 |
 | Services
| |
 |
Aliases & Descriptions for PACSIN1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA1379 2, 3, 5 | | OTTHUMP00000016231 2 | | SDPI 1, 2 |
| | | Descriptions |
|---|
| protein kinase C and casein kinase substrate in neurons 1 2 | | syndapin I 2 |
|
| | Search outside databases for aliases for PACSIN1 genePrevious GC identifers: GC06P034435 GC06P034480 |
Summaries for PACSIN1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: PACN1_HUMAN, Q9BY11Function: May play a role in vesicle formation and transportGene Wiki entry for PACSIN1 |
Genomic Location for PACSIN1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PACSIN1 gene 
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.3PACSIN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P034541:
(about GC identifiers)
Start:
|
34,541,883 bp from pter |
End:
|
34,610,984 bp from pter |
Size:
|
69,102 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14
| Proteins for PACSIN1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PACN1_HUMAN, Q9BY11 (See
protein sequence)Recommended Name: Protein kinase C and casein kinase substrate in neurons protein 1 Size: 444 amino acids; 50966 Da
Subunit: Homo- and hetero-aggregates with other PACSINs. Binds dynamin I, synaptojanin, synapsin I and the neural Wiskott-Aldrich syndrome protein (N-WASP) (By similarity)
Subcellular location: Cytoplasm (By similarity). Note=Colocalizes with dynamin I at vesicular structures in the cell body and neurites (By similarity)
Secondary accessions: Q9P2G8Post-translational modifications:
Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) (Probable)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_065855.1
ENSEMBL proteins: ENSP00000363155 ENSP00000244458
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
NAS | -- | | GO:0030137 | COPI-coated vesicle |
IEA | -- | About this table
Antibodies for PACSIN1: Assays for PACSIN1: | Protein
Domains/ Families for PACSIN1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BY11
ProtoNet protein and cluster: Q9BY11 2 Blocks protein families: IPB001060 Cdc15/Fes/CIP4 IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: PACN1_HUMAN, Q9BY11Similarity: Belongs to the PACSIN familySimilarity: Contains 1 FCH domainSimilarity: Contains 1 SH3 domain | Gene Function for PACSIN1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020804
Applied Biosystems Silencer® siRNAs for PACSIN1
Sigma-Aldrich siRNA for PACSIN1  Sigma-Aldrich shRNA Panels and shRNA for PACSIN1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020804                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020804                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020804 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020804
UniProtKB/Swiss-Prot: PACN1_HUMAN, Q9BY11Function: May play a role in vesicle formation and transport2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004672 | protein kinase activity |
NAS | -- | | GO:0008092 | cytoskeletal protein binding |
IEA | -- | About this table | Pathways & Interactions for PACSIN1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for PACSIN1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for PACSIN1 
5/6 Interacting proteins for PACSIN1 (Q9BY111, 2 ENSP000002444583) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045806 | negative regulation of endocytosis |
IEA | -- | About this table
|
Drugs & Compounds for PACSIN1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PACSIN1
|
Transcripts for PACSIN1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020804
Sigma-Aldrich siRNA for PACSIN1  Sigma-Aldrich shRNA Panels and shRNA for PACSIN1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020804 REFSEQ mRNAs for PACSIN1 gene: NM_020804.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020804               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020804                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020804                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020804  Additional cDNA sequence: AB037800.2 AF242529.1 AK289956.1 AK294132.1 AL834211.1 BC040228.1 BC128219.1 BC128220.1 CR612772.1 6 DOTS entries: DT.112551 DT.100650803 DT.100698861 DT.40113398 DT.92421140 DT.97776342 24/100 AceView cDNA sequences (see all 100
):BM693384 BM703989 T09405 AI822046 CF453906 CR612772 H43777 BM668658 NM_020804 BF953173 F03627 BX094526 AB037800 BC040228 BU193429 AL834211 BE254304 AA323180 AI804979 Z42045 BP348926 AF242529 BM548244 BF128697
highest scoring ESTs for PACSIN1:N47315 AA323180 AA324499 AA350673 AB037800 AF242529 AI017889 AI199526 AI804979 AI864586 Unigene Cluster for PACSIN1: Protein kinase C and casein kinase substrate in neurons 1 Hs.520087 [show with all ESTs]Unigene Representative Sequence: BC040228
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000374043
ENST00000244458
|
Expression for PACSIN1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PACSIN1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PACSIN1
1 / 2 / 3 6 probe-sets matching PACSIN1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATTGTGTAAT
SOURCE GeneReport for Unigene cluster: Hs.520087 UniProtKB/Swiss-Prot: PACN1_HUMAN, Q9BY11Tissue specificity: Highly expressed in brain and in a lesser extent in heart, pancreas and liver |
Orthologs for PACSIN1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PACSIN1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for PACSIN1
ENSEMBL Gene Tree for PACSIN1 | Paralogs for PACSIN1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PACSIN1 gene
- PACSIN22 PACSIN32
|
SNPs/Variants for PACSIN1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PACSIN1 (up to first 250kb)
|
Disorders & Mutations for PACSIN1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606512
Human Genome Epidemiology Navigator: PACSIN1 (1 document)
|
Medical News for PACSIN1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PACSIN1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/21 PubMed articles for PACSIN1 gene (see all 21
): |
Search for PACSIN1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PACSIN1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PACSIN1
(According to HUGE)
About This Section
| |
Specialized Databases showing PACSIN1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PACSIN1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PACSIN1:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for PACSIN1 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|