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PACSIN3 Gene

protein-coding   GIFtS: 55
GCID: GC11M047199

Protein Kinase C And Casein Kinase Substrate In Neurons...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase C And Casein Kinase Substrate In Neurons 31 2
Syndapin III1 2
SH3 Domain-Containing Protein 65112 3
SDPIII2
Protein Kinase C And Casein Kinase Substrate In Neurons Protein 32

External Ids:    HGNC: 85721   Entrez Gene: 297632   Ensembl: ENSG000001659127   OMIM: 6065135   UniProtKB: Q9UKS63   

Export aliases for PACSIN3 gene to outside databases

Previous GC identifers: GC11M049138 GC11M048076 GC11M047230 GC11M047163 GC11M047155 GC11M046898


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PACSIN3 Gene:
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein
is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for PACSIN3 Gene:
PACSIN3 (protein kinase C and casein kinase substrate in neurons 3) is a protein-coding gene. Diseases associated with PACSIN3 include neuronitis, and wiskott-aldrich syndrome. GO annotations related to this gene include lipid binding and calcium channel inhibitor activity. An important paralog of this gene is PACSIN2.

UniProtKB/Swiss-Prot: PACN3_HUMAN, Q9UKS6
Function: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression
impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell
membrane. Inhibits the TRPV4 calcium channel activity (By similarity)

Gene Wiki entry for PACSIN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the PACSIN3 gene promoter:
         AhR   STAT1   NF-1   NF-1/L   AML1a   COMP1   STAT1beta   STAT1alpha   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPACSIN3 promoter sequence
   Search Chromatin IP Primers for PACSIN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PACSIN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p12-p11.12   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p12-p11

PACSIN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PACSIN3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M047199:  view genomic region     (about GC identifiers)

Start:
47,199,073 bp from pter      End:
47,208,010 bp from pter
Size:
8,938 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PACN3_HUMAN, Q9UKS6 (See protein sequence)
Recommended Name: Protein kinase C and casein kinase substrate in neurons protein 3  
Size: 424 amino acids; 48487 Da
Subunit: Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and
WASL. Interacts with TRPV4 (By similarity)
Secondary accessions: A6NH84 Q9H331 Q9NWV9

Explore the universe of human proteins at neXtProt for PACSIN3: NX_Q9UKS6

Explore proteomics data for PACSIN3 at MOPED

Post-translational modifications: 

  • Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) (Probable)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PACSIN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171903.1  NP_001171904.1  NP_057307.2  

    ENSEMBL proteins: 
     ENSP00000298838   ENSP00000431948   ENSP00000433962   ENSP00000437252   ENSP00000431924  
     ENSP00000434521   ENSP00000434699   ENSP00000435638   ENSP00000435672   ENSP00000431861  
     ENSP00000440945  

    PACSIN3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001060 FCH_dom
     IPR001452 SH3_domain
     IPR028523 PACSIN3

    Graphical View of Domain Structure for InterPro Entry Q9UKS6

    ProtoNet protein and cluster: Q9UKS6

    2 Blocks protein domains:
    IPB001060 Cdc15/Fes/CIP4
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: PACN3_HUMAN, Q9UKS6
    Domain: The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation
    Similarity: Belongs to the PACSIN family
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 SH3 domain


    PACSIN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PACN3_HUMAN, Q9UKS6
    Function: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression
    impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell
    membrane. Inhibits the TRPV4 calcium channel activity (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10531379
    GO:0008092cytoskeletal protein binding ISS--
    GO:0008289lipid binding IDA--
    GO:0019855calcium channel inhibitor activity ISS--
         
    PACSIN3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PACSIN3
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    miRNA
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    miRTarBase miRNAs that target PACSIN3:
    hsa-mir-124-3p (MIRT022858), hsa-mir-155-5p (MIRT020805), hsa-mir-1 (MIRT023821), hsa-mir-16-5p (MIRT031829), hsa-mir-24-3p (MIRT030478)

    Block miRNA regulation of human, mouse, rat PACSIN3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PACSIN3:
    hsa-miR-374c hsa-miR-655 hsa-miR-3127-5p hsa-miR-3182 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidPACSIN3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PACSIN3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): PACSIN3 (NM_016223)
    Sino Biological Human cDNA Clone for PACSIN3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACSIN3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACSIN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PACN3_HUMAN, Q9UKS6: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
    Note=Detected at the inner aspect of the plasma membrane in myotubes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    PACSIN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PACSIN3
    Interactions:

        GeneGlobe Interaction Network for PACSIN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PACSIN3 (Q9UKS61, 2, 3 ENSP000002988384) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0045806negative regulation of endocytosis ISS--
    GO:0051044positive regulation of membrane protein ectodomain proteolysis IMP15280379
    GO:0051926negative regulation of calcium ion transport ISS--
    GO:0097320membrane tubulation IDA--

    PACSIN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PACSIN3 (PACN3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PACSIN3 gene (3 alternative transcripts): 
    NM_001184974.1  NM_001184975.1  NM_016223.4  

    Unigene Cluster for PACSIN3:

    Protein kinase C and casein kinase substrate in neurons 3
    Hs.334639  [show with all ESTs]
    Unigene Representative Sequence: NM_001184975
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298838(uc001ndy.3 uc001ndx.3) ENST00000532457 ENST00000533686
    ENST00000528462 ENST00000530513 ENST00000528201 ENST00000531226 ENST00000525725
    ENST00000530405 ENST00000524509 ENST00000539589(uc001ndw.3)

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate PACSIN3:
    hsa-miR-374c hsa-miR-655 hsa-miR-3127-5p hsa-miR-3182 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidPACSIN3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): PACSIN3 (NM_016223)
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      QuantiTect SYBR Green Assays in human, mouse, rat PACSIN3
      QuantiFast Probe-based Assays in human, mouse, rat PACSIN3

    Additional mRNA sequence: 

    AF130979.1 AF149825.1 AF242530.1 AK000577.1 AK300658.1 AK300968.1 BC007914.2 BC011889.2 

    10 DOTS entries:

    DT.212767  DT.100795763  DT.101970421  DT.100795762  DT.95101690  DT.120707370  DT.87014814  DT.120707471 
    DT.91742427  DT.92053221 

    Selected AceView cDNA sequences (see all 713):

    BQ934475 BM833030 AI688448 BM828157 BE275083 AW273866 BM773370 AI140280 
    AI242872 AV725693 BP344658 BM044239 AI197967 NM_032389 AV645750 BE893319 
    AF242530 BU630871 AA595719 AI280249 BM704415 AW732250 BQ070295 CB152274 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PACSIN3 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:              -     -     -     -           -                                                                                             
    SP2:              -     -     -     -           -                                                                                             
    SP3:                    -     -     -           -                                                                                             
    SP4:              -     -     -     -           -     -     -                                                                                 
    SP5:              -     -     -     -           -     -     -                                                                                 


    ECgene alternative splicing isoforms for PACSIN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PACSIN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGGCCAC
    PACSIN3 Expression
    About this image


    PACSIN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Heart (Cardiovascular System)
     
     Skeletal Muscle (Muscoskeletal System)
    PACSIN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PACSIN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334639

    UniProtKB/Swiss-Prot: PACN3_HUMAN, Q9UKS6
    Tissue specificity: Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in
    placenta, liver and pancreas, and very low levels in brain, lung and kidney

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACSIN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PACSIN3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pacsin31 , 5 protein kinase C and casein kinase substrate in neurons more1, 5 87.58(n)1
    94.34(a)1
      2 (50.61 cM)5
    807081  NM_028733.31  NP_083009.11 
     912559545 
    chicken
    (Gallus gallus)
    Aves PACSIN31 protein kinase C and casein kinase substrate in neurons more 71.39(n)
    70.21(a)
      423186  NM_001044652.1  NP_001038117.1 
    lizard
    (Anolis carolinensis)
    Reptilia PACSIN36
    protein kinase C and casein kinase substrate in ne...
    65(a)
    1 ↔ 1
    1(43623691-43665251)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC526832 similar to protein kinase C and casein kinase substrate more 71.79(n)    BC041726.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pacsin31 protein kinase C and casein kinase substrate in neurons more 64.77(n)
    62.22(a)
      393964  NM_200989.1  NP_957283.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Synd6
    Syndapin
    35(a)
    1 → many
    3R(16658507-16665840)
    worm
    (Caenorhabditis elegans)
    Secernentea sdpn-16
    Protein SDPN-1, isoform a (sdpn-1) mRNA, complete ...
    27(a)
    1 → many
    X(7988939-7998133) WBGene00018467


    ENSEMBL Gene Tree for PACSIN3 (if available)
    TreeFam Gene Tree for PACSIN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PACSIN3 gene
    PACSIN22  PACSIN12  
    6 SIMAP similar genes for PACSIN3 using alignment to 9 protein entries:     PACN3_HUMAN (see all proteins):
    PACSIN2    PACSIN1    SH3GL2    ARHGEF7    ITSN1    FCHO1

    PACSIN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PACSIN3 (see all 213)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409836861,2
    C--47200745(+) TGGCCC/TGTGGG 6 R G mis11Minor allele frequency- T:0.00NA 4546
    rs1501488661,2
    C--47200766(+) CCAGCG/ACAGAT 6 /R /C mis11Minor allele frequency- A:0.00NA 4550
    rs1414604581,2
    C,F--47200818(+) CGGTGG/CAGTTC 6 /L syn12Minor allele frequency- C:0.00NA EU 5873
    rs1996384731,2
    --47200914(+) TGGAGG/TAGACC 3 -- int10--------
    rs1470008091,2
    C--47200966(+) CTTCTC/TACTGC 6 K E mis11Minor allele frequency- T:0.00NA 4538
    rs1389480431,2
    C,F--47200991(+) TGCTGG/ATGTAA 6 /H syn11Minor allele frequency- A:0.00NA 4544
    rs349156441,2
    C--47201029(-) GCCAGC/TGGCTT 6 R W mis11Minor allele frequency- T:0.02NA 56
    rs2020654511,2
    --47201034(+) GCTGGC/TGCTCG 6 H R mis10--------
    rs2008755571,2
    --47201038(+) GCGCTC/TGGCGG 6 K E mis10--------
    rs1999022501,2
    C--47201041(+) CTCGGC/TGGCCT 6 T A mis10--------

    HapMap Linkage Disequilibrium report for PACSIN3 (47199073 - 47208010 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PACSIN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897323CNV Loss21882294
    nsv897324CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PACSIN3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606513    OMIM disorders: --

    5 diseases for PACSIN3:    
    About MalaCards
    neuronitis    wiskott-aldrich syndrome    alzheimer's disease    cerebritis
    breast cancer


    PACSIN3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for PACSIN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PACSIN3 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with PACSIN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. (PubMed id 10531379)1, 2, 3 Howard L.... Blobel C.P. (J. Biol. Chem. 1999)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family. (PubMed id 11179684)1, 2 Sumoy L.... Escarceller M. (Gene 2001)
    6. All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. (PubMed id 11082044)1, 2 Modregger J.... Plomann M. (J. Cell Sci. 2000)
    7. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules. (PubMed id 22573331)1 Bai X.... Zheng X. (J. Biol. Chem. 2012)
    10. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 29763 HGNC: 8572 AceView: PACSIN3andZNF289 Ensembl:ENSG00000165912 euGenes: HUgn29763
    ECgene: PACSIN3 H-InvDB: PACSIN3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PACSIN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PACSIN3 gene:
    Search GeneIP for patents involving PACSIN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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