Aliases for PADI2 Gene
External Ids for PADI2 Gene
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for PADI2 Gene
PADI2 (Peptidyl Arginine Deiminase, Type II) is a Protein Coding gene. Diseases associated with PADI2 include alzheimer disease. GO annotations related to this gene include calcium ion binding and protein-arginine deiminase activity. An important paralog of this gene is PADI3.
UniProtKB/Swiss-Prot for PADI2 Gene
Catalyzes the deimination of arginine residues of proteins.