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Aliases & Descriptions for PACSIN2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000028650 2 | | SDPII 1, 2 |
| | | Descriptions |
|---|
| pacsin 2 2 | | protein kinase C and casein kinase substrate in neurons 2 2 | | syndapin II 2 |
|
| | Search outside databases for aliases for PACSIN2 genePrevious GC identifers: GC22M039868 GC22M041496 |
Summaries for PACSIN2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: PACN2_HUMAN, Q9UNF0Function: May play a role in vesicle formation and transportGene Wiki entry for PACSIN2 |
Genomic Location for PACSIN2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PACSIN2 gene 
Entrez Gene cytogenetic band: 22q13.2-q13.33 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2-q13.33PACSIN2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M041590:
(about GC identifiers)
Start:
|
41,595,721 bp from pter |
End:
|
41,741,095 bp from pter |
Size:
|
145,375 bases |
Orientation:
|
minus strand |
| Proteins for PACSIN2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PACN2_HUMAN, Q9UNF0 (See
protein sequence)Recommended Name: Protein kinase C and casein kinase substrate in neurons protein 2 Size: 486 amino acids; 55739 Da
Subunit: Homo- and hetero-aggregates with other PACSINs. Binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP) (By similarity)
Subcellular location: Cytoplasmic vesicle (By similarity). Note=Vesicle-like cytoplasmic distribution (By similarity)
Secondary accessions: O95921 Q96HV9 Q9H0D3 Q9NPN1 Q9Y4V2Alternative splicing: 2 isoforms: Q9UNF0-1 Q9UNF0-2 Post-translational modifications:
Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_009160.2
ENSEMBL proteins: ENSP00000385372 ENSP00000385040 ENSP00000385952 ENSP00000338379 ENSP00000263246
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: PACSIN2 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for PACSIN2: Assays for PACSIN2: | Protein
Domains/ Families for PACSIN2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UNF0
ProtoNet protein and cluster: Q9UNF0 2 Blocks protein families: IPB001060 Cdc15/Fes/CIP4 IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: PACN2_HUMAN, Q9UNF0Similarity: Belongs to the PACSIN familySimilarity: Contains 1 FCH domainSimilarity: Contains 1 SH3 domain | Gene Function for PACSIN2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007229
Applied Biosystems Silencer® siRNAs for PACSIN2
Sigma-Aldrich siRNA for PACSIN2  Sigma-Aldrich shRNA for PACSIN2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007229                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007229                                  untagged cDNA clone in CMV expression vector: NM_007229 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007229
UniProtKB/Swiss-Prot: PACN2_HUMAN, Q9UNF0Function: May play a role in vesicle formation and transportGenatlas biochemistry entry for PACSIN2:protein kinase C and casein kinase substrate in neurons 22 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for PACSIN2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for PACSIN2 
5/9 Interacting proteins for PACSIN2 (Q9UNF02 ENSP000002632463) via UniProtKB, MINT, and/or STRING (see all 9
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030036 | actin cytoskeleton organization |
TAS | 10431838 | | GO:0045806 | negative regulation of endocytosis |
IEA | -- | About this table
|
Drugs & Compounds for PACSIN2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PACSIN2
|
Transcripts for PACSIN2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007229
Sigma-Aldrich siRNA for PACSIN2  Sigma-Aldrich shRNA for PACSIN2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007229 REFSEQ mRNAs for PACSIN2 gene: NM_007229.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007229               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007229                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007229                                  untagged cDNA clone in CMV expression vector: NM_007229  24/512 AceView cDNA sequences (see all 512
):AI554275 BQ921162 BM758341 BM749809 BM748478 AW959836 BM757730 BM758991 AU279714 BM784825 AI049750 BM747236 BQ921618 BP346018 BM758980 BG338085 AA402698 AW337798 Z44878 BM090836 CB409673 AI095801 AI754874 CB146436
highest scoring ESTs for PACSIN2:AA814516 AF128536 BE560201 BE903213 BF203478 BF689783 BG036861 BG389589 BG419281 BG423017
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PACSIN2 (see all 10
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for PACSIN2
5 Ensembl transcripts including schematic representations: ENST00000403744
ENST00000402229
ENST00000407585
ENST00000337959
ENST00000263246
|
Expression for PACSIN2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PACSIN2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PACSIN2
1 / 2 / 3 5 probe-sets matching PACSIN2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTAGTATTT
Expression variation in blood from EXPOLDB for PACSIN2 UniProtKB/Swiss-Prot: PACN2_HUMAN, Q9UNF0Tissue specificity: Ubiquitously expressed |
Orthologs for PACSIN2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PACSIN2 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for PACSIN2
ENSEMBL Gene Tree for PACSIN2 | Paralogs for PACSIN2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PACSIN2 gene
- PACSIN32 PACSIN12
|
SNPs/Variants for PACSIN2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PACSIN2 (up to first 250kb)
|
Disorders & Mutations for PACSIN2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604960
|
Medical News for PACSIN2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PACSIN2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for PACSIN2 gene (see all 18
):- PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins. (PubMed id 10431838)1, 2, 3, 4 Ritter B.... Plomann M. (1999)
- All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. (PubMed id 11082044)1, 2, 3, 4 Modregger J....Plomann M. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)3, 4 Collins J.E.... Dunham I. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)3, 4 Dunham I....O'Brien K.P. (1999)
- PACSIN proteins bind tubulin and promote microtubule assembly. (PubMed id 18456257)1, 3 Grimm-Gunter E.M....Plomann M. (2008)
- PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family. (PubMed id 11179684)1, 3 Sumoy L.... Escarceller M. (2001)
- Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network. (PubMed id 16551695)3 Kessels M.M....Qualmann B. (2006)
|
Search for PACSIN2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PACSIN2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PACSIN2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PACSIN2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PACSIN2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PACSIN2:

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Incremental update: 13 Oct 2009
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