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PACS1 Gene

protein-coding GIFtS: 53

GC11P065595

phosphofurin acidic cluster sorting protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ10209 ^¹, ²
KIAA1175 ^¹, ², ³
PACS-1 ^³

Descriptions
cytosolic sorting protein PACS-1 ^²
phosphofurin acidic cluster sorting protein 1 ^²

External Ids
HGNC: 30032¹
Entrez Gene: 55690²
UniProtKB: Q6VY07³
Ensembl: ENSG00000175115⁷

Search outside databases for aliases for PACS1 gene

Previous GC identifers: GC11P067519 GC11P066088 GC11P065613

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PACS1:

This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN)

membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat

protein indicate a role in directing TGN localization of furin by binding to the protease's

phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated

downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune

surveillance. [provided by RefSeq]

UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07

Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane

proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of

furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic

domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated

membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN

Gene Wiki entry for PACS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PACS1 gene

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1-q13.2

PACS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P065595: (about GC identifiers)

Start:	65,594,400 bp from pter
End:	65,768,789 bp from pter
Size:	174,390 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07 (See protein sequence)

Recommended Name: Phosphofurin acidic cluster sorting protein 1

Size: 963 amino acids; 104898 Da

Subunit: Interacts with HIV-1 Nef, AP-1 and AP-3 but not with AP-2. Forms a ternary complex with

furin and AP-1. Combines with Nef to usurp the ARF6 endocytic pathway by a PI3K-dependent process

to remove cell surface MHC-I molecules

Subcellular location: Golgi apparatus, trans-Golgi network (By similarity). Note=Localizes in the

perinuclear region, probably the TGN (By similarity)

Secondary accessions: Q6PJY6 Q6PKB6 Q7Z590 Q7Z5W4 Q8N8K6 Q96MW0 Q9NW92 Q9ULP5

Alternative splicing: 2 isoforms: Q6VY07-1 Q6VY07-2

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060496.2

ENSEMBL proteins:

ENSP00000316454

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PACS1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--
GO:0005829	cytosol	EXP	15569716
GO:0030137	COPI-coated vesicle	IEA	--

About this table

Antibodies for PACS1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PACS1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PACS1)
	Search Novus for antibodies for PACS1

Assays for PACS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q6VY07

ProtoNet protein and cluster: Q6VY07

UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07

Similarity: Belongs to the PACS family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PACS1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018026

Applied Biosystems Silencer® siRNAs for PACS1

Sigma-Aldrich siRNA for PACS1

Sigma-Aldrich shRNA for PACS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PACS1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018026
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018026
untagged cDNA clones in CMV expression vector (see all 2): NM_018026

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018026

UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07

Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane

proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of

furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic

domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated

membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	10707087

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for PACS1

5/19 Interacting proteins for PACS1 (ENSP00000316454³ Q6VY07²) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GGA3	Q9NZ52²	STRING (score=.964) MINT-3372280 MINT-3372692 MINT-3372076 MINT-3372146 MINT-3372174
IGF2R	P11717²	STRING (score=.935) MINT-3372458 MINT-3372208
CSNK2A1P	P68400²	STRING (score=.925) MINT-3372672
CSNK2B	P67870²	MINT-3372585 MINT-3372614 MINT-3372643
ENSG00000206300	P67870²	MINT-3372585 MINT-3372614 MINT-3372643

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000042	protein targeting to Golgi	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PACS1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PACS1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018026

Sigma-Aldrich siRNA for PACS1

Sigma-Aldrich shRNA for PACS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018026

REFSEQ mRNAs for PACS1 gene:

NM_018026.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018026

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018026
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018026
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_018026

Additional cDNA sequence:

AB033001.1 AK001071.1 AK056361.1 AK096644.1 AK293966.1 AL137271.1 AY320283.1 BC003173.1

BC009936.1 BC010096.1 BC042909.1 BC052577.1 BC055288.1 CR608717.1 CR617326.1

22 DOTS entries:

DT.100806911 DT.317672 DT.95364091 DT.100650493 DT.100816207 DT.91700233 DT.120693861 DT.100697231

DT.100816203 DT.100816205 DT.439237 DT.75170033 DT.91980868 DT.100816202 DT.101971580 DT.120693960

DT.91979774 DT.95206307 DT.100816199 DT.100816200 DT.91821416 DT.95364094

24/367 AceView cDNA sequences (see all 367 ):

CN483113 BQ932365 AI298911 BU685782 BC052577 BQ772654 BU956895 CR617326

BQ670055 BF371511 AI052087 BQ052853 BM931039 NM_018026 T33490 Z40056

BM695954 AK056361 BU956502 AI590037 BM747618 BI335899 AA381307 BC042909

highest scoring ESTs for PACS1:

AA401796 AA040331 AA160898 AA253478 AA284913 AA284962 AA285084 AA285120 AA311047 AA405719

Unigene Cluster for PACS1:

Phosphofurin acidic cluster sorting protein 1

Hs.644326 [show with all ESTs]

Unigene Representative Sequence: NM_018026

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PACS1 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20a	·	20b	^	21	^	22a	·
SP1:															-														-																-						-
SP2:
SP3:
SP4:																																																			-
SP5:

ExUns:	22b	·	22c	·	22d	^	23	^	24a	·	24b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PACS1

1 Ensembl transcript including schematic representation:

ENST00000320580

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PACS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PACS1

¹ / ² / ³

5 probe-sets matching PACS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48875_at²^{, 3}	U95-C	2	1.00	0.97	1.00	1.00	AA401796	1.00	1.00	1.00	1
224658_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL530612	0.60	1.00	0.82	1
220557_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018026	0.60	1.00	0.82	1
224658_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220557_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGTCTGTGG

SOURCE GeneReport for Unigene cluster: Hs.644326

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PACS1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PACS1¹	--	phosphofurin acidic cluster sorting protein 1	92.34(n) 97.86(a)	483716 XM_540837.2 XP_540837.2
chimpanzee (Pan troglodytes)	PACS1¹	--	phosphofurin acidic cluster sorting protein 1	99.83(n) 99.9(a)	466669 XM_001170787.1 XP_001170787.1
cow (Bos taurus)	PACS1¹	--	phosphofurin acidic cluster sorting protein 1	91.93(n) 97.3(a)	514313 XM_592144.3 XP_592144.3
rat (Rattus norvegicus)	Pacs1¹	--	phosphofurin acidic cluster sorting protein 1	89.18(n) 97.81(a)	171444 NM_134406.1 NP_599233.1
mouse (Mus musculus)	Pacs1^{1, 5}	19⁵	phosphofurin acidic cluster sorting protein 1^{1, 5}	89.91(n)¹ 97.71(a)¹	107975¹ NM_153129.2¹ NP_694769.2¹ AI325977⁵ AI844597⁵ (see all 19)

About this table Species with no ortholog for PACS1

ENSEMBL Gene Tree for PACS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PACS1 gene

PACS2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/856 NCBI SNPs in PACS1 are shown (see all 856 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 227)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2298466^1,2	A,C,F,H	65767856(+)	`GCTTCT/CCAAGG`	1	--	ut3¹ ese³		7		EA MN EU WA	2252
	rs2254388^1,2	A	65594175(+)	`GCGCGC/TGCTGG`	1	--	ng5¹		0	--	--	--	--
--	rs11547809^1,2	C	65765564(+)	`GACAAG/TAGGGA`	1	K/N	mis¹ ese³		1		EA	172
	rs12577564^1,2	H	65754977(+)	`GGGCCA/TCAGCA`	1	H/L	mis¹ ese³		4		EU EA WA	418
	rs12798701^1,2	H	65740782(+)	`GAAGAA/GGACCC`	1	K/R	mis¹		4		EU EA WA	416
	rs12798852^1,2	H	65740750(+)	`TTGTTC/ATACGA`	1	L/F	mis¹ ese³		4		EU EA WA	406
	rs572697^1,2	F,H	65758246(+)	`GATTCT/AGGTTG`	1	S/S	syn¹ ese³		5		MN EU EA WA	604
	rs10437716^1,2	H	65756294(+)	`TCATTC/TTGGTG`	1	L/L	syn¹ ese³		4		EU EA WA	420
	rs527897^1,2	A,C,F,H,O	65657353(-)	`CTCTAC/TCTTGC`	1	--	int¹		13		MN EU EA WA NA	1236
	rs2293121^1,2	A,C,F,H,O	65717923(-)	`CTAGTA/CATTTC`	1	--	int¹		10		EA EU WA NA	2294

About this table

HapMap Linkage Disequilibrium images for PACS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607492

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/27 PubMed articles for PACS1 gene (see all 27 ):

AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1. (PubMed id 14608369)^{1, 2, 3} Hinners I....Tooze S.A. (2003)
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. (PubMed id 10707087)^{1, 3, 4} Piguet V....Trono D. (2000)
Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development. (PubMed id 12855553)^{1, 2, 3} Stove V....Verhasselt B. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. (PubMed id 12526811)^{3, 4} Blagoveshchenskaya A.D....Thomas G. (2002)
PACS-1 binding to adaptors is required for acidic cluster motif- mediated protein traffic. (PubMed id 11331585)^{3, 4} Crump C.M....Thomas G. (2001)
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{3, 4} Hirosawa M....Ohara O. (1999)
A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. (PubMed id 16977309)^{1, 3} Scott G.K....Thomas G. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55690	HGNC: 30032	AceView: PACS1	Ensembl:ENSG00000175115	euGenes: HUgn55690
ECgene: PACS1	H-InvDB: PACS1

(According to HUGE)
About This Section

HUGE: KIAA1175

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PACS1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PACS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PACS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PACS1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PACS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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PACS1 Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for PACS1

Summaries
for PACS1

Genomic Location
for PACS1

Proteins
for PACS1

Protein Domains/
Families
for PACS1

Gene Function
for PACS1

Pathways & Interactions
for PACS1

Drugs & Compounds
for PACS1

Transcripts
for PACS1

Expression
for PACS1

Orthologs
for PACS1

Paralogs
for PACS1

SNPs/Variants
for PACS1

Disorders & Mutations
for PACS1

Medical News
for PACS1

Publications
for PACS1

Search for PACS1

Genome Databases showing PACS1

Other Databases showing PACS1

Specialized Databases showing PACS1

Licensable Technologies
for PACS1

Services
for PACS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PACS1 Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor PACS1

Summariesfor PACS1

Genomic Locationfor PACS1

Proteinsfor PACS1

Protein Domains/Familiesfor PACS1

Gene Functionfor PACS1

Pathways & Interactionsfor PACS1

Drugs & Compoundsfor PACS1

Transcriptsfor PACS1

Expression for PACS1

Orthologsfor PACS1

Paralogsfor PACS1

SNPs/Variantsfor PACS1

Disorders & Mutationsfor PACS1

Medical Newsfor PACS1

Publicationsfor PACS1

Search for PACS1

Genome Databases showing PACS1

Other Databases showing PACS1

Specialized Databases showing PACS1

Licensable Technologiesfor PACS1

Servicesfor PACS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PACS1

Summaries
for PACS1

Genomic Location
for PACS1

Proteins
for PACS1

Protein Domains/
Families
for PACS1

Gene Function
for PACS1

Pathways & Interactions
for PACS1

Drugs & Compounds
for PACS1

Transcripts
for PACS1

Expression
for PACS1

Orthologs
for PACS1

Paralogs
for PACS1

SNPs/Variants
for PACS1

Disorders & Mutations
for PACS1

Medical News
for PACS1

Publications
for PACS1

Licensable Technologies
for PACS1

Services
for PACS1