Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PADI1 Gene

protein-coding   GIFtS: 55
GCID: GC01P017531

Peptidyl Arginine Deiminase, Type I

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Peptidyl Arginine Deiminase, Type I1 2     EC 3.5.3.153 8
HPAD-Colony 101 2     Peptidylarginine Deiminase Type I1
Protein-Arginine Deiminase Type-11 2     HPAD102
Peptidylarginine Deiminase I2 3     PAD12
Protein-Arginine Deiminase Type I2 3     PDI2
PDI12 3     

External Ids:    HGNC: 183671   Entrez Gene: 299432   Ensembl: ENSG000001426237   OMIM: 6079345   UniProtKB: Q9ULC63   

Export aliases for PADI1 gene to outside databases

Previous GC identifers: GC01P017269 GC01P016572 GC01P016912 GC01P017276 GC01P017404 GC01P015775


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PADI1 Gene:
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the
post-translational deimination of proteins by converting arginine residues into citrullines in the presence of
calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns.
The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and
keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This
enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous
genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for PADI1 Gene:
PADI1 (peptidyl arginine deiminase, type I) is a protein-coding gene. Diseases associated with PADI1 include epidermolytic hyperkeratosis, and oral squamous cell carcinoma. GO annotations related to this gene include protein-arginine deiminase activity and calcium ion binding. An important paralog of this gene is PADI2.

UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6
Function: Catalyzes the deimination of arginine residues of proteins (By similarity)

Gene Wiki entry for PADI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PADI1 gene promoter:
         COUP-TF1   Sp1   COUP   HNF-4alpha2   HNF-4alpha1   GATA-2   AREB6   COUP-TF   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPADI1 promoter sequence
   Search Chromatin IP Primers for PADI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PADI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

PADI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PADI1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P017531:  view genomic region     (about GC identifiers)

Start:
17,531,621 bp from pter      End:
17,572,501 bp from pter
Size:
40,881 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6 (See protein sequence)
Recommended Name: Protein-arginine deiminase type-1  
Size: 663 amino acids; 74666 Da
Cofactor: Calcium (By similarity)
Secondary accessions: A1L4K6 Q70SX6

Explore the universe of human proteins at neXtProt for PADI1: NX_Q9ULC6

Explore proteomics data for PADI1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PADI1 (Q9ULC6) (see all 11)
     VSPPVTV  LASPSAC  APWIMTP  PTHAVCV 


    See PADI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037490.2  
    ENSEMBL proteins: 
     ENSP00000364620   ENSP00000444032   ENSP00000396697   ENSP00000444833  

    PADI1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PADI1
    OriGene Protein Over-expression Lysate for PADI1
    OriGene MassSpec for PADI1
    OriGene Custom Protein Services for PADI1
    GenScript Custom Purified and Recombinant Proteins Services for PADI1
    Novus Biologicals PADI1 Protein
    Novus Biologicals PADI1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PADI1

    PADI1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PADI1
    Novus Biologicals PADI1 Antibodies
    Abcam antibodies for PADI1
    Cloud-Clone Corp. Antibodies for PADI1
    ThermoFisher Antibodies for PADI1
    LSBio Antibodies in human, mouse, rat for PADI1

    PADI1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PADI1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PADI1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PADI1
    Cloud-Clone Corp. CLIAs for PADI1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PADI: Peptidyl arginine deiminases

    Selected InterPro protein domains (see all 6):
     IPR013733 Prot_Arg_deaminase_cen_dom
     IPR013732 PAD_N
     IPR008972 Cupredoxin
     IPR004303 PAD
     IPR016296 Protein-arginine_deiminase_sub

    Graphical View of Domain Structure for InterPro Entry Q9ULC6

    ProtoNet protein and cluster: Q9ULC6

    1 Blocks protein domain: IPB004303 Protein-arginine deiminase

    UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6
    Similarity: Belongs to the protein arginine deiminase family


    PADI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PADI1_HUMAN, Q9ULC6
    Function: Catalyzes the deimination of arginine residues of proteins (By similarity)
    Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)

         Enzyme Number (IUBMB): EC 3.5.3.151 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004668protein-arginine deiminase activity IEA--
    GO:0005509calcium ion binding IEA--
         
    PADI1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PADI1:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PADI1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PADI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PADI1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PADI1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PADI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PADI1 (see all 10):
    hsa-miR-330-5p hsa-miR-520a-5p hsa-miR-877* hsa-miR-637 hsa-miR-525-5p hsa-miR-326 hsa-miR-4310 hsa-miR-532-3p
    SwitchGear 3'UTR luciferase reporter plasmidPADI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PADI1
    Predesigned siRNA for gene silencing in human, mouse, rat PADI1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PADI1

    Clone
    Products:
         
    OriGene clones in human, mouse for PADI1 (see all 5)
    OriGene ORF clones in mouse, rat for PADI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PADI1 (NM_013358)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PADI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PADI1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PADI1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PADI1_HUMAN, Q9ULC6: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    PADI1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PADI1 About    
    See pathways by source

    SuperPathContained pathways About
    1protein citrullination
    protein citrullination


    1 BioSystems Pathway for PADI1
        protein citrullination


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PADI1
    Interactions:

        GeneGlobe Interaction Network for PADI1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PADI1 (Q9ULC63 ENSP000003646204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0018101protein citrullination IEA--

    PADI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PADI1

    3 HMDB Compounds for PADI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PADI1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--15150696



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PADI1 gene: 
    NM_013358.2  

    Unigene Cluster for PADI1:

    Peptidyl arginine deiminase, type I
    Hs.412941  [show with all ESTs]
    Unigene Representative Sequence: AK026652
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375471(uc001bah.1 uc010oco.1 uc010ocp.1 uc010ocq.1)
    ENST00000483501 ENST00000460293(uc009vpb.1) ENST00000537499 ENST00000413717
    ENST00000536552
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PADI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PADI1 (see all 10):
    hsa-miR-330-5p hsa-miR-520a-5p hsa-miR-877* hsa-miR-637 hsa-miR-525-5p hsa-miR-326 hsa-miR-4310 hsa-miR-532-3p
    SwitchGear 3'UTR luciferase reporter plasmidPADI1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PADI1
    Predesigned siRNA for gene silencing in human, mouse, rat PADI1
    Clone
    Products:
         
    OriGene clones in human, mouse for PADI1 (see all 5)
    OriGene ORF clones in mouse, rat for PADI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PADI1 (NM_013358)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PADI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PADI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PADI1
      QuantiTect SYBR Green Assays in human, mouse, rat PADI1
      QuantiFast Probe-based Assays in human, mouse, rat PADI1

    Additional mRNA sequence: 

    AB033768.2 AK026652.1 AK225541.1 AK293275.1 AK298538.1 AK298892.1 AK309106.1 AK314644.1 
    BC130574.1 BC136402.1 

    4 DOTS entries:

    DT.204987  DT.121405147  DT.101976294  DT.95127162 

    22 AceView cDNA sequences:

    AW192295 AK127515 BQ641703 AI367538 AI378607 AL698692 BX284037 BM050686 
    AI685069 AA495868 BF509503 AI126015 BG680542 BM781897 AA912338 AI738723 
    AK026652 NM_013358 AB033768 BM008704 AI129820 BF757553 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PADI1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
    SP1:        -           -     -                             -                                               -     -                           
    SP2:                    -     -                                                                                                               
    SP3:                                                                                                                                          
    SP4:        -                                                                                                                                 
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for PADI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PADI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTCTTAA
    PADI1 Expression
    About this image

    PADI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PADI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412941

    UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6
    Tissue specificity: Epidermis, prostate, testis, placenta, spleen and thymus

        Custom PCR Arrays for PADI1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PADI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PADI1
    QuantiTect SYBR Green Assays in human, mouse, rat PADI1
    QuantiFast Probe-based Assays in human, mouse, rat PADI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PADI1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Padi11 , 5 peptidyl arginine deiminase, type I1, 5 78.65(n)1
    77.04(a)1
      4 (72.62 cM)5
    185991  NM_011059.21  NP_035189.11 
     1408129835 
    chicken
    (Gallus gallus)
    Aves PADI11 peptidyl arginine deiminase, type I 65.3(n)
    59.42(a)
      428171  XM_004947299.1  XP_004947356.1 
    zebrafish
    (Danio rerio)
    Actinopterygii padi26
    peptidyl arginine deiminase, type II
    45(a)
    1 → many
    6(47784349-47806450) ENSDARG00000044167


    ENSEMBL Gene Tree for PADI1 (if available)
    TreeFam Gene Tree for PADI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PADI1 gene
    PADI22  PADI42  PADI32  
    4 SIMAP similar genes for PADI1 using alignment to 4 protein entries:     PADI1_HUMAN (see all proteins):
    PADI4    PADI3    PADI2    PADI6

    PADI1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PADI1 (see all 1240)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468575281,2
    C--17529633(+) TCTAAA/TGGGAA 1 -- us2k10--------
    rs1396812281,2
    --17529644(+) CACACC/TCATGT 1 -- us2k10--------
    rs1144259591,2
    F--17529685(+) CATTCC/TATTCC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1815627661,2
    --17529706(+) GACACA/GTTTAT 1 -- us2k10--------
    rs1155854061,2
    F--17529710(+) CGTTTA/CTGTCA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1168174261,2
    F--17529819(+) TGTATC/ACATGG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1863787621,2
    --17529824(+) CCATGA/GGGTAA 1 -- us2k10--------
    rs66651281,2
    C,F,A--17529913(+) AAAAAT/GATCTT 1 -- us2k11Minor allele frequency- G:0.11WA 118
    rs1445552721,2
    --17529923(+) TCAAAA/GTCAAA 1 -- us2k10--------
    rs1511032171,2
    --17529979(+) CTAATC/GAGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PADI1 (17531621 - 17572501 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PADI1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744530CNV Deletion23290073
    esv1009642CNV Deletion20482838
    esv1398963CNV Deletion17803354
    esv2744552CNV Deletion23290073
    esv2744541CNV Deletion23290073
    esv2422314CNV Duplication17116639
    esv1489199CNV Insertion17803354
    nsv508958CNV Insertion20534489
    nsv470700CNV Loss18288195
    nsv871364CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PADI1
    DNA2.0 Custom Variant and Variant Library Synthesis for PADI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607934    OMIM disorders: --

    4 diseases for PADI1:    
    About MalaCards
    epidermolytic hyperkeratosis    oral squamous cell carcinoma    squamous cell carcinoma    prostatitis


    PADI1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PADI1

    Export disorders for PADI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PADI1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with PADI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I. (PubMed id 12416996)1, 2, 3, 9 Guerrin M.... Serre G. (Biochem. J. 2003)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PubMed id 15087120)1, 2 Chavanas S.... Simon M. (Gene 2004)
    4. Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13. (PubMed id 15150696)1, 7 Iida A. and Nakamura Y. (J. Hum. Genet. 2004)
    5. Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes. (PubMed id 17851584)1, 9 Dong S.... Takahara H. (J. Invest. Dermatol. 2008)
    6. Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. (PubMed id 18669583)1, 9 Chen C....Zhao L.P. (amp 2008)
    7. An intronic enhancer driven by NF-I_B contributes to transcriptional regulation of peptidylarginine deiminase type I gene in human keratinocytes. (PubMed id 20596086)1 Ying S....Takahara H. (J. Invest. Dermatol. 2010)
    8. Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. (PubMed id 18710930)1 Proost P.... Van Damme J. (J. Exp. Med. 2008)
    9. Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis. (PubMed id 16973334)1 Chavanas S....Simon M. (J. Dermatol. Sci. 2006)
    10. The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations. (PubMed id 16091842)1 MAcchin M.C....Simon M. (Cell. Mol. Life Sci. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29943 HGNC: 18367 AceView: PADI1 Ensembl:ENSG00000142623 euGenes: HUgn29943
    ECgene: PADI1 H-InvDB: PADI1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PADI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PADI1 gene:
    Search GeneIP for patents involving PADI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PADI1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PADI1  
     OriGene MassSpec something-or-other for PADI1   OriGene clones in human, mouse for PADI1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PADI1   OriGene Purified Protein for PADI1  
     OriGene ORF clones in mouse, rat for PADI1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PADI1   OriGene Custom Protein Services for PADI1  

     
     
     Block miRNA regulation of human, mouse, rat PADI1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PADI1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PADI1 Predesigned siRNA for gene silencing in human, mouse, rat PADI1
     QuantiFast Probe-based Assays in human, mouse, rat PADI1 QuantiTect SYBR Green Assays in human, mouse, rat PADI1
     Custom PCR Arrays for PADI1 Search Chromatin IP Primers for PADI1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PADI1  GeneGlobe Interaction Network for PADI1
     Regulatory tfbs in PADI1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PADI1 GenScript cDNA clones with any tag delivered in your preferred vector for PADI1
     GenScript Custom Assay Services for PADI1 GenScript Custom overexpressing Cell Line Services for PADI1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PADI1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PADI1 antibodies
     PADI1 proteins
     PADI1 lysates
     Antibodies for PADI1
     See all of Abcam's Antibodies, Kits and Proteins for PADI1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PADI1
     Antibodies for PADI1
     ELISAs for PADI1
     CLIAs for PADI1



     Browse ESI BIO Cell Lines and PureStem Progenitors for PADI1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PADI1
     SwitchGear 3'UTR luciferase reporter plasmids for PADI1
     SwitchGear Promoter luciferase reporter plasmids for PADI1
     ThermoFisher Antibodies for PADI1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PADI1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PADI1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PADI1
     LSBio Antibodies in human, mouse, rat for PADI1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PADI1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4