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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PADI2 Gene

protein-coding   GIFtS: 61
GCID: GC01M017393

peptidyl arginine deiminase, type II
 Explore 9 diseases affiliated with
PADI2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PADI2    

Aliases
for PADI2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Peptidyl Arginine Deiminase, Type II1 2     EC 3.5.3.153 8
PDI21 2 3     PAD22
KIAA09941 3     Peptidlyarginine Deiminase Type II2
Peptidylarginine Deiminase II2 3     Protein Arginine Deiminase2
Protein-Arginine Deiminase Type II2 3     Protein-Arginine Deiminase Type-22
PAD-H192 3     

External Ids:    HGNC: 183411   Entrez Gene: 112402   Ensembl: ENSG000001171157   OMIM: 6079355   UniProtKB: Q9Y2J83   

Export aliases for PADI2 gene to outside databases

Previous GC identifers: GC01M017130 GC01M016434 GC01M016775 GC01M016776 GC01M017138 GC01M017265 GC01M015637


Summaries
for PADI2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PADI2:
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational
deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family
members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most
widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous
system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and
progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also
been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8
Function: Catalyzes the deimination of arginine residues of proteins (By similarity)

Gene Wiki entry for PADI2


Genomic Views
for PADI2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PADI2 gene promoter:
         AhR   Max1   NF-1   NF-1/L   Sp1   RREB-1   E47   Arnt   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PADI2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PADI2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PADI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p35.2-p35.1

PADI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PADI2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M017393:  view genomic region     (about GC identifiers)

Start:
 17,393,256 bp from pter      End:
 17,445,948 bp from pter
Size:
 52,693 bases      Orientation:
 minus strand

Proteins
for PADI2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8 (See protein sequence)
Recommended Name: Protein-arginine deiminase type-2  
Size: 665 amino acids; 75564 Da
Cofactor: Calcium (By similarity)
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAA76838.1; Type=Erroneous initiation;
Secondary accessions: Q9UPN2

Explore the universe of human proteins at neXtProt for PADI2: NX_Q9Y2J8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2J8

    • 4/5 DME Specific Peptides for PADI2 (Q9Y2J8) (see all 5)
     VSPPVTV  APWIMTP  AQQVQAPV  LGIPKPFGP 

    PADI2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_031391.2  
    ENSEMBL proteins: 
     ENSP00000364635   ENSP00000364630   ENSP00000405894  

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    Novus Biologicals PADI2 Protein
    Novus Biologicals PADI2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PADI2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    PADI2 for ontologies           About GeneDecksing



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    Uscn Antibodies for PADI2
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    Uscn ELISAs and CLIAs for PADI2

    Protein Domains /
    Families
    for PADI2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PADI2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013733 Prot_Arg_deaminase_cen_dom
     IPR013732 PAD_N
     IPR008972 Cupredoxin
     IPR004303 PAD
     IPR016296 Protein-arginine_deiminase_sub

    Graphical View of Domain Structure for InterPro Entry Q9Y2J8

    ProtoNet protein and cluster: Q9Y2J8

    1 Blocks protein family: IPB004303 Protein-arginine deiminase

    UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8
    Similarity: Belongs to the protein arginine deiminase family


    Function
    for PADI2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PADI2_HUMAN, Q9Y2J8
    Function: Catalyzes the deimination of arginine residues of proteins (By similarity)
    Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)

    Enzyme Number (IUBMB): EC 3.5.3.151 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PADI2
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate PADI2 (see all 29):
    hsa-miR-328 hsa-miR-19b-2* hsa-miR-507 hsa-miR-766 hsa-miR-3150a-3p hsa-miR-629* hsa-miR-3116 hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: PADI2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PADI2 (see all 7)
    OriGene shRNA RFP: PADI2
    OriGene siRNA: PADI2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PADI2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PADI2

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for PADI2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004668protein-arginine deiminase activity IEA--
    GO:0005509calcium ion binding IEA--


    PADI2 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Padi2):
     immune system 

    PADI2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PADI2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1protein citrullination
    		protein citrullination1.00


    1 BioSystems Pathway for PADI2 
        protein citrullination


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PADI2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PADI2 (Q9Y2J83 ENSP000003646354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0018101peptidyl-citrulline biosynthetic process from peptidyl-arginine IEA--


    PADI2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PADI2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PADI2

    3 HMDB Compounds for PADI2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PADI2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--15854045

    Search CenterWatch for drugs/clinical trials and news about PADI2 

    Transcripts
    for PADI2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PADI2 gene: 
    NM_007365.2  

    Unigene Cluster for PADI2:

    Peptidyl arginine deiminase, type II
    Hs.33455  [show with all ESTs]
    Unigene Representative Sequence: NM_007365
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375486(uc001baf.3 uc010ocm.2) ENST00000479534 ENST00000466151
    ENST00000375481(uc001bag.1) ENST00000444885

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PADI2
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate PADI2 (see all 29):
    hsa-miR-328 hsa-miR-19b-2* hsa-miR-507 hsa-miR-766 hsa-miR-3150a-3p hsa-miR-629* hsa-miR-3116 hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: PADI2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PADI2 (see all 7)
    OriGene shRNA RFP: PADI2
    OriGene siRNA: PADI2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PADI2
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PADI2
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    Additional cDNA sequence: 

    AB023211.1 AB030176.1 AK123164.1 AK295783.1 BC009701.1 

    4 DOTS entries:

    DT.111082  DT.101979860  DT.95371178  DT.91825782 

    24/78 AceView cDNA sequences (see all 78):

    AA873108 AB023211 BX500321 F31655 BQ233161 BQ189298 AA379165 BQ639564 
    AA670309 AA701093 BC009701 BG741069 BX452760 BM984900 BE906933 AB030176 
    BV166926 BI488709 BX114050 BE907422 AK123164 CK299263 BE089551 AA988751 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PADI2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                    -     -                             -                       -                 -                                       
    SP2:                    -     -                             -                       -                                                         
    SP3:                                                                                                  -                                       
    SP4:                                                                                -                                                         
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for PADI2

    Expression
    for PADI2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PADI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTCTTCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PADI2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PADI2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PADI2

    SOURCE GeneReport for Unigene cluster: Hs.33455
        SABiosciences Custom PCR Arrays for PADI2
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    In Situ
    Assay Products:     
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    Orthologs
    for PADI2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PADI2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PADI21 peptidyl arginine deiminase, type II 70.54(n)
    68.78(a)    		   428172  XM_425730.3  XP_425730.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PADI26
    		 --
    		 79(a)
    		 1 ↔ 1
    		 AAWZ02037362(4-16958)
    African clawed frog
    (Xenopus laevis)    		 Amphibia padi2-prov2 peptidyl arginine deiminase, type 2 75.75(n)    BC046745.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb9682 sbcb968 76.7(n)   386792  BC057513.1 


    ENSEMBL Gene Tree for PADI2 (if available)
    TreeFam Gene Tree for PADI2 (if available) 

    Paralogs
    for PADI2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PADI2 gene
    PADI42  PADI12  PADI32  
    4 SIMAP similar genes for PADI2 using alignment to 3 protein entries:     PADI2_HUMAN (see all proteins):
    PADI3    PADI1    PADI4    PADI6

    PADI2 for paralogs           About GeneDecksing



    Genomic Variants
    for PADI2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1135 NCBI SNPs in PADI2 are shown (see all 1135)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs27465341,2
    		C,F,A,H,--17392951(-) tggccG/Agcgca 1 -- ds500110Minor allele frequency- A:0.06NS EA NA WA CSA 666
    rs121345821,2
    		C,F,A,H,--17392980(+) GTTCCT/CGAATG 1 -- ds500126Minor allele frequency- C:0.44NS EA NA WA CSA 2774
    rs1822802881,2
    		--17393016(+) AACCCA/CATCAG 1 -- ds50010--------
    rs1859763301,2
    		--17393324(+) GATCTC/TCACCA 1 -- ut310--------
    rs748472601,2
    		C,F,--17393475(+) CCTACA/CTTTAT 1 -- ut311Minor allele frequency- C:0.02EA 120
    rs1909849931,2
    		--17393492(+) TGGGGG/TTGGGG 1 -- ut310--------
    rs350233931,2
    		C--17393698(+) AGACT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1138928911,2
    		C--17393709(+) AAAAAA/GAAAAA 1 -- ut313Minor allele frequency- G:0.00NA CSA 4
    rs1995391701,2
    		--17393709(+) AAAAA-/GAAAAA 1 -- ut310--------
    rs75159261,2
    		A--17393713(+) agaaaA/Gaaaag 1 -- ut31 trp30--------

    HapMap Linkage Disequilibrium report for PADI2 (17393256 - 17445948 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PADI2
         3 CNVs: 5200 4212 3284

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    Disorders / Diseases
    for PADI2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PADI2 for disorders           About GeneDecksing

    OMIM gene information: 607935    OMIM disorders: --

    9 diseases for PADI2:    About MalaCards
    glaucoma    multiple sclerosis    alzheimer's disease    hereditary night blindness
    night blindness    rheumatoid arthritis    arthritis    blindness
    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: PADI2 (2 documents)

    Export disorders for PADI2 gene to outside databases

    Publications
    for PADI2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PADI2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with PADI2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PubMed id 15087120)1, 2 Chavanas S.... Simon M. (2004)
    3. Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. (PubMed id 12392711)1, 2 Ishigami A....Maruyama N. (2002)
    4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    5. Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase. (PubMed id 2768262)1, 3 Watanabe K. and Senshu T. (1989)
    6. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. (PubMed id 15854045)7, 9 Dong S....Takahara H. (2005)
    7. Increased peptidylarginine deiminase type II in hypoxic astrocytes. (PubMed id 15555572)1, 9 Sambandam T....Nicholas A.P. (2004)
    8. Comparison of enzymatic properties between hPADI2 and hPADI4. (PubMed id 15629448)1, 9 Nakayama-Hamada M.... Yamamoto K. (2005)
    9. Comparative analysis of peptidylarginine deiminase-2 e xpression in canine, feline and human mammary tumours. (PubMed id 22520816)1 Cherrington B.D....Wakshlag J.J. (2012)
    10. Contact with stimulated T cells up-regulates expressio n of peptidylarginine deiminase 2 and 4 by human monocytes. (PubMed id 22614825)1 Ferrari-Lacraz S....Dayer J.M. (2012)

    External Searches for PADI2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing PADI2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11240 HGNC: 18341 AceView: PADI2 Ensembl:ENSG00000117115 euGenes: HUgn11240
    ECgene: PADI2 H-InvDB: PADI2

    Other Databases showing PADI2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0994

    Specialized Databases showing PADI2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PADI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PADI2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PADI2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PADI2 gene:
    Search GeneIP for patents involving PADI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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