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Aliases & Descriptions for PACSIN3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Endophilin I 3 | | SH3 domain-containing protein 6511 2, 3 | | protein kinase C and casein kinase substrate in neurons 3 2 | | syndapin III 2 |
|
| | Search outside databases for aliases for PACSIN3 genePrevious GC identifers: GC11M049138 GC11M048076 GC11M047230 GC11M047163 |
Summaries for PACSIN3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: PACN3_HUMAN, Q9UKS6Function: May play a role in vesicle formation and transportGene Wiki entry for PACSIN3 |
Genomic Location for PACSIN3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PACSIN3 gene 
Entrez Gene cytogenetic band: 11p12-p11.12 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p12-p11PACSIN3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M047155:
(about GC identifiers)
Start:
|
47,155,654 bp from pter |
End:
|
47,164,534 bp from pter |
Size:
|
8,881 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_009237.17
| Proteins for PACSIN3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PACN3_HUMAN, Q9UKS6 (See
protein sequence)Recommended Name: Protein kinase C and casein kinase substrate in neurons protein 3 Size: 424 amino acids; 48487 Da
Subunit: Homo- and hetero-aggregates with other PACSINs. Binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). Also interacts with MDC9 and MDC15 (By similarity)
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the inner aspect of the plasma membrane in cells or myotubes
Secondary accessions: A6NH84 Q9H331 Q9NWV9Post-translational modifications:
Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) (Probable)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057307.2
ENSEMBL proteins: ENSP00000298838
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: PACSIN3 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for PACSIN3: Assays for PACSIN3: | Protein
Domains/ Families for PACSIN3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UKS6
ProtoNet protein and cluster: Q9UKS6 2 Blocks protein families: IPB001060 Cdc15/Fes/CIP4 IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: PACN3_HUMAN, Q9UKS6Similarity: Belongs to the PACSIN familySimilarity: Contains 1 FCH domainSimilarity: Contains 1 SH3 domain | Gene Function for PACSIN3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016223
Applied Biosystems Silencer® siRNAs for PACSIN3
Sigma-Aldrich siRNA for PACSIN3  Sigma-Aldrich shRNA for PACSIN3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016223                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016223                                  untagged cDNA clones in CMV expression vector (see all 2): NM_016223 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016223
UniProtKB/Swiss-Prot: PACN3_HUMAN, Q9UKS6Function: May play a role in vesicle formation and transport1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008092 | cytoskeletal protein binding |
ISS | -- | About this table | Pathways & Interactions for PACSIN3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for PACSIN3 
5/14 Interacting proteins for PACSIN3 (ENSP000002988383 Q9UKS61, 2) via UniProtKB, MINT, and/or STRING (see all 14
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045806 | negative regulation of endocytosis |
ISS | -- | | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
IMP | 15280379 | About this table
|
Drugs & Compounds for PACSIN3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PACSIN3
|
Transcripts for PACSIN3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016223
Sigma-Aldrich siRNA for PACSIN3  Sigma-Aldrich shRNA for PACSIN3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016223 REFSEQ mRNAs for PACSIN3 gene: NM_016223.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016223               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016223                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016223                                  untagged cDNA clones in CMV expression vector (see all 2): NM_016223  Additional cDNA sequence: AF130979.1 AF149825.1 AF242530.1 AK000577.1 AK300658.1 AK300968.1 AK310819.1 BC007914.2 BC011889.2 CR595171.1 CR600161.1 CR601247.1 CR606050.1 CR613894.1 CR624285.1 11 DOTS entries: DT.212767 DT.100795763 DT.101970421 DT.100795762 DT.95101690 DT.120707370 DT.87014814 DT.120707471 DT.40218044 DT.91742427 DT.92053221 24/713 AceView cDNA sequences (see all 713
):BM910653 AI197967 AI568284 BM044239 AI689497 CA309915 AI251129 AI140280 BQ946737 AU279596 BU630871 CA313336 CR595171 BF513176 CB153664 CR598905 CB163548 BQ228103 CB113119 Z38509 BQ070295 F26225 BQ614613 AI598200
highest scoring ESTs for PACSIN3:AF130979 AF149825 AF242530 BC007914 BC011889 BE727121 BG762641 BM273299 BM545612 BM924792 Unigene Cluster for PACSIN3: Protein kinase C and casein kinase substrate in neurons 3 Hs.334639 [show with all ESTs]Unigene Representative Sequence: AF130979
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PACSIN3 (see all 10
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | |
| SP1: | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for PACSIN3
1 Ensembl transcript including schematic representation: ENST00000298838
|
Expression for PACSIN3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PACSIN3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PACSIN3
1 / 2 / 3 4 probe-sets matching PACSIN3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACTGGCCAC
SOURCE GeneReport for Unigene cluster: Hs.334639 UniProtKB/Swiss-Prot: PACN3_HUMAN, Q9UKS6Tissue specificity: Expressed in heart and skeletal muscle, lung, kidney, adrenal gland and placenta |
Orthologs for PACSIN3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PACSIN3 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for PACSIN3
ENSEMBL Gene Tree for PACSIN3 | Paralogs for PACSIN3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PACSIN3 gene
- PACSIN22 PACSIN12
|
SNPs/Variants for PACSIN3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PACSIN3 (up to first 250kb)
|
Disorders & Mutations for PACSIN3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606513
|
Medical News for PACSIN3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PACSIN3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/22 PubMed articles for PACSIN3 gene (see all 22
):- Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. (PubMed id 10531379)2, 3, 4 Howard L.... Blobel C.P. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family. (PubMed id 11179684)3, 4 Sumoy L.... Escarceller M. (2001)
- All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. (PubMed id 11082044)3, 4 Modregger J....Plomann M. (2000)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
- Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. (PubMed id 18174177)3 D'hoedt D....Nilius B. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
|
Search for PACSIN3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PACSIN3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PACSIN3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PACSIN3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PACSIN3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PACSIN3:

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Incremental update: 13 Oct 2009
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