Aliases for PACS2 Gene
External Ids for PACS2 Gene
Previous HGNC Symbols for PACS2 Gene
Previous GeneCards Identifiers for PACS2 Gene
GeneCards Summary for PACS2 Gene
PACS2 (Phosphofurin Acidic Cluster Sorting Protein 2) is a Protein Coding gene. An important paralog of this gene is PACS1.
UniProtKB/Swiss-Prot for PACS2 Gene
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.