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Aliases & Descriptions for PADI2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.5.3.15 3 | | KIAA0994 1, 2, 3 | | OTTHUMP00000002403 2 | | OTTHUMP00000044625 2 | | PAD-H19 2, 3 | | PAD2 2 | | PDI2 1, 2, 3 |
| | | Descriptions |
|---|
| Peptidylarginine deiminase II 3 | | Protein-arginine deiminase type II 3 | | peptidlyarginine deiminase type II 2 | | peptidyl arginine deiminase, type II 2 | | protein arginine deiminase 2 | | protein-arginine deiminase type-2 2 |
|
| | Search outside databases for aliases for PADI2 genePrevious GC identifers: GC01M017130 GC01M016434 GC01M016775 GC01M016776 GC01M017138 |
Summaries for PADI2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PADI2: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq] UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8Function: Catalyzes the deimination of arginine residues of proteins (By similarity)Gene Wiki entry for PADI2 |
Genomic Location for PADI2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PADI2 gene 
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p35.2-p35.1PADI2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M017265:
(about GC identifiers)
Start:
|
17,265,843 bp from pter |
End:
|
17,318,535 bp from pter |
Size:
|
52,693 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004610.18
| Proteins for PADI2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8 (See
protein sequence)Recommended Name: Protein-arginine deiminase type-2 Size: 665 amino acids; 75564 Da
Cofactor: Calcium (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: Q9UPN2REFSEQ proteins: NP_031391.2
ENSEMBL proteins: ENSP00000364630 ENSP00000364635
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for PADI2: Assays for PADI2: | Protein
Domains/ Families for PADI2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y2J8
ProtoNet protein and cluster: Q9Y2J8 1 Blocks protein family: IPB004303 Protein-arginine deiminase
UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8Similarity: Belongs to the protein arginine deiminase family | Gene Function for PADI2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007365
Applied Biosystems Silencer® siRNAs for PADI2
Sigma-Aldrich siRNA for PADI2  Sigma-Aldrich shRNA for PADI2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007365                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007365                                  untagged cDNA clone in CMV expression vector: NM_007365 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007365
UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8Function: Catalyzes the deimination of arginine residues of proteins (By similarity)Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)Enzyme Number (IUBMB): EC 3.5.3.15 1 MGI phenotypic allele for Padi2 (no phenotypes)
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004668 | protein-arginine deiminase activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- | | GO:0016787 | hydrolase activity |
IEA | -- | About this table | Pathways & Interactions for PADI2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for PADI2 
1 Interacting protein for PADI2 (ENSP000003646353) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | protein modification process |
IEA | -- | | GO:0018101 | peptidyl-citrulline biosynthetic process from peptidyl-arginine |
IEA | -- | About this table
|
Drugs & Compounds for PADI2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PADI2
|
Transcripts for PADI2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007365
Sigma-Aldrich siRNA for PADI2  Sigma-Aldrich shRNA for PADI2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007365 REFSEQ mRNAs for PADI2 gene: NM_007365.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007365               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007365                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007365                                  untagged cDNA clone in CMV expression vector: NM_007365  Additional cDNA sequence: AB023211.1 AB030176.1 AK123164.1 AK295783.1 BC009701.1 4 DOTS entries: DT.111082 DT.101979860 DT.95371178 DT.91825782 24/78 AceView cDNA sequences (see all 78
):BQ639564 AA379165 BQ189298 AA873108 AA670309 BX500321 AB023211 BQ233161 BC009701 F31655 AA701093 BE906933 AB030176 BG678750 CK299263 T34748 BM984900 Z28656 BQ711193 BI488709 NM_007365 BV166926 BX114050 AK123164
highest scoring ESTs for PADI2:AB023211 AB030176 BC009701 BE907422 BI757602 BM925667 BQ233161 AA151676 AA442724 AA483340 Unigene Cluster for PADI2: Peptidyl arginine deiminase, type II Hs.33455 [show with all ESTs]Unigene Representative Sequence: NM_007365
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PADI2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for PADI2
2 Ensembl transcripts including schematic representations: ENST00000375481
ENST00000375486
|
Expression for PADI2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PADI2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PADI2
1 / 2 / 3 5 probe-sets matching PADI2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCTCTTCCCC
SOURCE GeneReport for Unigene cluster: Hs.33455
Expression variation in blood from EXPOLDB for PADI2 |
Orthologs for PADI2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PADI2 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for PADI2
ENSEMBL Gene Tree for PADI2 | Paralogs for PADI2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PADI2 gene
- PADI42 PADI12 PADI62 PADI32
|
SNPs/Variants for PADI2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PADI2 (up to first 250kb)
|
Disorders & Mutations for PADI2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607935
|
Medical News for PADI2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PADI2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/21 PubMed articles for PADI2 gene (see all 21
):- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PubMed id 15087120)3, 4 Chavanas S.... Simon M. (2004)
- Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. (PubMed id 12392711)3, 4 Ishigami A....Maruyama N. (2002)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)3, 4 Nagase T....Ohara O. (1999)
- Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase. (PubMed id 2768262)2, 3 Watanabe K. and Senshu T. (1989)
- Increased peptidylarginine deiminase type II in hypoxic astrocytes. (PubMed id 15555572)1, 3 Sambandam T....Nicholas A.P. (2004)
- Comparison of enzymatic properties between hPADI2 and hPADI4. (PubMed id 15629448)1, 3 Nakayama-Hamada M.... Yamamoto K. (2005)
- Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis. (PubMed id 18668562)3 Kinloch A....Venables P.J. (2008)
- Kinetics of human peptidylarginine deiminase 2 (hPAD2)--reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains. (PubMed id 18923545)3 Musse A.A....Harauz G. (2008)
- Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PubMed id 18645041)3 Loos T.... Proost P. (2008)
|
Search for PADI2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PADI2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PADI2
(According to HUGE)
About This Section
| |
Specialized Databases showing PADI2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PADI2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PADI2:

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Incremental update: 13 Oct 2009
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