PACS1 Gene
protein-coding GIFtS: 55
GCID: GC11P065837
|
|
phosphofurin acidic cluster sorting protein 1
| |
Aliases
for PACS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphofurin Acidic Cluster Sorting Protein 11 2 | | KIAA11751 3 | | PACS-12 3 | | FLJ102091 | | MRD172 | | Cytosolic Sorting Protein PACS-12 |
Export aliases for PACS1 gene to outside databasesPrevious GC identifers: GC11P067519 GC11P066088 GC11P065613 GC11P065595 GC11P062163 |
Summaries
for PACS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PACS1:
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins.Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGNlocalization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human proteinplays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1to escape immune surveillance. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that containacidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor byconnecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1(AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cellsurface to the TGN
Gene Wiki entry for PACS1
|
Genomic Views
for PACS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PACS1 gene promoter:
Max1 RFX1 AP-1 RREB-1 p300 ATF-2 Evi-1 FOXO4 c-Jun c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for PACS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PACS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1-q13.2 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1-q13.2PACS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P065837: view genomic region
(about GC identifiers)
Start:
|
65,837,824 bp from pter |
End:
|
66,012,218 bp from pter |
Size:
|
174,395 bases |
Orientation:
|
plus strand |
|
Proteins
for PACS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07 (See
protein sequence)Recommended Name: Phosphofurin acidic cluster sorting protein 1 Size: 963 amino acids; 104898 Da
Subunit: Interacts with HIV-1 Nef. Associates with AP-1 and AP-3 but not with AP-2 complexes. Interacts with NPHP1; theinteraction is dependent of NPHP1 phosphorylation by CK2
Subcellular location: Golgi apparatus, trans-Golgi network (By similarity). Note=Localizes in the perinuclear region,probably the TGN (By similarity)
Sequence caution: Sequence=AAH09936.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAB71164.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6PJY6 Q6PKB6 Q7Z590 Q7Z5W4 Q8N8K6 Q96MW0 Q9NW92 Q9ULP5Alternative splicing: 2 isoforms: Q6VY07-1 Q6VY07-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PACS1: NX_Q6VY07
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6VY07
PACS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060496.2
ENSEMBL proteins: ENSP00000316454 ENSP00000437150 ENSP00000432639 ENSP00000437274 ENSP00000435037 ENSP00000432858 ENSP00000437052 ENSP00000433991 ENSP00000434012 ENSP00000432365 Reactome Protein details: Q6VY07
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PACS1 for ontologies About GeneDecksing
PACS1 Antibody Products:
Assay Products for PACS1: |
Protein
Domains /
Families
for PACS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PACS1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6VY07ProtoNet protein and cluster: Q6VY07 UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07Similarity: Belongs to the PACS family |
Function
for PACS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PACS1_HUMAN, Q6VY07Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that containacidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor byconnecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1(AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cellsurface to the TGN
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PACS1 (NM_018026) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PACS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACS1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACS1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
PACS1 for ontologies About GeneDecksing
|
Pathways & Interactions
for PACS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | | | 2 | HIV Infection | | | 3 | Disease | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for PACS1 (see all 7)
PACS1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PACS1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/23 Interacting proteins for PACS1 (Q6VY072, 3 ENSP000003164544) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000042 | protein targeting to Golgi |
IEA | -- | | GO:0016032 | viral reproduction |
TAS | -- | | GO:0019048 | virus-host interaction |
IEA | -- | | GO:0032092 | positive regulation of protein binding |
-- | -- | | GO:0034613 | cellular protein localization |
-- | -- |
PACS1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PACS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PACS1
1 HMDB Compound for PACS1 About this table
Search CenterWatch for drugs/clinical trials and news about PACS1
|
Transcripts
for PACS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PACS1 gene: NM_018026.3 Unigene Cluster for PACS1: Phosphofurin acidic cluster sorting protein 1 Hs.644326 [show with all ESTs]Unigene Representative Sequence: NM_01802615 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000527224(uc001ogz.1) ENST00000320580(uc001oha.2 uc010rou.2)
ENST00000533756 ENST00000527380 ENST00000531298 ENST00000524784 ENST00000533811
ENST00000534273 ENST00000529757 ENST00000528935 ENST00000529795 ENST00000525798
ENST00000524815 ENST00000531597 ENST00000529677
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PACS1 (NM_018026) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PACS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACS1 |
Additional cDNA sequence: AB033001.1 AK001071.1 AK056361.1 AK096644.1 AK293966.1 AL137271.1 AY320283.1 BC003173.1 BC009936.1 BC010096.1 BC042909.1 BC052577.1 BC055288.1 22 DOTS entries: DT.100806911 DT.317672 DT.95364091 DT.100650493 DT.100816207 DT.120693861 DT.100697231 DT.100816203 DT.100816205 DT.439237 DT.75170033 DT.91980868 DT.100816200 DT.100816202 DT.101971580 DT.120693960 DT.91700233 DT.91979774 DT.95206307 DT.100816199 DT.91821416 DT.95364094 24/367 AceView cDNA sequences (see all 367): BC003173 BQ052853 AK098336 AL137271 BC042909 CF136871 NM_018026 T33490 BC010096 BU856845 BM993302 AL525662 BQ932365 AL120682 AI052087 BM927762 BC052577 BU729199 CN483113 BC009936 AI590037 BQ670055 BQ772654 BF371511
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PACS1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22b | · | 22c | · | 22d | ^ | 23 | ^ | 24a | · | 24b |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PACS1
|
Expression
for PACS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PACS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTCTGTGG
About this image
See PACS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PACS1
SOURCE GeneReport for Unigene cluster: Hs.644326
SABiosciences Custom PCR Arrays for PACS1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PACS1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PACS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PACS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PACS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACS1 |
Orthologs
for PACS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PACS1 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PACS11 |
phosphofurin acidic cluster sorting protein 1 |
64.53(n)
58.74(a) |
|
421254 XM_419325.3 XP_419325.3 |
lizard
(Anolis carolinensis) |
Reptilia |
PACS16 |
-- |
82(a) |
1 ↔ 1 |
GL343519.1(140611-194059) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CA986917.12 |
-- |
75.69(n) |
|
CA986917.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
pacs1a1 |
phosphofurin acidic cluster sorting protein 1a |
67.89(n)
69.62(a) |
|
569034 NM_001098748.1 NP_001092218.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
KrT95D6 |
Krueppel target at 95D |
26(a) |
1 → many |
3R(19824162-19857532) |
worm
(Caenorhabditis elegans) |
Secernentea |
tag-2321 |
Protein TAG-232 |
41.72(n)
31.98(a) |
|
179304 NM_072986.4 NP_505387.1 |
ENSEMBL Gene Tree for PACS1 (if available)
TreeFam Gene Tree for PACS1 (if available) |
Paralogs
for PACS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PACS1 gene
- PACS22
1 SIMAP similar gene for PACS1 using alignment to 11 protein entries: PACS1_HUMAN (see all proteins):PACS2
PACS1 for paralogs About GeneDecksing
|
Genomic Variants
for PACS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PACS1 (65837824 - 66012218 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for PACS1
7 CNVs: 85825 35002 37486 10365 65975 75681 48870
2 Indels: 48871 85824 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PACS1 |
|
Disorders
/ Diseases
for PACS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PACS1 for disorders About GeneDecksing
OMIM gene information: 607492
OMIM disorders: --
5  diseases for PACS1: About MalaCardscystic kidney cervical cancer cervicitis immunodeficiency
neuronitis
Human Genome Epidemiology (HuGE) Navigator: PACS1 (1 document)
Export disorders for PACS1 gene to outside databases
|
Publications
for PACS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PACS1 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with PACS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. (PubMed id 16308564)1, 2, 9 Schermer B....Benzing T. (2005)
- AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1. (PubMed id 14608369)1, 3, 9 Hinners I....Tooze S.A. (2003)
- HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. (PubMed id 10707087)1, 2, 9 Piguet V....Trono D. (2000)
- Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development. (PubMed id 12855553)1, 3, 9 Stove V....Verhasselt B. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. (PubMed id 12526811)1, 2 Blagoveshchenskaya A.D....Thomas G. (2002)
- PACS-1 binding to adaptors is required for acidic cluster motif- mediated protein traffic. (PubMed id 11331585)1, 2 Crump C.M....Thomas G. (2001)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. (PubMed id 16977309)1, 9 Scott G.K....Thomas G. (2006)
|
External Searches for PACS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PACS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PACS1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing PACS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PACS1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PACS1 gene:
Search GeneIP for patents involving PACS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PACS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PACS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PACS1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PACS1 | | OriGene 3'-UTR Clone for PACS1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PACS1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PACS1 | | OriGene Custom Protein Services for PACS1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PACS1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PACS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PACS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PACS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PACS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PACS1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for PACS1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | PACS1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACS1 |
|  |  |  | | | | ThermoFisher Antibodies for PACS1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACS1 |
|
|
|
|
