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Aliases & Descriptions for PADI3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.5.3.15 3 | | MGC126307 2 | | MGC126308 2 | | OTTHUMP00000002484 2 | | PAD3 2 | | PDI3 1, 2, 3 |
| | | Descriptions |
|---|
| Peptidylarginine deiminase III 3 | | Protein-arginine deiminase type III 2, 3 | | peptidyl arginine deiminase, type III 2 | | peptidylarginine deiminase type III 2 |
|
| | Search outside databases for aliases for PADI3 genePrevious GC identifers: GC01P017313 GC01P016616 GC01P016956 GC01P017320 |
Summaries for PADI3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PADI3: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq] UniProtKB/Swiss-Prot: PADI3_HUMAN, Q9ULW8Function: Catalyzes the deimination of arginine residues of proteinsGene Wiki entry for PADI3 |
Genomic Location for PADI3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PADI3 gene 
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13PADI3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P017448:
(about GC identifiers)
Start:
|
17,448,180 bp from pter |
End:
|
17,483,315 bp from pter |
Size:
|
35,136 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004610.18
| Proteins for PADI3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PADI3_HUMAN, Q9ULW8 (See
protein sequence)Recommended Name: Protein-arginine deiminase type-3 Size: 664 amino acids; 74743 Da
Cofactor: Calcium (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: Q58EY7 Q70SX5REFSEQ proteins: NP_057317.2
ENSEMBL proteins: ENSP00000364609
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for PADI3: Assays for PADI3: | Protein
Domains/ Families for PADI3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9ULW8
ProtoNet protein and cluster: Q9ULW8 1 Blocks protein family: IPB004303 Protein-arginine deiminase
UniProtKB/Swiss-Prot: PADI3_HUMAN, Q9ULW8Similarity: Belongs to the protein arginine deiminase family | Gene Function for PADI3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016233
Applied Biosystems Silencer® siRNAs for PADI3
Sigma-Aldrich siRNA for PADI3  Sigma-Aldrich shRNA for PADI3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016233                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016233                                  untagged cDNA clone in CMV expression vector: NM_016233 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016233
UniProtKB/Swiss-Prot: PADI3_HUMAN, Q9ULW8Function: Catalyzes the deimination of arginine residues of proteinsCatalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)Enzyme Number (IUBMB): EC 3.5.3.15 1 MGI phenotypic allele for Padi3 (no phenotypes)
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for PADI3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for PADI3 
4 Interacting proteins for PADI3 (ENSP000003646093) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | protein modification process |
IEA | -- | | GO:0018101 | peptidyl-citrulline biosynthetic process from peptidyl-arginine |
IEA | -- | About this table
|
Drugs & Compounds for PADI3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PADI3
|
Transcripts for PADI3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016233
Sigma-Aldrich siRNA for PADI3  Sigma-Aldrich shRNA for PADI3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016233 REFSEQ mRNAs for PADI3 gene: NM_016233.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016233               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016233                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016233                                  untagged cDNA clone in CMV expression vector: NM_016233  Additional cDNA sequence: AB026831.1 BC041592.1 BC109091.1 BC109092.1 1 DOTS entry: DT.75150995 20 AceView cDNA sequences:BC041592 BM908529 BM549909 BM018564 BI085444 BM016595 BI085442 AB026831 BM908844 BE735575 BM020359 BE182919 AL710699 BM019318 NM_016233 AI246243 BE563328 BM017129 BX283443 BM016592
highest scoring ESTs for PADI3:AB026831 AI246243 BC041592 BE182919 BE563328 BE735575 BM016595 BM020359 BM549909 AL710699 Unigene Cluster for PADI3: Peptidyl arginine deiminase, type III Hs.149195 [show with all ESTs]Unigene Representative Sequence: BC041592
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000375460
|
Expression for PADI3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PADI3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PADI3
1 / 2 / 3 2 probe-sets matching PADI3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTTGACTATG
SOURCE GeneReport for Unigene cluster: Hs.149195 UniProtKB/Swiss-Prot: PADI3_HUMAN, Q9ULW8Tissue specificity: Hair follicles, and epidermis at very low levels |
Orthologs for PADI3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PADI3 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for PADI3
ENSEMBL Gene Tree for PADI3 | Paralogs for PADI3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PADI3 gene
- PADI22 PADI42 PADI12 PADI62
|
SNPs/Variants for PADI3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PADI3 (up to first 250kb)
|
Disorders & Mutations for PADI3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606755
|
Medical News for PADI3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PADI3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for PADI3 gene (see all 18
):- Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin. (PubMed id 11069618)1, 2, 3, 4 Kanno T.... Takahara H. (2000)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PubMed id 15087120)3, 4 Chavanas S.... Simon M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. (PubMed id 16671893)1, 3 Dong S....Takahara H. (2006)
- Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte. (PubMed id 18923650)1, 3 Chavanas S....Simon M. (2008)
- Long-range enhancer differentially regulated by c-Jun and JunD controls peptidylarginine deiminase-3 gene in keratinocytes. (PubMed id 18952102)3 Adoue V....Simon M. (2008)
- Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle. (PubMed id 18083705)3 Kizawa K....Heizmann C.W. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
- Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis. (PubMed id 16973334)3 Chavanas S....Simon M. (2006)
|
Search for PADI3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PADI3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PADI3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PADI3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PADI3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for PADI3:

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Incremental update: 13 Oct 2009
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