Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PACS1 Gene

protein-coding   GIFtS: 55
GCID: GC11P065837

phosphofurin acidic cluster sorting protein 1

 Explore 5 diseases affiliated with
PACS1 via our new
 Human Malady Compendium 
Biological research products
for PACS1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Phosphofurin Acidic Cluster Sorting Protein 11 2
KIAA11751 3
PACS-12 3
FLJ102091
MRD172
Cytosolic Sorting Protein PACS-12

External Ids:    HGNC: 300321   Entrez Gene: 556902   Ensembl: ENSG000001751157   OMIM: 6074925   UniProtKB: Q6VY073   

Export aliases for PACS1 gene to outside databases

Previous GC identifers: GC11P067519 GC11P066088 GC11P065613 GC11P065595 GC11P062163


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PACS1:
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins.
Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN
localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein
plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1
to escape immune surveillance. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07
Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain
acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by
connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1
(AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell
surface to the TGN

Gene Wiki entry for PACS1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PACS1 gene promoter:
         Max1   RFX1   AP-1   RREB-1   p300   ATF-2   Evi-1   FOXO4   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPACS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PACS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PACS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1-q13.2   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1-q13.2

PACS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PACS1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065837:  view genomic region     (about GC identifiers)

Start:
65,837,824 bp from pter      End:
66,012,218 bp from pter
Size:
174,395 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07 (See protein sequence)
Recommended Name: Phosphofurin acidic cluster sorting protein 1  
Size: 963 amino acids; 104898 Da
Subunit: Interacts with HIV-1 Nef. Associates with AP-1 and AP-3 but not with AP-2 complexes. Interacts with NPHP1; the
interaction is dependent of NPHP1 phosphorylation by CK2
Subcellular location: Golgi apparatus, trans-Golgi network (By similarity). Note=Localizes in the perinuclear region,
probably the TGN (By similarity)
Sequence caution: Sequence=AAH09936.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB71164.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6PJY6 Q6PKB6 Q7Z590 Q7Z5W4 Q8N8K6 Q96MW0 Q9NW92 Q9ULP5
Alternative splicing: 2 isoforms:  Q6VY07-1   Q6VY07-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PACS1: NX_Q6VY07

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6VY07

  • PACS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060496.2  
    ENSEMBL proteins: 
     ENSP00000316454   ENSP00000437150   ENSP00000432639   ENSP00000437274   ENSP00000435037  
     ENSP00000432858   ENSP00000437052   ENSP00000433991   ENSP00000434012   ENSP00000432365  
    Reactome Protein details: Q6VY07
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for PACS1 
    GenScript Custom Purified and Recombinant Proteins Services for PACS1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PACS1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0030137COPI-coated vesicle IEA--
    GO:0048471perinuclear region of cytoplasm ----


    PACS1 for ontologies           About GeneDecksing



    PACS1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PACS1 
    GenScript Custom Superior Antibodies Services for PACS1
    Novus Biologicals PACS1 Antibody
    Search for Antibodies for PACS1 at Abcam  
    Uscn Antibodies for PACS1
    ThermoFisher Antibodies for PACS1

    Assay Products for PACS1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PACS1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PACS1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PACS1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019381 Phosphofurin_acidic_CS-1

    Graphical View of Domain Structure for InterPro Entry Q6VY07

    ProtoNet protein and cluster: Q6VY07

    UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07
    Similarity: Belongs to the PACS family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07
    Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain
    acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by
    connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1
    (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell
    surface to the TGN

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: PACS1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PACS1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PACS1 (see all 20):
    hsa-miR-596 hsa-miR-1287 hsa-miR-485-5p hsa-miR-148b* hsa-miR-765 hsa-miR-449a hsa-miR-3116 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidPACS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PACS1 (see all 6)
    OriGene siRNA: PACS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PACS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PACS1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PACS1 (NM_018026)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PACS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACS1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PACS1
    Search LifeMap BioReagents cell lines for PACS1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACS1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10707087
    GO:0044325ion channel binding IPI15692563


    PACS1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters1.00
    Degradation of MHC I Complex0.48
    The role of Nef in HIV-1 replication and disease pathogenesis0.75
    Nef mediated downregulation of MHC class I complex cell surface expression0.48
    2HIV Infection
    HIV Infection1.00
    Host Interactions of HIV factors0.64
    3Disease
    Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/7        Reactome Pathways for PACS1 (see all 7)
        HIV Infection
    The role of Nef in HIV-1 replication and disease pathogenesis
    Nef mediated downregulation of MHC class I complex cell surface expression
    Degradation of MHC I Complex
    Disease



    PACS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PACS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/23 Interacting proteins for PACS1 (Q6VY072, 3 ENSP000003164544) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-3372585 MINT-3372614 MINT-3372643 I2D: score=1 
    GGA3Q9NZ522, 3, ENSP000002455414MINT-3372280 MINT-3372692 MINT-3372076 MINT-3372146 MINT-3372174 I2D: score=3 STRING: ENSP00000245541
    IGF2RP117172, 3, ENSP000003494374MINT-3372458 MINT-3372208 I2D: score=2 STRING: ENSP00000349437
    CSNK2A1P684002, 3, ENSP000002172444MINT-3372672 I2D: score=3 STRING: ENSP00000217244
    AP1G1O437472, 3, ENSP000003771484MINT-3372236 I2D: score=1 STRING: ENSP00000377148
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000042protein targeting to Golgi IEA--
    GO:0016032viral reproduction TAS--
    GO:0019048virus-host interaction IEA--
    GO:0032092positive regulation of protein binding ----
    GO:0034613cellular protein localization ----


    PACS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PACS1

    1 HMDB Compound for PACS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Mannose 6-phosphateD-Mannose 6-phosphate (see all 10)3672-15-9--
    Search CenterWatch for drugs/clinical trials and news about PACS1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PACS1 gene: 
    NM_018026.3  

    Unigene Cluster for PACS1:

    Phosphofurin acidic cluster sorting protein 1
    Hs.644326  [show with all ESTs]
    Unigene Representative Sequence: NM_018026
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527224(uc001ogz.1) ENST00000320580(uc001oha.2 uc010rou.2)
    ENST00000533756 ENST00000527380 ENST00000531298 ENST00000524784 ENST00000533811
    ENST00000534273 ENST00000529757 ENST00000528935 ENST00000529795 ENST00000525798
    ENST00000524815 ENST00000531597 ENST00000529677

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: PACS1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PACS1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PACS1 (see all 20):
    hsa-miR-596 hsa-miR-1287 hsa-miR-485-5p hsa-miR-148b* hsa-miR-765 hsa-miR-449a hsa-miR-3116 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidPACS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PACS1 (see all 6)
    OriGene siRNA: PACS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PACS1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PACS1 (NM_018026)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PACS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACS1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PACS1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PACS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PACS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PACS1

    Additional cDNA sequence: 

    AB033001.1 AK001071.1 AK056361.1 AK096644.1 AK293966.1 AL137271.1 AY320283.1 BC003173.1 
    BC009936.1 BC010096.1 BC042909.1 BC052577.1 BC055288.1 

    22 DOTS entries:

    DT.100806911  DT.317672  DT.95364091  DT.100650493  DT.100816207  DT.120693861  DT.100697231  DT.100816203 
    DT.100816205  DT.439237  DT.75170033  DT.91980868  DT.100816200  DT.100816202  DT.101971580  DT.120693960 
    DT.91700233  DT.91979774  DT.95206307  DT.100816199  DT.91821416  DT.95364094 

    24/367 AceView cDNA sequences (see all 367):

    BC003173 BQ052853 AK098336 AL137271 BC042909 CF136871 NM_018026 T33490 
    BC010096 BU856845 BM993302 AL525662 BQ932365 AL120682 AI052087 BM927762 
    BC052577 BU729199 CN483113 BC009936 AI590037 BQ670055 BQ772654 BF371511 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PACS1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a ·
    SP1:                                            -                                         -                                               -                 -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                                                                            

    ExUns: 22b · 22c · 22d ^ 23 ^ 24a · 24b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for PACS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PACS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTCTGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PACS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PACS1

    SOURCE GeneReport for Unigene cluster: Hs.644326
        SABiosciences Custom PCR Arrays for PACS1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PACS1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PACS1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PACS1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PACS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PACS1 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PACS11 phosphofurin acidic cluster sorting protein 1 64.53(n)
    58.74(a)
      421254  XM_419325.3  XP_419325.3 
    lizard
    (Anolis carolinensis)
    Reptilia PACS16
    --
    82(a)
    1 ↔ 1
    GL343519.1(140611-194059)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA986917.12   -- 75.69(n)    CA986917.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pacs1a1 phosphofurin acidic cluster sorting protein 1a 67.89(n)
    69.62(a)
      569034  NM_001098748.1  NP_001092218.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta KrT95D6
    Krueppel target at 95D
    26(a)
    1 → many
    3R(19824162-19857532)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2321 Protein TAG-232 41.72(n)
    31.98(a)
      179304  NM_072986.4  NP_505387.1 


    ENSEMBL Gene Tree for PACS1 (if available)
    TreeFam Gene Tree for PACS1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PACS1 gene
    PACS22  
    1 SIMAP similar gene for PACS1 using alignment to 11 protein entries:     PACS1_HUMAN (see all proteins):
    PACS2

    PACS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2586 NCBI SNPs in PACS1 are shown (see all 2586    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348414121,2
    C,--62267705(+) ACTTT-/TGACAG 1 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs1392267191,2
    --65836899(+) GACTAC/GAGCAG 1 -- us2k10--------
    rs1876902821,2
    --65836925(+) CCCATA/GGGCAT 1 -- us2k10--------
    rs22773031,2
    C--65837056(-) ATCTGG/AATCAT 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs1511859651,2
    C,--65837138(+) ACTCT-/AAAAGA 1 -- us2k10--------
    rs22543881,2
    C,F,A,--65837599(+) GCGCGT/CGCTGG 1 -- us2k14Minor allele frequency- C:0.23NA 126
    rs23762311,2
    --65837679(+) ccggcC/Gcggcc 1 -- us2k10--------
    rs1498763071,2
    --65837928(+) CGCCTC/GGGCCT 1 -- ut510--------
    rs753526461,2
    C,--65838059(+) CCGCCA/GCAGCA 2 P syn10--------
    rs118236181,2
    C,H,--65838530(+) CTTCTG/TTCCTC 1 -- int12Minor allele frequency- T:0.05WA 120

    HapMap Linkage Disequilibrium report for PACS1 (65837824 - 66012218 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for PACS1
         7 CNVs: 85825 35002 37486 10365 65975 75681 48870
         2 Indels: 48871 85824

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PACS1
    DNA2.0 Custom Variant and Variant Library Synthesis for PACS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PACS1 for disorders           About GeneDecksing

    OMIM gene information: 607492    OMIM disorders: --

    5 diseases for PACS1:    About MalaCards
    cystic kidney    cervical cancer    cervicitis    immunodeficiency
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: PACS1 (1 document)

    Export disorders for PACS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PACS1 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with PACS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. (PubMed id 16308564)1, 2, 9 Schermer B....Benzing T. (2005)
    2. AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1. (PubMed id 14608369)1, 3, 9 Hinners I....Tooze S.A. (2003)
    3. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. (PubMed id 10707087)1, 2, 9 Piguet V....Trono D. (2000)
    4. Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development. (PubMed id 12855553)1, 3, 9 Stove V....Verhasselt B. (2003)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. (PubMed id 12526811)1, 2 Blagoveshchenskaya A.D....Thomas G. (2002)
    8. PACS-1 binding to adaptors is required for acidic cluster motif- mediated protein traffic. (PubMed id 11331585)1, 2 Crump C.M....Thomas G. (2001)
    9. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
    10. A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. (PubMed id 16977309)1, 9 Scott G.K....Thomas G. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55690 HGNC: 30032 AceView: PACS1 Ensembl:ENSG00000175115 euGenes: HUgn55690
    ECgene: PACS1 H-InvDB: PACS1

    (According to HUGE)
    About This Section
    HUGE: KIAA1175

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PACS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PACS1 gene:
    Search GeneIP for patents involving PACS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PACS1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PACS1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PACS1   OriGene 3'-UTR Clone for PACS1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PACS1   OriGene Custom Protein Services for PACS1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PACS1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PACS1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PACS1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PACS1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PACS1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PACS1
     GenScript Custom Purified and Recombinant Proteins Services for PACS1 GenScript cDNA clones with any tag delivered in your preferred vector for PACS1
     GenScript Custom Assay Services for PACS1 GenScript Custom Superior Antibodies Services for PACS1
     GenScript Custom overexpressing Cell Line Services for PACS1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PACS1 promoter
     Search Chromatin IP Primers for PACS1
     RT2 qPCR Primer Assay in human, mouse, rat PACS1
     GNC Network for PACS1
     SABiosciences Custom PCR Arrays for PACS1
     Search Tocris compounds for PACS1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PACS1 antibodies
     Search for Antibodies for PACS1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PACS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PACS1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PACS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACS1
     SwitchGear 3'UTR luciferase reporter plasmids for PACS1
     SwitchGear Promoter luciferase reporter plasmids for PACS1
     ThermoFisher Antibodies for PACS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACS1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PACS1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4