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Aliases & Descriptions for PADI1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.5.3.15 3 | | HPAD10 1, 2 | | OTTHUMP00000002401 2 | | PAD1 1, 2 | | PDI 1, 2 | | PDI1 1, 2, 3 |
| | | Descriptions |
|---|
| Peptidylarginine deiminase I 3 | | Protein-arginine deiminase type I 3 | | hPAD-colony 10 2 | | peptidyl arginine deiminase, type I 2 | | peptidylarginine deiminase type I 2 | | protein-arginine deiminase type-1 2 |
|
| | Search outside databases for aliases for PADI1 genePrevious GC identifers: GC01P017269 GC01P016572 GC01P016912 GC01P017276 |
Summaries for PADI1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PADI1: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq] UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6Function: Catalyzes the deimination of arginine residues of proteins (By similarity)Gene Wiki entry for PADI1 |
Genomic Location for PADI1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PADI1 gene 
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13PADI1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P017404:
(about GC identifiers)
Start:
|
17,404,208 bp from pter |
End:
|
17,445,088 bp from pter |
Size:
|
40,881 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004610.18
| Proteins for PADI1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6 (See
protein sequence)Recommended Name: Protein-arginine deiminase type-1 Size: 663 amino acids; 74666 Da
Cofactor: Calcium (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: Q70SX6REFSEQ proteins: NP_037490.2
ENSEMBL proteins: ENSP00000364620
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for PADI1: Assays for PADI1: | Protein
Domains/ Families for PADI1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9ULC6
ProtoNet protein and cluster: Q9ULC6 1 Blocks protein family: IPB004303 Protein-arginine deiminase
UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6Similarity: Belongs to the protein arginine deiminase family | Gene Function for PADI1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013358
Applied Biosystems Silencer® siRNAs for PADI1
Sigma-Aldrich siRNA for PADI1  Sigma-Aldrich shRNA for PADI1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_013358                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_013358                                  untagged cDNA clone in CMV expression vector: NM_013358 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_013358
UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6Function: Catalyzes the deimination of arginine residues of proteins (By similarity)Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)Enzyme Number (IUBMB): EC 3.5.3.15 3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004668 | protein-arginine deiminase activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- | | GO:0016787 | hydrolase activity |
IEA | -- | About this table | Pathways & Interactions for PADI1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for PADI1 
2 Interacting proteins for PADI1 (ENSP000003646203) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | protein modification process |
IEA | -- | | GO:0018101 | peptidyl-citrulline biosynthetic process from peptidyl-arginine |
IEA | -- | About this table
|
Drugs & Compounds for PADI1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PADI1
|
Transcripts for PADI1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013358
Sigma-Aldrich siRNA for PADI1  Sigma-Aldrich shRNA for PADI1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_013358 REFSEQ mRNAs for PADI1 gene: NM_013358.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_013358               OriGene GFP tagged cDNA clone in CMV expression vector: NM_013358                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_013358                                  untagged cDNA clone in CMV expression vector: NM_013358  Additional cDNA sequence: AB033768.2 AK026652.1 AK225541.1 AK293275.1 AK298538.1 AK298892.1 AK309106.1 AK314644.1 BC130574.1 BC136402.1 4 DOTS entries: DT.204987 DT.121405147 DT.101976294 DT.95127162 22 AceView cDNA sequences:AW192295 BX284037 AI367538 AK127515 AI378607 AL698692 BQ641703 AA495868 BM781897 AI738723 BM008704 NM_013358 AB033768 AA912338 BM050686 BF509503 BG680542 AK026652 AI685069 AI126015 AI129820 BF757553
highest scoring ESTs for PADI1:AI685069 AA495868 AA912338 AB033768 AI126015 AI129820 AI367538 AI378607 AK026652 AW192295 Unigene Cluster for PADI1: Peptidyl arginine deiminase, type I Hs.412941 [show with all ESTs]Unigene Representative Sequence: AK026652
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PADI1 (see all 6
)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18a | · | 18b | |
| SP1: | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for PADI1
1 Ensembl transcript including schematic representation: ENST00000375471
|
Expression for PADI1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PADI1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PADI1
1 / 2 / 3 5 probe-sets matching PADI1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CATTTCTTAA
SOURCE GeneReport for Unigene cluster: Hs.412941 UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6Tissue specificity: Epidermis, prostate, testis, placenta, spleen and thymus |
Orthologs for PADI1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PADI1 gene from 5 species
About this table Species with no ortholog for PADI1
ENSEMBL Gene Tree for PADI1 | Paralogs for PADI1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PADI1 gene
- PADI22 PADI42 PADI62 PADI32
|
SNPs/Variants for PADI1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PADI1 (up to first 250kb)
|
Disorders & Mutations for PADI1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607934
|
Medical News for PADI1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PADI1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for PADI1 gene (see all 18
):- cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I. (PubMed id 12416996)1, 2, 3, 4 Guerrin M.... Serre G. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PubMed id 15087120)3, 4 Chavanas S.... Simon M. (2004)
- Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes. (PubMed id 17851584)1, 3 Dong S....Takahara H. (2008)
- Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. (PubMed id 18669583)1, 3 Chen C....Zhao L.P. (2008)
- Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. (PubMed id 18710930)3 Proost P....Van Damme J. (2008)
- Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis. (PubMed id 16973334)3 Chavanas S....Simon M. (2006)
- The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations. (PubMed id 16091842)3 Mechin M.C....Simon M. (2005)
- Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin. (PubMed id 15675958)3 Nachat R....Simon M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
|
Search for PADI1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PADI1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PADI1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PADI1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PADI1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PADI1:

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Incremental update: 13 Oct 2009
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