Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PADI2 Gene

protein-coding   GIFtS: 59
GCID: GC01M017393

Peptidyl Arginine Deiminase, Type II

  See PADI2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Peptidyl Arginine Deiminase, Type II1 2     PAD22
Protein-Arginine Deiminase Type II2 3     Protein-Arginine Deiminase Type-22
PAD-H192 3     KIAA09943
PDI22 3     Peptidylarginine Deiminase II3
EC 3.5.3.153 8     

External Ids:    HGNC: 183411   Entrez Gene: 112402   Ensembl: ENSG000001171157   OMIM: 6079355   UniProtKB: Q9Y2J83   

Export aliases for PADI2 gene to outside databases

Previous GC identifers: GC01M017130 GC01M016434 GC01M016775 GC01M016776 GC01M017138 GC01M017265 GC01M015637


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PADI2 Gene:
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the
post-translational deimination of proteins by converting arginine residues into citrullines in the presence of
calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns.
The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin
basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is
thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer
disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a
cluster with four other paralogous genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for PADI2 Gene:
PADI2 (peptidyl arginine deiminase, type II) is a protein-coding gene. Diseases associated with PADI2 include multiple sclerosis, and alzheimer's disease. GO annotations related to this gene include protein-arginine deiminase activity and calcium ion binding. An important paralog of this gene is PADI4.

UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8
Function: Catalyzes the deimination of arginine residues of proteins (By similarity)

Gene Wiki entry for PADI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PADI2 gene promoter:
         AhR   Max1   NF-1   NF-1/L   Sp1   RREB-1   E47   Arnt   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPADI2 promoter sequence
   Search Chromatin IP Primers for PADI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PADI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p35.2-p35.1

PADI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PADI2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M017393:  view genomic region     (about GC identifiers)

Start:
17,393,256 bp from pter      End:
17,445,948 bp from pter
Size:
52,693 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8 (See protein sequence)
Recommended Name: Protein-arginine deiminase type-2  
Size: 665 amino acids; 75564 Da
Cofactor: Calcium (By similarity)
Sequence caution: Sequence=BAA76838.1; Type=Erroneous initiation;
Secondary accessions: Q9UPN2

Explore the universe of human proteins at neXtProt for PADI2: NX_Q9Y2J8

Explore proteomics data for PADI2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PADI2 (Q9Y2J8) (see all 5)
     VSPPVTV  APWIMTP  AQQVQAPV  LGIPKPFGP 


    See PADI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031391.2  
    ENSEMBL proteins: 
     ENSP00000364635   ENSP00000364630   ENSP00000405894  

    PADI2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PADI2
    OriGene Protein Over-expression Lysate for PADI2
    OriGene MassSpec for PADI2
    OriGene Custom Protein Services for PADI2
    GenScript Custom Purified and Recombinant Proteins Services for PADI2
    Novus Biologicals PADI2 Protein
    Novus Biologicals PADI2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PADI2

     
    Search eBioscience for Proteins for PADI2 

    PADI2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PADI2
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PADI2
    Novus Biologicals PADI2 Antibodies
    Abcam antibodies for PADI2 (Q9Y2J8, Q96DA7)
    Cloud-Clone Corp. Antibodies for PADI2
    ThermoFisher Antibodies for PADI2
    LSBio Antibodies in human, mouse, rat for PADI2

    PADI2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PADI2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PADI2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PADI2
    Cloud-Clone Corp. CLIAs for PADI2
    Search eBioscience for ELISAs for PADI2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PADI: Peptidyl arginine deiminases

    Selected InterPro protein domains (see all 6):
     IPR013733 Prot_Arg_deaminase_cen_dom
     IPR013732 PAD_N
     IPR008972 Cupredoxin
     IPR004303 PAD
     IPR016296 Protein-arginine_deiminase_sub

    Graphical View of Domain Structure for InterPro Entry Q9Y2J8

    ProtoNet protein and cluster: Q9Y2J8

    1 Blocks protein domain: IPB004303 Protein-arginine deiminase

    UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8
    Similarity: Belongs to the protein arginine deiminase family


    Find genes that share domains with PADI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PADI2_HUMAN, Q9Y2J8
    Function: Catalyzes the deimination of arginine residues of proteins (By similarity)
    Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)

         Enzyme Number (IUBMB): EC 3.5.3.151 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004668protein-arginine deiminase activity IDA12392711
    GO:0005509calcium ion binding IEA--
    GO:0030331estrogen receptor binding IPI--
         
    Find genes that share ontologies with PADI2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Padi2):
     hematopoietic system  immune system 

    Find genes that share phenotypes with PADI2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PADI2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PADI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PADI2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PADI2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PADI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PADI2 (see all 29):
    hsa-miR-328 hsa-miR-19b-2* hsa-miR-507 hsa-miR-766 hsa-miR-3150a-3p hsa-miR-629* hsa-miR-3116 hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidPADI2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PADI2
    Predesigned siRNA for gene silencing in human, mouse, rat PADI2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PADI2

    Clone
    Products:
         
    OriGene clones in human, mouse for PADI2 (see all 8)
    OriGene ORF clones in mouse, rat for PADI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PADI2 (NM_007365)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PADI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PADI2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PADI2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PADI2_HUMAN, Q9Y2J8: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    cytoskeleton1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12392711
    GO:0035327transcriptionally active chromatin IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PADI2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PADI2
    Interactions:

        GeneGlobe Interaction Network for PADI2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PADI2 (Q9Y2J83 ENSP000003646354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0010848regulation of chromatin disassembly IDA--
    GO:0018101protein citrullination IDA12392711
    GO:0021762substantia nigra development IEP--
    GO:0030520intracellular estrogen receptor signaling pathway IMP--

    Find genes that share ontologies with PADI2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PADI2

    3 HMDB Compounds for PADI2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PADI2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--15854045



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PADI2 gene: 
    NM_007365.2  

    Unigene Cluster for PADI2:

    Peptidyl arginine deiminase, type II
    Hs.33455  [show with all ESTs]
    Unigene Representative Sequence: NM_007365
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375486(uc001baf.3 uc010ocm.2) ENST00000479534 ENST00000466151
    ENST00000375481(uc001bag.1) ENST00000444885
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PADI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PADI2 (see all 29):
    hsa-miR-328 hsa-miR-19b-2* hsa-miR-507 hsa-miR-766 hsa-miR-3150a-3p hsa-miR-629* hsa-miR-3116 hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidPADI2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PADI2
    Predesigned siRNA for gene silencing in human, mouse, rat PADI2
    Clone
    Products:
         
    OriGene clones in human, mouse for PADI2 (see all 8)
    OriGene ORF clones in mouse, rat for PADI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PADI2 (NM_007365)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PADI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PADI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PADI2
      QuantiTect SYBR Green Assays in human, mouse, rat PADI2
      QuantiFast Probe-based Assays in human, mouse, rat PADI2

    Additional mRNA sequence: 

    AB023211.1 AB030176.1 AK123164.1 AK295783.1 BC009701.1 

    4 DOTS entries:

    DT.111082  DT.101979860  DT.95371178  DT.91825782 

    Selected AceView cDNA sequences (see all 78):

    BQ189298 AA701093 BX500321 AB023211 AA873108 BQ639564 AA670309 BC009701 
    F31655 BQ233161 AA379165 AK127006 AB030176 T34748 BG678750 BQ711193 
    BI041939 BG741069 BE089551 BV173911 F32047 NM_007365 Z28656 BV166926 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PADI2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                    -     -                             -                       -                 -                                       
    SP2:                    -     -                             -                       -                                                         
    SP3:                                                                                                  -                                       
    SP4:                                                                                -                                                         
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for PADI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PADI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTTCCCC
    PADI2 Expression
    About this image


    PADI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
     
     Colon (Gastrointestinal Tract)
    PADI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PADI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.33455
        Custom PCR Arrays for PADI2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PADI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PADI2
    QuantiTect SYBR Green Assays in human, mouse, rat PADI2
    QuantiFast Probe-based Assays in human, mouse, rat PADI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PADI2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Padi21 , 5 peptidyl arginine deiminase, type II1, 5 88.02(n)1
    93.23(a)1
      4 (73.01 cM)5
    186001  NM_008812.21  NP_032838.21 
     1409063445 
    chicken
    (Gallus gallus)
    Aves PADI21 peptidyl arginine deiminase, type II 70.44(n)
    68.78(a)
      428172  XM_425730.4  XP_425730.3 
    lizard
    (Anolis carolinensis)
    Reptilia PADI26
    peptidyl arginine deiminase, type II
    79(a)
    1 ↔ 1
    AAWZ02037362(4-16958)
    African clawed frog
    (Xenopus laevis)
    Amphibia padi2-prov2 peptidyl arginine deiminase, type 2 75.75(n)    BC046745.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb9682 sbcb968 76.7(n)   386792  BC057513.1 


    ENSEMBL Gene Tree for PADI2 (if available)
    TreeFam Gene Tree for PADI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PADI2 gene
    PADI42  PADI12  PADI32  
    4 SIMAP similar genes for PADI2 using alignment to 3 protein entries:     PADI2_HUMAN (see all proteins):
    PADI3    PADI1    PADI4    PADI6

    Find genes that share paralogs with PADI2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PADI2 (see all 1362)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27465341,2
    C,F,A,H--17392951(-) tggccG/Agcgca 1 -- ds500110Minor allele frequency- A:0.06NS EA NA WA CSA 666
    rs121345821,2
    C,F,A,H--17392980(+) GTTCCT/CGAATG 1 -- ds500126Minor allele frequency- C:0.44NS EA NA WA CSA 2774
    rs1822802881,2
    --17393016(+) AACCCA/CATCAG 1 -- ds50010--------
    rs1859763301,2
    --17393324(+) GATCTC/TCACCA 1 -- ut310--------
    rs748472601,2
    C,F--17393475(+) CCTACA/CTTTAT 1 -- ut311Minor allele frequency- C:0.02EA 120
    rs1909849931,2
    --17393492(+) TGGGGG/TTGGGG 1 -- ut310--------
    rs350233931,2
    C--17393698(+) AGACT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs7192621,2
    C,A--17393709(+) AAAAAA/GAAAAA 1 -- ut31 trp36Minor allele frequency- G:0.00NA WA CSA 10
    rs1995391701,2
    C--17393709(+) aaaaa-/Gaaaaa 1 -- ut310--------
    rs75159261,2
    A--17393713(+) agaaaA/Gaaaag 1 -- ut31 trp30--------

    HapMap Linkage Disequilibrium report for PADI2 (17393256 - 17445948 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PADI2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422314CNV Duplication17116639
    esv274605CNV Insertion20981092
    esv269737CNV Insertion20981092
    nsv460662CNV Loss19166990
    nsv834280CNV Loss17160897
    nsv428421CNV Gain+Loss18775914
    dgv40e1CNV Complex17122850
    dgv29e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PADI2
    DNA2.0 Custom Variant and Variant Library Synthesis for PADI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607935    OMIM disorders: --

    2 diseases for PADI2:    
    About MalaCards
    multiple sclerosis    alzheimer's disease


    Find genes that share disorders with PADI2           About GenesLikeMe

    Genetic Association Database (GAD): PADI2
    Human Genome Epidemiology (HuGE) Navigator: PADI2 (2 documents)

    Export disorders for PADI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PADI2 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with PADI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. A two-stage case-control association study of PADI2 with schizophrenia. (PubMed id 19478818)1, 4 Watanabe Y....Someya T. (J. Hum. Genet. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PubMed id 15087120)1, 2 Chavanas S.... Simon M. (Gene 2004)
    5. Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. (PubMed id 12392711)1, 2 Ishigami A....Maruyama N. (Arch. Biochem. Biophys. 2002)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    7. Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase. (PubMed id 2768262)1, 3 Watanabe K. and Senshu T. (J. Biol. Chem. 1989)
    8. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. (PubMed id 15854045)7, 9 Dong S....Takahara H. (J. Invest. Dermatol. 2005)
    9. Increased peptidylarginine deiminase type II in hypoxic astrocytes. (PubMed id 15555572)1, 9 Sambandam T....Nicholas A.P. (Biochem. Biophys. Res. Commun. 2004)
    10. Comparison of enzymatic properties between hPADI2 and hPADI4. (PubMed id 15629448)1, 9 Nakayama-Hamada M.... Yamamoto K. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11240 HGNC: 18341 AceView: PADI2 Ensembl:ENSG00000117115 euGenes: HUgn11240
    ECgene: PADI2 H-InvDB: PADI2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0994

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PADI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PADI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PADI2 gene:
    Search GeneIP for patents involving PADI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for PADI2 (PADI2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PADI2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PADI2  
     OriGene MassSpec something-or-other for PADI2   OriGene clones in human, mouse for PADI2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PADI2   OriGene Purified Protein for PADI2  
     OriGene ORF clones in mouse, rat for PADI2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PADI2   OriGene Custom Protein Services for PADI2  

     
     
     Block miRNA regulation of human, mouse, rat PADI2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PADI2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PADI2 Predesigned siRNA for gene silencing in human, mouse, rat PADI2
     QuantiFast Probe-based Assays in human, mouse, rat PADI2 QuantiTect SYBR Green Assays in human, mouse, rat PADI2
     Custom PCR Arrays for PADI2 Search Chromatin IP Primers for PADI2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PADI2  GeneGlobe Interaction Network for PADI2
     Regulatory tfbs in PADI2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PADI2 GenScript cDNA clones with any tag delivered in your preferred vector for PADI2
     GenScript Custom Assay Services for PADI2 GenScript Custom overexpressing Cell Line Services for PADI2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PADI2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PADI2 antibodies
     PADI2 proteins
     PADI2 lysates
     Antibodies for PADI2
     See all of Abcam's Antibodies, Kits and Proteins for PADI2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PADI2
     Antibodies for PADI2
     ELISAs for PADI2
     CLIAs for PADI2



     Browse ESI BIO Cell Lines and PureStem Progenitors for PADI2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI2
     SwitchGear 3'UTR luciferase reporter plasmids for PADI2
     SwitchGear Promoter luciferase reporter plasmids for PADI2
     ThermoFisher Antibodies for PADI2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PADI2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PADI2
     LSBio Antibodies in human, mouse, rat for PADI2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PADI2
      Search eBioscience for proteins for PADI2
      Search eBioscience for elisas for PADI2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PADI2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4