Aliases for PACS2 Gene
External Ids for PACS2 Gene
Previous Symbols for PACS2 Gene
GeneCards Summary for PACS2 Gene
PACS2 (Phosphofurin Acidic Cluster Sorting Protein 2) is a Protein Coding gene. An important paralog of this gene is PACS1.
UniProtKB/Swiss-Prot for PACS2 Gene
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.