside databases for aliases for PADI4 gene

Previous GC identifers: GC00U991184 GC01P016675 GC01P017015 GC01P017379

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PADI4:

This gene is a member of a gene family which encodes enzymes responsible for the conversion of

arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage

development leading to inflammation and immune response. [provided by RefSeq]

UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07

Function: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates

histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation

by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142',

which favors its interaction with NCOA2/GRIP1

Gene Wiki entry for PADI4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PADI4 gene

Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13

PADI4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P017507: (about GC identifiers)

Start:	17,507,277 bp from pter
End:	17,563,082 bp from pter
Size:	55,806 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004610.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07 (See protein sequence)

Recommended Name: Protein-arginine deiminase type-4

Size: 663 amino acids; 74095 Da

Cofactor: Binds 5 calcium ions per subunit

Subcellular location: Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of

eosinophils and neutrophils

PDB structures from and Proteopedia :

1WD8 (3D)

1WD9 (3D)

1WDA (3D)

2DEW (3D)

2DEX (3D)

2DEY (3D)

2DW5 (3D)

Secondary accessions: Q5VTZ8 Q70SX4

REFSEQ proteins: NP_036519.2

ENSEMBL proteins:

ENSP00000364602 ENSP00000351690 ENSP00000364597

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PADI4 / PAD4)
	Human Recombinant Proteins from Abnova (PADI4)

OriGene Purified Recombinant Human Protein: PADI4

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for PADI4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for PADI4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PADI4 / PAD4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PADI4)
	Novus Biologicals Antibodies for PADI4

Assays for PADI4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UM07

ProtoNet protein and cluster: Q9UM07

1 Blocks protein family: IPB004303 Protein-arginine deiminase

UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07

Similarity: Belongs to the protein arginine deiminase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PADI4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PADI4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012387

Applied Biosystems Silencer® siRNAs for PADI4

Sigma-Aldrich siRNA for PADI4

Sigma-Aldrich shRNA for PADI4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PADI4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_012387
Myc/DDK tagged cDNA clone in CMV expression vector: NM_012387
untagged cDNA clones in CMV expression vector (see all 3): AF229067

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012387

UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07

Function: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates

histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation

by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142',

which favors its interaction with NCOA2/GRIP1

Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)

Biophysicochemical properties: Kinetic parameters: KM=0.055 mM for fibrinogen; KM=0.064 mM for

filaggrin; Vmax=33.2 umol/h/mg enzyme toward fibrinogen; Vmax=8.0 umol/h/mg enzyme toward

filaggrin; pH dependence: Optimum pH is 6.5-9.0;

Enzyme Number (IUBMB): EC 3.5.3.15

1 MGI phenotypic allele for Padi4 (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004668	protein-arginine deiminase activity	TAS	10488123
GO:0005509	calcium ion binding	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for PADI4

5/7 Interacting proteins for PADI4 (ENSP00000364597³) via UniProtKB, MINT, and/or STRING (see all 7 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN22	ENSP00000352833³	STRING (score=.887)
TP53	ENSP00000269305³	STRING (score=.845)
CARM1	ENSP00000325690³	STRING (score=.814)
RUNX1	ENSP00000300305³	STRING (score=.795)
FCRL3	ENSP00000357169³	STRING (score=.742)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006464	protein modification process	TAS	10488123
GO:0016568	chromatin modification	IEA	--
GO:0018101	peptidyl-citrulline biosynthetic process from peptidyl-arginine	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PADI4
4 Novoseek chemical compound relationships for PADI4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acpa	76.34	2	18476880 (2)
baee	73.50	3	11017707 (2)
fibrinogen	22.32	1	16892136 (1)
calcium	10.72	4	12586539 (1), 16892136 (1), 15625577 (1), 19004619 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PADI4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PADI4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012387

Sigma-Aldrich siRNA for PADI4

Sigma-Aldrich shRNA for PADI4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012387

REFSEQ mRNAs for PADI4 gene:

NM_012387.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012387

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012387
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012387
                                 untagged cDNA clones in CMV expression vector (see all 3): AF229067

Additional cDNA sequence:

AB017919.1 AF229067.1 AK290507.1 AK309637.1 AK314839.1 BC025718.1

6 DOTS entries:

DT.200682 DT.92424921 DT.91944157 DT.95097226 DT.95154884 DT.95218477

24/56 AceView cDNA sequences (see all 56 ):

BF942697 CB241171 BM676574 BX280830 BM713957 AA682801 BU502414 BX492929

BI021411 BX492994 BI836729 AB017919 NM_012387 BI019938 BC025718 BI905950

BX493079 BI025762 CB146134 BI020543 BU600065 AI766115 AW467231 BI910127

highest scoring ESTs for PADI4:

AA682801 AB017919 AI766115 AW084484 AW467326 BC025718 BF895958 BF896009 BF896025 BF896041

Unigene Cluster for PADI4:

Peptidyl arginine deiminase, type IV

Hs.522969 [show with all ESTs]

Unigene Representative Sequence: BC025718

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000375453 ENST00000358829 ENST00000375448

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PADI4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PADI4

¹ / ² / ³

8 probe-sets matching PADI4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
86508_at²^{, 3}	U95-D	2	1.00	0.94	0.93	1.15	T92118	0.80	1.00	0.91	1
75941_at²^{, 3}	U95-D	4	1.00	0.89	0.99	0.86	AA682801	1.00	1.00	1.00	1
220001_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012387	0.60	1.00	0.82	1
211413_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF229067	0.40	1.00	0.76	1
211412_at²^{, 3}	U133-A	1	0.82	1.00	--	--	AF229067	0.40	1.00	0.76	1
220001_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211413_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211412_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks PADI4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGCCCTGAG

SOURCE GeneReport for Unigene cluster: Hs.522969
UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07
Tissue specificity: Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes
or lymphocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PADI4 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PADI4¹	--	peptidyl arginine deiminase, type IV	83.61(n) 76.85(a)	606921 XM_843401.1 XP_848494.1
chimpanzee (Pan troglodytes)	PADI4¹	--	peptidyl arginine deiminase, type IV	95.34(n) 94.21(a)	456530 XM_513116.2 XP_513116.2
cow (Bos taurus)	PADI4¹	--	peptidyl arginine deiminase, type IV	83.03(n) 74.32(a)	508161 XM_584904.3 XP_584904.3
rat (Rattus norvegicus)	Padi4¹	--	peptidyl arginine deiminase, type IV	80.01(n) 74.62(a)	29512 NM_017227.1 NP_058923.1
mouse (Mus musculus)	Padi4^{1, 5}	4 (71.00 cM)⁵	peptidyl arginine deiminase, type IV^{1, 5}	80.16(n)¹ 73.87(a)¹	18602¹ NM_011061.1¹ NP_035191.1¹ AB013850⁵ AB121692⁵ (see all 10)

About this table Species with no ortholog for PADI4

ENSEMBL Gene Tree for PADI4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PADI4 gene

PADI2² PADI1² PADI6² PADI3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/604 NCBI SNPs in PADI4 are shown (see all 604 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 226)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1408422^1,2	A,C,F,H,O	17563502(-)	`CCATCA/GAGTTT`	1	--	ng3¹		11	EU EA WA NA	978
	rs2501795^1,2	A,C,F,H	17506086(+)	`CAAACA/GCAAGA`	1	--	ng5¹		8	EU EA WA	832
	rs11203367^1,2	A,C,F,H	17530203(+)	`GAAAGC/TGGCCA`	1	A/V	mis¹		17	EU EA WA NA	1740
	rs2501796^1,2	A,C,F,H	17506109(+)	`GAAACA/GCTCTA`	1	--	ng5¹		8	EU EA WA	838
	rs1748020^1,2	A,C,F,H	17541196(-)	`GGTTGG/AACGTG`	1	F/S	mis¹ ese³		9	EU EA WA NA	914
	rs874881^1,2	A,C,F,H	17533086(+)	`CACCGC/GGGTGG`	1	A/G	mis¹ ese³		10	EA EU WA NA	2414
	rs11203366^1,2	A,C,F,H	17530121(+)	`CCCACA/GGCCCT`	1	S/G	mis¹		9	EU EA WA NA	906
	rs2477134^1,2	A,C,F,H	17506159(-)	`CCCAAA/CAAGGA`	1	--	ng5¹		4	EU EA WA	418
	rs2477133^1,2	A,C,F,H	17506479(-)	`GCTTAG/TTATTA`	1	--	ng5¹		4	EU EA WA	420
	rs11579504^1,2	A,C,F,H	17505833(+)	`GATAAA/GTTTTG`	1	--	ng5¹		7	EU EA WA NA	554

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HapMap Linkage Disequilibrium images for PADI4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605347 disorders: 180300

UniProtKB/Swiss-Prot: PADI4_HUMAN, Q9UM07

PADI4 is thought to be a rheumatoid arthritis susceptibility locus [MIM:180300]. Could

have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of

proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break

in tolerance to citrullinated peptides processed and presented in the appropriate HLA context

10 Novoseek disease relationships for PADI4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rheumatoid arthritis	78.84	38	15485997 (4), 17216583 (2), 15077293 (2), 15814578 (2) (see all 24)
rheumatic diseases	59.86	2	17968335 (1), 16134727 (1)
autoimmunity	47.82	2	18645041 (2)
lupus erythematosus systemic	38.66	2	17968335 (1), 15080264 (1)
autoimmune diseases	38.03	1	17868046 (1)
multiple sclerosis	35.61	4	16828881 (2), 15080264 (1), 18476880 (1)
inflammation	28.20	4	16245073 (2), 15814578 (1), 18645041 (1)
osteoarthritis	21.54	2	17968929 (1)
arthritis	8.51	3	17968929 (2)
leukemia	0.00	3	17216583 (1), 16502257 (1)

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Genetic Association Database: PADI4
Human Genome Epidemiology Navigator: PADI4 (31 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/99 PubMed articles for PADI4 gene (see all 99 ):

High variability of peptidylarginine deiminase 4 (PADI4) in a healthy white population: characterization of six new variants of PADI4 exons 2-4 by a novel haplotype-specific sequencing-based approach. (PubMed id 15338034)^{1, 3, 4, 6} Hoppe B....Salama A. (2004)
Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3). (PubMed id 10488123)^{1, 2, 3, 4} Nakashima K.... Yamada M. (1999)
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. (PubMed id 12833157)^{3, 4, 6} Suzuki A.... Yamamoto K. (2003)
Genetic and genomic studies of PADI4 in rheumatoid arthritis. (PubMed id 15814578)^{1, 3, 6} Harney S.M....Brown M.A. (2005)
A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans. (PubMed id 16385500)^{1, 3, 6} Kang C.P....Bae S.C. (2006)
Association between PADI4 and rheumatoid arthritis: a replication study. (PubMed id 16200584)^{1, 3, 6} Ikari K....Kamatani N. (2005)
Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis. (PubMed id 15731287)^{1, 3, 6} Barton A....Silman A. (2005)
Histone deimination antagonizes arginine methylation. (PubMed id 15339660)^{1, 3, 4} Cuthbert G.L.... Kouzarides T. (2004)
A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population. (PubMed id 15077293)^{1, 3, 6} Barton A....Worthington J. (2004)
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population. (PubMed id 15998632)^{1, 3, 6} Martinez A....Urcelay E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23569	HGNC: 18368	AceView: PADI4	Ensembl:ENSG00000159339	euGenes: HUgn23569
ECgene: PADI4	H-InvDB: PADI4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PADI4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PADI4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PADI4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PADI4		Antibodies for PADI4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PADI4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PADI4)
	Antibodies (PADI4)
	Chimera RNAi (PADI4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PADI4 / PAD4)
	Antibodies (PADI4 / PAD4)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for PADI4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PADI4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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PADI4 Gene at Home site.
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PADI4 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for PADI4

Summaries
for PADI4

Genomic Location
for PADI4

Proteins
for PADI4

Protein Domains/
Families
for PADI4

Gene Function
for PADI4

Pathways & Interactions
for PADI4

Drugs & Compounds
for PADI4

Transcripts
for PADI4

Expression
for PADI4

Orthologs
for PADI4

Paralogs
for PADI4

SNPs/Variants
for PADI4

Disorders & Mutations
for PADI4

Medical News
for PADI4

Publications
for PADI4

Search for PADI4

Genome Databases showing PADI4

Other Databases showing PADI4

Specialized Databases showing PADI4

Licensable Technologies
for PADI4

Services
for PADI4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PADI4 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor PADI4

Summariesfor PADI4

Genomic Locationfor PADI4

Proteinsfor PADI4

Protein Domains/Familiesfor PADI4

Gene Functionfor PADI4

Pathways & Interactionsfor PADI4

Drugs & Compoundsfor PADI4

Transcriptsfor PADI4

Expression for PADI4

Orthologsfor PADI4

Paralogsfor PADI4

SNPs/Variantsfor PADI4

Disorders & Mutationsfor PADI4

Medical Newsfor PADI4

Publicationsfor PADI4

Search for PADI4

Genome Databases showing PADI4

Other Databases showing PADI4

Specialized Databases showing PADI4

Licensable Technologiesfor PADI4

Servicesfor PADI4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PADI4

Summaries
for PADI4

Genomic Location
for PADI4

Proteins
for PADI4

Protein Domains/
Families
for PADI4

Gene Function
for PADI4

Pathways & Interactions
for PADI4

Drugs & Compounds
for PADI4

Transcripts
for PADI4

Expression
for PADI4

Orthologs
for PADI4

Paralogs
for PADI4

SNPs/Variants
for PADI4

Disorders & Mutations
for PADI4

Medical News
for PADI4

Publications
for PADI4

Licensable Technologies
for PADI4

Services
for PADI4