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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PACS2 Gene

protein-coding   GIFtS: 53
GCID: GC14P105767

Phosphofurin Acidic Cluster Sorting Protein 2

(Previous name: phosphofurin acidic cluster sorting protein 1-like)
(Previous symbol: PACS1L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphofurin Acidic Cluster Sorting Protein 21 2
PACS1L1 2 3
PACS-22 3
PACS1-Like Protein2 3
Phosphofurin Acidic Cluster Sorting Protein 1-Like1
KIAA06023

External Ids:    HGNC: 237941   Entrez Gene: 232412   Ensembl: ENSG000001793647   OMIM: 6104235   UniProtKB: Q86VP33   

Export aliases for PACS2 gene to outside databases

Previous GC identifers: GC14P104839 GC14P085962


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PACS2 Gene: 
PACS2 (phosphofurin acidic cluster sorting protein 2) is a protein-coding gene. Diseases associated with PACS2 include kaposi's sarcoma, and sarcoma. An important paralog of this gene is PACS1.

UniProtKB/Swiss-Prot: PACS2_HUMAN, Q86VP3
Function: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication,
including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic
inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of
mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death.
May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct
subcellular compartments




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PACS2 gene promoter:
         c-Fos   p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPACS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PACS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PACS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32

PACS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PACS2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P105767:  view genomic region     (about GC identifiers)

Start:
105,766,900 bp from pter      End:
105,864,484 bp from pter
Size:
97,585 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PACS2_HUMAN, Q86VP3 (See protein sequence)
Recommended Name: Phosphofurin acidic cluster sorting protein 2  
Size: 889 amino acids; 97702 Da
Subunit: Interacts with BID and PKD2. Interacts with HIV-1 Nef
Subcellular location: Endoplasmic reticulum lumen. Mitochondrion
Sequence caution: Sequence=BAA25528.1; Type=Erroneous initiation;
Secondary accessions: A2VDJ9 O60342 Q6P191 Q96FL7
Alternative splicing: 3 isoforms:  Q86VP3-1   Q86VP3-2   Q86VP3-3   (No experimental confirmation available. Incomplete sequence)

Explore the universe of human proteins at neXtProt for PACS2: NX_Q86VP3

Explore proteomics data for PACS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VP3

  • PACS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PACS2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001094383.2  NP_001230056.1  NP_056012.2  

    ENSEMBL proteins: 
     ENSP00000393524   ENSP00000321834   ENSP00000399732   ENSP00000449525   ENSP00000447229  
     ENSP00000449254   ENSP00000447544   ENSP00000393559  

    Human Recombinant Protein Products for PACS2: 
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    OriGene Protein Over-expression Lysate for PACS2
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    Novus Biologicals PACS2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PACS2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IDA15692563
    GO:0005788endoplasmic reticulum lumen IEA--

    PACS2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for PACS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019381 Phosphofurin_acidic_CS-1

    Graphical View of Domain Structure for InterPro Entry Q86VP3

    ProtoNet protein and cluster: Q86VP3

    UniProtKB/Swiss-Prot: PACS2_HUMAN, Q86VP3
    Similarity: Belongs to the PACS family


    PACS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PACS2_HUMAN, Q86VP3
    Function: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication,
    including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic
    inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of
    mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death.
    May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct
    subcellular compartments

    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pacs2):

     behavior/neurological  cellular  growth/size  homeostasis/metabolism 

    PACS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PACS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PACS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PACS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PACS2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PACS2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate PACS2 (see all 33):
    hsa-miR-125a-5p hsa-let-7d hsa-miR-181c hsa-miR-485-3p hsa-let-7c hsa-miR-20b* hsa-let-7g hsa-miR-548g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector (see all 2): PACS2 (NM_015197)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PACS2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for PACS2 (Q86VP32, 3 ENSP000003935594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3976506 I2D: score=1 
    YWHAZP631042, 3, ENSP000003095034MINT-8008995 I2D: score=1 STRING: ENSP00000309503
    PKD2Q135633, ENSP000002375964I2D: score=2 STRING: ENSP00000237596
    BIDP559573I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0072661protein targeting to plasma membrane IMP15692563

    PACS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PACS2

    Search CenterWatch for drugs/clinical trials and news about PACS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PACS2 gene (3 alternative transcripts): 
    NM_001100913.2  NM_001243127.2  NM_015197.3  

    Unigene Cluster for PACS2:

    Phosphofurin acidic cluster sorting protein 2
    Hs.525626  [show with all ESTs]
    Unigene Representative Sequence: NM_001100913
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430725 ENST00000325438 ENST00000458164 ENST00000547217 ENST00000548265
    ENST00000546915 ENST00000552138 ENST00000551692 ENST00000547903 ENST00000551743
    ENST00000549030 ENST00000548796 ENST00000551801 ENST00000550790 ENST00000447393(uc001yqs.2 uc001yqu.3 uc001yqt.3 uc001yqv.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PACS2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate PACS2 (see all 33):
    hsa-miR-125a-5p hsa-let-7d hsa-miR-181c hsa-miR-485-3p hsa-let-7c hsa-miR-20b* hsa-let-7g hsa-miR-548g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PACS2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PACS2 (NM_015197)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PACS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACS2
    Sirion Biotech Customized lentivirus for stable overexpression of PACS2 
                         Customized lentivirus expression plasmids for stable overexpression of PACS2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PACS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PACS2

    Additional mRNA sequence: 

    AB011174.1 AB072449.1 AK098354.1 AY320284.2 BC010663.1 BC050351.1 BC065220.1 BC131591.1 

    17 DOTS entries:

    DT.95340845  DT.75136750  DT.100784499  DT.100784498  DT.99931200  DT.104677  DT.91725829  DT.100028808 
    DT.100737432  DT.100784500  DT.120730234  DT.40314722  DT.75113716  DT.91723664  DT.91723668  DT.95173287 
    DT.40253424 

    24/183 AceView cDNA sequences (see all 183):

    BG290468 BM764368 BU172061 AB011174 AI262885 BU179180 Z45646 CR609884 
    AW516912 BM772566 CA388842 BU617075 CO246386 BC065220 BQ877534 BC010663 
    CA388843 BQ435362 BM699971 AI419333 BQ086326 BQ100979 AJ713931 BQ881472 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PACS2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:        -           -                                               -                                                                                   -   
    SP2:        -           -                                               -                                   -                                         -     -   
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 21b · 21c · 21d ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c · 27d
    SP1:  -                       -     -     -                                                   
    SP2:  -                       -     -     -                                                   
    SP3:                          -     -     -                                                   
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for PACS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PACS2 expression in normal human tissues (normalized intensities)      PACS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCGCTCA
    PACS2 Expression
    About this image


    PACS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             ganglion/cranial/facial VII   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Crest (Sensory Organs)
             sensory organ/nose/vomeronasal organ   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See PACS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PACS2

    SOURCE GeneReport for Unigene cluster: Hs.525626

    UniProtKB/Swiss-Prot: PACS2_HUMAN, Q86VP3
    Tissue specificity: Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas
    and testis

        SABiosciences Custom PCR Arrays for PACS2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PACS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PACS2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pacs21 , 5 phosphofurin acidic cluster sorting protein 21, 5 88.08(n)1
    94.6(a)1
      12 (61.57 cM)5
    2178931  NM_001081170.11  NP_001074639.11 
     1130145085 
    chicken
    (Gallus gallus)
    Aves PACS21 phosphofurin acidic cluster sorting protein 2 78.81(n)
    86.38(a)
      424375  XM_422219.3  XP_422219.3 
    lizard
    (Anolis carolinensis)
    Reptilia PACS26
    Uncharacterized protein
    76(a)
    1 ↔ 1
    4(74152761-74225182)
    zebrafish
    (Danio rerio)
    Actinopterygii pacs21 phosphofurin acidic cluster sorting protein 2 69.91(n)
    75.95(a)
      794778  NM_001122751.1  NP_001116223.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta KrT95D6
    Krueppel target at 95D
    21(a)
    1 → many
    3R(19824162-19857532)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2326
    Protein TAG-232, isoform a
    14(a)
    1 → many
    V(9213754-9217242)


    ENSEMBL Gene Tree for PACS2 (if available)
    TreeFam Gene Tree for PACS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PACS2 gene
    PACS12  
    1 SIMAP similar gene for PACS2 using alignment to 7 protein entries:     PACS2_HUMAN (see all proteins):
    PACS1

    PACS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1842 SNPs in PACS2 are shown (see all 1842)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008869831,2
    C--105783953(+) GCCAG-/TTTTTT 3 -- int10--------
    rs1483938161,2
    --105784257(+) GCGACA/GCTTTT 3 -- int10--------
    rs1873636511,2
    --105784503(+) GTTGCA/GGAGAC 3 -- int10--------
    rs128860641,2
    C,F,H--105784571(+) cacctC/Tggcct 3 -- int18Minor allele frequency- T:0.02NS EA NA 536
    rs1156302681,2
    C,F--105784579(+) CCTCCC/TGAAGT 3 -- int11Minor allele frequency- T:0.03WA 118
    rs96718901,2
    C,F,A,H--105784680(+) TGGCTC/G/TGATCA 3 -- int111NS EA NA WA CSA 544
    rs101341921,2
    C,F--105784927(+) gactaC/Taggcg 3 -- int11Minor allele frequency- T:0.50NA 4
    rs574691621,2
    C--105784931(+) ACAGGC/TGCCTG 3 -- int10--------
    rs1920723781,2
    --105785046(+) GCTGGA/TGTGCA 3 -- int10--------
    rs1835808241,2
    --105785124(+) CCGAGC/TAGCTG 3 -- int10--------

    HapMap Linkage Disequilibrium report for PACS2 (105766900 - 105864484 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for PACS2 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749292CNV Deletion23290073
    esv1001547CNV Insertion20482838
    dgv2033n71CNV Loss21882294
    nsv832890CNV Loss17160897
    nsv902473CNV Loss21882294
    dgv2025n71CNV Loss21882294
    dgv2035n71CNV Loss21882294
    nsv902477CNV Loss21882294
    esv29986CNV Loss17803354
    esv24753CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610423    OMIM disorders: --

    3 diseases for PACS2:    About MalaCards
    kaposi's sarcoma    sarcoma    endotheliitis


    PACS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PACS2
    Human Genome Epidemiology (HuGE) Navigator: PACS2 (2 documents)

    Export disorders for PACS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PACS2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with PACS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. (PubMed id 15692567)1, 2, 3 Simmen T.... Thomas G. (2005)
    2. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    3. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    4. HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice. (PubMed id 18296443)1, 2 Atkins K.M....Thomas G. (2008)
    5. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. (PubMed id 15692563)1, 2 Koettgen M.... Walz G. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    8. An interdomain binding site on HIV-1 Nef interacts wit h PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. (PubMed id 22496420)1 Dikeakos J.D....Thomas G. (2012)
    9. Tumor necrosis factor-related apoptosis-inducing ligan d (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is m ediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). (PubMed id 22645134)1 Werneburg N.W....Gores G.J. (2012)
    10. Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef. (PubMed id 22844345)1 Saxena S.K....Nair M.P. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23241 HGNC: 23794 AceView: KIAA0602 Ensembl:ENSG00000179364 euGenes: HUgn23241
    ECgene: PACS2 H-InvDB: PACS2

    (According to HUGE)
    About This Section
    HUGE: KIAA0602

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PACS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PACS2 gene:
    Search GeneIP for patents involving PACS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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